[HN Gopher] Funding for Covid-19 Projects
       ___________________________________________________________________
        
       Funding for Covid-19 Projects
        
       Author : molecule
       Score  : 218 points
       Date   : 2020-03-15 16:35 UTC (6 hours ago)
        
 (HTM) web link (blog.samaltman.com)
 (TXT) w3m dump (blog.samaltman.com)
        
       | intended wrote:
       | Can someone just sell Bidets = better for the environment, and
       | this ridiculous fighting over TP in the developed world ends.
        
         | spookthesunset wrote:
         | If you look on amazon, lots of them are getting sold out. This
         | might be what changes people's view on it...
        
         | the_af wrote:
         | I come from a country where bidets are very popular, and I of
         | course own one: you still need toilet paper. Think when you
         | wash your hands, how do you dry them? ;)
        
         | TeMPOraL wrote:
         | Fights over TP should disappear soon. It's just a supply shock,
         | but unlike with PPE, the coronavirus doesn't affect the rate at
         | which people go through TP, so it should be one time. People
         | who hoarded will just take more time to buy again.
        
       | fortran77 wrote:
       | An AI system that has been trained on survivability based on
       | easily cheked comorbidities (age, BMI, smoker) that can instantly
       | do triage and let hospitals know whether or not to allocate a
       | hospital bed/ventilator to an incoming patient.
        
       | supernintendo wrote:
       | Please make sure any startup you fund doesn't take a selfish
       | approach to patents and intellectual property. Any progress on
       | fighting Covid-19 needs to be shared with the world and not used
       | as a cynical tool for profit.
        
         | vikramkr wrote:
         | What counts as selfish? If someone is developing a drug for it
         | but can't make the money back they spent on it because they
         | don't have patent protection, they're not going to do it in the
         | first place. A startup will fundamentally need to have
         | profitability to be worth developing the drug. The government
         | is a different story, and of course there's a chance the
         | vaccines come out of the NIH etc. But if it comes out of a
         | startup in particular, the people behind it we're only driven
         | to create it for profit (why are they founding a startup
         | instead of working through academia, or doing it as a
         | startup/funding a startup instead of as a nonprofit?) And if
         | that profit motive was required to make this work, then profit
         | was the tool used to fight Covid, not the other way around, no?
        
       | d_burfoot wrote:
       | Thanks SamA!
        
       | fludlight wrote:
       | You can also try emailing K-12 (6-12 really) schools offering
       | tech support helping teachers and students set up and use tele-
       | learning software.
        
         | codingdave wrote:
         | I'd suggest that the K-5 crowd needs more help than 6-12. My
         | older children already did some of their work online, and when
         | the schools shut down, the teachers emailed the students to let
         | them know that they'd be using their existing tools... just
         | expanding the content.
         | 
         | But my younger kids have never even used the online tools. They
         | need more help, and the teachers need more help transitioning
         | their curriculum to remote classrooms.
        
       | tcbawo wrote:
       | There are a lot of mom and pop stores and restaurants that will
       | suffer and may go out of business. If there is a secure,
       | convenient website to set up gift card purchases, it might keep
       | these places afloat.
        
         | wenc wrote:
         | I was thinking this too, but I'm not convinced the gift card
         | idea, as it stands, will work for all businesses. There needs
         | to be some creative thinking to make it truly help small
         | businesses.
         | 
         | Gift cards are a deferred liability -- they help cash flow now
         | but in the future when everybody redeems them, they're going to
         | eat away at future income, which doesn't leave the mom and pop
         | store necessarily in a better state. The hope is: (1) a large
         | percentage of folks never redeem their gift cards; (2) mom-and-
         | pops can accommodate the increased demand in the future and
         | still make future income. (3) they can set really limited
         | expiry dates. But if these assumptions are not true, they will
         | still have to close. (but yes, let's do gift cards for
         | businesses where these assumptions are true)
         | 
         | In some cases, gift cards are not useful especially for non-
         | scalable businesses like barbershops, which have a finite
         | number of appointment slots. Gift cards just delay the
         | inevitable. Barbers can extend hours and open up more slots but
         | they might never catch up.
         | 
         | A more appealing idea is a temporary UBI but then we're wading
         | into political territory. And even with a UBI, it doesn't help
         | businesses with uncertain demand and perishable inventories.
         | 
         | I really want to help small businesses: any thoughts from other
         | folks here? Is there something else we can do? Are there
         | good/better solutions?
        
           | tcbawo wrote:
           | Maybe something like GoFundMe but with gift cards that have
           | <100% redemption value, so it's neither entirely charity or
           | unfunded liability. You need some transparency into the
           | funding goals. Maybe even provide some sliding scale where
           | after a certain amount purchased, the gift cards trend
           | upwards towards 100%.
        
       | andrewfromx wrote:
       | Sam's ending line "And of course, I think the best thing to do is
       | still to get people to stay home." makes me think we need this
       | app asap: https://news.ycombinator.com/item?id=22585852
        
       | samirillian wrote:
       | What about more social network type projects? As someone living
       | in a relatively cheap apt building in Chicago, I was thinking
       | that this could be an opportunity to get people to actually
       | interact more with the aid of technology, form local support
       | networks for sharing information and other resources, make sure
       | the most vulnerable people have some support, etc. Lots of people
       | are stuck at home, lots of people are nervous, lots of people may
       | need help in the coming weeks. I wish our apartment building had
       | at least a forum for sharing a little info.
        
       | bryanrasmussen wrote:
       | I guess fixing the problems listed here would be the most useful
       | to invest in startup wise https://www.wired.com/story/high-
       | stakes-security-set-ups-mak... as they will be problems that
       | persist after the pandemic is over, and can secure clients in
       | wealthy firms for the product that fixes them.
        
       | pkaye wrote:
       | The US ventilator companies say they can already ramp up
       | production 5x. They just need the orders. And they can probably
       | make more basic units which might be sufficient
       | 
       | https://www.forbes.com/sites/baldwin/2020/03/14/ventilator-m...
        
