[HN Gopher] Anxiety, depression, and PTSD may be adaptive respon... ___________________________________________________________________ Anxiety, depression, and PTSD may be adaptive responses to adversity: study Author : firstbase Score : 278 points Date : 2020-09-03 09:00 UTC (14 hours ago) (HTM) web link (www.psychologytoday.com) (TXT) w3m dump (www.psychologytoday.com) | podgaj wrote: | As someone on disability with a mood disorder I can say without | reservation that that article was mostly horrible. | | I will agree with them that there is a mismatch, but the mismatch | is between each individuals genetics and environment. so they are | still disorders, it is just that they have not found the right | treatment. | | And as someone who has been hospitalized several times it is | amazing to me how little testing they do for people with serious | mental illnesses. It was not until after I had to learn genetics | and neurobiology that I forced them to give me a simple serum | amino acid test that showed something atypical was going on. | Turned out I have a BH4 (tetrahydrobiopterin) deficiency that | limits the amount of serotonin and dopamine I make. BH4 | deficiency has already been show to be a cause for anxiety and | depression. | | So Mood Disorders are all environmental illnesses. I am off of | all my medications and I control my mental health by diet and | environmental changes. But some neurological damage has been done | that I might have to live with. So you youngins heed my advice, | if something feels bad, don't do it. | kbos87 wrote: | This feels so obvious. 30 years from now, we might very well look | back at these labels we applied to people, implying something is | wrong with them for responding to their negative circumstances, | and feel like we were living in the dark ages. | | When we see historic rises in mental disorders following an | external event like the coronavirus pandemic, is it not something | we should reasonably expect? I can accept that some sliver of the | population has an unreasonable reaction to something like this, | but for most people, it isn't a problem in their head as modern | psychology tends to imply. | | https://www.google.com/amp/s/www.washingtonpost.com/health/2... | arethuza wrote: | I remember reading about the first expeditions to the Artic by | the Royal Navy in the 19th century - they initially found some | sailors exhibiting the symptoms of being drunk and would punish | them harshly. It took them a while to realise that the symptoms | of severe hypothermia and drunkenness are actually pretty | similar.... | | See: | https://www.goodreads.com/en/book/show/878082.Barrow_s_Boys | Cthulhu_ wrote: | I hope so, and that what we now call depression will be | considered as silly a moniker as hysteria or "troubled humours" | back when. | proverbialbunny wrote: | Exactly. When it comes to depression the chemical imbalance | theory comes from Zoloft. It is a drug that accidentally had | the side effect of reducing depression in some patients. | Curious scientists wanted to figure out why, so they examined | it. Turns out Zoloft boosts serotonin in the brain. This | created the chemical imbalance theory, but since then study | after study for decades has disproved this, yet for some sort | of reason the theory stays in the mainstream. | | Ibuprofen can cause an ulcer. Imagine some primitive ape sees | this blood loss and assumes the blood loss is what reduces | inflammation. The Zoloft serotonin study follows the same | faulty logic. | SeanFerree wrote: | This makes sense that ADHD could be a result from physical | inactivity. Add the fact that most kids stare at a screen after | school while also sitting. This could explain the increases in | ADHD. Anxiety is a learned trait I believe. Increased depression | seems to me to be due to social media, which allows people to | constantly compare their life with others | softwaredoug wrote: | The ACE (adverse childhood experiences) study might be one of the | most important health findings since Germ theory. In the sense | that it finds a true root cause for a lot of health maladies, as | well as physical mechanisms that cause these health issues in | traumatized kid (all animals respond maladaptively to stress | hormones introduced too early in development) | | I'd recommend people read "The Deepest Well" - a great book on | this topic. | throwaway4747l wrote: | Ah yes, yet another occurence of adaptationists trying to | shoehorn literally every single trait into their framework. It's | basically intelligent design that doesn't say its name. | whearyou wrote: | No way! /s | anonzzz wrote: | "there is little in our evolutionary history that accounts for | children sitting at desks quietly while watching a teacher do | math equations at a board." | | In the section that discusses labels, I am particularly struck by | this quote. So many things in our evolutionary history seem | contrary to the way we live, learn, and interact. Perhaps this is | the catalyst that ignites the evolutionary flames. I often think | that we are just hitting our heads against a wall and expecting | different results other than a bloody head. | anm89 wrote: | I'm not a psychologist but this feels pretty intuitively self | evident to me. Did anyone ever think otherwise? | mlthoughts2018 wrote: | This is an interesting read on a similar take on major | depression, | | https://grasshoppermouse.github.io/2018/12/16/seven-reasons-... | solinent wrote: | I used to get severely depressed, and it was often stress- | related; adversity, work, even sickness would make things worse. | I completely changed my lifestyle and started working out almost | 3 hours a day (walking counts)in addition to removing | carbohydrates from my diet almost entirely. After this change, I | only get depressed for a second, then I realize I can take | action, and then I take action, and it leads to happiness. | | YMMV. | | my personal theory is that it's related to bacteria in your gut-- | working out helps promote a good gut microbiome (this is well | studied) and removing carbohydrates removes all those bacteria | such as lactobactilla which will literally cause psychological | changes, these bacteria are part of the metabolic process | converting carbohydrates to blood glucose, and they are literally | interacting with the nerves in your gut making you feel | depressed. It's a biological thing. Psychology never helped me, | instead it actively harmed me. The lectures of Robert Sapolsky | and the concepts of cognitive behavioral therapy helped the most | from the psychological perspective, however. This combination of | advice is purely anecdotal of course, but all the steps I took | have been widely studied. It's hard to create an industry around | the removal of a product, I guess. | insickness wrote: | Trying to decide if mental disorders are disorders or adaptations | is a false dichotomy. They can be both. For example, the 'dark | triad', narcissism, Machiavellianism, and psychopathy, can help | an individual succeed. Studies have shown that women are | attracted to these personality traits in men. | | On a group level, anxiety in individuals may be evolutionarily | advantageous to the group while being disadvantageous to the | individual. If a person is hyper alert, it may help the group to | become aware of danger but cause tremendous stress to the | individual. | proverbialbunny wrote: | The key criteria for something to be called a psychological | disorder is it has to hurt the patient in some way, causing | them a disadvantage in life. | | To flesh this out: | | >Studies have shown that women are attracted to these | personality traits in men. | | Woman are attracted to men who are as successful or are more | successful as them. NPDs and ASPDs (though more rare than NPDs) | can fake being successful and others fall for it. This | relationship is often short lived once they realize they were | tricked. | | The most common form of employment for someone who is ASPD | (what you're calling psychopathy) is being a homeless | alcoholic. The second most common is being in prison. The | leading theory is ASPD is an adult who did not grow out of | their terrible twos. This does not help an individual succeed | in any shape or form. ASPDs do not and can not maintain | relationships for a long period of time, and the few high | functioning ones not in prison or homeless roam around like | nomads from town to town leaving once they are no longer | welcome. | | Machiavellianism is a philosophy or a set of beliefs. It is not | a psychological disorder. It does not harm the belief holder. | Machiavellianism is a sort of game theory on a macro nationwide | scale. | | I can continue with NPD (narcissistic personality disorder), | but I can assure you in the long run it does not benefit them. | They believe manipulating people is better for them and will | jump through mental hoops to justify their behavior to | themselves. When someone is thought of as a con artist or a | gold digger, that is most likely someone who is NPD. | | >On a group level, anxiety in individuals may be evolutionarily | advantageous | | Anxiety is assuming (usually unconsciously) a negative outcome | will happen. It's a danger feeling. When anxiety moves from a | rare feeling to a disorder, it's because they're overly | assuming/believing faulty futures. This can come from faulty | logic, or being told incorrect beliefs during childhood, or | many other situations. Anxiety as a disorder has no advantage | to the user. | tomhoward wrote: | Out of necessity (after existing conventional treatments offered | little help) I've been conducting a 10+ year self-experiment | related to this topic. | | Like others have described, when I started experiencing symptoms | of conditions resembling anxiety, depression, ADHD, mild bipolar, | paranoia and CFS/ME, I initially sought mainstream medical | psychiatric treatment and undertook talk therapy and was | prescribed anti-anxiety (benzos) and antidepressant (SSRI) | medications. There was some relief but there were also unpleasant | side-effects, and I just had a strong feeling these treatments | were not really addressing the core problems, and indeed I even | felt like the symptoms were fairly normal reactions to the life | experiences I'd endured. | | Later I tried to heal myself with nutritional and exercise-based | approaches, and relatively conventional emotional approaches like | meditation. Again, some mild/temporary improvements were | noticeable, but they were inadequate, and it still felt like | there was something deeper I needed to connect with. | | About 8 years ago, I found an approach that involves identifying | and releasing traumas, attitudes, behavioural patterns, self- | perceptions and defense mechanisms that are held in the | subconscious mind, particularly ones that have been attained in | early life and have snowballed through repetition compulsion [1] | (a concept that Freud first articulated). | | I've been undertaking these approaches continually since I | discovered them, and bit by bit all the symptoms have resolved. | | My experience has confirmed, at least to me, that these | conditions are "adaptive responses to adversity" (or something | else related to that concept), and that in order to heal the | symptoms, I needed to understand their basis at a very deep | level; as Jung said, "making the unconscious conscious" [2]. | | Once that had been done, adopting new, healthy attitudes and | behaviours and living free of those symptoms has been fairly | easy; i.e., healthier behaviours just emerged naturally once the | causes of the unhealthy behaviours were identified and | understood. | | If any researchers or laypeople are interested to know more about | the techniques I've used and the results I've experienced, I'm | happy to be contacted (email address in profile). None of the | approaches I've used or their underlying hypotheses are novel; | it's been written/spoken about extensively by veteran experts on | mind+body health including Mate and Bruce Lipton. But there | doesn't seem to be much in the way formal studies into these | concepts, so I'd be happy to connect with anyone working in the | field or anyone else interested to explore further. | | [1] https://en.wikipedia.org/wiki/Repetition_compulsion | | [2] https://www.goodreads.com/quotes/44379-until-you-make-the- | un... | RankingMember wrote: | Can you give us an example of one of the techniques you used? | tomhoward wrote: | https://news.ycombinator.com/item?id=24365937 | vanderZwan wrote: | While I'm very happy that this worked out for you, and I'm also | sure that your scenario will apply to others, maybe even many | people, even then I have to add a word of caution: generalizing | from the experiences of _one_ person to _all_ psychological | conditions would be a scientifically unsound position to take | (I know that this not what you are saying, but it is possible | to walk away with that conclusion). | | For example, many of the issues that you mentioned (anxiety, | depression, etc) are _symptoms_ that can have wildly varying | causes. It 's similar to, say, a fever: if you have a fever it | can be completely different reason than what causes it for | someone else: one can develop a fever from an infection, or | from stress alone - so a psychosomatic cause. It's even | possible to have chronic fever due to brain damage! It has to | be evaluated on a case-by-case basis | tomhoward wrote: | Sure, thanks, but remember we're adults here, and pretty well | educated ones at that, so, the need for caution and | discernment can be presumed to be understood by readers on | this site :) | | For what it's worth, plenty of books have been written about | these concepts over several decades; some authors include | Gabor Mate, Bruce Lipton, Stanislav and Christina Grof, Peter | Levine and Iain McGilchrist, all of whom have advanced | academic credentials in psychiatry or biomedical science. | | So, yeah, there's no "generalizing from the experiences of | one person to all psychological conditions"; there's sharing | one anecdote as an example of what many experts have known | for years (even if those experts' research findings aren't | used much in formulating the DSM or applied by your average | neighborhood psychiatrist, for reasons that are a whole other | discussion!). | phkahler wrote: | I completely agree. In my experience, most therapists have been | given very powerful tools but are not really equipped to handle | them. It has led me to understanding these concepts much like | you. As for this: | | as Jung said, "making the unconscious conscious" | | I may be misquoting but "until