[HN Gopher] Hydroxychloroquine Update for April 6 ___________________________________________________________________ Hydroxychloroquine Update for April 6 Author : hprotagonist Score : 27 points Date : 2020-04-06 16:02 UTC (6 hours ago) (HTM) web link (blogs.sciencemag.org) (TXT) w3m dump (blogs.sciencemag.org) | kevingadd wrote: | The possible high-mortality interaction with metformin is a | terrifying prospect. Diabetes is so common... hopefully it's | something that doesn't apply to humans. | m0zg wrote: | Counterpoint: http://www.leparisien.fr/societe/sante/chloroquine- | ne-perdon... | | You can do double blind studies until your patients are literally | blue in the face, or you can try what works now. That is | literally the choice at the moment. | | According to Peter Navarro, a good percentage of NYC patients are | getting HCQ at the onset of symptoms now. Kentucky is giving it | to patients, too. Italy saw its numbers of deaths stabilize once | they started giving it. Marseille (where Raoult's hospital is) | has the lowest fatality rate in all of France. If it works, we | should see the recoveries shoot up in 5-7 days. | | HCQ is also available _over the counter_ in some countries, and | is given out like candy all over Africa where there's risk of | malaria. | kevingadd wrote: | The fact that you can buy the drug over the counter doesn't | mean it's universally safe. The people being hospitalized here | are already doing poorly so exposing them to additional risk is | not something you should just do on a whim. As the linked post | mentions, there are clear signs of potential risks associated | with the use of HCQ. I hope for the patients being dosed with | it now that it both works and is safe, but it's incredibly | reckless to go 'it's over the counter so it's fine'. A healthy | person taking a reasonable dose as a malaria countermeasure is | not the same as a person on a ventilator in the ICU. Their | immune system is in a different condition, so is their heart. | tptacek wrote: | Substantial numbers of C19 patients are being given HCQ, but | more than that, substantial numbers of newly-diagnosed C19 | patients are _already taking HCQ_ , since it's part of the | standard of care for widespread conditions like rheumatoid | arthritis. And those patients will of course have had the HCQ | intervention before acquiring C19. It doesn't look like anyone | is reporting unusual clinical success for those patients, while | you can find clinical reports of QT disturbances (so: people | _are_ paying attention to this stuff). | ceejayoz wrote: | " You can do double blind studies until your patients are | literally blue in the face, or you can try what works now." | | https://en.wikipedia.org/wiki/Politician%27s_syllogism | ck2 wrote: | While other drugs are looking far more promising, there might be | an obvious reason why despite lack of clear proof/results the | president is pushing it so hard like everything else that | motivates him: https://lawandcrime.com/covid-19-pandemic/major- | producer-of-... ___________________________________________________________________ (page generated 2020-04-06 23:00 UTC)