         | olalonde wrote:
         | Why haven't they? There's a worldwide shortage of ventilators
         | and prices are through the roof.
        
           | pkaye wrote:
           | > The German government just placed an order for 10,000
           | mechanical ventilators. What's the U.S. government doing
           | about a potential shortage here? Not much, it seems.
           | President Trump alluded to the matter in a press conference
           | but did not spell out any plans.
           | 
           | I guess there is not action at the top level. This is a
           | national emergency and they should be cranking them out like
           | tanks during a war and distribute to where its most needed.
        
           | hanniabu wrote:
           | > They just need the orders.
        
         | jonas21 wrote:
         | Or rather, one small US ventilator company says they can ramp
         | up their production by 5x in 3 to 4 months. From your link:
         | 
         |  _"We could increase production five-fold in a 90- to 120-day
         | period," says Chris Kiple, chief executive of Ventec Life
         | Systems ... The seven-year-old, 135-employee Ventec is a fairly
         | small player in a market dominated by Medtronic (under the
         | Puritan Bennett brand), GE Healthcare and Allied Healthcare in
         | the U.S._
         | 
         | Not to mention that there's a big difference between producing
         | ventilators at 5x the current rate and having 5x as many total
         | ventilators available.
        
         | brian-armstrong wrote:
         | Hospitals also need beds and staff to care for patients on
         | ventilators. They could be well-equipped with the ventilators
         | themselves and be bottlenecked on people to operate them.
        
       | aabajian wrote:
       | You can use an ECMO instead of ventilation:
       | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185806/
       | 
       | Here's a fringe idea in the worse case: Connect one ECMO
       | oxygenator to multiple patients at once using Type-O negative
       | blood. You'd have to filter out the O-negative RBC's as they come
       | in.
        
         | hn_throwaway_99 wrote:
         | This seems pretty insane to me. ECMO in general is _much_ more
         | dangerous than mechanical ventilation because the risk of
         | infection and sepsis is so much higher. Certainly understand it
         | as a last ditch effort, but the resources and risks WRT ECMO is
         | much higher than mechanical ventilation.
        
         | blackRust wrote:
         | Unfortunately the number of ECMO machines is far cry away from
         | what is required for this to work:
         | https://en.wikipedia.org/wiki/Extracorporeal_membrane_oxygen...
         | 
         | Even if you manage to double or triple capacity unfortunately
         | it is no match to the exponential growth.
        
           | haldujai wrote:
           | We have a lot more ECMO capacity than people think, CPB
           | machines from heart surgery cases can be used to provide ECMO
           | which are at least an order of magnitude more common than
           | classic ECMO machines.
        
         | bryanrasmussen wrote:
         | I'm somewhat dense - why Type-O?
        
           | ipostonthisacc wrote:
           | it is somewhat universal. type-O blood can be used for all
           | groups (in general), but type-O patients can only receive own
        
           | aabajian wrote:
           | O-negative means the red blood cells lack the A, B and Rh
           | antigens on their cell membrane. It is these antigens that
           | (most) often lead to a host immune response.
        
           | Spooky23 wrote:
           | Type O is the universal donor.
        
         | haldujai wrote:
         | This is an extremely flawed idea.
         | 
         | Not only does transfusion present a big risk, we quote ~20%
         | risk of adverse events (minor to severe), but what you're
         | suggesting massive transfusion protocol (DIC, hemolysis, TRALI,
         | TACO) AND ECMO which itself is orders of magnitude more
         | dangerous than ventilation.
         | 
         | The risks are numerous but for brevity sake you have: Acute
         | limb ischemia, DIC/other coagulopathies and spontaneous
         | hemorrhage which carry huge mortality.
         | 
         | It would be way simpler and safer to connect multiple patients
         | to the same ventilator who are all on CMV with similar
         | settings.
         | 
         | ECMO is not saving many people with severe COVID-19 related
         | illness. It depends on buying time for your body to recover.
         | Nearly every case I've read about that required ECMO the
         | patient died because of multiorgan failure and sepsis. ECMO
         | only works well in patients with isolated lung (and some
         | circumstances heart) problems.
        
       | danenania wrote:
       | I wonder how much home pneumonia treatment options like
       | humidifiers, steam, and drinking tons of fluids can impact the
       | hospitalization rate? Quitting/taking a break from smoking has to
       | be a big one too. Can we find ways to encourage more people to do
       | these things, like some kind of viral science-based "Lower Your
       | Covid Risk" website or app? It could promote social distancing
       | too.
       | 
       | One of the biggest problems so far imo is lack of clear,
       | unambiguous guidance from authority figures. People in the
       | general population still have wildly misinformed views. Finding
       | creative ways to inject this kind of crucial information into the
       | collective consciousness could have a big impact.
        
       | fovc wrote:
       | There was a comment yesterday about how easy it is to manufacture
       | iron lungs. A quick search indicates they might be effective
       | (https://www.ncbi.nlm.nih.gov/pubmed/15065832)
       | 
       | Is this being explored?
        
         | haldujai wrote:
         | The mechanism of respiratory failure is different in COPD vs
         | ARDS (in the case of COVID), hypercarbic vs hypoxemic. There is
         | minimal human research in the use of NPV/iron lungs with ARDS.
         | As far as I'm aware the technology does not even exist for many
         | of the ventilation modes we use today with NPV which was
         | designed for people with polio and paralyzed breathing muscles
         | rather than "fluid in their lungs" causing the respiratory
         | failure.
        
         | tcbawo wrote:
         | If cheap improvised medical equipment turns out to be feasible,
         | I hope government will provide adequate legal cover for those
         | willing/able to do R&D, manufacture, and distribution.
        