you make the unconcious | concious, it will control you life and you will call it fate." | Or something close to that. I agree, we often do things for | reasons we dont fully understand. We can offer an explanation | that sounds plausible, but there may well be more to it that | even we haven't really explored. | novok wrote: | This is known as psychodynamic therapy for others who want a | name for it. There are therapists that specialize in it. I must | warn you its a very long type of therapy with a lot of | sessions, so it will cost you $$$. Also some people use it as a | weekly whining session for years and never get anywhere with | it, so please go into it trying to get results. | mettamage wrote: | > Also some people use it as a weekly whining session for | years and never get anywhere with it, so please go into it | trying to get results. | | A bit harshly formulated, but I agree. I've seen people being | quite aimless in their therapy. I'd recommend becoming an | expert on your own condition. | astrocat wrote: | _The Trauma of the Gifted Child_ by Alice Miller is probably a | good read to throw in here if this is the direction you 're | looking to explore - especially if you can get an early edition | that hasn't been watered down. Some of her perspectives into | experiences as a child that are commonly accepted as "normal" | but are often experienced by the child as trauma and grow into | dysfunction as adults were interesting. | Ancapistani wrote: | Is it "Trauma" or "Drama"? The version I'm seeing on Amazon | is "The Drama of the Gifted Child". | | ETA: I found this interesting, too - the author's own child | wrote a book about his negative childhood experiences: | https://www.haaretz.com/life/books/.premium-mother- | dearest-1... | thebean11 wrote: | It's "Drama" | kej wrote: | >an approach that involves identifying and releasing traumas, | attitudes, behavioural patterns, self-perceptions and defense | mechanisms that are held in the subconscious mind | | Could you elaborate on this part? What does "identifying and | releasing" look like, in practice? | tomhoward wrote: | Hehe, this is where discussions about this stuff can go off | the rails, as the main modality I've used has links to the | chiropractic profession (even though I think that profession | is highly dysfunctional and many or even most of its | practitioners are quacks at best and frauds at worst). | | Anyway, the modality I've used is a technique called NET | (neuro-emotional technique), which (I believe) is similar to | a practice called Psych-K (I've never done this one but I'm | told they're similar). Both of them use muscle-testing to | identify incongruences between the conscious and subconscious | mind. | | I've also done plenty of Holotropic Breathwork and | Ericksonian Hypnosis, some EMDR, some EFT/Tapping, and some | use of basic affirmations. Someone else I know well has done | a lot of a practice called Family Constellations, as well as | another practice that focuses on healing the trauma of birth | - though I've not done either of those practices. | RankingMember wrote: | Hey if worked for you, it worked for you. Thanks for laying | it out there regardless of what I think of some of these | techniques. | iamdbtoo wrote: | This has been my experience as well, but I found it through | talk therapy, medication and some philosophy. | | Almost all of my negative emotions on a day to day basis are | generated by defenses I developed as a child to make being a | kid with undiagnosed ADHD workable. It worked while I was a | kid, but became untenable as I got older. | | Once I discovered the ADHD as a basis for this thinking, | everything started falling into place and as I started exposing | these thought patterns to myself, they started going away. | leto_ii wrote: | Here's a personal anecdote of the moment when I realized that | perhaps mental disorders are not disorders at all: | | A few years ago I had a job that made me deeply unhappy. The | unhappiness came about gradually, but in my last year there it | was overwhelming. In my last year on the job I spent a good chunk | of my working hours holding back feelings of deep frustration and | anger over how things were progressing and over how I was being | treated by my boss and by a few coworkers. At times I considered | going to see a therapist, but in the end I opted for a more | direct solution - I spontaneously quit the job. | | Even though my financial situation became a lot less secure, my | state of mind improved greatly. I started sleeping better, some | stress related physical symptoms went away, I started working on | personal projects that I had been neglecting etc. | | I'm pretty sure that, had I gone to the therapist, I would have | been diagnosed with some sort of depressive disorder and probably | would have been prescribed some sort of medication. I probably | would have still been in the job I actually hated and I wouldn't | have made as much progress in understanding what I actually | wanted from my life. | frizzx wrote: | I had a similar situation, although I had already been | diagnosed with anxiety and depression multiple times. | Medication never had a positive impact other than temporary | fixes for anxiety so I reject any daily antidepressents. | | Last year I was in a similar work situation but did decide to | go to therapy as a kind of check to see if my feelings seemed | warranted or if it was maybe something else.Ultimately decided | to leave that job. It took 8 months for me to figure out what I | wanted to do and actually start working again. | | Extremely happy I made those decisions as I've doubled my | salary, left an industry that was wrecked by COVID and got into | one that has had accelerated growth for the same reason. I | think it's good to trust your instincts, even though we both | made different decisions they seem to have been the right ones | for our particular situations. | slothtrop wrote: | > I'm pretty sure that, had I gone to the therapist, I would | have been diagnosed with some sort of depressive disorder and | probably would have been prescribed some sort of medication | | 100%, everything is a nail to them. Diagnosis is really not | that rigorous. | | It's amazing to me that the very first course of action | suggested is not lifestyle changes, but medication. But money | talks and here we are with over-medicated nations. | podgaj wrote: | This is like saying people with heart disease do not have a | disease because they stopped eating poorly and the heart | disease went away. | | You did have a metal disorder. You were just lucky to find the | cause. The cause was job stress. | | I have a mental disorder that was harder to find the cause. But | I did as well. | leto_ii wrote: | > You did have a metal disorder. You were just lucky to find | the cause. The cause was job stress. | | You could phrase it that way, but the fact remains that for | me, I feel, there was an objective external cause to my | unhappiness. It wasn't a spontaneous and inexplicable | 'chemical imbalance in the brain'. It was a reasonable | reaction to a shitty life experience. | | > I have a mental disorder that was harder to find the cause. | But I did as well. | | Indeed I may have stated my conclusion too broadly. I'm sure | there are problems out there that can't be fixed by changing | your lifestyle/job etc. and that may require serious effort, | therapy, medication. | podgaj wrote: | But you see, I was hospitalized several times for my mood | disorder. I have come to find out that there was an | objective external cause of that as well. | | The problem is not with the psychiatric "cures", the | problem is the psychiatrists. It took a test to LOOK at my | brain chemistry form them to see what was going on with me. | It took 25 years of convincing them to give me the test. | THAt is the disorder. | | Shitty life experiences, and almost every environmental | input, will affect chemicals in our brain and body. I mean, | how do you think saddness happens? It just appears out of | no where? NOPE. | | https://www.sciencedirect.com/science/article/abs/pii/S0165 | 0... | proverbialbunny wrote: | >Shitty life experiences, and almost every environmental | input, will affect chemicals in our brain and body. | | I think that is a key point many people fail to see. Our | present moment (including our thoughts and beliefs in the | present moment) determine what chemicals get released in | the brain. | | Calling something a chemical disorder is overlooking | correlation is not causation. (That does not imply pills | can not be helpful and should not be considered.) | | Did you end up finding a cure on your end? What was it? | podgaj wrote: | I was recently diagnosed with a genetic condition, GCH1 | deficiency, which lowers the amount of serotonin and | dopamine I make and increases the amount of trace amines. | (Trace amines are similar to methamphetamines.) | maxlamb wrote: | Heart disease means presence of plaque in arteries, it is | physically verifiable, the plaque is physically stuck to the | artery walls and is much harder to get rid of. If you are | doing something that makes you unhappy because you really | need the money and then as soon as you stop doing it you are | happy again, I really don't see how you can define this | period of unhappiness as a mental disease. | anoncake wrote: | Depression is not just being unhappy. | proverbialbunny wrote: | The sad fact about anti-depressants is they prolong depression | for the average person who takes them. Yes, the average person | recovers from depression without anti-depressants, but taking | anti-depressants stifles that. | | I can only theorize, so grain of salt, but I've noticed people | who are on anti-depressants are less likely to work on their | issues, improving and growing. Many get satisfied in that semi- | depressed state. This might be why taking an anti-depressant | can prolong depression. | ddorian43 wrote: | Sorry man, the therapist can't prescribe. You are free to read | "The body keeps the score" to understand why everything you | wrote is wrong/false. | | To the downvoters: | | Things in life are in different levels. Your knee may hurt a | little, you may tear 1 ACL in your knee, you tear all ligaments | in your knee, your knee got chopped off, etc etc. | | Going to the doctor, doesn't 100% mean your knee will go into | surgery. Sometimes, you may just need a professional consult, | etc etc. | leto_ii wrote: | > everything you wrote is wrong/false. | | Well now, this is a bit too harsh. I presented my anecdote as | such, not as some universal conclusion that applies to | everybody and every life situation. | | > Going to the doctor, doesn't 100% mean your knee will go | into surgery. | | You are right. I do however feel that psychiatry is not | exactly as much of a science as other medical fields. I'm not | convinced that what is considered a disorder according to the | DSM is exactly as much a disorder as, let's say, a vision | defect. I'm also really reluctant to try out medication that | will alter my mood and mental acuity in unpredictable ways. | As much as possible I would prefer to not take things for | years and to not end up depending on them for good | functioning in the world. | [deleted] | ferros wrote: | Telling somebody else they are wrong about their own personal | experience deserves a downvote, which I don't have enough | points to give you. | ddorian43 wrote: | Here's a personal anecdote when I realized that perhaps | "knee medical issues" are not "medical issues" at all: | | I was once running and my knee started hurting. I kept | running and it kept hurting. I then saw that the reason my | knee kept hurting was because I was using the wrong shoe, | or was running not at the right form. After I changed | these, the knee didn't hurt no more. | | _Had I gone to a physiotherapist or an orthopedist, they | would 've put me into surgery for ACL/MLC reconstruction | and 6+ months of therapy so my knee worked again._ | | I would still be running after the surgery, not | understanding why my knee would hurt. I wouldn't have made | as much progress in understanding what I actually wanted | from my knee. | anoonmoose wrote: | How do you know they wouldn't have told you to use better | shoes or better form? This isn't even an anecdote, it's | more like half of one. | [deleted] | tsimionescu wrote: | The reason your assumption doesn't ring true while | leto_ii's assumption does is that we have a much, much | better understanding of the knee than we do of the human | mind, and much more objective tests for knee injuries | than for depressive disorders. | | So your assumption that you would have been given surgery | seems extremely unlikely, while the assumption that a | person with depressive symptoms would be prescribed | psychiatric treatment rather than being recommended to | leave their job seems possible. | | For your anecdote, I would expect that you would be given | a physical exam and then some kind of imaging | investigation before proceeding to surgery. Even if the | doctor you went to was incompetent during the physical | scan, the imaging would very quickly show whether there | is a need for some kind of surgery. Unfortunately, we | don't have any equivalent tests for psychiatric problems. | If your psychiatrist is incompetent, you may well be | prescribed medication that other psychiatrists may have | found unnecessary, and your only recourse is to trust | your own judgement above theirs (which has its own | problems, if you already suspect you have a mental | disorder). | | Of course, per their story, leto_ii didn't seek | professional help, so we can't know what the professional | conclusion would have been. Have you ever heard though of | psychiatrists recommending job changes to their patients? | More so, recommending they leave their job on the spot, | without securing another job before hand? | [deleted] | JimTheMan wrote: | I think people just need to realise that depression is going to | come from when the stressors in our environment overwhelm our | ability to cope. It's not just something that arises from out | of nowhere for most people. For instance I bet a great swathe | of the unemployed would not be depressed if they had a job. | | Sounds like you were able to adapt and start doing things that | would reduce your stressors. | | However I don't think its a 100% correct to equate therapy with | medication. If you visited a clinical psychologist they would | have probably worked on increasing your awareness of stressors, | thoughts and how to increase your ability to cope with them. | | Edit: And I just realised you may not have actually had a | disorder of