Subj : SpaceX Starship reaches orbit 🚀, DNA foundational models 🧬, curse of senior devs 👨‍💻 To : tldr@synchro.net From : TLDR Date : Fri Mar 15 2024 10:39 am --HD8p8Yrp Content-Type: text/plain; charset=utf-8 Content-Transfer-Encoding: quoted-printable SpaceX's Starship rocket flew halfway around the world yesterday=C2=A0=20 = Sign Up [1] | Advertise [2]|View Online [3]=20 =09=09TLDR=20 =09= =09TOGETHER WITH [https://arstechnica.com/space/2024/03/after-its-third-t= est-flight-spacexs-starship-could-soon-carry-satellites/] [4] TLDR 2= 024-03-15 WANT TO=C2=A0ADVERTISE=C2=A0IN=C2=A0TLDR? (SPONSOR) [5]=20 = Fortune 50 companies like AWS and Google Cloud as well as fast growin= g startups like Vercel and Secureframe work with=C2=A0TLDR=C2=A0to reach = our audience of over 4 million tech-savvy=C2=A0decision=C2=A0makers=C2= =A0with highly customized campaigns (like this one!). We help manage= your campaigns from end=C2=A0to end, ensuring that your performance mark= eting efforts hit your internal KPIs without breaking your budget.=C2= =A0Learn more about working with us [5]. =F0=9F=93=B1=20 BIG TECH &= STARTUPS SPACEX CELEBRATES MAJOR PROGRESS ON THE THIRD FLIGHT OF STA= RSHIP (7 MINUTE READ) [6]=20 SpaceX's Starship rocket flew halfway ar= ound the world yesterday, accomplishing a key demonstration of its abilit= y to carry heavy payloads into low-Earth orbit. The successful launch bui= lds on two previous flights last year. Thursday's flight tested Starship'= s payload bay door and performed a precursor test of an in-orbit refuel= ing system. Photos from the launch are available in the article. W= HO COULD BUY TIKTOK? THESE ARE THE PEOPLE WHO COULD ACQUIRE THE APP (7 MI= NUTE READ) [7]=20 ByteDance may have to sell TikTok in the US if a prop= osed bill passes the Senate. Some high-profile investors, including forme= r Treasury Secretary Steven Mnuchin, online video platform Rumble, and fo= rmer Activision Blizzard CEO Bobby Kotick, have expressed interest in a= cquiring the app. This article presents a list of known potential buyers = along with a primer on companies that have previously tried to purchase T= ikTok.=20 =F0=9F=9A=80=20 SCIENCE & FUTURISTIC TECHNOLOGY EVO: = DNA FOUNDATION MODELING FROM MOLECULAR TO GENOME SCALE (9 MINUTE READ) [8= ]=20 Evo is a long-context biological foundation model capable of both= prediction tasks and generative design, from molecular to whole genome= scale. The model generalizes across the fundamental languages of biolo= gy, DNA, RNA, and proteins to generate DNA sequences using a context leng= th of 131k tokens. It is based on StripedHyena, a deep signal processing = architecture designed to improve efficiency and quality over prevailing T= ransformer architecture. A playground is available where users can genera= te DNA in their browsers using Evo.=20 GENETICALLY MODIFIED COW MAKES M= ILK WITH HUMAN INSULIN (5 MINUTE READ) [9]=20 Researchers have engine= ered a cow capable of producing milk that contains human insulin. This co= uld result in an alternative for insulin production. The process involves= inserting human DNA coding for insulin into cow embryos. It could dramat= ically simplify the process and cost of producing the drug. A single cow = can produce enough milk every day to supply thousands of type 1 diabetes = patients with their daily insulin for an entire month. Scaling up product= ion, ensuring the health and welfare of the transgenic cows, and navigati= ng regulatory approvals are still huge challenges that lie ahead before= the process can replace conventional methods of insulin production.=20 = =F0=9F=92=BB=20 PROGRAMMING, DESIGN & DATA SCIENCE =F0=9F=94= =92 ENHANCE YOUR APPSEC: 5 STRATEGIC CHECKPOINTS! =F0=9F=94=8D (SPONSOR) = [10]=20 =F0=9F=9A=80 Prepare for ASPM implementation with SNYK'S CHEAT = SHEET 5 STRATEGIC SECURITY CHECKPOINTS! [10]Analyze app inventory, compli= ance, risks, vulnerabilities, and controls for a robust security program.