[HN Gopher] The most important scientific problems have yet to b...
       ___________________________________________________________________
        
       The most important scientific problems have yet to be solved (1897)
        
       Author : anarbadalov
       Score  : 133 points
       Date   : 2020-01-08 19:10 UTC (3 hours ago)
        
 (HTM) web link (thereader.mitpress.mit.edu)
 (TXT) w3m dump (thereader.mitpress.mit.edu)
        
       | [deleted]
        
       | yters wrote:
       | Most of reality is inexplicable according to modern science. So,
       | there are probably vast quantities of discoveries to still be
       | made.
        
       | scottlocklin wrote:
       | One of the great Spanish thinkers, criminally underrated in Anglo
       | countries.
       | 
       | https://en.wikipedia.org/wiki/Santiago_Ram%C3%B3n_y_Cajal
        
         | enriquto wrote:
         | I'd rather say he's criminally underrated in Spain.
         | 
         | It is definitely easier to hear casually about Ramon y Cajal in
         | "anglo countries" than in Spain. For example, I have spent my
         | childhood in the spanish state, and I first heard about Ramon y
         | Cajal during the first conference that I attended, in
         | Switzerland, from a lovely presentation by an English
         | professor.
         | 
         | One of the dramatically few spanish first-rate scientists, and
         | he's not a household name. Very, very sad state of affairs.
        
           | scottlocklin wrote:
           | I learned about him talking to a Spanish plumber while eating
           | a bocadillo.
        
           | iagovar wrote:
           | I'd say he's pretty well known in Spain. I knew about him
           | from school, so maybe your school didn't teach you about him
           | or you didn't pay attention.
           | 
           | I studied first in Madrid and later in Galicia.
        
           | yiyus wrote:
           | I do not know what you are talking about. We study Ramon y
           | Cajal in school, the most important grants in Spain are named
           | after him, there is a Ramon y Cajal square or street in every
           | city... Even the most ignorant Spaniard knows him and will
           | tell you that he is our most respected scientist from all
           | time.
           | 
           | Science, in general, is criminally underrated in Spain, but
           | Ramon y Cajal is literally the household name.
        
         | buboard wrote:
         | He s known as the father of Neuroscience, i don't think he s
         | underrated
        
       | luhn wrote:
       | (1897)
       | 
       | An excerpt from _Advice for a Young Investigator_.
       | https://www.goodreads.com/book/show/437689.Advice_for_a_Youn...
        
       | breck wrote:
       | Impressive how timeless this is.
       | 
       | I would say the great problem of science right now is integrating
       | all of the knowledge there is.
       | 
       | It's time scientists stopped publishing dumb weakly connected
       | PDFs, and start switching to a GitHub like pull request model.
       | 
       | We could build a single strongly typed peer-reviewed repo of all
       | of the world's scientific information, complete with definitions,
       | experiment protocols and data, and make it universally
       | downloadable and usable by all.
        
         | walleeee wrote:
         | I think you're describing something like a hybrid social
         | network/semantic web with versioning, knowledge provenance, and
         | asynchronous peer review.
         | 
         | One serious problem for any such system is ontology selection:
         | how is one to represent the entire body of scientific knowledge
         | under a single type system? Different fields of inquiry make
         | use of extremely diverse conceptual models. I suppose
         | mathematics are in a way a unifying language, but there's
         | hardly a single homogeneous mathematical discipline.
         | 
         | The present "weakly" connected network has almost zero
         | technical barriers to entry. It uses well-established
         | technology within a well-established workflow, and it offloads
         | the hard, fuzzy work (e.g., all the model-binding that would
         | presumably take place in the proposed system) to the most
         | flexible computing device we know of: the brain. Everything is
         | already freely downloadable/usable, for the most part (lots of
         | research is open access, and what isn't can often be obtained
         | from the investigators by request).
         | 
         | That said, maybe the sort of thing you describe could be
         | translated into a research question. One could try to compare
         | the shape of various data under different encodings, for
         | instance (some sort of topological analysis?) to identify
         | similar structure? I think category theory has been used to
         | unify previously disparate regions of mathematics.
         | 
         | There are already a few entries in the social network/resource-
         | sharing platform space. Have a look at Open Science Foundation.
         | Academia and ResearchGate are similar, but without the
         | materials-and-data-sharing.
        
         | yiyus wrote:
         | Having such a repo would be great, but IMO we'd still need
         | those dumb PDFs.
        
           | breck wrote:
           | Okay okay you can still have your PDFs, but only after you
           | submit your pull requests.
        
         | hyperbovine wrote:
         | Ah yes, the old everything-is-broken-and-software-engineering-
         | has-all-the-answers trope.
        