any type. A psychologist would have been able to | assess you and see if you were just in an acute situation or | not. | bluntfang wrote: | >For instance I bet a great swathe of the unemployed would | not be depressed if they had a job. | | I think this is worth a rephrase. Something like: | | I bet a great swathe of people wouldn't be depressed if they | didn't have to trade their time for food and housing tokens. | JimTheMan wrote: | I suppose I am speaking from experience. I feel no | financial pressure but am greatly unhappy after being made | redundant. Work gave me purpose that is hard to replace. | podgaj wrote: | I agree, and this is why I say the majority of mood | disorders are environmental, even ones as bad as mine. | nverno wrote: | That is an unconvincing rephrasing though. The benefits of | hard (rewarding?) work to mental health seem obvious [to me | subjectively ofc] | bluntfang wrote: | It seems you're equating the requirement for a job with | hard and rewarding work. What makes you think people | won't do hard or rewarding work without the forced | incentive of housing? What makes you think most people | are doing "hard" and "rewarding" work at their jobs? | nverno wrote: | incentives drive outcomes- incentives to work cause | people people to work [paid or unpaid, for pleasure or | profit]. I wasn't making judgements on the reasons we | need to work, only taking issue with the idea that | working was causing depression. | Cthulhu_ wrote: | I've had something similar, not depression or whatever, just | not feeling in the right place at work. I was offered an | (external) career coach to help with it, also because I didn't | really want to quit because it was a fairly cushy job with high | potential to be challenging. But it hadn't been challenging or | gratifying for two+ years at that point. | | The tldr with the career coach was to do more about it myself | (very generic I know), eventually last year I looked for jobs | critically and found one that ticked a lot of boxes. I'm pretty | content right now. | pessimizer wrote: | > I probably would have still been in the job I actually hated | | If modern psychology has any goals, they are 1) to keep you at | work with minimal days off and high productivity, and 2) to | keep you from annoying your family. You would have been a | success story. | bmitc wrote: | I would recommend people watch this lecture by Stanford professor | Robert Sapolsky, who studies these things in depth and is an | actual expert. | | https://www.youtube.com/watch?v=NOAgplgTxfc | | There is a lot of arm-chair thoughts on this matter in this | thread, and I feel this lecture sets a lot of things straight. | | A helpful quote from the talk: "...the single point I want to | hammer in here over, and over, and over, is something that people | with depression constantly battle with. Back to semantics, we all | get depressed. Bad stuff happens to us. We all get depressed. We | feel lousy. We feel withdrawn. We feel a sense of grief. And | we're not taking much pleasure. And we withdraw. And then we get | better. We cope. We heal. We deal with things in life. What's the | deal with you that you can't do that? And there's this lurking | sense given that all of us have periods of being depressed and | come out the other end. When you look at people who instead go | down and stay down there to this crippling extent, there's always | this little voice between the lines there of, come on, pull | yourself together. We all deal with this sort of thing. I will | make the argument throughout here that depression is as real of a | biological disorder as is juvenile diabetes." | bernardlunn wrote: | This will help a lot of people avoid unnecessary anxiety and | shame/guilt. | heisenbit wrote: | Insights from psychology today from an article originally in | Forbes. | | About the Author: A pediatrician and writer, Dr. Escalante is on | a mission... | usgroup wrote: | +1 but let's see where your comment ends up ranked in the | thread at days' end. | podgaj wrote: | +2 | | "Dr. Escalante understands because she is a recovering | worried mother herself. " | | I am tired of people prescribing their cure to everyone else | in the world. Great, it worked for her. And I get it, the | whole world is neurotic, but to say it is not a disorder is | idiotic. | | If I make a mess of my room, it is just disordered. It is | just that simple. | vanderZwan wrote: | > _If ADHD is not a disorder, but a mismatch with a human | environment, then suddenly it's not a medical issue. It's an | issue for educational reform. And that is a compelling thought, | given the evidence that kids' focus and cognition are improved by | physical activity. Still, we need to take this study with a grain | of salt. There is a large body of research showing other | biological factors when it comes to ADHD. For instance, there is | evidence that premature birth increases rates of ADHD later._ | | So speaking as someone with adult ADHD who is getting by without | medication with the right lifestyle choices, this sounds a bit | like arguing that cardiovascular diseases are not medical issues, | they're lifestyle problems. | | I mean, yeah, in both cases the problems very much _are_ largely | caused by our lifestyles. But these lifestyles still affects me | differently than how it affects most other people. Don 't get me | wrong, I'd be very happy if we get rid of the _disorder_ label, | not to mention societal stigmas surrounding mental illnesses and | /or being neuro-atypical in general, but I don't see why we'd | have to choose between (in this example) educational reform and | psychiatric therapy when both seem valid options that complement | each other. | | EDIT: also, if you _really_ want a good example of dystopian | victim blaming in psychology, I 'd suggest checking out | "opppositional defiant disorder" and imagining how _that_ label | can be abused | | https://en.wikipedia.org/wiki/Oppositional_defiant_disorder | podgaj wrote: | Thank you, yes, I said the same thing in another reply. | | I am Bipolar getting by without meds. I do not have a disorder, | I have a difference. So I need to live and eat differently. | Pelic4n wrote: | Sorry but that attitude is extremely dangerous. Maybe you | have a less severe case that's manageable without treatment | but that's not the case for everyone. Mania states are | actively brain damaging and can blow into full-on psychosis. | There is no lifestyle change, diet or essential oil that's | going to stop that from happening for folks with a severe | bipolar disorder, which is absolutely a disease since it | destroys your brain if left unchecked. | | Spreading such misinformation can lead to people not seeking | treatment and getting hurt. Your case is absolutely not the | canonic case for people with bipolar disorder. | ColanR wrote: | > Spreading such misinformation can lead to people not | seeking treatment and getting hurt. | | Misinformation? Unless you have expert knowledge in that | domain - and unless the alternatives podgaj describes have | been exhaustively eliminated by a body of peer-reviewed | research - you have absolutely no justification to label | that as misinformation. | SketchySeaBeast wrote: | > and unless the alternatives podgaj describes have been | exhaustively eliminated by a body of peer-reviewed | research - you have absolutely no justification to label | that as misinformation. | | That's not how that should work. If I say that my farts | cure cancer, it's not the job of peer-review research to | disprove me, and until then we all just assume that the | information I'm giving is good. | ColanR wrote: | > until then we all just assume that the information I'm | giving is good. | | Fallacy of the excluded middle. There's other | alternatives to a) saying it's outright false and b) | saying it's outright true. I'm saying it shouldn't be | labeled "misinformation" without extensive evidence to | back it up, just as you're saying it shouldn't be labeled | "truth" without the same level of evidence. | | Instead, it's actually possible that we could discuss the | theory as if it _might_ be true, or false, until there 's | sufficient evidence to rule out one or the other. It's | Pelic4n's refusal to do this that I take issue with. | SketchySeaBeast wrote: | Ok, so misinformation may be too strong a word - really | it's just unfounded, so that labeling IS wrong. I still | think we need to treat it as false until we have evidence | it works. I'm sure you wouldn't treat my farts as curing | cancer if I made the claim unless there was proof. | ColanR wrote: | Glad we agree on the essentials. There was anecdotal | evidence to back up the claim, however; it's not | "unfounded." While that's not enough evidence to make any | real claims, it is enough evidence to have a | conversation. | | A conversation is a prelude to an exploration, and an | exploration is a prelude to a hypothesis, which is the | beginning of an experiment. An experiment is where we | obtain the evidence to begin to say that it might be | true, or false. | | It's entirely possible to think about something and even | discuss it without labeling it as either true or false - | to be simply agnostic. We don't need to jump to | conclusions. If we aren't jumping to conclusions, then it | would be incorrect to say that we treat it as false, just | as it would be incorrect to say that we treat it as true. | captainredbeard wrote: | I recommend looking into the few longitudinal studies for | dopaminergic illness involving anti-psychotics -- the new | "front line" bipolar treatment -- and long term prognosis. | The severity and frequency of episodes increases. | podgaj wrote: | Less sever case!!! Ahahahahhah! Uhm, no, I assure you this | is not the case. Hospitalized four times, suicide attempts, | psychosis, hallucination, on permanent disability, my | mother and brothers have it and attempted suicide, my | nephew, suicide. At one pint I was on lithium, zyprexa, | lamictal, and prozac all at the same time. They also | thought I had MS at times because of all the neurological | stuff that was happening. | | You can say what you want, but they found I have problems | metabolizing amino acids (BH4 deficiency) and this is fixed | by a low protein diet. (More technically, I have GCH1 | deficiency.) Now I only need Klonopin in emergency cases. | But watching my exposure to oxidative stressors is | important because it destroys BH4. | | And you do not even know what causes Bipolar disorder so | how the hell could you know what might help it? And this is | another problem, no matter how good we feel with lifestyle | changes, no one will believe us or even think we were ever | sick. They tel me stress is a trigger for my illness yet | they make me homeless and do not provide me with stable | housing. | Pelic4n wrote: | Thanks for your insights and sorry for having supposed | you had a less severe case, but all of that happened to | you and you think it's not a disorder or a disease ? | podgaj wrote: | Disease: A particular distinctive process in the body | with a specific cause and characteristic symptoms. | | Disorder: Irregularity, disturbance, or interruption of | normal functions. | | Syndrome: A number of symptoms occurring together and | characterizing a specific disease. | | I do not care which it is. I just focused on my symptoms | and what made them worse and what made them better. To me | is is a difference, that is the best way I can put it. | tremon wrote: | Stop labeling someone who doesn't want to be labeled. | least wrote: | Different treatments affect different people differently. | This isn't particularly controversial, but the layman | suggesting that they know better than scientists/doctors | is kind of dangerous. There is of course room to be | skeptical and ultimately you know what's going on better | in your head than anyone else does, but that's not really | actionable across an entire population of people | suffering from something similar to you. | | It's also dangerous because you're telling people they | don't have a problem they need to address and that if | they do address it, they just need to eat differently, | neither of which are applicable broadly to people with | bipolar disorder. Medications that didn't work for you | might work for them and are worth pursuing. | proverbialbunny wrote: | There is a problem with how we diagnosis illness today. | We diagnose off of symptoms and symptoms only. The reason | this is a problem is there can be multiple different | things that cause identical or nearly identical symptoms. | Today we think of those multiple things as one, but | they're not one thing, they're different things. If they | were the same, they would have the same cure. | | Parent knows he has a BH4 deficiency. Instead of calling | that bi-polar, we could instead call it eg, 'bi-polar | type 5' out of, say, 12, where 12 is the number of cures | we've found for bipolar. Eventually, as time passes, we | can map all if the cures, mapping all of the types. | However, we can not do this if we think of an illness as | a singular thing. This person has one specific type of | bi-polar, and just because it only cures a subset of bi- | polar patients does not mean it should be dismissed. It | should be documented so we can have a list of cures. | | Once there is a list of cures a doctor can walk through | this list and eventually find the correct cure for the | patient. Once everything is mapped it becomes possible to | have a 100% cure rate. This is something no single pill | can do. | | This is why we should not force a one shoe fits all | approach. It is toxic behavior to dismiss a solution just | because it only works on a subset of patients. If I had | bi-polar I'd be glad to know their story, so I could try | it and see if it would work on myself. Dismissing | psychological solutions is a toxic behavior we as a | culture share. Let's do our part to make the world a | better place and end this behavior. | slothtrop wrote: | > the layman suggesting that they know better than | scientists/doctors is kind of dangerous | | That's a strawman. | podgaj wrote: | Thank you. Yes, a strawman and so frustrating since I | literally have the metabolic and genetic proof that I | found out what was causing my mood disorder. And as a | result the doctors are providing better and different | treatment. This what this "layman" discovered. | least wrote: | Do you or don't you have a disorder? In the first post | you made in this thread you very clearly stated you | don't. Now you're saying you do. | | The problem with your post is that you very discretely | stated that you don't have a disorder even though