= Don't leave your app vulnerable! =F0=9F=92=AA Download the Cheat Sheet [= 10]=20 FALSEHOODS PROGRAMMERS BELIEVE ABOUT TIME ZONES (10 MINUTE READ)= [11] Building a time zone conversion layer on top of a datetime l= ibrary sounds like an easy task, but it isn't. This article lists 21 mi= sconceptions about time zones the author had before attempting to write a= time zone conversion app as well as extra misconceptions from readers. T= hese misconceptions include thinking that there are more countries in the= world than time zones, that every time zone has exactly one agreed-upon = name, or that time zones are always offset from UTC by an integer number = of hours.=20 HTTP/2 AND HTTP/3 EXPLAINED (25 MINUTE READ) [12]=20 T= he first HTTP draft had only one method, GET - there were no headers or s= tatus codes, and the only data format available was HTML. The protocol ha= s evolved significantly since then. HTTP/3 is designed for unstable conne= ctions, resulting in performance tradeoffs. HTTP/2 offers better performa= nce on reliable and stable connections than HTTP/3. Servers can accept bo= th HTTP/2 and HTTP/3 connections so clients can make the decision of whic= h version to use.=20 =F0=9F=8E=81=20 MISCELLANEOUS THE TOP 100 = GEN AI CONSUMER APPS (11 MINUTE READ) [13]=20 AI-native products and co= mpanies are growing faster and engaging users more deeply than ever befor= e. Over the coming decade, AI will likely underpin category-defining comp= anies. This article examines data on the most popular generative AI produ= cts to uncover patterns on how consumers are using the technology. It loo= ks at the rate of progress in the industry, emerging categories, hot nich= es, the mobile vs web split, and AI as a global pursuit.=20 THE CURSE= OF THE SENIOR SOFTWARE ENGINEER (11 MINUTE READ) [14]=20 Titles help n= ormalize pay ranges and allow for progression and evaluation. People who = are not job hoppers or get stuck in the same company and title due to laz= iness, comfort, or other reasons are unfortunately prone to 'The Curse of= the Senior Software Engineer'. This is when an engineer who has been sen= ior for too long finds themselves between two worlds upon their next job = search: they are too senior to be hired as a senior or they have too litt= le leadership experience to be hired in a leadership position. Avoiding t= he curse involves either playing by corporate rules or exiting the game b= y switching to self-employment.=20 =E2=9A=A1=20 QUICK LINKS S= NAPCHAT WILL ALLOW USERS TO SAVE DMS (2 MINUTE READ) [15]=20 Snapchat i= s experimenting with an 'Infinite Retention Mode' that will allow users t= o save their direct messages.=20 AFTER AWS AND GOOGLE, MICROSOFT SAYS I= T=E2=80=99S REMOVING AZURE =E2=80=98EGRESS=E2=80=99 DATA TRANSFER FEES = =E2=80=94 BUT WITH CAVEATS (3 MINUTE READ) [16]=20 Microsoft will all= ow business customers to transfer data out of its Azure cloud infrastruct= ure with no egress fees to align with stipulations set out in the Europea= n Data Act, but only for customers looking to completely end their associ= ation with Azure.=20 THE MOST IMPORTANT SKILL IN STARTUP ENGINEERING LE= ADERSHIP (4 MINUTE READ) [17]=20 The singular skill that ultimately d= ecides the success of a leader and their team is pacing - leaders must be= in tune with their and their team's abilities and stamina.=20 THE FU= TURE OF FARCASTER WITH DAN ROMERO (22 MINUTE READ) [18]=20 Dan Romero, = the founder of Farcaster, a disruptive social network, talks in this inte= rview about competing directly against Elon Musk, nerd sniping, predictio= n markets, and new business models.=20 TO THE SPACE STATION (WEBSITE) [= 19]=20 This page explains SpaceX's Dragon's docking and reentry procedu= res.=20 DIGITAL FORGERIES ARE HARD (6 MINUTE READ) [20]=20 Expert w= itnesses on both sides of the case over whether Craig Wright is Satoshi N= akamoto agree that much of the digital evidence provided by Wright is unr= eliable in one way or another.=20 Love TLDR and want free stuff? = =F0=9F=8E=81 Share TLDR with your friends and get rewards when they s= ubscribe. Simply send them your referral link below!