           | breck wrote:
           | Sometimes things do.
        
         | cs02rm0 wrote:
         | Wikipedia?
        
         | at_a_remove wrote:
         | I am attempting to imagine the horror of wading through all of
         | the pull requests received by, say, the physics department.
         | Requests were awful enough when postage stamps were required.
         | 
         | You underestimate the number of cranks who have "great ideas"
         | and "just need someone else to work out the math."
        
           | throwaway_tech wrote:
           | >You underestimate the number of cranks who have "great
           | ideas" and "just need someone else to work out the math."
           | 
           | You're not wrong, but, it is important to note there also
           | isn't a shortage of great physicist who "just need someone
           | else to work out the math."
           | 
           | For example in 1846, Faraday proposed that visible light is a
           | form of electromagnetic radiation. But because he couldn't
           | back up the idea with mathematics, his colleagues ignored it.
           | It took 18 years for Maxwell to come along and prove it.
           | 
           | This sentiment about math is so cringe, because it is the
           | same type of prejudice of social class that Faraday himself
           | fought against his whole life being the son of a poor smith.
           | Not to mention physicists such as Carl Sagen, generally held
           | in high esteem within the physics community, always preached
           | of an eventual point in physics that transcends math (i.e.
           | something more fundamental and basic) to describe the
           | universe.
        
             | at_a_remove wrote:
             | It isn't prejudice, or classism, or any -ism, it pure
             | numbers. We have billions of people who have ideas about
             | how the world works and a much smaller number of people who
             | can work to disprove those ideas.
             | 
             | Camp out in an IRC channel like #physics on any network and
             | prepare to be bombarded by idea people who just want
             | someone else to do the heavy lifting, from math to the
             | experiments. And woe betide those who want to say "by the
             | way, your idea leads to perpetual motion/faster-than-light
             | travel, so I will not bother." I personally have
             | experienced _soul-crushing_ numbers of philosophers who
             | happen to think they 've disproven special relativity who
             | are also under the impression that the Michelson-Morley
             | experiment was performed precisely once and everyone just
             | sort of ... ran with it, never looking back.
             | 
             | Who has time to weed through this sort of thing? It isn't
             | ideas that physicists lack for, not in the least.
        
               | throwaway_tech wrote:
               | >We have billions of people who have ideas about how the
               | world works and a much smaller number of people who can
               | work to disprove those ideas.
               | 
               | Like I said you aren't wrong...its just important to
               | note, that some of the best minds in physics didn't have
               | the math chops to prove their ideas. But if we ask why
               | there are so many more people with ideas of how the world
               | works and such a small number that can validate/disprove
               | them speaks directly to classism. Being able to
               | prove/disprove physics theories is generally, going to
               | require a significant investment in education from early
               | childhood that has been, and still is, out of reach for
               | most. Its not a lack of intellect or talent, but lack of
               | investment across the board.
               | 
               | In other words until the ideas are disproven you
               | shouldn't call them a cranks simply on the basis they
               | don't have the math chops to prove their own theories.
               | 
               | >Camp out in an IRC channel like #physics on any network
               | and prepare to be bombarded by idea people who just want
               | someone else to do the heavy lifting, from math to the
               | experiments.
               | 
               | Seems to be a pretty efficient strategy. The entire point
               | of this website is to support a similar model where YC is
               | bombarded by investors who want someone else to do the
               | heavy lifting, and business and make the returns.
        
               | at_a_remove wrote:
               | No, it is not classism, it is finiteness of resources.
               | The constraining factor is the number of experiments we
               | can perform based on what we have. Those accelerators do
               | not just whiff themselves into existence as fast as
               | people have ideas. We could wave our CRISPR wand and
               | produce an army of geniuses, we would still need those
               | experimental setups to test out the ideas, and those
               | costs both money and time.
               | 
               | Cranks are cranks. I will most definitely call them that
               | and continue to do so. I no longer camp out like that
               | because I could not bear it any longer. If you would like
               | to spend your life attempting to work out the particulars
               | of some FTL drive that supposedly works by repeatedly
               | raising magnets above the Curie temperature and then
               | lowering them back under it, have at it. Fire up IRC. I
               | suspect you will spend much time laboring to support the
               | ideas of cranks because it simply is not a good use of
               | your time. It was a good use not of my time, either.
               | 
               | That's all it is -- efficient allocation of limited
               | resources. My time, your time, someone else's time. How
               | are these decisions made? How do we decide which of the
               | ideas do we examine first?
               | 
               | If it is "possible greatest payout," then we would spend
               | all of our collective time on perpetual motion devices.
               | They would, after all, be the greatest payout. And yet
               | the patent office won't even look at them.
               | 
               | No, our first filter is: can this be tested? And to test,
               | we must measure. To measure, we must calculate. And there
               | is our math.
               | 
               | Good ideas will bubble up from the bottom, and more than
               | one person will have a good idea. If one of those people
               | does not have the math and another does, then science
               | will eventually get around to the person who has the
               | math.
               | 
               | What's _your_ algorithm for deciding whose ideas get
               | worked on? I bet that it has some kind of criteria
               | attached to it. I doubt you are suggesting selecting
               | humans from across the planet purely at random and asking
               | for their scientific ideas.
               | 
               | Simply put, this is the scientific method. Make a new,
               | better scientific method if you have a better (by whose
               | standards?) algorithm for deciding whose ideas are worth
               | examining first.
        