       | dnautics wrote:
       | How about a project to understand who is NOT getting Covid-19?
       | There are almost certainly healthcare workers in heavily infected
       | areas who "should have gotten it but haven't". Understanding this
       | could rapidly lead to:
       | 
       | - screens to identify who's vulnerable and who's not
       | 
       | - therapeutic strategies (probably not ready for this round, but
       | for future rounds)
       | 
       | edit: removed errant footnote reference
        
         | thih9 wrote:
         | > There are almost certainly healthcare workers in heavily
         | infected areas who "should have gotten it but haven't"[0]
         | 
         | It looks like the link is missing. Does anyone have it?
        
           | dnautics wrote:
           | no, sorry, I was going to add more text and put the bullets
           | into a footnote, but went back to coding.
           | 
           | If you would like more information on something similar,
           | consider:
           | 
           | https://www.theguardian.com/world/2007/may/27/aids.features
           | 
           | The flip side of this is that I used to work in structural
           | biology, and there were tons of structural biology grants
           | flying around justifying studying these antibodies on the
           | grounds that they might lead directly to vaccination
           | strategies. Well, that is highly unlikely because some of
           | these antibodies have a germline (versus adaptive immunity
           | internal random generator) mutation that fundamentally
           | changes the higher-order architecture of their antibodies
           | that makes them not comparable to the antibodies that the
           | rest of us have. The blatant (deliberate or brainless, I
           | wasn't sure) mischaracterization by the PIs and the brazen
           | funding of these proposals (deliberate or brainless, I wasn't
           | sure) by the grant program managers that contributed me to
           | leaving academia. I just wish they were honest and said "we
           | are studying this because it's interesting and we would like
           | to know more about the universe".
        
         | [deleted]
        
         | bastawhiz wrote:
         | I've read multiple reports online that truvada and descocy (HIV
         | medication sold as a prophylactic, largely to LGBT individuals)
         | may offer some resistance to COVID-19. I think it's largely
         | bunk speculation, but research into whether existing, mass-
         | produced pharmaceuticals would help could be incredibly
         | valuable.
        
           | tjoff wrote:
           | Don't know about trubada/descocy but they are doing exactly
           | that. Still, takes many months to get results though.
        
       | davmar wrote:
       | for any of sam's startup ideas to have an impact on the current
       | Covid-19 pandemic, they need to:
       | 
       | 0. raise a lot of money because vaccine/therapeutic development
       | is $$$. it's probably not seed funding.
       | 
       | 1. be successful in researching and developing an approach that
       | works with a novel, unproven approach
       | 
       | 2. get that approach certified
       | 
       | 3. scale the manufacturing of the novel approach
       | 
       | 4. deliver the drugs to patients who need it
       | 
       | 5. do it all in a timeframe that is faster than what existing
       | companies can do, and within the budget of the money that you've
       | raised.
       | 
       | i don't think novel vaccines and therapeutics made by startups
       | are likely to work in time to have an impact on this coronavirus.
       | 
       | but, sam's funding can help out if he suggests different
       | problems: logistics planning, increasing care capacity, and
       | increased political pressure.
       | 
       | - in the open letter to mike pence
       | (https://medium.com/@maxinedexter/open-letter-to-vice-preside...)
       | they call for call centers to "coordinate transfers of patients
       | to areas with higher levels or greater capacity for delivering
       | care." if it doesn't exist, software should power this.
       | 
       | - same letter: "A tracking method at the state level for people
       | self quarantined must be instituted for public health
       | surveillance and follow up."
       | 
       | - cities need additional mobile quarantine facilities. build them
       | out of box shipping containers or something.
       | 
       | for this pandemic, we're already behind the 8 ball so i suggest
       | picking simpler projects. if you want to fund novel approaches
       | that require r&d, that's probably more likely to help with the
       | next pandemic.
        
       | taytus wrote:
       | >You can email me if you want.
       | 
       | What is Sam's email?
       | 
       | Thanks!
        
         | mceoin wrote:
         | samaltman@ycombinator.com gives a hit in Superhuman.
        
       | ISL wrote:
       | Finding ways to mitigate the economic impact of Covid-19 is less
       | sexy, but it is likely to be the place where investors can make
       | the biggest difference to other humans.
       | 
       | Zero/low-interest loans will stem the inevitable downward spiral
       | that comes with loss of free cash flow from otherwise great
       | businesses. This is the time to ensure the stable capitalization
       | of good businesses (and investors are likely to get paid back in
       | spades in karma, if not cash, for doing so).
        
         | Theodores wrote:
         | Well said.
         | 
         | The lockdown presents an opportunity. Imagine you run a small
         | customer facing business where the premises could do with
         | refurbishment.
         | 
         | Under normal circumstances you cannot close the doors for
         | however long it takes to redecorate the place, maybe putting in
         | modern lighting and air conditioning. Too much revenue would be
         | lost plus there would be the matter of goodwill with customers
         | discovering rival shops.
         | 
         | Most of these businesses are cash driven, there isn't a lot in
         | the bank. So, right now the business has to shut up shop, game
         | over thanks to consequences of the virus.
         | 
         | Now, if you did have the capital to spend on the premises, you
         | could shut the doors to the customers and hire the usual team
         | to help out on the refurbishment. They might not have the
         | paperwork for the HVAC work or for doing electrical work but
         | they could put everything in place for when times change and
         | the electrician or HVAC engineer could be called out. Painting
         | the walls or assembling shop fittings can be done by almost
         | anyone, albeit not as quickly or proficiently as the
         | professionals.
         | 
         | When the hysteria is over and 'herd immunity' is reached then
         | the refurbished business can reopen. With more up to date
         | premises and a fresh look this should result in better sales.
         | 
         | Sometimes 'charity starts at home' and helping one's preferred
         | local business to make something of the opportunity rather than
         | close is worth a go. If you are a customer then even just
         | talking to your favourite shop about opportunities is useful,
         | 'customer feedback'. It could be your hairdresser, a cafe or a
         | shop that could do with the suggestion. Perhaps they don't
         | notice the grubby walls as they work there day in and day out,
         | whereas, you as a customer, might notice such things but never
         | say anything as you like the staff. Time to speak up before
         | they close.
        
