(DIR) Home Systemic antibiotics in first year of life tied to higher atopic dermatitis risk (HTM) Source ---------------------------------------------------------------------- by Lori Solomon Systemic antibiotic exposure in the first year of life is associated with higher atopic dermatitis (AD) risk in a dose-response fashion, according to a study published online April 24 in the _Journal of Allergy and Clinical Immunology_. Courtney Hoskinson, from the University of British Columbia in Vancouver, Canada, and colleagues examined the timing and specific factors mediating the relationship among systemic (oral or intravenous) antibiotic usage, the gut microbiome, and AD. The researchers found that systemic antibiotics during the first year of life, as compared with later, were associated with AD risk (adjusted odds ratio, 1.81), with an increased number of antibiotic courses corresponding to a dose-response increased risk for AD (adjusted odds ratios, 1.67 and 2.16 for one and two or more courses, respectively). Microbiome alterations associated with both AD and systemic antibiotic usage fully mediate the effect of antibiotic usage on the development of AD. Among participants who would later develop AD, alterations in the one-year infant gut microbiome included increased _Tyzzerella_ nexilis, increased monosaccharide utilization, and parallel decreased Bifidobacterium, Eubacterium _spp_., and fermentative pathways. "Our findings indicate that early-life antibiotic usage, especially in the first year of life, modulates key gut microbiome components that may be used as markers to predict and possibly prevent the development of AD," the authors write. **More information:** Courtney Hoskinson et al, Antibiotics within first year are linked to infant gut microbiome disruption and elevated atopic dermatitis risk, _Journal of Allergy and Clinical Immunology_ (2024). DOI: 10.1016/j.jaci.2024.03.025 Copyright © 2024 HealthDay. All rights reserved. **Citation** : Systemic antibiotics in first year of life tied to higher atopic dermatitis risk (2024, May 8) retrieved 31 May 2024 from https://medicalxpress.com/news/2024-05-antibiotics-year-life-higher- atopic.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. ______________________________________________________________________ Served by Flask-Gopher/2.2.1