=20 https://refer= ..tldr.tech/1fd848fa/ [1]=20 =09=09 Earn a TLDR T-shirt =F0=9F=91=95, sli= des =F0=9F=A9=B4, or even an autobiography about your life! =F0=9F=A4= =AF [21]=20 Want more TLDR? We also write newsletters for Web Dev,= AI, Information Security, Product Management, DevOps, Founders, Design, = Marketing, and more!=20 SIGN UP NOW! [22]=20 Want to advertise in TLD= R? =F0=9F=93=B0 If your company is interested in reaching an audience= of tech executives, decision-makers and engineers, you may want to ADVER= TISE WITH US [23].=20 If you have any comments or feedback, just resp= ond to this email!=20 Thanks for reading,=20 Dan Ni [24] & Stephen Fland= ers [25]=20 If you don't want to receive future editions of TLDR, please= =C2=A0click here to unsubscribe [26].=20 =C2=A0=20 =20 Links: = ------ [1] https://refer.tldr.tech/1fd848fa/ [2] https://advertise.tldr= ..tech/?utm_source=3Dtldr&utm_medium=3Dnewsletter&utm_campaign=3Dadvertiseto= pnav [3] https://actions.tldrnewsletter.com/web-version?ep=3D1&lc=3Db5bb3= 9ac-a04f-11ee-8692-6388dbdd6fd1&p=3D07062272-e2a4-11ee-a59a-f5a3f84ab852&pt= =3Dcampaign&t=3D1710499170&s=3D02ce829bcdfd38a16647cdeef0caf6cd1c3abc0f5cf9= 43f048dcce76336acfbe [4] SpaceX%20celebrates%20major%20progress%20on%20th= e%20third%20flight%20of%20Starship%20(7%20minute%20read) [5] https://adve= rtise.tldr.tech/?utm_source=3Dtldr&utm_medium=3Dnewsletter&utm_campaign=3Dp= rimary03072024 [6] https://arstechnica.com/space/2024/03/after-its-third-= test-flight-spacexs-starship-could-soon-carry-satellites/?utm_source=3Dtldr= newsletter [7] https://www.nbcnews.com/tech/social-media/tiktok-ban-sale-= buy-bill-law-download-app-senate-date-rcna143413?utm_source=3Dtldrnewslette= r [8] https://arc-website-git-foundation-model-tool-arc-institute.vercel.= app/news/blog/evo?utm_source=3Dtldrnewsletter [9] https://www.zmescience.= com/medicine/cow-human-insulin/?utm_source=3Dtldrnewsletter [10] https://= go.snyk.io/aspm-evaluating-you-appsec-landscape.html?utm_campaign=3Ddm_pp-t= ldr_240315_con_240213_ad_aspm_evaluating_your_appsec_landscape&utm_medium= =3Dem-pa&utm_source=3Dtldr&utm_content=3Dcon_240213_ad_aspm_evaluating_your= _appsec_landscape [11] https://www.zainrizvi.io/blog/falsehoods-programme= rs-believe-about-time-zones/?utm_source=3Dtldrnewsletter [12] https://ale= xandrehtrb.github.io/posts/2024/03/http2-and-http3-explained/?utm_source=3D= tldrnewsletter [13] https://a16z.com/100-gen-ai-apps/?utm_source=3Dtldrne= wsletter [14] https://www.yieldcode.blog/post/the-curse-of-the-senior-eng= ineer/?utm_source=3Dtldrnewsletter [15] https://www.axios.com/2024/03/14/= snapchat-messages-disappear-save-imessage-whatsapp?utm_source=3Dtldrnewslet= ter [16] https://techcrunch.com/2024/03/14/after-aws-and-google-microsoft= -says-its-removing-azure-egress-data-transfer-fees-but-with-caveats/?utm_so= urce=3Dtldrnewsletter [17] https://danielmangum.com/posts/most-important-= skill-startup-engineering-leadership/?utm_source=3Dtldrnewsletter [18] ht= tps://www.generalist.com/briefing/the-future-of-farcaster-with-dan-romero?u= tm_source=3Dtldrnewsletter [19] https://www.spacex.com/launches/mission/?= missionId=3Dstarship-flight-3&utm_source=3Dtldrnewsletter [20] https://mj= g59.dreamwidth.org/69507.html?utm_source=3Dtldrnewsletter [21] https://hu= b.sparklp.co/sub_32edf8dd66ae/1 [22] https://tldr.tech/subscribed?email= =3Dtldr%40synchro.net [23] https://advertise.tldr.tech/?utm_source=3Dtldr= &utm_medium=3Dnewsletter&utm_campaign=3Dadvertisecta [24] https://twitter= ..com/tldrdan [25] https://twitter.com/SteveFlanders22 [26] https://acti= ons.tldrnewsletter.com/unsubscribe?ep=3D1&l=3Dcfa2d55a-b7be-11e8-a3c9-06b79= b628af2&lc=3Db5bb39ac-a04f-11ee-8692-6388dbdd6fd1&p=3D07062272-e2a4-11ee-a5= 9a-f5a3f84ab852&pt=3Dcampaign&pv=3D4&spa=3D1710496820&t=3D1710499170&s=3Dd0= 5fa4b68694388cb39d57082ddf19bb1a470969d9d32817c911a68c3650388a --HD8p8Yrp Content-Type: text/html; charset=utf-8 Content-Transfer-Encoding: quoted-printable
SpaceX's Starship rocket flew halfway around the world yesterday&nb= sp;