       | voidmain wrote:
       | Someone should look at Sterilray and Ushio 222nm KrCl excimer
       | lamps. Light at that frequency is extremely effective at
       | destroying viruses but probably does not cause much skin cancer
       | or eye damage like other UV because it is absorbed so fast it
       | doesn't make it through the dead layer of skin etc. There are at
       | least some studies but no FDA approval or mass production. If
       | they work these might make a big difference in transmission in
       | public spaces, especially via surfaces.
        
         | deftnerd wrote:
         | Even if 222nm has its purposes, the market is crying out for
         | inexpensive and plentiful UV-C 253nm LED's.
         | 
         | You can get UV LED's in different wavelengths, but 253nm is the
         | very effective for disinfection (even though it does suffer
         | from the other UV damage that you mentioned). It's slightly
         | wider wavelength might make it more possible to make using
         | existing LED manufacturing techniques.
         | 
         | This would open up a lot of possible germicidal sanitation
         | technologies from integrated germicidal LED's on door handles,
         | bulbs used with home automation to disinfect a whole home once
         | everyone has left for the day, to Roomba-like devices that
         | disinfect floors.
        
       | Animats wrote:
       | On the ventilator front, a good start would be to order one each
       | of the available ventilators on Alibaba, express shipping. For
       | all the ones that show up, get them examined and tested and torn
       | down if necessary. Publish the results. Get emergency FDA
       | approval. Order in bulk. Make arrangements with the better
       | suppliers to go to three shifts. Arrange for large air shipments
       | of the good ones to where they are needed. Find out if there's
       | something the supplier needs and get it from them. Basically, use
       | money to overcome all normal obstacles to getting those things
       | where they are needed.
        
         | spodek wrote:
         | Any tinkerers want to help these low tech versions
         | https://www.notechmagazine.com/2020/03/open-source-breathing...
         | 
         | Helping create versions 3d printable or mass manufacturable
         | could save countless lives.
        
         | timcederman wrote:
         | This is spot on. I emailed officials in my city and county with
         | this suggestion earlier this weekend and received some mild
         | interest. From my research into the situation they do have
         | stock and the current bottleneck is shipping, but stock is
         | making it over in 2-3 weeks.
        
         | ma2rten wrote:
         | I doubt that there are going to be a bunch of ventilators that
         | you can just order on Alibaba.
        
           | jacquesm wrote:
           | Take your pick:
           | 
           | https://www.alibaba.com/showroom/emergency-ventilator.html
        
             | BurningFrog wrote:
             | You can order. But will they arrive?
        
               | jacquesm wrote:
               | That is a good question. I suppose there _was_ some stock
               | of these before the crisis but those are very likely all
               | depleted. Still, with this many suppliers it might not
               | hurt to ask. Dutch proverb:  "If you don't shoot you will
               | certainly miss".
        
               | microcolonel wrote:
               | For what it's worth, China has literally turned around
               | pending export medical supplies, and banned certain
               | exports. Ventilators seem like they would be on that
               | list, if it has not been withdrawn yet.
        
               | thaumasiotes wrote:
               | > Dutch proverb: "If you don't shoot you will certainly
               | miss".
               | 
               | Huh. The idea is certainly around in the US, but I'm kind
               | of surprised I can't think of a matching proverb.
               | 
               | We have a very close match, but it's considered a witty
               | quote from a particular person (no consensus on who) --
               | "you miss 100% of the shots you don't take".
               | 
               | There's also something along the lines of "you can't get
               | what you don't ask for". There's also an individually
               | attributed version of this: "if you don't ask, you don't
               | get". I had to look this up. There is no really common
               | version.
               | 
               | And of course, there's "ninety percent of success is
               | showing up". Again this is attributed -- quote trackers
               | seem to agree that it should be "80%", not "90%". But
               | this one is common enough that I could see it becoming a
               | proverb eventually. On the other hand, this has gone
               | somewhat afield from "if you don't shoot, you won't hit".
        
               | stormtroper1721 wrote:
               | "You miss 100% of the shots that you don't take" is one
        
             | ma2rten wrote:
             | Fair enough, but I checked the first one. They were already
             | certified by western agencies.
        
         | genbit wrote:
         | Here you go, startup idea: emergency logistics. Company that
         | can quickly ship and verify good quality approved medical
         | equipment and supplies to the epidemic area.
        
           | jacquesm wrote:
           | That's called the Red Cross.
        
       | mceoin wrote:
       | Mycology. Not a company but a novel and underinvested space with
       | 3000+ yr history with antiviral applications. Paul Stamets is the
       | go-to guy here but likely slammed. His talk, into the mycoverse,
       | goes into detail about how he was brought in to do battery
       | testing post-9/11 and how basically all polypore mushrooms
       | (common globally) have some antiviral properties. Some are super-
       | potent. At risk of being called "the crazy mushroom guy" I'm
       | including here because I know this is a vastly underinvested in
       | space and has huge latent potential WRT antivirals. The reason it
       | is underinvested in is because patents are hard (used for 1000s
       | of years) so big pharma stay away. Long shot, but also could be
       | tested everywhere, reasonably cheaply.
       | https://www.youtube.com/watch?v=f0rkcrWqsV4
        
         | Alex3917 wrote:
         | Are there any mushrooms that have shown antiviral effects
         | against SARS or other viruses in the Coronavirus family?
         | 
         | I know there are a ton of studies on this for plant-based
         | medicine in relation to SARS and MERS, but I haven't looked
         | much into mushrooms for this. (Even as an amateur mycologist.)
         | 
         | I know folks have been recommending cordyceps for COVID-19, but
         | not because it has antiviral properties. Given that hunting for
         | cordyceps is about the only safe thing to do in NYC right now,
         | maybe this will be the year I actually find it for myself.
         | (Albeit the species that's common in NYC doesn't have any
         | history of being used medicinally afaik.)
        