       | raymondrussell wrote:
       | Ramon Y Cajal was a contrarian when this was written, but he had
       | great timing. In the late 19th century, it was fairly popular to
       | believe that all the laws of physics had already been established
       | --remaining progress would come from improvements in experimental
       | methods. There's a famous "physics is over" quote misattributed
       | to Lord Kelvin (actually said by Michelson, the guy who measured
       | the speed of light).
       | 
       | A few years after this was written, Planck proposed energy
       | quanta. And in 1905, Einstein published his four Annus Mirabilis
       | papers, introducing the photoelectric effect (applying quantum),
       | special relativity, and the mass-energy relationship.
        
         | DevX101 wrote:
         | Thanks for the context. Thought that this was contemporary. The
         | language did seem antiquated.
        
         | dekhn wrote:
         | This book tries to argue that we've got as close to objective
         | truth about the universe as we'll ever do:
         | 
         | https://www.amazon.com/End-Science-Knowledge-Twilight-Scient...
         | 
         | and that most remaining science is just find of filling in the
         | tiny bits.
         | 
         | I personally don't expect anything that will change with
         | respect to backwards time travel or faster than light travel.
        
           | ivalm wrote:
           | And like all such books, almost certainly it is wrong.
           | 
           | Backwards time travel or FTL are not measure of progress.
           | Even with the field of "fundamental" physics:
           | 
           | 1. There are lots of things we do not understand in cosmology
           | (cosmological constant, nature of dark matter,
           | matter/antimatter asymmetry, force unification at very high
           | energy scales, gravity at high energies, etc). Each of those
           | could potentially revolutionize our understanding of the
           | universe
           | 
           | 2. There are lots of things we do not understand at small
           | scales (Casimir effect/vacuum energy relationship, plank
           | scale effects, why the particle soup, gravity on very small
           | scale, reason behind asymmetry in helicity/weak interaction
           | and other parity/symmetry related effects, doing "useful"
           | calculation with renormalization group, etc). Each of those
           | could potentially revolutionize our understanding of the
           | universe.
           | 
           | There is also a lot to be done in our understanding of
           | computing (as in, nature of computation)
           | 
           | 1. Computation related problems (Church-Turing thesis, novel
           | algorithmics + computing platforms such as quantum
           | computing). Is approximately correct/probabilistic computing
           | a loophole for getting essentially/mostly correct results in
           | P time for NP-hard problems? Nature of AGI/what enables
           | sapience when doing computing.
           | 
           | Of course as we go into "less fundamental" sciences like
           | chemistry/biology/etc then the amount to be learned is just
           | overwhelming, we truly know very little.
        
             | HenryKissinger wrote:
             | The difference between the problems physicists were
             | tackling at the turn of the 20th century and the ones we're
             | trying to tackle today is that we don't have the technology
             | or the resources required to build the kind of experiments
             | that would allow us to study these phenomena at a
             | meaningful scale and test out our hypotheses.
             | 
             | E.g. https://gizmodo.com/we-could-solve-the-mysteries-of-
             | time-and...
             | 
             | "We Could Solve the Mysteries of Time and Space--If We Had
             | a Particle Accelerator the Size of the Solar System"
             | 
             | That's the problem. Our collective civilization will need
             | to move a few levels forward before we can afford to tackle
             | these problems.
        
               | cosmodisk wrote:
               | But the same was 100,200,300 and so years ago. Thete were
               | always some sort of limitations, mostly technological.
               | I'm not saying that we'll build solar system size
               | colliders any time soon, however 50-100 more years and we
               | should be much much more sophisticated in terms of what
               | we can do in space and back on the earth.
        
               | Koshkin wrote:
               | Linear extrapolation is not always adequate. I tend to
               | agree with GP that we may be close to a saturation point.
        