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Big Tech & Startups

SpaceX celebrates major pro= gress on the third flight of Starship (7 minute read)

SpaceX's Starship rocket flew halfway a= round the world yesterday, accomplishing a key demonstration of its ability= to carry heavy payloads into low-Earth orbit. The successful launch builds= on two previous flights last year. Thursday's flight tested Starship's pay= load bay door and performed a precursor test of an in-orbit refueling syste= m. Photos from the launch are available in the article.
Who could buy TikTok? These= are the people who could acquire the app (7 minute read)

ByteDance may have to sell TikTok in th= e US if a proposed bill passes the Senate. Some high-profile investors, inc= luding former Treasury Secretary Steven Mnuchin, online video platform Rumb= le, and former Activision Blizzard CEO Bobby Kotick, have expressed interes= t in acquiring the app. This article presents a list of known potential buy= ers along with a primer on companies that have previously tried to purchase= TikTok.
=F0=9F= =9A=80

Science & Futuristic Technology

Evo: DNA foundation modelin= g from molecular to genome scale (9 minute read)

Evo is a long-context biological founda= tion model capable of both prediction tasks and generative design, from mol= ecular to whole genome scale. The model generalizes across the fundamental = languages of biology, DNA, RNA, and proteins to generate DNA sequences usin= g a context length of 131k tokens. It is based on StripedHyena, a deep sign= al processing architecture designed to improve efficiency and quality over = prevailing Transformer architecture. A playground is available where users = can generate DNA in their browsers using Evo.
Genetically modified cow ma= kes milk with human insulin (5 minute read)

Researchers have engineered a cow capab= le of producing milk that contains human insulin. This could result in an a= lternative for insulin production. The process involves inserting human DNA= coding for insulin into cow embryos. It could dramatically simplify the pr= ocess and cost of producing the drug. A single cow can produce enough milk = every day to supply thousands of type 1 diabetes patients with their daily = insulin for an entire month. Scaling up production, ensuring the health and= welfare of the transgenic cows, and navigating regulatory approvals are st= ill huge challenges that lie ahead before the process can replace conventio= nal methods of insulin production.
=F0=9F= =92=BB

Programming, Design & Data Science

=F0=9F=94=92 Enhance Your A= ppSec: 5 Strategic Checkpoints! =F0=9F=94=8D (Sponsor)

=F0=9F=9A=80 Prepare for ASPM implement= ation with Snyk's cheat shee= t 5 Strategic Security Checkpoints! Analyze app invento= ry, compliance, risks, vulnerabilities, and controls for a robust security = program. Don't leave your app vulnerable! =F0=9F=92=AA Download the Cheat Sheet
Falsehoods programmers beli= eve about time zones (10 minute read)