           | mceoin wrote:
           | I haven't seen anything specifically related to COVID-19 and
           | won't speculate. I'm also not a scientist or medical
           | professional, so just think of me as some guy on the Internet
           | saying "mycology is an interesting non-big-pharma industry
           | that has bio-prospecting potential due to its anti-viral
           | properties", and Paul Stamets is the source of that
           | statement.
           | 
           | (Personally, I'm making a lot of Reishi tea and taking a
           | spectrum of polypore supplements as a general immune booster,
           | not a specific defense against COVID-19).
           | 
           | P.S. good luck finding cordyceps!
        
       | andreyk wrote:
       | "I'm trying to fund startups/projects helping with COVID-19,
       | because it's basically the one thing I know how to do that can
       | help. "
       | 
       | You can... donate to the many existing efforts already fighting
       | this?
        
         | natalyarostova wrote:
         | Sam's expertise isn't just about money. It's about identifying
         | the good ideas in the sea of ideas, and helping them get
         | connected.
        
           | hanniabu wrote:
           | It doesn't look like the items identified in his list are
           | things that can really help now though. They seem like
           | they're things that will only be useful in future pandemics.
        
             | zmj wrote:
             | Like the second wave of COVID-19 next winter?
        
       | DoreenMichele wrote:
       | I'm going to note two things here:
       | 
       | First, Sam Altman is no longer president of YC and this is his
       | personal blog. So I think it is probably a mistake to conflate
       | his writing with YC policy.
       | 
       | Second, I've been posting here more than a decade. I was
       | initially very open about my diagnosis and my pursuit of non-drug
       | solutions, but that went weird and problematic places, in part
       | because people on the leader made problematic comments at times
       | that looked to me like the baked in assumption was "She's just a
       | girl. She couldn't possibly come up with a brilliant idea like Do
       | A Website about her health stuff." The website in question was
       | listed in my profile at the time. He hadn't taken thirty seconds
       | to look at my profile before opening mouth and inserting foot.
       | 
       | Sadly the person may have been trying to flirt with me. It's a
       | debacle I feel my reputation has never recovered from.
       | 
       | I still don't know how to get taken seriously and I absolutely
       | can't single-handedly dream up a fix here.
       | 
       | I can't figure out what to talk about without engagement. I can't
       | self promote when various gatekeepers actively exclude me for not
       | having the right kind of mostly male-coded credentials because I
       | was a homemaker and full-time mom for a lot of years.
       | 
       | I've spent nearly 19 years getting better while the world calls
       | me crazy and actively denies me support. The odds are extremely
       | poor that I will ever get taken seriously.
       | 
       | But if it genuinely bothers you that people are dying from this
       | infection, maybe stop and consider setting aside your sexist,
       | classist prejudices about me and try to find some way to help me
       | find my voice and share what I know that has allowed me to
       | successfully get off all the drugs and generally grow healthier
       | while the world laughs in face and tells me I'm a liar and
       | nutcase.
       | 
       | And if insisting I'm a lunatic who deserves zero respect matters
       | to you more, then you don't really want a solution to this
       | problem more than you want to remain married to unpleasant
       | character traits.
       | 
       | Because you have this person in your midst whose very life
       | depends upon such expertise and would love to share useful
       | information and that's not a secret. It's just absolutely not
       | taken at all seriously and I'm routinely attacked for trying to
       | talk about health stuff at all, even when I'm doing so for my own
       | edification with zero intent to convince anyone else of anything
       | at all.
        
         | taytus wrote:
         | I read your post 4 times. I still have no clue what you are
         | talking about.
        
       | adamsea wrote:
       | Wouldn't it make more sense, from a public health perspective, to
       | put that money into the existing local institutions (hospitals,
       | health clinics, food banks) which are vital and soon may be
       | strained to the breaking point?
        
       | CPLX wrote:
       | The thing Sam Altman could have done, and still could do, that
       | would have by far the most impact in this and similar crises, is
       | support the adoption of universal health coverage and sick leave
       | policies, as well as financial assistance for those devastated by
       | these shutdowns.
       | 
       | Startups are cool. But to the extent the Silicon Valley community
       | has fought against a social safety net and effective public
       | sector they're part of the problem.
       | 
       | Not singling him out specifically here as my understanding is
       | that he actually has done some political work along those lines,
       | but the first sentence here implies that investing in startups is
       | the only thing he knows how to do. That rings false.
       | 
       | He's very wealthy and powerful. He has enormous influence over
       | people who set employee policies at important companies and has
       | the ear of world leaders.[0]
       | 
       | There's many things he could do that are much more effective than
       | investing in startups.
       | 
       | [0] https://youtu.be/rKoACC5iOhQ
        
         | pmorici wrote:
         | This seems obviously false. Italy has universal health coverage
         | and they have one of the worst outbreaks and worse fatality
         | rates of any country. This doesn't feel like the right time to
         | promote preferred political agendas. Doesn't matter who pays
         | for it when there is no vaccine and no cure.
        
           | melenaboija wrote:
           | Partially agree with you.
           | 
           | Universal health coverage in this situation is meant to treat
           | everybody in equality for same problem and I would say it
           | doesn't matter who pays for it as long as everybody will get
           | treated in a similar way.
           | 
           | Agree on European governments did not the right thing, but
           | again, not sure if that has something to do with universal
           | health.
        
           | nrp wrote:
           | On universal paid sick leave, the intent is to enable people
           | to not go into their workplace when they could be contagious.
           | The choice between risking getting others sick or going broke
           | and getting evicted isn't one people should be forced to
           | make.
           | 
           | On universal health coverage, the major difference is what
           | the recovery looks like (potentially after the vaccine in
           | countries where it's too late for containment). If there's
           | any silver lining to this pandemic, hopefully it's that
           | politicians who oppose universal health coverage become
           | unelectable.
        
             | pmorici wrote:
             | I understand that but the op is advocating that those
             | things would do more than having an ample supply of PPE and
             | an effective treatment and vaccine which is total nonsense.
        