               | ivalm wrote:
               | This is not clear to me at all. I don't think "bigger
               | particle accelerators" is what we need, and lots of the
               | questions I posted are not necessarily solvable by
               | particle accelerators. We do need new experiments, but
               | probably in a sense of "new ways to observe the universe"
               | rather than "old ways to observe the universe scaled
               | bigger."
        
             | earlINmeyerkeg wrote:
             | I personally believe a lot of that stuff cannot be further
             | studied unless we are able to divert solutions to other
             | problems in our society first. I'm saying that we need to
             | have things like mass quantity sustainable energy,
             | significant automation, global unification and standards,
             | higher minimum education levels.
             | 
             | I'm saying that imagine 50% of the population works in blue
             | collar general labor or semi-skilled labor fields. Now in
             | this hypothetical worlds, all those jobs are managed by
             | autonomous robots. Also we have a green power that is
             | sustainable, storable, sufficient for even double the
             | population, and can be held in high densities at low
             | volumes. So there are now innumerable sectors within the
             | economy that we don't need people themselves to learn. That
             | leaves more time for people to take extended amounts of
             | time to learn and study. I mean quite literally a Star-Trek
             | "post-scaricity world" in a lot of ways. People use time to
             | further themselves and expend time on cultural or
             | scientific endeavors. Life is no longer about struggle and
             | survival since money clearly would have no value if any and
             | everything can be made or consumed for free. I mean it's
             | really interesting to think that the only "conflict" that
             | would exist is between people trying to min-max life in
             | terms of achievement. There would be no achievement in
             | religion, money, or ownership since everybody can do it.
             | 
             | Ultimately what I'm saying is that a lot of our advances
             | are contingent upon other sectors becoming automated and
             | allow for more people to get into academic sectors.
        
           | AareyBaba wrote:
           | The origin of life, why life is evolvable, the evolution of
           | the complexity in a eukaryote cell, and multicellular
           | consciousness/intelligence are to me big unanswered questions
           | in science.
           | 
           | Although, life can be reduced to chemistry and chemistry to
           | physics I feel we are missing some high-level self-organizing
           | principle of the universe.
        
             | ggggtez wrote:
             | >why life is evolvable
             | 
             | Sorry, could you explain why you think life _is not
             | evolvable_ exactly? Assuming you take the existence of a
             | single celled organism with DNA as a given (we still don 't
             | know the origin of life), evolution gets you the rest of
             | the way rather nicely. Notably, "life" usually contains the
             | assumption that it is evolvable as part of the definition.
             | If the children of the organism can't adapt to the
             | environment, we don't consider those things to be "alive"
             | (e.g. a 3d printer that can print a copy of itself isn't
             | _alive_ ).
             | 
             | As for the origin of life, all serious scientists are
             | onboard with abiogenesis, though we don't know the
             | mechanism. Every year, new science comes out showing how
             | microfluid droplets with organic compounds + the natural
             | environment, can result in behavior that looks similar to a
             | cell.
             | 
             | For example, this one shows fairly interesting "cell like"
             | movement without any life, and there was another last year
             | that proposed a possible abiogenesis of cell walls through
             | evaporation and organic compounds that suck up large
             | molecules into the interior when evaporated.
             | 
             | https://qz.com/487712/why-these-colored-water-droplets-
             | seem-...
        
               | AareyBaba wrote:
               | We know that life is evolvable because life exists and we
               | know the biochemical mechanisms involved (DNA + cellular
               | biochemistry).
               | 
               | Evolution implies a relatively smooth path through "DNA
               | space" from, say for example, an early single cell
               | eukaryote to a mushroom. However the search space is
               | enormous. Even if we account for billions of years of
               | evolution and a trillions of evolutionary experiments
               | each year, a simple random walk with selection through
               | DNA space should go nowhere because of the numbers
               | involved. The curse of dimensionality[0] means there has
               | to be some other principle of nature to make the search
               | space yield a path from one viable life form to another.
               | The search space of life would have to be 'smooth' in
               | some sense. That 'smoothness' is something we don't
               | understand.
               | 
               | If DNA space is just 256 bits (as a dramatic
               | simplification), then 2^256 is a very very big space to
               | search just by chance [1]. Now imagine a space orders of
               | magnitude bigger.
               | 
               | [0] https://en.wikipedia.org/wiki/Curse_of_dimensionality
               | 
               | [1] https://youtu.be/S9JGmA5_unY?t=22 (3Blue1Browns
               | wonderful illustration of how large 2^256 is)
        
           | ggggtez wrote:
           | Physics might be bumping up against limits of knowledge, but
           | I think it's quite short sighted to claim that this means all
           | of Science is bumping up against fundamental limits.
           | 
           | Just because many of the questions we want to solve today are
           | of practical significance (inventing new medicines, perhaps)
           | doesn't make it any less scientific.
           | 
           | Indeed, almost 20 years after the Human Genome Project, we
           | have only scratched the surface on how to understand what any
           | particular genes are doing, and are very far from doing
           | anything more than "hacking" on existing genes, let alone
           | writing a biological program from the ground up.
        