you | admit to being bipolar. Despite the fact that your | "difference" has pushed you to suicide attempts, | psychosis, and more. The fact that an effective treatment | for you specifically was a low protein diet (which by | your own admission still didn't remove the requirement | for medication) doesn't make it not a disorder. | | The attitude is dangerous because you are spreading | misinformation about something you are suffering from, | which in turn can result in someone else being harmed. | podgaj wrote: | I only have the disorder when I have symptoms. You get | it? Those symptoms are caused by my diet and environment. | | I am not "Bipolar" because everyone is bipolar, every one | has these states, mine are just more extreme when faced | with environmental challenges. | | If someone has a peanut allergy do they have a disease or | a disorder? no, they have a different response when | exposed to peanuts. | | I use the term Bipolar Disorder because that is what | people understand and it is the current medical | terminology. | | As far as your idiotic comment about the medication I | need everyone and a while. Well, have you ever taken as | aspirin for a headache? Same thing. The aspirin is only | needed when you have a headache. Do you have a headache | disorder still? | | What I am suffering from was clinically diagnosed. I am | no longer considered by my doctors to have Bipolar | Disorder. Isn't that crazy!? After 35 years of being told | this? | least wrote: | > If someone has a peanut allergy do they have a disease | or a disorder? no, they have a different response when | exposed to peanuts. | | They have an "allergy," which is just another medical | term like disease or disorder to define something which | is abnormal which negatively affects life. If everyone | had an "allergy" to peanuts then we'd just call them | poisonous. | | > As far as your idiotic comment about the medication I | need everyone and a while. Well, have you ever taken as | aspirin for a headache? Same thing. The aspirin is only | needed when you have a headache. Do you have a headache | disorder still? | | No, because a headache is atypical, while bipolar | disorder isn't, like other mental health issues. We | define bipolar disorder differently from mood swings. If | someone with epilepsy finds improvement in their | condition from following a ketogenic diet, that is also | them finding an effective treatment for their condition. | It does not mean they don't have epilepsy. | | > What I am suffering from was clinically diagnosed. I am | no longer considered by my doctors to have Bipolar | Disorder. Isn't that crazy!? After 35 years of being told | this? | | What's important ultimately is you found something that | works for you and makes your life better for it. Your | insights can be valuable but shouldn't be seen as | prescriptive to people that aren't you. | podgaj wrote: | You say bipolar is atypical, but you are wrong. I can go | months with no symptoms, just like people with headaches | can go months without one. Then I have a trigger; stress, | diet, pollution, etc. | | and I have never said that my fix was for everyone. Not | once ever. It is that thinking that kept me sick for so | many years in the hands of the psychiatrists. | zepto wrote: | The viewpoint that bipolar (and other brain differences) | is a difference rather than a disorder can enable a | person to have self compassion, and find peace and self | acceptance, even though the condition will continue to | affect them. | | The idea that it's a disorder and can be treated as such | is a reasonable hypothesis for medical science to pursue, | but that is all it is. Outside of that it's just a source | of stigma and misinformation. | least wrote: | The viewpoint is based in the reality we live in where we | stigmatize abnormality. The correct response isn't to try | and normalize abnormality, but to try and remove the | stigma surrounding it. Suggesting that it is normal | actually creates a stigma for those who are suffering | from it from pursuing treatment because they're supposed | to feel that way because it's "normal." | podgaj wrote: | In no way do I think my symptoms are normal and just | different. What I am saying is that what causes my | symptoms is a different response to a similar | environmental input that most people do not react to, ie, | diet. | | I want you to consider it being like an allergy, not that | I have some sort of histmagenic response, just that when | you take my trigger away I have no symptoms. | zepto wrote: | Who said anything about normalizing abnormality? | | If by abnormality, you mean traits that are far from the | center of a population normal distribution, then I agree | that this is essential information for a person to have | about themselves. Nobody is encouraging people to think | they aren't different from the norm, when they in fact | are. | | Abnormal, disordered, or diseased are very different | things, and should not be confused. | | As for treatment - nobody should seek treatment because | someone else has told them they are abnormal, or because | they are not close to the center of the bell curve for a | given trait. This is simply a bad reason. | | People should seek treatment if it will help improve | their quality of life, _and_ they are willing to accept | the trade-offs that come with it. Whether they are | 'normal' or not is irrelevant. | least wrote: | > Who said anything about normalizing abnormality? | | It's implicit in the original comment i responded to. | | > If by abnormality, you mean traits that are far from | the center of a population normal distribution, then I | agree that this is essential information for a person to | have about themselves. Nobody is encouraging people to | think they aren't different from the norm, when they in | fact are. | | People are encourage others to think they aren't | different from the norm, this is prevalent throughout | society at large, not just in cases of mental wellbeing. | | > Abnormal, disordered, or diseased are very different | things, and should not be confused. | | Disorders and Diseases are both abnormalities. | | > As for treatment - nobody should seek treatment because | someone else has told them they are abnormal, or because | they are not close to the center of the bell curve for a | given trait. This is simply a bad reason. | | This isn't true. Symptoms can manifest without an | individual noticing it themself. Another trusted person | telling you about these abnormalities to your behavior or | physicality is a perfectly valid reason to seek | treatment, even if it doesn't result in anything. | | > People should seek treatment if it will help improve | their quality of life, and they are willing to accept the | trade-offs that come with it. Whether they are 'normal' | or not is irrelevant. | | Which was largely my point from the get go. The exception | being cases where their lack of treatment being a danger | to others. | zepto wrote: | You seem to be someone who has a very deep trust in | medicine and in particular psychiatry to produce good | outcomes for people. | | I can respect that difference of opinion. | least wrote: | I don't have a particularly deep trust in either medicine | or psychiatry. My personal experiences with dealing with | humans in either has been largely negative. That said, I | largely attribute that to the people i've interacted with | and not with medicine in general. | Pelic4n wrote: | >So speaking as someone with adult ADHD who is getting by | without medication with the right lifestyle choices | | How do you do it exactly? Without ADHD medication I can't | function on a basic level, and even then it's pretty hard. (Yes | that's just ADHD, I tried every antidepressant and mood | stabilizer under the sun for years before getting diagnosed | with ADHD) | vanderZwan wrote: | Well, I have the inattentive subtype, without hyperactivity | or much of the associated impulsivity. So I guess I'm already | in a starting point that is easier to compensate for. | | I pay a _lot_ of attention to my sleep - I 'm a chronic | insomniac. And keep in mind that it's not just about sleep | time, it's also about sleep _quality_. So sleep hygiene is | really crucial. No caffeine after lunch, and no alcohol in | general (unless you know you can afford to be less well- | rested the next day) because that might make you drowsy but | it prevents entering the deep sleep cycle. Low-dosage | melatonin seems to help me, not so much with falling asleep | as it does with ensuring that once I _do_ manage to sleep, I | hit that "deep sleep" cycle that is absolutely necessary to | recover. | | I'm very sensitive to disturbances at night, noises can drive | me _nuts_. So I spent a _lot_ of time finding comfortable | ear-plugs. They are essential for uninterrupted sleep for me, | which again is crucial for hitting the deep sleep cycle. | | Then there is the question of _falling_ asleep. If I have | trouble with that (which is almost every night), I get out of | bed and go read in the living room, so that my brain keeps | associating the bedroom with rest. Sometimes I start having | ideas just before falling asleep, I then try to write those | down on paper, and maybe work them out a bit - I realized | that part of why late night thinking keeps me awake is that I | 'm afraid to forget all the ideas, so writing it down gives | me peace, and doing so by hand also calms forces me to slow | down. Meditation is also good for slowing down racing | thoughts, but it really depends on what the thoughts in | question are. | | Then there's diet. I don't know if I can generalize what | works for me specifically, but lots of leafy greens in | general. There is evidence that berries and other sources of | polyphenols help a lot with children with ADHD, and in | general those are supposedly really healthy, so I figure they | won't hurt me either. Avoid things that give sugar | rushes/crashes. Finally I take supplements for common | deficiencies that apparently disproportionately affect people | with ADHD (B, zinc, magnesium). | | Exercise helps because the cerebellum is involved with | regulating attention. So I try to start the day with some | mild exercise (like a short run) to really activate it. I've | noticed that this helps with my attention regulation | throughout the day. Sitting all day programming reduces | activity again, so sometimes I take short "activation breaks" | where I just do ten squats or burpees or whatever, not to | exercise but to wake up the cerebellum. | | Therapy is important. The overlap between ADHD symptoms and | co-morbid/complex PTSD symptoms is large, leading me to | believe that maybe people with ADHD are just more likely to | end up in traumatizing situations (in my case: other kids | _loved_ to provoke temper tantrums in me) and part of their | symptoms are really just a consequence of the resulting PTSD. | As difficult as it was to process my past, therapy helped me | a lot. It seems to have reduced some of my ADHD symptoms a | bit, but even if it didn 't: someone with ADHD is likely to | have a lot of pain to process as a result of their condition. | Doing so means having one burden less to carry, making it | easier to cope with the remaining issues. | | One very important thing I learned: ADHD means that | _inevitably_ I will slip up at some point and forget an | important appointment or something. The screw-up itself is | punishment enough, so if I hate myself for always screwing up | too I 'm just punishing myself twice. So learn to be kind to | yourself and forgive yourself when that happens, that makes | it easier to pick yourself up, fix the problem, and move on | when this happens. | | Therapy also helped me with being better at being brutally | honest about my limitations. No, I cannot plan five things in | a day when I know that I can't complete more than two. If I | know I'll likely forget _something_ at home when I go | somewhere, even with checklists, leave early so I can go back | to pick it up when I inevitably remember I forgot it five | minutes after leaving the house. Try to develop good habits. | More importantly, _only try to develop one habit at a time, | and give it enough time to really become a habit._ And so on. | | And finally: use that ADHD hyperfocus to your advantage, and | do deep dives into learning as much as you can about how to | ADHD works and what you can do about it. | podgaj wrote: | And this is what I hate about these article, they leave | people out in the cold who are suffering. | | Start with getting your genetics, your full genome if you can | afford it. This is something that saved my life. | | Could be something as simple as nutrients, like B6 (P5P): htt | ps://www.researchgate.net/profile/Marnina_Stimmel/publica... | framecowbird wrote: | I'm most surprised to learn that this _isn't_ the current | prevailing view in the medical profession. I am not a doctor, but | it's always seemed more natural to me to view depression and | anxiety as adaptive behaviours - albeit perhaps ones that can end | up being triggered too far. | | I read an article once (wish I could find it) that one advantage | of mild depression was as sort a "call for help and support" from | other embers of a close-knit social group, although I'm not sure | how well-founded the claim was. | DarkWiiPlayer wrote: | I'm not a doctor, but I was also very surprised that this is | "news" to the medical world. I has just always assumed that | this was a well known thing, because it just seems completely | logical to me. | | Just asking "what could the evolutionary purpose of depression | be?" should already lead to the conclusion that it's most | likely a mental defense mechanism, or byproduct of one, that | can most likely be triggered by experiences rather than just be | part of a persons genetics. | | But apparently it wasn't all that obvious after all. | svachalek wrote: | There are lots of obvious and completely logical things about | the world, like the sun and planets go around the earth, | animals cannot feel pain, and insects form spontaneously from | rotten matter. But some of them are not correct despite being | obvious and logical to everyone, and thus we have science. | Avshalom wrote: | There is no a priori reason to think depression has an | "evolutionary purpose" any more than to think a broken bone | does. | [deleted] | auganov wrote: | Going with a very medicalized framework could very well be an | adaptive behavior on part of the professionals too. | | The common sense approach makes it much harder to build a rich | field of scientific looking knowledge and products. | wittyreference wrote: | Largely because