           | js2 wrote:
           | We'll soon see how America's broken healthcare system
           | combines with its undocumented immigrants and homeless.
        
             | Alex3917 wrote:
             | And also people of color not filling out the census because
             | they're afraid the government is going to send people to
             | lynch them. Healthcare resources are completely
             | misallocated because people are scared to tell the
             | government where they live. During the last census, the
             | response rate in Harlem was something like only 65%, which
             | the government can tell based on electricity usage and
             | toilet flush data.
        
         | adrr wrote:
         | Sick leave is in the house bill that passed yesterday along
         | with paid family leave. White house supports it so it should
         | pass the senate with little problems.
        
           | CPLX wrote:
           | No it isn't. It excludes almost everyone.
           | 
           | That bill is an embarrassment. Doing something about _that_
           | is kind of exactly what I'm talking about.
        
           | [deleted]
        
           | gji wrote:
           | Those benefits only apply to people who work at companies
           | that have less than 500 employees. Unfortunately, that leaves
           | most people in the lurch.
           | 
           | https://www.nytimes.com/2020/03/14/opinion/coronavirus-
           | pelos...
        
             | cheez wrote:
             | Those are the companies that won't survive without it. The
             | bigger companies are expected to fund it themselves.
        
         | throwaway8291 wrote:
         | How true. I believe the US will see an even worse fallout than
         | Italy - because people who can afford private medical personal
         | tend to question whether healthcare is a business model at all
         | ("Is curing patients a sustainable business model?", GS).
         | 
         | America has the most uplifting and free-spirited legacy, but it
         | has been transformed in the past decades into the most
         | primitive form of greed and selfishness possible. Covid-19 is
         | only the eye-opener.
         | 
         | FTR: I believe the US will lose 5% of its population to the
         | coronavirus in 2020. Not being panicky, just multiplying.
        
           | ma2rten wrote:
           | Coronavirus has death rate of 1-2%. It might be slightly
           | higher if the health care system gets overwhelmed, but the US
           | has a head start on Italy/China in terms of social distancing
           | measures.
        
             | varjag wrote:
             | 3.4%
        
               | ma2rten wrote:
               | That number is a crude estimate based on reported cases.
               | The real number of cases is obviously higher than the
               | ones being reported.
        
               | varjag wrote:
               | These are WHO figures. You are speculating.
        
           | ISL wrote:
           | What odds are you giving for the 5% prediction?
           | 
           | COVID-19 is going to hit us hard, but I believe deeply in
           | America's ability to adapt and pull together. We are
           | fractured and almost-leaderless today, but the United States
           | tends to do very well against a common challenge, once the
           | scale of the challenge is understood.
        
             | [deleted]
        
             | aaronbrethorst wrote:
             | The United States's greatest challenges of the 20th century
             | were only dealt with _after_ the country had strong
             | leadership at the top. There is zero chance the U.S. will
             | get that aforementioned strong leadership before January
             | 2021 at the earliest.
        
           | darawk wrote:
           | I will make a bet with you for whatever amount of money that
           | you want that every single prediction you just made is false.
           | On a per capita basis, the US will have a better time than
           | Italy. The US will lose _nowhere near_ 5% of its population.
           | Not even 1%.
           | 
           | Happy to formalize it and bet for real, if you'd like.
        
           | CyanLite2 wrote:
           | 5%? That's like 15-20 million people. Doubt it. We, the
           | United States, have a lot of problems. We're greedy. We're
           | arrogant. While we can't prevent all deaths, we're not going
           | to let 15-20 million people die to a virus in this modern age
           | of technology and healthcare.
        
             | throwaway8291 wrote:
             | I hope for the best.
        
             | onetimemanytime wrote:
             | >> _we 're not going to let 15-20 million people die to a
             | virus in this modern age of technology and healthcare._
             | 
             | well, you have to take measures weeks and months ahead, or
             | else it doesn't matter...lungs need oxygen.
        
             | heretoo wrote:
             | Technology doesn't help once the number of cases needing
             | intensive care exceed the capacity. Healthcare doesn't
             | exist without technology.
             | 
             | Italy exceeded that limit in the last two days, so now they
             | have to decide who has the highest chance of survival, and
             | those people get intensive care, if it is available.
        
         | i_am_proteus wrote:
         | Neither agreeing nor disagreeing with your point, but
         | deliberating over what could have been done in the past does
         | not help solve a crisis in the present.
        
           | hn_throwaway_99 wrote:
           | I very much disagree. The mistakes that were previously made
           | (both broadly socially and specific instances, such as
           | closing the pandemic response team and the delay in testing)
           | were all incredibly foreseeable. I find it the height of
           | dishonesty to say "Gosh, we had no idea what would have
           | happened, we just have to focus on the present". Now, I don't
           | think you're saying that, and you're right that the current
           | situation is where we are and we should focus on what we can
           | actually do. In the "never let a good crisis go to waste"
           | vein, though, one thing we can actually do is make people
           | realize that the health and well-being of your neighbors is
           | inextricably linked to your own.
        
           | CPLX wrote:
           | I mean today, literally, he could call Nancy Pelosi, who most
           | certainly knows who he is and would call him back, and scream
           | at her for the insane lack of direct federal action to help
           | regular workers affected financially by this crisis in the
           | bill they just passed.
           | 
           | If enough _people like him_ did that to our world leaders you
           | can be damm sure it would make a difference.
        
             | whiddershins wrote:
             | Who isn't affected? Are you arguing we should
             | simultaneously bail out the whole country?
        
               | CPLX wrote:
               | Yes of course. The government should take steps to
               | stabilize the whole country and reduce the damage caused
               | by mass disaster events. That's what governments are for.
        
               | whiddershins wrote:
               | I don't disagree, but I find your general stance of "of
               | course my ideology is reality" totally problematic.
               | 
               | Edit: To clarify there is a wide array of opinions about
               | "what government are for" and "what governments should
               | do" ... I think it is important to acknowledge that when
               | expressing an opinion about what you think.
        