           | LiquidSky wrote:
           | This seems like the kind of thing people a hundred years from
           | now will point at and laugh about how quaint our time was.
        
           | whatshisface wrote:
           | Why are time machines and Starship Enterprises a good
           | standard of scientific progress? Why not immorality, sentient
           | computers, and stuff like that, which is equally science-
           | fictiony but possible?
        
             | dekhn wrote:
             | I just said time machines and faster than light travel are
             | unlikely to ever occur; I do think life extension and AGI
             | are not technically impossible, but rather inevitable (my
             | training is in biology, and I work on machine learning).
             | 
             | For the first two, we'd need to have a radically different
             | physics than the current model, while the last two, they
             | seem like reasonable extrapolations from modern technology.
        
               | whatshisface wrote:
               | A radically different paradigm of physics would result in
               | technologies that can't be imagined in the present
               | paradigm of physics. For example nobody had even remotely
               | guessed that transistors were possible until well in to
               | the development of solid state theory.
        
               | dekhn wrote:
               | we have plenty of unrealized technologies that can be
               | imagined in the present paradigm but that we're not
               | exploiting yet (see for example recent advances in 2D
               | topological materials).
               | 
               | (based on my understanding of transistors, the first ones
               | were conceived before the theory for them existed, and
               | the first ones were built around the same time the
               | quantum theory for them was expressed).
        
               | nostrademons wrote:
               | The nature of a paradigm shift is that it recasts all the
               | existing laws of nature as special cases of a more
               | powerful, more general model of reality.
               | 
               | Who knows, maybe we'll find that we actually are living
               | in a simulation and then figure out how to hack the
               | matrix. The idea of "travel" and "time" would become
               | obsolete then; you'd just poke new values for your wave
               | function into the simulation's RAM.
        
               | dekhn wrote:
               | This seems implausible for many reasons, it seems more
               | likely that if we're living in a simulation, we'll have
               | trouble figuring out how to proloxify the feeblegarps.
        
             | whack wrote:
             | "Immorality" is not only theoretically possible, it has
             | been thoroughly mastered by many ;)
             | 
             | I think there's a noteworthy distinction between science
             | and its applications. In my mind, science is about
             | understanding the world, whereas fields like
             | engineering/medicine are about their practical
             | applications.
             | 
             | I do think that there's a tremendous amount of progress
             | that could be made in sciences like Biology, Psychology
             | etc. But I would draw a distinction between the things that
             | fundamentally change the way we understand the world, vs
             | building really cool toys that we would love to have.
        
               | dekhn wrote:
               | I think the point of the "End of Science" argument is
               | that any discoveries in biology (and physics) will merely
               | be elaborations of basic principles that already exist,
               | rather than elucidations of any as-yet undiscovered
               | principles.
               | 
               | For example, CRISPR. Many people think that CRISPR was an
               | amazing discovery, but really, it's just a biological
               | system that has existed for a long, long time, where a
               | collection of smart people realized that with some
               | engineering it could be used for effective genetic
               | modifications with high precision and no need for
               | engineering custom proteins to bind specific sequences.
               | That seems fundamentally different from, for example, the
               | experiments that established that DNA is the molecule of
               | heredity when nobody had an idea how DNA could encode
               | information.
        
               | epistasis wrote:
               | DNA as the molecule of encoding information for heredity
               | is also "merely" a discovery of an ancient biological
               | system. However, it's not as though physics predicts the
               | existence of DNA specifically, or CRISPR, yet these
               | things are important for understanding biology, and in
               | the case of CRISPR it's been turned into a technology
               | that humans can use. Which is why I have a lot of
               | complaints about the commonly held belief such as this
               | one:
               | 
               | > merely be elaborations of basic principles that already
               | exist, rather than elucidations of any as-yet
               | undiscovered principles.
               | 
               | This is not a meaningful or thoughtful examination of
               | even chemistry. 3D structure of proteins is "merely" an
               | elaboration of physical properties, yet "physics" doesn't
               | have the tools to make much progress on solving the 3D
               | structure of a sequence of amino acids, despite it being
               | a purely physics process.
               | 
               | Is the world "physical" in the sense that probably don't
               | have new fundamental forces of nature? Of course. That
               | doesn't mean that physics helps understand much of the
               | physical world, because the "elaboration" in the "merely
               | elaboration" has nothing to do what physicists or other
               | scientists consider "physics."
        