articles like this generally focus on what I | think of as "layman's depression", or "layman's anxiety." That | is, a mild form of the condition that straddles the gray area | between "personality" and "mild personality disorder," that | diminishes quality of life in a perceptible but not devastating | way. | | Then you go work on a psych floor and meet people whose | depression is so severe it induces catatonia; people who look | and feel like zombies and who would end their lives if given | the chance; people whose depression comes with a healthy side- | order of delusions. Extreme things that render someone | incapable of even mild functioning. | | Or severe anxiety - patients whose worry comes from no external | stimulant, renders them incapable of anything but physically | sickening levels of worry, and if you manage to somehow help | them reason through the thing they are currently worried about | ... find a new thing to attach their emotions to. Look at | something like OCD, wherein one - for instance - May | obsessively wash hands to stymie an overpowering anxiety that | ones house may burn down (OCD sometimes has logical triggers | between ritual and anxiety; often not.) | | Interpreting that as "an adaptive response" is ridiculous. | | An adaptive response "taken too far", on the other hand, is the | very definition of wide swaths of disease - autoimmune, cancer, | etc. | | I find the "gosh it's just cultural mismatch" theory to be a | modern stigma against mental disease. You can break any bone or | system in the body - except for neuro/behavioral, that's just | another type of person that needs some cultural adaptation. | /That's/ never really broken. | vmchale wrote: | > I find the "gosh it's just cultural mismatch" theory to be | a modern stigma against mental disease. You can break any | bone or system in the body - except for neuro/behavioral, | that's just another type of person that needs some cultural | adaptation. | | Also ties into minimization of mental illness, which is a | form of stigma! | LatNax wrote: | The examples you have given seem to be outliers where the | system "human" broke out of its basic parameters, causing | multiple other subsystems to fire out of control. | 1_player wrote: | How common is that extreme form of depression? Sounds like we | need two different names for two very different diseases (or | perhaps only one is actually a disease) | podgaj wrote: | There are no diseases, only symptoms. We can name diseases | forever but that gets us nowhere. They just have more | depression, or are more depressed. | | By the way, why don't people get SSRI's when they are | depressed with a flu? I mean that is caused my lower | serotonin as well. So for some reason we accept that | depression because we have a reason for it? | | https://www.inverse.com/article/40843-what-f-lu-do-es-t-o- | yo... | | You see, depression is fundamentally and immune disorder. | We react negatively to something in the environment, like a | bad job or marriage. | elliekelly wrote: | > You see, depression is fundamentally and immune | disorder. We react negatively to something in the | environment, like a bad job or marriage. | | This is an atrociously overly simplistic statement. There | are plenty of people who suffer from depression despite | having everything going for them. A person can have not a | single thing in the world to complain about and still | have depression. | nitrogen wrote: | I'd still argue that a person with "everything going for | them" can still have a "reason" to be depressed. Maybe | they do a really good duck impression -- calm on the | surface, kicking frantically below. That is, maybe there | is something wrong with their life or their past that | isn't visible to others, or even to themselves. Or maybe | they have been pursuing the checklists of society and | found that they aren't personally fulfilled by them, and | must seek fulfillment elsewhere. Maybe they have a desire | to be living one kind of life but can only excel in a | different kind of life that only looks good from the | outside. | zepto wrote: | "A person can not have a single thing in the world to | complain about" | | What person? | podgaj wrote: | Gautama Buddha! =) | podgaj wrote: | What about all the other things that might affect their | immune system? Have they ruled them all out? Latent viral | or bacterial infection? Allergies? Diet? Look at diet and | Omega 6 consumption, that alone will screw with the | immune system and throw the catecholamines off kilter. | | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950146/ | _jal wrote: | > By the way, why don't people get SSRI's when they are | depressed with a flu? | | One reason is SSRIs typically require a a few weeks to | reach effective levels in your system; about how long it | takes to recover from the flu. | | > depression is fundamentally and immune disorder | | You appear to be playing a free association game with | words, not describing reality. | podgaj wrote: | The idea that it take weeks for antidepressants to reach | 'effective levels" is a misunderstanding of the science. | It is is true for MOST people that, for example, | fluoxetine and its metabolite, norfluoxetine will be at a | certain level in the serum before they have resolution of | symptoms, but this is not the case for all people. | | It takes a very small dose to inhibit serotonin reuptake | and this will happen with the first dose. | | https://www.nature.com/articles/1395757 "The single dose | caused only a slight increase in drug plasma | concentrations but relatively clear changes in sleep | structure." | | And I was hoping you would all chime in and say it is | useless for the flu. Because it might be very helpful | | https://www.sciencedaily.com/releases/2012/07/12072717191 | 9.h... | SketchySeaBeast wrote: | > You see, depression is fundamentally and immune | disorder. | | That's a lot of certainty for something that is still | very much uncertain. | | > By the way, why don't people get SSRI's when they are | depressed with a flu? | | Because that's a short term, acute condition that will | get better on its own? That's the same as saying "People | in the hospital who can't breath are given oxygen, so why | aren't runners who are breathing hard?" Because long term | major depressive disorder is totally different than | having a down couple of days. | podgaj wrote: | More certain than ever actually: | | https://www.sciencedirect.com/science/article/pii/S266635 | 462... | | Regarding oxygen use during running, it is already | something: https://trainright.com/hyperoxic-training- | little-know-traini... | SketchySeaBeast wrote: | As best I can tell there's not implication of causation | there - it could be that depression causes the immune | disorder, just as it causes any other number of | conditions. I don't know the value in assuming we can | categorize it like that. | | I assume with the oxygen thing you're intentionally | missing my point which is that a regular momentary | disruption isn't considered a disorder. | podgaj wrote: | I agree with you, depression alters the immune system and | the immune system can cause depression. But it is through | the immune system that we feel the effect. | | "momentary disruption isn't considered a disorder" | | By definition it is. Duration is irrelevant. My panic | attacks can last for only 2 minutes. | filleduchaos wrote: | > That is, a mild form of the condition that straddles the | gray area between "personality" and "mild personality | disorder," that diminishes quality of life in a perceptible | but not devastating way. | | I otherwise agree with your comment, but depression and | anxiety aren't personality disorders or personality related | at all. Depression is an affective disorder. Anxiety is its | own class of disorder. | wittyreference wrote: | You're quite right. That was a typo/brain fart, and by the | time I noticed it my comment was past editing. | tremon wrote: | _Interpreting that as "an adaptive response" is ridiculous. | | An adaptive response "taken too far", on the other hand, is | the very definition of wide swaths of disease - autoimmune, | cancer, etc._ | | These two statements don't add up for me. If you do accept | that various autoimmune disorders and cancers are essentially | adaptive responses taken too far, then why can't depression | similarly be considered the same? Or is your point that | depression is simply an adaptive response, and it's not | "taken too far" until people are at the catatonic state? | novok wrote: | You don't have depression if you really hate your job / | university degree / sad your mom died, you just hate your | job / sad your mom died. | wittyreference wrote: | Sorry, your question is fair -- let me elaborate: | | I feel the OP puts forward two statements, categorizing | depression as "adaptive", or "adaptive response taken too | far." I wish to address each of these separately. | | Having seen what these maladies do, I believe that | categorizing them as "adaptive" is a position that can only | be borne from "have never seen these diseases in their full | spectrum, largely responding to mild, layman's-presented | versions of them." | | Separately, addressing the concept of them being "adaptive | responses being taken too far," I find essentially | tautological. Give me a little leeway to oversimplify when | I say that there are two broad categories of disease: | exogenous (trauma, infection - things done to us by the | external environment) and endogenous (things that occur | from dysregulation of human physiology). | | ((Aside: the above is, like all models, _wrong_. There are | interactions and predispositions between biology, exposure, | etc. I aim to use the above to illustrate a point about | "adaptive response gone too far", not to overlook the full | biopsychosocial model of disease.)) | | Calling a non-exogenous disease "an adaptive response taken | too far" is a tautology. All human physiology arises from | homeostasis - it's all "adaptive" in purpose, if not in | effect. So all endogenous disease can be described as | "adaptive response that is acting maladaptively." | proverbialbunny wrote: | This is horrible. If a therapist thinks depression is purely | neurological then they will not try to cure the person and | instead resort to talking to help comfort them. | | This view needs to change. | johndevor wrote: | I agree, especially since the ACE Study was released decades | ago: | | https://en.wikipedia.org/wiki/Adverse_Childhood_Experiences_... | [deleted] | nunb wrote: | Could the article have been by Robert Sapolsky? He discusses | something like that in one of his later books, the one with a | chimp on the cover where he talks about how male chimps leave | their childhood tribes and head out to seek mates... and the | adjustment of moving from a close-knit social group to a new | alien group is covered. | | He's an endocrinologist/anthropologist by profession I think, | but his books are sort of more about anthropology and | psychology. | throwaway57867 wrote: | I went to therapy because of this. When I chose the therapist I | focussed on choosing one that has a proper website and appears | to use modern methods. Actually it was also the therapist's | opinion that certain behaviours made sense at some point. In | fact the therapy method didn't even require making a formal | diagnosis because all these diagnoses are just summaries of | statistics and not necessarily match the black box inside our | head. Instead after the 3rd or 4th session I got a | questionnaire in which I had to fill in what should be improved | and what the goals should be. | | Also of course there was some kind of homework after each | session. Usually the therapist then asked me how I could | accomplish that goal. Then I came up with something and the | therapist also told me "you are an expert for yourself, you | know this best". That was both really surprising and | encouraging. The therapy actually really improved my quality of | life tenfold. I'm still wondering whether it was the method | (Systemic therapy) or just the overall setup that made it so | successful. | hh3k0 wrote: | I've read a similar article although with a different angle, | stating that the advantage of depression is that members of a | tribe which are a burden to the rest will eventually withdraw | completely and/or kill themselves and therefore cease being a | burden to the tribe. That said, I don't know how well-founded | the claim was either. | Voliokis wrote: | It's hard to determine what our ancestors actually did. I'm | sure you could argue any number of solutions they might have | used. I'm wondering though what the prevalence is of these | afflictions were back then or now in modern hunter-gatherer | societies. The latter is not proof of anything, but it would | be an indication of what a possibility might be like. | browserface wrote: | But this doesn't make economic sense. Billions could be lost | from prescription revenues worldwide if this became the | prevailing view. Hence, we will all continue to be "sick" and | treatable with medication, rather than adaptively responding to | adversity. | raxxorrax wrote: | Indeed. Although many practitioners are open about it that they | cannot really influence those factors, so the try to offer the | best individualized solutions to for respective patients. | | But to claim there are no environmental factors that might | benefit depression is very likely just plain wrong. But in | practice these factors are declared out of scope because | neither patient nor psychologist can change those. | | Of course numbing yourself down with meds has other | repercussions and maybe hinders that environmental factors are | considered and changed. | skissane wrote: | There is a movement within psychiatry that wants to take a view | similar to yours, although it is very much in a minority. I | would point to figures such as the British psychiatrists Sami | Timimi [1] and Joanna Moncrieff [2], associated with the groups | "Council for Evidence-Based Psychiatry" [3] and "Critical | Psychiatry Network" [4]. | | The emphasise the ideas that psychotropic medications are | overprescribed (they are not totally opposed to their use in | all cases, but do think that the evidence for their benefit is | often overstated, and the evidence of harmful side effects is | often unfairly minimised), that the DSM-5 and ICD-10/11 | diagnostic manuals have very weak science behind them and | encourage blaming the patient's brain for the patient's | problems (in a very general way - advocates of the biological | model can rarely point to anything specifically wrong with a | given individual