Building a time zone conversion layer o= n top of a datetime library sounds like an easy task, but it isn't. This ar= ticle lists 21 misconceptions about time zones the author had before attemp= ting to write a time zone conversion app as well as extra misconceptions fr= om readers. These misconceptions include thinking that there are more count= ries in the world than time zones, that every time zone has exactly one agr= eed-upon name, or that time zones are always offset from UTC by an integer = number of hours.
HTTP/2 and HTTP/3 explained= (25 minute read)

The first HTTP draft had only one metho= d, GET - there were no headers or status codes, and the only data format av= ailable was HTML. The protocol has evolved significantly since then. HTTP/3= is designed for unstable connections, resulting in performance tradeoffs. = HTTP/2 offers better performance on reliable and stable connections than HT= TP/3. Servers can accept both HTTP/2 and HTTP/3 connections so clients can = make the decision of which version to use.
=F0=9F= =8E=81

Miscellaneous

<= /div>
The Top 100 Gen AI Consumer= Apps (11 minute read)

AI-native products and companies are gr= owing faster and engaging users more deeply than ever before. Over the comi= ng decade, AI will likely underpin category-defining companies. This articl= e examines data on the most popular generative AI products to uncover patte= rns on how consumers are using the technology. It looks at the rate of prog= ress in the industry, emerging categories, hot niches, the mobile vs web sp= lit, and AI as a global pursuit.
The Curse of the Senior Sof= tware Engineer (11 minute read)

Titles help normalize pay ranges and al= low for progression and evaluation. People who are not job hoppers or get s= tuck in the same company and title due to laziness, comfort, or other reaso= ns are unfortunately prone to 'The Curse of the Senior Software Engineer'. = This is when an engineer who has been senior for too long finds themselves = between two worlds upon their next job search: they are too senior to be hi= red as a senior or they have too little leadership experience to be hired i= n a leadership position. Avoiding the curse involves either playing by corp= orate rules or exiting the game by switching to self-employment.
=E2=9A= =A1

Quick Links

Snapchat will allow users t= o save DMs (2 minute read)

Snapchat is experimenting with an 'Infi= nite Retention Mode' that will allow users to save their direct messages.
After AWS and Google, Micro= soft says it=E2=80=99s removing Azure =E2=80=98egress=E2=80=99 data transfe= r fees =E2=80=94 but with caveats (3 minute read)

Microsoft will allow business customers= to transfer data out of its Azure cloud infrastructure with no egress fees= to align with stipulations set out in the European Data Act, but only for = customers looking to completely end their association with Azure.
The Most Important Skill in= Startup Engineering Leadership (4 minute read)

The singular skill that ultimately deci= des the success of a leader and their team is pacing - leaders must be in t= une with their and their team's abilities and stamina.
The Future of Farcaster wit= h Dan Romero (22 minute read)

Dan Romero, the founder of Farcaster, a= disruptive social network, talks in this interview about competing directl= y against Elon Musk, nerd sniping, prediction markets, and new business mod= els.
To The Space Station (Websi= te)

This page explains SpaceX's Dragon's do= cking and reentry procedures.
Digital forgeries are hard = (6 minute read)

Expert witnesses on both sides of the c= ase over whether Craig Wright is Satoshi Nakamoto agree that much of the di= gital evidence provided by Wright is unreliable in one way or another.

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Share TLDR with your friends and get rewards when they subscribe. Simply se= nd them your referral link below!
Earn a TLDR T-shirt =F0=9F=91=95, slides =F0=9F=A9=B4, = or even an autobiography about your life! =F0=9F=A4=AF

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We also write newsletters for Web Dev, AI, Information Security, Product Management, <= span>DevOps, Founders, Design, Marke= ting, and more!

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Want to advertise in TLDR? =F0=9F=93=B0

If your company is interested in reaching an audience of tech executives, d= ecision-makers and engineers, you may want to advertise with us.

If you have any comments or feedback, just respond to this email!

Thanks for reading,
Dan Ni &a= mp; Stephen = Flanders


If you don't want to receive fu= ture editions of TLDR, please click here to unsubscribe.

 
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