               | charlieflowers wrote:
               | > "Immorality" is not only theoretically possible, it has
               | been thoroughly mastered by many ;)
               | 
               | Well done!
        
               | izzydata wrote:
               | Apparently it was the first thing humankind mastered.
        
               | ggggtez wrote:
               | Obviously, we are discussing immortality of non-human
               | species.
               | 
               | However, we more or less understand that morality of
               | larger lifeforms is encoded in our DNA (e.g. telemers).
               | Mortality seems to be a defense against cancer.
               | 
               | There is no particular reason that a human _needs_ to
               | grow old, except for the accidents of evolution.
        
               | baddox wrote:
               | > But I would draw a distinction between the things that
               | fundamentally change the way we understand the world, vs
               | building really cool toys that we would love to have.
               | 
               | It may very well be that understanding emergent
               | phenomenon at the appropriate level of emergence will
               | turn out to be vitally important, and that reductionism
               | (while undoubtedly useful in many scenarios) is impeding
               | our understanding of emergent phenomena like
               | consciousness and evolution.
        
             | gmuslera wrote:
             | You don't send a message if the receiver can't understand
             | it.
             | 
             | People need to have a point of contact with that
             | extrapolated future to became a popular science fiction
             | work, even the culture in the far future fiction is usually
             | pretty similar to our own (or at least, the one of the
             | moment where that book was written).
             | 
             | Present works (not the ones with inherited universes from
             | old ones) are updated to our current expectations of the
             | future, so you have sentient computers and other "possible"
             | technology, and probably in 50 years we will have a
             | different set of standards and not something as naive as
             | what used to stand as possible 50 years before.
        
             | gooseus wrote:
             | Why not better understanding of complexity and complex
             | systems?
             | 
             | The assumption that any of these new technologies would be
             | desirable and create a net positive effect in the world
             | sounds very naive after seeing the results of something as
             | simple as "connecting the world".
             | 
             | We need to have a better understanding of how new
             | technologies interact with our existing technologies
             | (including institutions and communities) and our
             | environment, or else we risk (further) destabilizing
             | everything that has allowed us to get this far.
        
               | iCodeSometime wrote:
               | nah
        
               | dekhn wrote:
               | personally I believe that improving the techniques we use
               | to study complexity is the most important thing in
               | science today. In many fields we are now drowned in tons
               | of high quality data, yet scientists struggle to store,
               | process, and turn that data into knowledge.
        
         | jhbadger wrote:
         | As typical with contrarians, Ramon y Cajal said some things
         | that held up well and others that didn't. In the same book
         | "Advice for a Young Investigator" that this excerpt is from he
         | also gave his view of theorists: "Basically a theorist is a
         | lazy person masquerading as a diligent one because it is easier
         | to fashion a theory than to discover a phenomenon"!
        
           | glial wrote:
           | At least in the psychological sciences, he's not wrong.
        
           | [deleted]
        
           | cryptonector wrote:
           | How is that wrong? Clearly anyone who says that is being
           | somewhat facetious / comedic.
        
             | jhbadger wrote:
             | Well, it's true that we can't really tell how serious he
             | was being. And it is worth remembering he was a
             | neuroscientist who studied neurons. He was probably
             | thinking of people who made complex theories about "how the
             | brain works" without ever designing experiments to test
             | them, not physics theorists.
        
             | jonny_eh wrote:
             | > Basically a theorist is a lazy person masquerading as a
             | diligent one
             | 
             | Tell that to Einstein.
        
               | behringer wrote:
               | Didn't we recently confirm gravitational waves by
               | checking out a couple interacting black holes, originally
               | theorized by Einstein 100 years ago? I think even
               | Einstein would agree that it was much harder to discover
               | it than to theorize it.
        
       | prostaff wrote:
       | www.aeroworxglobal.com We can sovle them!
        
       | nxpnsv wrote:
       | Well, if they were solved, then they would not be regarded as
       | problems...
        
       | deith wrote:
       | Ramon and Cajal, two great thinkers.
        
         | gfiorav wrote:
         | If this was a joke, it's a pretty good one
        
           | deith wrote:
           | It's probably one of the most widely known jokes in Spain.
        
       | anarbadalov wrote:
       | Just a quick note to the moderators: thanks for adding (1897) to
       | the title and clearing up the confusion that i caused! i assumed
       | Ramon y Cajal was more of a household name.
        
