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       Systemic antibiotics in first year of life tied to higher atopic
       dermatitis risk
        
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       by Lori Solomon
        
       Systemic antibiotic exposure in the first year of life is associated
       with higher atopic dermatitis (AD) risk in a dose-response fashion,
       according to a study published online April 24 in the _Journal of
       Allergy and Clinical Immunology_.
        
       Courtney Hoskinson, from the University of British Columbia in
       Vancouver, Canada, and colleagues examined the timing and specific
       factors mediating the relationship among systemic (oral or
       intravenous) antibiotic usage, the gut microbiome, and AD.
        
       The researchers found that systemic antibiotics during the first year
       of life, as compared with later, were associated with AD risk
       (adjusted odds ratio, 1.81), with an increased number of antibiotic
       courses corresponding to a dose-response increased risk for AD
       (adjusted odds ratios, 1.67 and 2.16 for one and two or more courses,
       respectively).
        
       Microbiome alterations associated with both AD and systemic antibiotic
       usage fully mediate the effect of antibiotic usage on the development
       of AD. Among participants who would later develop AD, alterations in
       the one-year infant gut microbiome included increased _Tyzzerella_
       nexilis, increased monosaccharide utilization, and parallel decreased
       Bifidobacterium, Eubacterium _spp_., and fermentative pathways.
        
       "Our findings indicate that early-life antibiotic usage, especially in
       the first year of life, modulates key gut microbiome components that
       may be used as markers to predict and possibly prevent the development
       of AD," the authors write.
        
       **More information:** Courtney Hoskinson et al, Antibiotics within
       first year are linked to infant gut microbiome disruption and elevated
       atopic dermatitis risk, _Journal of Allergy and Clinical Immunology_
       (2024). DOI: 10.1016/j.jaci.2024.03.025
        
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       **Citation** : Systemic antibiotics in first year of life tied to
       higher atopic dermatitis risk (2024, May 8) retrieved 31 May 2024 from
       https://medicalxpress.com/news/2024-05-antibiotics-year-life-higher-
       atopic.html
        
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