         | kick wrote:
         | I think implying that he doesn't support those isn't
         | necessarily in line with his previous statements.
         | 
         | He's previously made statements in favor of _at least_
         | universal healthcare, and it seems incredibly unlikely that he
         | doesn 't support sick leave policies.
        
           | claudeganon wrote:
           | Ycombinator funds several startups whose success depends on
           | Medicare for All not happening.
        
             | kick wrote:
             | They've also funded startups in bids to try and make
             | universal healthcare happen:
             | 
             | https://blog.ycombinator.com/yc-research-universal-
             | healthcar...
             | 
             | Also, you shouldn't refer to universal healthcare/single-
             | payer as a concept with "Medicare for All." Medicare for
             | All is a compromised American policy proposal inferior to
             | what most countries have had for years.
        
               | claudeganon wrote:
               | Medicare for All is the only meaningful proposal with
               | mass support inside the Overton Window of American
               | politics right now. I'd prefer a robust national
               | healthcare service, but that's not on the table.
               | 
               | Watsi is more akin to GoFundMe for care in the developing
               | world, which, while admirable, has little to do with
               | creating a universal healthcare system anywhere.
        
         | dang wrote:
         | Please don't take HN threads on generic tangents. They're
         | predictable.
         | 
         | https://hn.algolia.com/?dateRange=all&page=0&prefix=false&qu...
        
         | throwGuardian wrote:
         | Italy has both universal health coverage and sick leave
         | policies, but is still reeling with a 7% mortality rate [1] and
         | crisis. Neither replaces good leadership and policy/decision
         | making by public health officials, and certainly has ZERO
         | effect on pandemics.
         | 
         | FYI, countries routinely provide free health care [2] during
         | pandemics because it typically is an existential crisis for
         | it's civil society and economy.
         | 
         | [1]: https://www.ccn.com/coronavirus-death-rate-soars-to-7-in-
         | ita...
         | 
         | [2] : announcement about US COVID-19 testing and treatment:
         | 
         | For USA -
         | 
         | Where to get COVID-19 test?
         | 
         | Enter your zip code to find out the nearest COVID-19 test site.
         | (from US HRSA.gov website) https://findahealthcenter.hrsa.gov/
         | 
         | 1. Go to clinics instead of crowded large facilities.
         | 
         | 2. Fees: Testing and Treatments are free.
         | 
         | If confirmed, home isolation for 14 days, please help stop
         | spreading COVID-19. Proactive screening to stop the spreads.
        
           | randomsearch wrote:
           | > 7% mortality rate
           | 
           | Please don't use such misleading figures. Spreading fear is
           | dangerous. This number is known as a "naive case fatality
           | rate", with the emphasis on naive. And you're even quoting
           | just for one country - cherry-picking.
           | 
           | The UK CMO has said the mortality rate for COVID-19 is likely
           | 1% or less.
           | 
           | Please, act responsibly. The situation is serious and
           | difficult enough.
        
             | throwGuardian wrote:
             | The only person taking anything I said out of context is
             | you. I've been very specific about the 7% estimate being
             | unique to Italy, replete with a source. I've never claimed
             | that to be the overall wordlwide mortality rate, so read
             | before accusing someone.
             | 
             | > Please, act responsibly ..
             | 
             | I suggest you practice what you preach, and read someone
             | else's well intentioned, informed opinion without
             | attributing malice or intent to spread falsehoods.
             | 
             | Most of all, the false narrative that a universal health
             | care system somehow handles pandemics any better is clearly
             | being proven wrong in the case of Italy, which is what I
             | was trying to point out
        
             | danenania wrote:
             | No one really knows how the number will turn out. There are
             | factors that could push it down: lack of testing, lots of
             | mild cases; and factors that could push it up: the disease
             | takes a long time to either recover or succumb to, so many
             | of those who will end up dying from it haven't died yet.
             | 
             | Resiliency of healthcare systems also clearly has a _major_
             | impact. It might be well under 1% in a  "first world"
             | country where hospitals can keep up, and well over 10% in a
             | "third world" country where they can't.
             | 
             | While a 7% mortality rate certainly isn't some kind of
             | objective fact, it's unfortunately not out of the realm of
             | possibility for us in a worst-case scenario where the
             | healthcare system is completely inundated. It's better to
             | face up to that possibility than downplay it even if it
             | scares people, because we urgently need people to act so it
             | doesn't get that bad. While I agree that people shouldn't
             | fear-monger, it's far more irresponsible at this point to
             | downplay the risk than to (arguably) overstate it.
        
         | whiddershins wrote:
         | This is a negative and overall unhelpful comment.
         | 
         | Not only do I not agree with your characterization of what is
         | useful for him to do, your ideas about health care policies and
         | mandatory sick are irrelevant, distracting, unimaginative, and
         | an example of moral posturing that takes the form of demanding
         | employers somehow take this burden, basically it is moral for
         | you to demand someone-not-you foot the bill for something you
         | think should happen.
         | 
         | I deeply wish this wasn't the highest voted comment on this
         | submission.
        
           | saiya-jin wrote:
           | Well here is where you disagree with most of the HN crowd
           | including me. Maybe you are rich enough or insensitive enough
           | to not care. That in fact doesn't matter at all.
           | 
           | Free/almost free good enough healthcare, and education in
           | similar vein are cornerstones of any society that would like
           | to call itself fair, just and overall good place to live, not
           | only for few elites. Everybody benefits from it, whole effin'
           | mankind benefits from it long term.
           | 
           | Heck, even though I am relatively young and properly healthy,
           | so I don't need to spend a cent on healthcare, I am happy to
           | pay (swiss) one so that other benefit. Fuck society that
           | doesn't do that.
        