       | [deleted]
        
       | carapace wrote:
       | ORT (Only Read Title) but uh...
       | 
       | WTF is gravity? Why is gravitational mass and intertial mass
       | identical (in all known situations)?
       | 
       | Do we orbit the Sun or the image of the Sun? In other words,
       | what's the _speed_ of gravity?
       | 
       |  _Can we control gravity?_
       | 
       | - - - -
       | 
       | What is subjectivity?
       | 
       | Why is "it" always _now?_
       | 
       | "You" and "now" are synonyms, why?
       | 
       | - - - -
       | 
       | WTF is up w/ the structure and dynamics of the Solar System? (
       | 97.77deg axial tilt!? Go home Uranus you're drunk!)
       | 
       | - - - -
       | 
       | QM and Relativity, chocolate and peanut butter?
       | 
       | Or the Universe is messing with us and actually _is_ describable
       | by multiple _irreconcilable_ models?
        
         | earenndil wrote:
         | > WTF is gravity?
         | 
         | That's metaphysics, not science.
         | 
         | > Do we orbit the Sun or the image of the Sun? In other words,
         | what's the speed of gravity?
         | 
         | The image. Speed of gravity is the same as the speed of light.
        
       | AmericanChopper wrote:
       | > It is nevertheless true that if we arrived on the scene too
       | late for certain problems, we were also born too early to help
       | solve others.
       | 
       | I think this could be used to describe almost any point in
       | history though. The greatest discoveries in science have always
       | required massive breakthroughs in thinking, that typically defy
       | conventional intuition. Perhaps there are some rare moments in
       | time following a major discovery where the fruitful areas of
       | inquiry seem obvious. But "I don't even know where to start
       | looking for the next major scientific discovery" or "this
       | hypothesis might be wrong and we could potentially spend the rest
       | of time investigating it" seems to be the default state of trying
       | to make major breakthroughs in science.
        
       | lordnacho wrote:
       | Well written. One thing that I keep thinking is that even if you
       | know the law, there's still a lot of applications where its use
       | is unobvious.
       | 
       | For instance, you might be satisfied you know how a pendulum
       | works. Now put another pendulum on it.
       | 
       | Or you think you understand gravity, because you got taught the
       | inverse square law. And you then get Kepler's laws. But then with
       | three bodies, things get really hairy.
       | 
       | Or you understand statics and materials. But how do we shove that
       | into finite elements? Not an obvious thing, and required some
       | real investigation.
       | 
       | There's also completely new ways of seeing things. Who would come
       | up with information theory? Doesn't seem like something that
       | would obviously be found, despite not really requiring any
       | physical experiment.
       | 
       | And then there's things like algorithm research that turn out to
       | be really big once there's a bit of computational power on the
       | horizon. (Probably people think about the algo before they can
       | try it on a machine.)
        
       | commandlinefan wrote:
       | Well I definitely didn't expect to see this at the end:
       | 
       |  _Santiago Ramon y Cajal (1852 - 1934)_
       | 
       | But I believe he's probably still right in 2020.
        
       | mtnGoat wrote:
       | Why come up with new ideas and solve hard problems when you can
       | just be the User for X and become a unicorn based no nothing but
       | smoke, mirrors and clever accounting like WeWork?
        
         | dang wrote:
         | " _Eschew flamebait. Don 't introduce flamewar topics unless
         | you have something genuinely new to say. Avoid unrelated
         | controversies and generic tangents._"
         | 
         | https://news.ycombinator.com/newsguidelines.html
        
           | mtnGoat wrote:
           | strange how this is selectively enforced around here. :x
        
             | dang wrote:
             | It always feels that the mods are against you. The other
             | side feels the same way.
             | 
             | https://hn.algolia.com/?dateRange=all&page=0&prefix=false&q
             | u...
        
       | sadmann1 wrote:
       | I do wonder if every generation picks slightly higher hanging
       | fruits in science will there come a time when a single human
       | lifetime won't be enough to digest even the most specialised
       | domain of science in order to build upon it
        
         | 6gvONxR4sf7o wrote:
         | Right now, science has an emphasis on causal discovery. Showing
         | that X is a mechanism by which Y happens. That includes finding
         | the different X's for a Y and finding evidence for the
         | relationship between a given X and Y. Once you know _how_ a
         | thing works, that doesn 't necessarily make it easy to work
         | with it. For example in quantum mechanics, a common phrase is
         | "shut up and calculate" because the mental models are all
         | messy.
         | 
         | But as we all know (especially those of us who have refactored
         | many systems), every once in a while you find a new way of
         | looking at a thing that makes it all much simpler. A geometric
         | way to look at an algebraic thing, or vice versa. Or a unifying
         | structure to combine disparate pieces. Or just a "wow that was
         | dumb" undoing of unnecessary complexity. It makes further
         | progress easier.
         | 
         | I could imagine that, as the boundaries of science get more
         | complex, there will be more scientists working on making the
         | rest of it less complex. Meanwhile, maybe we get smarter and
         | live longer. The calculations involved with many areas of
         | modern science have already outpaced what we can do by hand,
         | but we invented computers, so I can take the mean of a zillion
         | numbers without much effort and spend my time elsewhere.
         | 
         | And in med school, apparently they say "half of what we teach
         | you will be false, but we don't know which half." As science
         | progresses, you don't just add, you prune too.
        
