[HN Gopher] Hallucinogenic Fish
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       Hallucinogenic Fish
        
       Author : ajaviaad
       Score  : 25 points
       Date   : 2020-02-12 21:12 UTC (1 hours ago)
        
 (HTM) web link (en.wikipedia.org)
 (TXT) w3m dump (en.wikipedia.org)
        
       | eindiran wrote:
       | There was an episode of Hamilton's Pharmaopoeia about
       | hallucinogenic fish that was quite interesting. I can't find the
       | whole episode on YouTube, but here is a clip from it:
       | 
       | https://www.youtube.com/watch?v=6N3j5g066CU
        
         | EamonnMR wrote:
         | I watched it. He only got confused, pained looks from people he
         | asked about the fish and did not achieve any sort of mind
         | alteration.
        
       | ConsiderCrying wrote:
       | > Ingesting the dreamfish Sarpa salpa can result in
       | hallucinations that last for several days.
       | 
       | I wonder why this fish hasn't been 'mined' for its hallucinogenic
       | properties yet. Surely some of the more adventurous drug users
       | would jump at a chance to try something this powerful? The
       | article on the fish itself seems to state that it was available
       | in restaurants, so it's not exactly a rare find, I assume.
        
         | eindiran wrote:
         | Almost all hallucinogenic drugs lasting for more than 18 hours
         | are considered bad drugs. Eg the DOx series psychedelic
         | amphetamines (excluding DOM, which people like for some
         | reason), most of the benzofurans, the alkaloids of the Datura
         | plant, etc. Even non-hallucinogenic drugs with long half-lives
         | are considered not ideal (see the long lasting benzodiazepines
         | especially).
         | 
         | [0] https://en.wikipedia.org/wiki/DOx
         | 
         | [1] https://en.wikipedia.org/wiki/Substituted_benzofuran
         | 
         | [2] https://en.wikipedia.org/wiki/Datura
        
       | JTechno wrote:
       | This fish is eaten in some places in spain, I've tried it myself
       | but never had hallucinations.
        
       | slim wrote:
       | This fish is quite common on the markets in Tunisia. We actually
       | avoid it in the hallucination season because it mostly causes bad
       | trips. It tastes good.
        
         | aldoushuxley001 wrote:
         | What is a good trip on it like?
        
       | andrewflnr wrote:
       | It's really surprising to me that psychoactive chemicals are so
       | common in the natural world. Why do so many chemicals designed
       | for pretty unrelated roles have effects on human brains? I would
       | naively expect that to happen approximately never.
        
         | akiselev wrote:
         | It's a combination of factors but it's mostly evolution
         | converging on very similar systems across the plant and animal
         | kingdom. Most neurotransmitters are relatively simple molecules
         | while the ion channels on neurons are relatively complex. They
         | have a high surface are for all those neurotransmitter,
         | inhibitor, regulator, etc. molecules to bind to and the entire
         | system is extremely sensitive to small changes.
         | 
         | Take cannabis, for example: the endocannabinoid system in our
         | central and peripheral nervous systems effects a variety of
         | things (memory, sleep, appetite, etc.) but it's also useful to
         | plants, which evolved the system roughly 500 million years ago,
         | independently of animals.
        
       | jborichevskiy wrote:
       | I found this sentence entertaining:
       | 
       | > Hallucinogenic fish can be contrasted with psychedelic fish.
       | Psychedelic fish do not produce hallucinations if eaten, but look
       | as if they were the product of a psychedelic hallucination.
        
       | bllguo wrote:
       | > The active agent(s) that cause hallucinations in humans, and
       | the origin of these agents, are not clear. Some authors think
       | they could come from toxins associated with macroalgae that
       | accumulate in the flesh of the fish.
       | 
       | does anyone know why we can't tell what substances cause the
       | hallucinogenic effects? to a complete layman (i.e. me) this seems
       | like the kind of thing modern science should be able to determine
        
       | teslaberry wrote:
       | reminds me of fugu but doesnt kill. you presumably.
        
       | beepboopbeep wrote:
       | See also: Sea sponges https://en.wikipedia.org/wiki/5-Bromo-DMT
        
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       (page generated 2020-02-12 23:00 UTC)