Recently I ran into an issue where a Creative Sound Blaster Audigy RX 7.1
PCI-e card would not work on an ASUS Prime X570-P motherboard. This is an
AMD Ryzen CPU motherboard with the X570 chipset with MS Windows 10 (gasp).
We tried every slot to no avail. Searching the UEFI BIOS proved fruitless.
Bad audio card? A quick online search should a number of issue getting the
Audigy R and Z series cards operational in both Win10 and Linux on newer
AMD motherboards. Rather than disable secure boot etc so that I could boot
my trusty Slackware Live USB stick, I moved the card to the the Gigabyte
X570 Aorus running Slackware64. The card worked! So what was the
difference?
(n.b.: Win10 and it's secure boot was installed on this PC over my objections)

My Gigabyte X570 is using a Creative Sound Blaster Audigy Z that worked
out-of-the-box. A bit more searching suggested that there my be a
motherboard firmware issue. I had recently upgraded the Gigabyte board's
firmware recently for various Rysen CPU and DDR4 memory updates. A quick
download from the Asus support site and the BIOS was updated from 2019
vintage to 2021. After the update, Win10 detected the Audigy RX, and we
could install the drivers.

Note 1:
Gigabyte provides a dedicated USB port that makes firmware updates easy.
Just download onto a USB stick and reboot into the UEFI Setup. Asus, however,
provides a Windows executable archive and a file renaming utility before
the UEFI setup can read the firmware from a USB stick. Idiocy.

Note 2:
I though this was a quirk of the Gigabyte motherboards, but the Asus did
this as well. When you upgrade the new X570 firmware (a) won't or load saved
settings form an older version, and (b) erases the EFI boot table with the
result that the motherboard reports no boot devices found. Make sure you
have USB or DVD boot media available to repair! I'm not sure about the
secure boot keys (I don't use them). I recommend leaving secure boot off
to be able to boot diagnostic OS other than Win10.