           | n4r9 wrote:
           | Nicely put. In fact a lot of the field of quantum foundations
           | (and interpretations) could be seen as an attempt to work
           | towards this sort of perspective/paradigm shift.
        
         | uoaei wrote:
         | Scientific "unified" models hide this complexity by abstracting
         | it away so we can keep chipping away at the next level. We can
         | navigate this hierarchy, up or down, to understand respectively
         | large- and small-scale behavior, and the hierarchical model
         | makes it so humans can still comprehend at a given level of
         | abstraction.
        
           | [deleted]
        
           | Enginerrrd wrote:
           | Sure, but this doesn't address the possibility that there may
           | well be problems of sufficient complexity that this model
           | doesn't work.
        
         | stabbles wrote:
         | That's an interesting question. In Kuhn's view on science the
         | tree would be replaced after a paradigm shift, meaning there is
         | enough low-hanging fruit in a period of normal science (between
         | two major breakthroughs). I wonder if Kuhn had any claims about
         | whether paradigm shifts would happen less often in time.
        
         | klyrs wrote:
         | In my exposure to number theory, this certainly seemed to be
         | approaching. Grad students barely have a grasp on the basic
         | definitions; postdocs seemed shaky but familiar; professors
         | "get it" but don't claim to understand. And sure, we've got
         | Terry Tao making everything look easy, but that isn't a
         | comfort.
        
         | clSTophEjUdRanu wrote:
         | Doubtful. Just look at computer science. How many people
         | actually grasp what the computer is doing at the lowest level?
         | Relatively few compared to the number of developers there are.
         | 
         | Abstractions are the key.
        
         | dumbfounder wrote:
         | We are still in an explosive growth mode, and probably will be
         | for a very long time (>100 years is my guess). But yes, it will
         | be asymptotic at some point, unless you think the amount of
         | science to grasp is infinite.
        
         | hinkley wrote:
         | A sometimes-spoken hope is that the universe is built on
         | relatively simple rules with complex behaviors. If fields grow
         | too complex, they hope to find some underlying principle that
         | explains (away) that complexity.
         | 
         | We started out that way, I dunno if we'll end that way.
         | 
         | And even if it does eventually come down to 30 rules that
         | explain everything? How many rules does Chess have? Way more
         | than Go, and both can take decades to really understand.
        
         | SonOfLilit wrote:
         | This is a wonderful short story related to this question:
         | https://slatestarcodex.com/2017/11/09/ars-longa-vita-brevis/
        
         | commandlinefan wrote:
         | https://slatestarcodex.com/2017/11/09/ars-longa-vita-brevis/
        
       | tom-thistime wrote:
       | The author of this essay died in 1934.
        
         | n4r9 wrote:
         | I was going to post a criticism along the lines that all the
         | historical examples given by the author were from the 19th
         | Century until I saw you point this out!
         | 
         | The date definitely changes my perspective but I still think
         | the essay is a little too waffley - it doesn't to give any
         | actual examples or indications or where the author thinks
         | important scientific problems lie. In fact it kind of begs the
         | question. In response to a concern over whether there are
         | important scientific problems left to solve, it simply lists
         | some historical important scientific breakthroughs.
         | 
         | I suppose the point is that breakthroughs are unexpected...
        
         | Animats wrote:
         | Right. _" Who, a few short years ago, would have suspected that
         | light and heat still held scientific secrets in reserve?
         | Nevertheless, we now have argon in the atmosphere, the x-rays
         | of Roentgen, and the radium of the Curies, all of which
         | illustrate the inadequacy of our former methods, and the
         | prematurity of our former syntheses."_ That had to be from the
         | early 20th century.
         | 
         | The problems today are either in areas where complexity is the
         | limiting factor, like biology, or beyond current experimental
         | reach, like string theory and dark matter. The complexity
         | problem can probably be overcome with computer assistance.
         | Experimental reach is harder.
        
       | rygh wrote:
       | May be it's yet to be discovered
        
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