             | whiddershins wrote:
             | These things aren't free. It is merely shifting the costs.
             | 
             | Shifting costs to employers (mandatory paid sick leave) is
             | generally immoral.
             | 
             | If people want to provide a benefit, do it with government
             | spending, and remind yourself it is your money (taxes) that
             | funds it.
             | 
             | If you are still willing to do it, at least you are putting
             | your money where your mouth is.
        
             | whiddershins wrote:
             | Also "Fuck Society that doesn't do that" [you are Swiss?]
             | Am I understanding you correctly?
             | 
             | That's grossly insulting and jingoistic. Maybe you should
             | rethink your nationalism and arrogance.
        
         | ma2rten wrote:
         | Health insurance companies have already said they will cover
         | COVID without copay/deductibles. I am sure that there will be
         | free/low cost options for people without any insurance.
         | 
         | The people who profit from the current system know that there
         | is a presidential election in November. They can't afford to
         | let public opinion go against them. Ironically, I think that
         | this event will cement the current system more.
        
           | claudeganon wrote:
           | > Health insurance companies have already said they will
           | cover COVID without copay/deductibles.
           | 
           | This has been said about testing and coverage for testing is
           | included in the bill that passed the house. But I've seen it
           | nowhere reported that this is true for treatment. What's the
           | source for this claim?
           | 
           | > I am sure that there will be free/low cost options for
           | people without any insurance.
           | 
           | The only provision currently on the table is Medicaid
           | expansion to states for treatment, but the amount of people
           | who are or will be ineligible for Medicaid (assuming they got
           | laid off) is quite large. I'm not certain how you can be
           | "sure" of this.
        
             | ma2rten wrote:
             | It turned out it was a misstatement by Trump:
             | 
             | https://www.cnn.com/2020/03/12/politics/fact-check-copays-
             | co...
        
           | amluto wrote:
           | Which means that, once a treatment or vaccine is available,
           | the vendor can charge essentially whatever they please.
           | 
           | I think the federal government should buy or acquire by fiat
           | the rights to produce remdesivir and contract, immediately,
           | with multiple vendors to start mass production. If the trial
           | pan out, the US alone may need enough to treat a few million
           | people. If the trials don't pan out, some money is lost.
           | 
           | (I'm not saying Gilead shouldn't be fairly compensated. By
           | all means, pay them a few billion dollars. But don't allow
           | them to extract $50k per case. And don't allow them to delay
           | widespread availability while negotiating.)
           | 
           | FWIW, China appears to be doing this right now. A Chinese
           | company is manufacturing the drug now and is essentially
           | ignoring the patent.
        
             | rjzzleep wrote:
             | Let's not forget that the US did that with the Anthrax
             | vaccination.
             | 
             | https://www.theguardian.com/business/2001/oct/23/anthrax.bu
             | s...
        
             | fma wrote:
             | If I recall, in addition to ignoring the patent, the
             | Chinese company is taking the Gilead drug, repurposing it
             | and then owning a new patent for the Corona virus...
        
               | amluto wrote:
               | To some extent the legal wrangling its irrelevant. China
               | is likely to want large amounts of the drug, and they
               | aren't waiting. Presumably there will be a lawsuit and a
               | settlement. Gilead has very little leverage in China,
               | unless they are able to outproduce the home grown
               | manufacturer.
        
       | felltrifortence wrote:
       | We are launching a initiative to showcase tech projects to fight
       | the covid-19 virus. Fell free to submit your projects
       | https://taikai.network/taikai/challenges/covid-19
        
       | andrewdubinsky wrote:
       | Quarantine Enforcement using GPS with Symptom Tracking
       | https://www.proveneapp.com
       | 
       | Video: https://vimeo.com/395294573 Deck:
       | https://www.dropbox.com/s/128ef7cmu62yv9i/Provene%20Quaranti...
       | 
       | It's a monitoring platform - Used for jail diversion, recidivism,
       | drug treatment, etc...Lots of great use cases around quarantine
       | and tracking.
        
       | [deleted]
        
       | nenadst wrote:
       | just heard this on https://peterattiamd.com/peterhotez/
       | 
       | apparently Dr.Hotez has a Sars-1 candidate vaccine antigen which
       | could be repurposed for Covid-19,
       | 
       | https://grantome.com/grant/NIH/R01-AI098775-03S1
       | 
       | but they don't have funding to move it to clinical trials ..
        
       | [deleted]
        
       | leakybit wrote:
       | There already exists a low cost ventilator that was designed for
       | the India market.
       | 
       | https://www.agvahealthcare.com/
       | 
       | but good luck getting fda approval.
        
         | jacquesm wrote:
         | If the choice is no FDA approved ventilator vs one that is not
         | approved I think the second option is the better one.
         | Emergencies will change the landscape rapidly to the point
         | where such luxuries as FDA approval will no longer matter as
         | much as they did before.
        
           | quaquaqua1 wrote:
           | The ventilator most likely is not approved for
           | political/cronyism reasons, rather than safe functionality
        
           | avip wrote:
           | FDA has emergency approval process and it'll be used when
           | shit hits the vent.
           | 
           | In fact it was just used like two days ago.
        
       | deepnotderp wrote:
       | I wonder if we can just use a $250 Jackson-Rees circuit and an
       | electric motor as a DIY ventilator in a pinch.
        
       | _hardwaregeek wrote:
       | This does seem to be a worthwhile effort and I have no doubt some
       | good will come of it. But I'm not sure targeting COVID is the
       | best idea. Projects can certainly help with that, but they need
       | to scale, fast. Plus any sort of physical requirements like
       | manufacturing is out of the question. What I'd be worried about
       | is the _next_ COVID. I don 't mean this in a literal, disease
       | based fashion. We should be asking about the next global
       | disaster. How can our infrastructure break down? What can we do
       | to strengthen it? Who is vulnerable?
       | 
       | Also I'm a little concerned about medical projects that are
       | created in an emergency and attempting to do fast track research.
       | Immediate solutions may sound great but we don't want to do more
       | damage in our hastiness. Urgency can lead to wishful thinking
       | which can lead to disaster.
        
       | [deleted]
        
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