patient's brain, just the faith that some | biological explanation is waiting to one day be discovered) | even while ignoring the factors in the patient's social | situation which may be a better explanation (but maybe a less | socially convenient one - blaming the brain rather than the | society eases society's conscience). | | [1] https://en.wikipedia.org/wiki/Sami_Timimi | | [2] https://joannamoncrieff.com | | [3] http://cepuk.org | | [4] | https://web.archive.org/web/20200225204400/http://criticalps... | frereubu wrote: | One thing that I learned during my psychology degrees that | always stuck with me was that mildly depressed people are | measurably better at judging probabilities of things happening. | (Unfortunately I can't remember off the top of my head the | structure of the study, or how much better they were). I wonder | if that might fit into this, in that if you're mildly depressed | presumably bad things are happening to you, so perhaps it's | adaptive to be more realistic about your situation. Pretty | hand-wavy stuff, but interesting to think about. | proverbialbunny wrote: | Those who are successful in life have walked a path of | failure, yet they keep getting up and trying again, learning | from their mistakes and growing. This at its heart is a | healthy kind of optimism. | | Those who call themselves a realist, who believe it will | fail, shoot themselves in the foot, because they do not get | to learn the valuable lesson that comes from that failure. | Without trying and failing growth is stunted. Trying is a | win-win. You either get what you aimed for, or you learn and | grow. | | One scenario is if one grows up in a dangerous situation, | you're shut down from risk taking, because taking a risk in a | situation like that could seriously harm you. Meanwhile those | who grew up in a safe environment could safely explore and | open themselves up to positive hypotheticals worth | attempting. | | Another scenario is that when one fails instead of learning | how to do better next time they create an assumption that any | remotely close scenario in the future will end in failure. | When one believes a negative dangerous outcome will happen, | and they're thrown into that situation, it creates anxiety. | This is why anxiety and depression often go hand in hand. | pessimizer wrote: | https://en.wikipedia.org/wiki/Depressive_realism | iamthepieman wrote: | I struggle with mild depression, especially in the long | winter months in the Northeast U.S. Anecdata, I know, but I'm | much better at estimating times (arrival times, how long it | will take to pack for a trip, when we will actually leave to | get to an appointment) than my wife who is eternally | optimistic. | | This comes in handy on estimating project times as well | though only for me internally as most people don't want to | hear realistic project times. | raxxorrax wrote: | I think there is also data that intelligent people are more | susceptible to depression, so that might influence that | result. Cannot find the source of it though. | b0rsuk wrote: | I remember reading an article like that. Also, it's a bit of | a meme that if depression was 100% harmful then it would | already be eliminated by evolution. I mean why shouldn't | people prone to depression die off? | | Don't make a mistake, I'm still working on improving my life | and uncovering the root causes. It is a silent thief of life. | gowld wrote: | The appendix is 100% harmful but not eliminated. As is | nearsightedness. | | Evolution is only affected by genotypes that prevent | reproduction. | tremon wrote: | That's a rather antiquated view. Nowadays, the appendix | is considered an active organ again, essentially a | spawning zone for the gut flora. I recall reading that | people that still have their appendix have a more diverse | gut microbiome, and more importantly, their gut flora | recover more quickly after antibiotic treatments. | tsimionescu wrote: | > The appendix is 100% harmful | | It is not. | | Much better examples would be cancer and auto-immune | diseases. Evolution is not magical, it can't produce 100% | fault-free organisms. Or maybe it will, given a few more | billion years. But in a limited time span, there is no | reason to expect it to correct any potential flaw in an | organism (and experience obviously shows that it hasn't). | podgaj wrote: | Uhm, no. | | https://academic.oup.com/mbe/article/35/12/2957/5112969 | | "the strongest signals of recent human adaptation in | Europe did not coincide with the Neolithic transition but | with more recent changes in environment, diet, or | efficiency of selection due to increases in effective | population size." | Nasrudith wrote: | Evolution does not and cannot give a shit about you is why | really. Elimination by evolution requires it to be both | utterly nonviable and not tied to anything else. Look at | sickle cell anemia - one copy protects against malaria via | mild blood cell deformation. Two makes them concave. | | There are plenty of non-optimal things kept around because | there isn't sufficient pressure to ensure it dies out. | robotresearcher wrote: | > Elimination by evolution requires it to be both utterly | nonviable and not tied to anything else. | | Neither of those things are required. Any disadvantage to | reproduction frequency of an allele can lead to its | extinction. Even a 'good' allele can lose to a 'better' | one. | | (The scare quotes are to acknowledge that these terms are | just frequency re-stated) | b0rsuk wrote: | Or sinuses! | | An Annoying Quirk Of Our Evolution | | https://www.youtube.com/watch?v=WSSmJLb468k | | But what I meant is that according to the theory of | evolution, individuals with disadvantageous traits | reproduce less often. If they reproduce less often, they | pass their genes less often. I think they say the trait | is regressive. | karlerss wrote: | > I mean why shouldn't people prone to depression die off? | | "Having a child will make me happy". And hell, maybe it | will - it's the perfect ruse by our genes - keep us | depressed until we reproduce. | grugagag wrote: | Or maybe we leading a path in life with no meaning causes | us to be depressed and seek a solution. Having a child | puts one in the present moment and does give some meaning | back though is not a cure for depression. I highly doubt | the genetics make us depressed to have children. | impendia wrote: | I don't know who conducted the original study, but I remember | that Martin Seligman opened his book _Learned Optimism_ with | a discussion of an experiment exactly along these lines. | | Two groups of people -- a group of clinically depressed | people, and a control group -- were asked to operate some | apparatus that was programmed to fail a certain percent of | the time. They were then asked to estimate how much actual | control they had over the apparatus. | | The control group consistently overestimated, while the | depressed people were spot on. | silveroriole wrote: | A try it yourself experiment: simply start giving accurate | time estimates to project managers, and see how long it | takes them to call you a pessimist :) | jon-wood wrote: | There's a general bucketing in the modern world of all | unhappiness being depression that should be treated, which I | don't think really fits what's going on. There are absolutely | cases where anxiety and depression are a medical issue which | warrant treatment with medication, but there are also | completely legitimate reasons for those conditions. If your | lifestyle is one of never leaving the house, zero social | contact, with the bank imminently foreclosing on your house | then depression and anxiety are entirely appropriate - so long | as those feelings then cause you to do something about the | problem. | playeren wrote: | I am a bit confused by your comment. When you write | 'legitimate reasons', do you mean from a _moral_ stand point? | I can't otherwise make sense of 'legitimacy' in this context. | | edit: Do you mean 'legitimate' in the context of it | increasing evolutionary fitness in some way? | agumonkey wrote: | Seems like depression is like tissue regeneration. It tries | to fix things then it bails out. Depression is often called a | pit, when you're in it, you haven't the slightest idea nor | capability to do whatever. The only evolutionnary value I see | in this is making you so sluggish you'll be left out by | whoever or whatever is harming you because time goes on and | they'll move. | Fishysoup wrote: | Naming these two medical conditions "Depression" and | "Anxiety" is pretty unfortunate. They are completely | different from"feeling depressed" and "feeling anxious". | Having depression or anxiety in the medical sense will not | cause you to do anything about any problem, because they are | debilitating. They reflect long-term changes to your brain | chemistry that may or may not respond to medication - | transiently feeling anxious or depressed is not that. | DanBC wrote: | > I'm most surprised to learn that this _isn't_ the current | prevailing view in the medical profession. | | In the UK I speak to very many mental health care | professionals, and I've only ever met one who pushed the | biological model above the bio-psycho-social model. Everyone | else is keenly aware of the wider determinants of mental | health. | | There's some attempt to build this into the system, but it's | pretty difficult because of the way the NHS and Public Health | are set up at the moment. There's a lot of regional variation. | johnchristopher wrote: | > I read an article once (wish I could find it) that one | advantage of mild depression was as sort a "call for help and | support" from other embers of a close-knit social group, | although I'm not sure how well-founded the claim was. | | In the same vein I also read something about how depression | helps in momentarily retiring from the group to be perceived as | a non-threat and the rumination is the symptom of a brain | dedicating resources to finding solutions to a problem. Pop | psychology most likely I suppose. | raducu wrote: | Because this actually IS the prevailing view, but it is not | really actionable. | | What is the alternative to drugs? | | A real advantage of depression is you won't challenge authority | so you'll be more likely to appease the Alpha members of the | group. | | So what? | | How would this help a doctor treat a mental health patient? | themgt wrote: | I would look at other fields of medicine, e.g. research | around how certain diets and fasting protocols can reverse | metabolic syndrome and type-ii diabetes along with a variety | of other positive health benefits. | | So what is a major focus of research? Finding ways to | isolate/synthesize specific compounds to make a patentable | drug that can be given in lieu of patients making lifestyle | changes, because a) you can't patent a lifestyle change and | put it in a pill and make billions of dollars off it and b) | because patients are generally assumed to be unwilling/unable | to make the lifestyle changes. | | So, "how would this help a doctor treat a mental health | patient?" is perhaps the wrong question, because it won't | because the doctor isn't interested or trained nor has the | time to guide a person through a lifestyle change. It | nonetheless may be very relevant to _you_ in deciding whether | you 'd rather be on insulin for the rest of your life vs. | finding a way to lose weight. Just as it may be helpful for | you to consider whether makes changes to lower/resolve | sources of stress and anxiety in your life is a better option | for managing mental distress than being on an SSRI/benzo | indefinitely. | | I wouldn't hold my breath waiting for the AstraZeneca "how to | be happy without psychopharmaceuticals" guide to living. | tokai wrote: | > A real advantage of depression is you won't challenge | authority | | Not true. It can give a fatalistic outlook and raise | aggression. I know a (depressed) guy that almost got himself | killed in traffic, because he would rather die than yielding | to a pushy road user. | nerdponx wrote: | A combination of targeted therapy and short courses of drugs | designed to ease the therapy process and control symptoms in | the short term? | InfiniteRand wrote: | In my experience most psychiatrists recommend some form of | talk therapy in addition to medication and my impression is | that the consensus view is medications + therapy are more | effective than either by themselves (also recommended are | exercising , sleeping well, and other general health stuff | most doctors lecture their patients about) | Red_Leaves_Flyy wrote: | What you you suggest doctors do when short term treatment | regimens become decades long? | | If only the symptoms are treated it is illogical to expect | the condition to go away. In fact, it's likely to get | worse. | raducu wrote: | That is also common knowledge and practice. | | My point when I said it is not actionable -- was that | removing adversity is actually impossible most of the time, | the therapist/psychiatrist has to give the client/patient | the tools so he can help himself out, to better cope with | adversity. | | The therapist knows you're anxious because you had shitty | parents, because you have a shitty boss and so on and so | on, but that knowledge in itself is not actionable. | | It would be great if we all stopped being pricks to one | another, make a big circle and hug eachother, but since | that's not going to happen anytime soon, we have to learn | how to cope with adversity. | pessimizer wrote: | > What is the alternative to drugs? | | A social safety net. A society that thinks providing the | communication resources and facilities for people with common | interests to socialize about those interests is as important | as providing highways. | | > How would this help a doctor treat a mental health patient? | | You don't have to be a doctor to dispense pills. You can | always anesthetize people who are panicking, but I'm not sure | that should be called "treatment." | | Talking therapy probably works because it's the opportunity | to talk to someone with no ulterior motives at length about | your problems. We could provide that. | gowld wrote: | > facilities for people with common interests to socialize | about those interests | | We have that. It's even _called_ a highway! The information | superhighway. | | It hasn't cured depression and anxiety, and may have | worsened it. | raducu wrote: | > A social safety net. | | I believe this would be great. But perhaps not, perhaps | this was only in the what Ovid calls the Golden Age -- | perhaps small communities of hunter-gatherers, perhaps | never in the way we imagined. | | But I don't see this happening unless we revert to much | smaller communities. | | I think we could realistically cut world military spending | by 90% before we could offer everybody that social safety | net. | | So we DO need pills, because we cannot realistically offer | 1 in X the support they need, the best we can do is offer | pills that work long enough that they help themselves or | some psychotherapy. | | Psychotherapy can be greatly helped in a lot of cases by | pills. | | I have seen the light when I started experimenting with | drugs(illegal and legal) -- it is such an incredible | release to know you have the power to change your mental | state, even if chemically. | | Having a Xanax in my walled, completely stopped my panic | attacks, I haven't had one in years. | slfnflctd wrote: | At first I viewed the depression I started fighting in my teens | as a scourge, a defect, something broken to be fixed. | | I have since come to see it as an important signal. When I am | managing my life and mental states well, it often fades into the | background. When it starts to flare up, like with some kind of | physical pain, that's telling me I need to pay attention and | change things up a bit. | | Furthermore - and perhaps most importantly - it is a preferred | failure mode to freaking out or engaging in suicidal ideation. | When I'm overwhelmed by that gloom, I remind myself that I could | have a stroke, aneurysm or heart attack at any moment, and I | think about what the consequences would be if I did. As long as | I'm in a safe situation, I can simply take my first opportunity | to Just. Stop. Taking time to shut down, and to cease forcing | yourself to engage with a world that would go on without you if | you suddenly died, is a good idea now & then. | | Yeah, at times I feel some twinges of guilt for doing this. It | seems selfish on the surface. But when you compare it to the | alternatives, well-- it's better than being dead, isn't it? I | feel like my ability to manage my life (and depression) has | improved considerably with this insight. If you need to stop, | stop. Rest. Let whatever is pushing you to the brink simmer in a | corner for a while, provided it is physically safe to do so. You | will be better equipped to deal with it when you've had a chance | to breathe, and to remind yourself that a temporary shutdown is | indeed better than being dead. | podgaj wrote: | Do you realize these two sentences say the same exact thing? | You have a pain, which is a signal of a disorder, and you need | to change something to fix it. | | "At first I viewed the depression I started fighting in my | teens as a scourge, a defect, something broken to be fixed." | | "I have since come to see it as an important signal. When I am | managing my life and mental states well, it often fades into | the background. When it starts to flare up, like with some kind | of physical pain, that's telling me I need to pay attention and | change things up a bit." | typicalset wrote: | I think these two sentences are different: it's analogous to | treating a symptom vs treating an underlying condition. | podgaj wrote: | Yeah, I agree with that distinction. This is am important | semantic discussion. | | But he just changed the name of the thing he wants to get | rid of from "pain" to "signal". The signal is still a | disorder. The signal is the thing that bothers us. | abdullahkhalids wrote: | I think they is saying that if you put your hand on a hot | thing, you get a signal. You can also call it pain. But | the problem is not an internal problem with your body, | but a consequence of your environment. So change your | environment or what you are doing and the pain will | disappear. Don't try to keep your environment the same | and try to change within. | | (I don't entirely agree with them, but that's my best | summary of their argument). | Solstinox wrote: | No. One sees the depression as something to be fixed, the | other sees the underlying problem causing the depression as | something to be fixed. | podgaj wrote: | Yeah, I agree. But the signal is still the disorder that | needs to be fixed. | | Any psychiatrist will tell you that psychiatric medications | only treat the symptoms of mood disorders and that they do | not know the cause of most of them. It is hogwash that they | think mood disorders are "only chemical imbalances in the | brain". They know these disorders are polygenic and | environmental. But for some people, a short dose of SSRI's | or antipsychotics can keep them alive long enough to find | out what it is that is giving them so much pain, i mean | singnals. | bluntfang wrote: | >It is hogwash that they think mood disorders are "only | chemical imbalances in the brain". | | Who are you quoting here? What psychiatrists think this? | AFAIK, this hasn't been the meta for a long time. | podgaj wrote: | No, I agree with you. I do not find psychiatrists believe | that mood disorders are only chemical imbalances in the | brain. | zepto wrote: | I have come across people have been led to believe it's a | chemical imbalance by psychiatrists, even in the last few | years. | | It may not be the modern psychiatric view, but it's also | true that psychiatrists are just doctors, and many of | them are very slow to change from what they were taught | in medical school. | agumonkey wrote: | it's a default API for brains, but ideas will trigger | neurochemistry too .. well I'm sure you got that already | perl4ever wrote: | I can't speak to exactly who uses this terminology, and I | have not heard it from a medical professional, but I feel | like it lingers on, like in medication pamphlets. | | Because fundamentally, I think, it is necessary to try to | get people to comply with medication that seems to help | sometimes, while avoiding the reality that the way it | works is not known. | User23 wrote: | Amphetamines have shown some promising results in | actually curing depression. There is a vicious cycle of | depression where the anhedonia and lack of motivation | cause the sufferer to allow the underlying causes to get | even worse leading to deeper depression. Amphetamines can | help break that cycle and ideally even start a virtuous | cycle where their use can be tapered and eventually | discontinued. It's vitally important though that the drug | treatment is combined with behavioral modification so | that the artificial stimulation of reward circuits can be | operant conditioned on behavior patterns that mitigate | the underlying cause of depression. Anyhow I might be off | on the jargon since college psychology was a long time | ago, but the basic concept strikes me as highly plausible | and consistent with what we know about the human mind. | And anecdotally I have friends who benefited from | amphetamines for depression. | | However used improperly it can end in amphetamine | addiction or even psychosis. It's not surprising most | mainstream psychiatrists don't like to use them for | depression, but it is a powerful tool in the box. | volkl48 wrote: | That seems perfectly reasonable to me as a line of | reasoning, and I'm not casting doubt on whether it could | work. | | With that said, I also wonder how many of those people | had undiagnosed ADHD/if such studies involved screening | for ADHD. | | Unmanaged ADHD leading to consistent failures in life and | other difficulties -> depression/depressive symptoms from | the consequences, lack of achievement, etc over the long | term, is a pretty common story. | | And obviously, the responsiveness of those with ADHD to | stimulants is pretty well-known. | [deleted] | dsego wrote: | > However used improperly it can end in amphetamine | addiction or even psychosis. | | Someone I know managed to do that, despite being on | intramuscular antipsychotics. Unfortunately no middle | ground, the meds keep him anhedonic and abulic, but | without them it's mania. I would be careful with | stimulants. | montagg wrote: | Are you familiar with what it's like to have depression? | It's not something you can really ever get rid of, even | if you can mitigate it with medication and lifestyle | changes. It's there, though not dominant, even when | things are going well and even when you're in a positive | mood. | | I struggle with similar feelings, and the idea that | depression becomes something that is there but can be put | to positive use absolutely tracks with my own experience. | BurningFrog wrote: | > _Are you familiar with what it's like to have | depression?_ | | Pretty sure there are _many_ distinct conditions that we | now call "depression". | | Your description is very true for some of them, and not | at all for others. | Delk wrote: | This probably varies by the person. | | Some people might get a single episode, then get through | it one way or another, and never have another one. | | Others might have a lifelong tendency or vulnerability to | it, and in that sense it might always be there in the | background. I'm fairly certain I was more or less | depressed (although not diagnosed) in my teenage years | and early 20's. In my later 20's things were brighter, | although I probably had a tendency for some amount of | depression, especially during the darker winter months of | the year (I live in the north). However, there were | definitely times when I wouldn't have considered myself | depressed. I'm not sure I'd even say it was "there" at | those times, in the sense of being actively present in | any way, even in a non-dominant way. | | Later on, I got another deeper episode of depression that | I'm still battling. | | Yet other people might have it always there in some way, | as you say. | podgaj wrote: | Please read my other posts. I have a 35 year history of | hospitalizations for both manic and depressive episodes | and I have attempted suicide twice. I have lived with 9 | month long depressions where all I could do was watch | cartoons and not enough energy to even brush my teeth. | | If one cannot get rid of depression then one cannot get | rid of heart disease or cancer. | throwaway_pdp09 wrote: | I had it a large chunk of my life. It went, eventually. | It can go but that's because it's not in my | nature/mind/brain/chemistry/whatever. In this I'm very | fortunate, but please don't completely rule out defeating | it, though the odds are poor. | TheAdamAndChe wrote: | I think depression can spiral into a positive feedback | loop that forms a depressive disorder. Mood affects life | which affects mood which affects life... | | Many people who haven't been stuck in that positive | feedback loop have still been blue. Their capacity to | feel happiness is muted just like ours, but they are | successfully able to get out of that with a behavioral | change. That's not always the case with a depressive | disorder, and it can take a multi-faceted approach of | medications, lifestyle change, sleep hygiene improvement, | sometimes electroshock therapy for those people to get | out of it. | GreenWatermelon wrote: | Is it really better than death? to me, death means salvation, | I'll no longer have to deal with troubles. | baron_harkonnen wrote: | "It is not worth the bother of killing yourself, since you | always kill yourself too late." | | -- E. Cioran | | The trouble with "death means salvation", and believe me I | know that yearning, is that you don't get to experience this | salvation. Suicide is literally not the answer, because you | will never get to experience the relief on the other end. | This is the essence of Cioran's quote here. It would have | been better to not exist, but it's too late for that now and | ceasing to exist will not, in fact, afford you any sense of | relief. The only relief you feel is in the fantasizing about | death itself. | | Eventually you will die and after that point it won't matter | how long or how painfully you've lived. From the perspective | of death life doesn't matter at all, but you won't be alive | to experience that perspective. | 3pt14159 wrote: | Believe me, I know what it is to suffer. But even though I | lean against suicide strongly since I've lived the whole | "if you're going through hell keep going" thing, and the | relief when the (years long) suffering is over is immense. | However, I struggle with things like a suicide pill given | to air force pilots. | | Would it be better to be tortured for years? To have your | family knowing that your fingernails got ripped out? That | you lost your genitals to electrocution? | | I'm not sure. Plenty of heroes committed suicide. | leetcrew wrote: | > However, I struggle with things like a suicide pill | given to air force pilots. | | it does raise an interesting, if morbid question. | personally, I think it is fine for someone to kill | themselves (or receive assistance in doing so) if they | are facing a near certainty of terrible suffering for the | rest of their life. the tricky part is the "certainty" | bit. many people experience varying degrees of suffering | at some point in their lives, but it is uncommon for it | to persist throughout their entire lives. | | if you are interested in a way to sidestep this specific | question, I would point out that the pills are not only | for the benefit of the pilots. the measure is also to | protect others who might be harmed by information | divulged under interrogation. | agumonkey wrote: | If GP meant what I think he meant and he did manage to swim | out of troubled waters.. I think yeah. And in general I | remember that I was born to survive not to die. That every | tuesday I get a happy moment.. so things are not fully | broken. But I need to remove the noxious part of my life so | more happy moments come than sad ones. | | Again it's not a universal solution but very often when you | change context, you find yourself having it easier. You're | not even trying to be happy, it just grows around. | hexxiiiz wrote: | This may make sense for you in particular, but it a lot of | people the signal provided by depression is distinct in its | persistent alarm about something that isn't really in the | present. Listening to the signal and stopping to take stock of | it and make changes is often what makes depression so | paralyzing, since it is characteristic of it that this doesnt | help. Depression for most people is that "stop, stop, rest" | happening indefinitely. This is not to say that what works for | you doesn't work for you. But, in general, treating depression | like an important signal of something really wrong in one's | life that one needs to stop and address before moving forward | is pretty much depression itself. | xhrpost wrote: | Interesting counterpoint, but if you don't make changes then, | aren't you just trying harder at the same thing every day, | expecting different results? I guess I sympathize with OP as | "try harder tomorrow" just hasn't seemed to work for me. What | is it you're suggesting if stop and rest is actually the | wrong thing to do? | burkaman wrote: | I think it's different for everyone, but therapy and/or | drugs are often effective when your own efforts aren't | enough. "Stop and rest" is not the wrong thing to do | though, it just might not help. | sassycassie wrote: | good points | golergka wrote: | > about something that isn't really in the present | | Or is it? Therapy, especially gestalt or existential, often | makes people realise that something really is off with their | outlook on life, relationships with other people or other | things like this -- something that they had paid no attention | to and perceived as "normal", that really wasn't. And in the | end, what started as their fight against depression ended up | as work to fix the core reason for which that depression was | only a symptom. | | I know this to be the case with myself and some close friends | of mine. I'm not a health professional, and this is anecdotal | evidence, but from talking to other people and therapists, I | hear about this quite often. | jiggybling wrote: | Can you give an example, personal or otherwise? | cbanek wrote: | Not the OP, but I'm in therapy personally, and just as a | personal example, didn't realize that some current | reactions and feelings were colored by past experiences. | In particular, this has to do with patterns I hadn't | noticed across different relationships and work. Like my | pathological independence and general lack of trust in | humanity. | taurath wrote: | Often the "answers" to why one is depressed can be hidden | under many layers. It can be from a psychological source, | a physiological/neurological source (an injury, etc), or | a physiological source BROUGHT ON BY a psychological | source, that may or may not continue to exist. | | The last part is in my experience the thing people are | missing that creates a lot of arguments, especially | around medication. I have gone through lots of trauma | growing up, and I only recently learned of the role of | the interplay between the physical and the mental. I had | always eschewed medication - and I still think it to be | /mostly/ a first-aid treatment. There's nothing to say | that someone has a long-term physiological imbalance, or | one that we don't know how to treat. Therefore its valid | if someone needs to be on a medication for the long term. | The saying goes amongst people I know - "If you can't | make your own neurochemicals, store bought is fine.". | | For me, medication allowed the relative calm in order to | directly tackle and address childhood trauma and patterns | of thinking that ultimately result in acute depression | and anxiety. Unawareness of those triggers or ways to | deal with them leads that acute depression/anxiety to | become chronic over time, where no trigger is necessary. | | CBT (cognative behavioral therapy) is a very good way to | identify patterns of thoughts or thinking that doesn't | make sense, or create a reaction that is far outside of | the range that a person would expect. You end up having | this moments of unclear thoughts when digging into past | events, or things that upset you, or thoughts about | yourself. I have learned to relish those - that means I'm | learning something or making a connection that I didn't | have before. | | Finally, approaching entirely from the psychological side | does not always give results. Having gone through lots | and lots of cognative behavioral therapy, I'm fully aware | when I'm being irrational or have a stronger than | expected emotional reaction to things. I even apologize | while I'm doing it! But it wasn't until I dug into a | different type of therapy, EMDR, that started to approach | from the physical side of things. I started to learn to | notice things that were making my hands ball up in anger, | even though I didn't notice them before. I learned that I | dissociate sometimes and don't form memories of when I'm | upset, which severely hampers my ability to address the | things. All of this to say, its complex. It all has | underlying rational reasons behind it, and seeking out | information and building your own mental model of, well, | your mental model, is a very helpful way to go about it, | though it takes a long time. | | So try medication, try therapy, try different types of | therapy. Its extremely difficult. Its sort of like | performing surgery on yourself. But there is always | another path and more things to learn about yourself. | golergka wrote: | This is not an anonymous nickname, so I wouldn't be able | to give you an honest and full answer. | derefr wrote: | For some people, these diseases (depression, anxiety, ADHD, | bipolar, schizophrenia, OCD, intermittent explosive | disorder, etc.) are lifelong maladies present from birth; | where even if the disease only "showed up" later on, it is | known from the person's genetics/neuroanatomy/etc. that it | was inevitable for this person to get them, eventually, | regardless of environment or lifestyle. | | Such cases are no more adaptive than Cystic Fibrosis is | adaptive. They're malfunctions. | j4nt4b wrote: | I would hesitate before calling these conditions | "lifelong maladies present from birth". It's much more | accurate to call them predispositions that may or may not | manifest. And even so, the degree of manifestation may | depend on the degree of trauma, addiction, or other | challenges the person happens to face in life. This | variation is what makes me doubt any clean division into | adaptive/maladaptive cases. Not everyone so predisposed | is triggered into these mental reactions through their | life experiences, and not everyone who is so diagnosed is | a lost cause, and furthermore, those who can manage their | conditions may take offence at being called | "malfunctioning" when they did in fact "adapt". | derefr wrote: | > those who can manage their conditions may take offence | at being called "malfunctioning" when they did in fact | "adapt". | | People don't malfunction; bodies do. People are | (cybernetic) systems, composed of a mind and a body; but | people's bodies _specifically_ , when taken on their own | --including their brains, when taken on their own as | organs!--are just complex machines, that can have | _organic diseases_. (In the case of the brain, we call | these | https://en.wikipedia.org/wiki/Organic_brain_syndrome s.) | | If your computer spontaneously powers off whenever you | open hit your keyboard's "A" key, that's a malfunction. | Computers, as machines, aren't supposed to do that. If | you avoid ever hitting the "A" key, _you_ might have | worked around the problem, but the problem itself is | still present-- _the computer_ , considered as a | standalone machine rather than a cybernetic operator- | machine system, is still malfunctioning. | | If you have an SNP in the gene DDC, causing | https://en.wikipedia.org/wiki/Aromatic_L- | amino_acid_decarbox..., that is a malfunction (or | manufacturing defect) in your brain-as-machine. _You_ -- | the mind-body system -- might learn to adapt to /work | around this malfunction; but that doesn't mean the brain- | as-machine isn't continuing to malfunction. A working | system can be constructed from unreliable components. | | > who is so diagnosed is a lost cause | | Who said anything about being a lost cause? For something | to be maladaptive, it simply has to reduce inclusive | genetic fitness, such that people with the condition | reproduce less than people without the condition. That | says nothing about whether you can live your life with | the condition. | | Whatever part of the human brain thinks getting a | vasectomy is a good idea, is extremely maladaptive! But | that's not to say that we don't _prefer_ things that way. | :) | texasbigdata wrote: | Very good book, "the Depths" about depression. It argues it's | partially an evolutionary response. | | Also "quiet" by Susan Cain is even more excellent and | insightful about introverts. | tabtab wrote: | Younger boys who get a lot of exercise consistently perform | better in school on average. The "problem" is that girls don't | need as much exercise. Coordinating the difference confounds US | schools. | HeckFeck wrote: | Honestly, this squares with personal experience. I've had long | periods of anxiety, which I'd describe as perceiving outside | things as greater threats than they are, excessive worry and | overthinking and withdrawal from outside world. I've also endured | depression, that is overmuch despair and lack of willpower to | complete even simple tasks. | | It plagued me for years, badly affecting much of my personal | life. I had some therapy (for 3 months), and interestingly a | doctor actually voiced the same view put forward in this article. | I never took medication. | | Latterly, after gaining more life experience and connecting some | dots, I realised much of this was fed by my environment when I | was growing up. I realised this comparing outcomes with others | who had stabler, supportive homes. Bad circumstances leading to | social ostracisation, which meant I never developed social skills | well, which meant I always dreaded social contact. This fed an | endless anxiety cycle. | | After ten painful years, wrangling and working through it, I've | eventually managed to make better friendships. As a result, my | anxiety has dropped and my overall social ability improved. | Nowadays, social contact has been reduced and I've been forced to | stay in my childhood home thanks to "lockdown". Curiously, I've | once again had more of the depression-like symptoms. | | I wonder how much of these afflictions are brought on by poor | family environments, and even when they are stronger the parents | providing little personal input into children's lives. Lack of | community generally and increased personal isolation. I'd put it | forward that medicalisation isn't the answer to all of life's | woes, or the problems we face individually or collectively. | godelzilla wrote: | Sure, the science seems obvious. But where's the profit in | dealing with adversity? The pharma/medical industry has gotta | keep pumping pills for cash. \s | sudofail wrote: | Couldn't a person have a biological makeup that predisposes them | to experience greater or lesser adversity? If mental disorders | are adaptive responses, that doesn't seem to rule out that some | people may be more prone to interpreting situations as | adversarial. | podgaj wrote: | Yes, a genetic make up. | | https://onlinelibrary.wiley.com/doi/full/10.1002/ajmg.b.3276... | tapland wrote: | Yes of course one could have more or less of a response. | Situations and circumstamces (we're talking about entire lives | worth of experiences) vary so much though that it would be | impossible for an outsider to state _you are weaker_ based on | the limited knowledge you can have about another person. | mlang23 wrote: | PTSD is quite obviously a response to adversity, that is already | implied by the name! What am I missing here? Why is this news? | MaxBarraclough wrote: | The point is whether it's _adaptive_ , i.e. whether it has | evolved because it is beneficial (such as our pain aversion), | rather than arising as an unfortunate bug in the system (such | as cystic fibrosis, a genetic disorder which seems pretty | clearly not to be adaptive). | mamon wrote: | Of course PTSD is beneficial: it gets you discharged from | military, for example, so the chances of you being in the | situation where someone is shooting bazooka at you drop to | zero. | | In general PTSD helps you avoid traumatic experience in | future. | blame_lewis wrote: | In many interpersonal relationships, a trauma response | causes you to become _more_ liable to ending up in the same | situation, not less. Do not underestimate how many people | end up reliving their trauma over and over because they can | 't overcome that response. | dboreham wrote: | Extra points for using the word "bazooka". | [deleted] | [deleted] | bjornsing wrote: | Well we surely did not evolve to be happy and content, that's for | sure. Sounds to me like a good bet that most mental disorders are | adaptations to adversity in evolutionary time, that are often | maladaptive in modern society. | molticrystal wrote: | We could rationalize an opposite hypothesis as well, perhaps they | are adaptive responses to lack of adversity. It would be | interesting if a good experiment can be formulated to figure it | out. | | One rationale is that life for billions of years and humans for | millions have faced harsh conditions never letting us rest and | relax for long. | | So if we are sitting still, relaxing, often it meant something | must be wrong(physically or mentally) and in less sympathetic | times mental illness would encourage culling, either by the tribe | or yourself to ensure the limited resources were spent on people | who are contributing more physical action. | | Roles that didn't have to deal with as much adversity obviously | formed eventually, but they took a long time to stabilize, likely | being poorly tolerated in most ages, and if the hypothesis was | true, were plagued more with the OP's issues. | nicoffeine wrote: | I have had similar thoughts. I think that's why exercise is so | much more effective than medicine - it's making your lower | physiological self think that you are doing something important | and exciting. It also explains why people get so invested in | the drama of others. In economically developed countries, we | have far fewer life and death situations that help us | appreciate it when things are going well. | | The other difficulty is that our higher order functions know | that exercise is, in the short term, a waste of energy and | time. It's not getting us any more resources. I include myself | in the subset of people with impulse and procrastination | issues, which makes it very difficult to invest in things that | pay off over the long term. Depression for me is being stuck in | that hole, knowing there may be a way to feel better, but | believing the world would be better if I was dead. Maybe my | evolutionary contribution would have been as a martyr if I | lived in a different circumstance. | | More generally, healthcare suffers from the idea that there is | "a" population. Our brains and bodies are unique, and until | they can identify types of brain patterns and perform studies | against those, it's really throwing pills at someone and hoping | for the best. Some parts of science have entered into a | dangerous dogmatic phase of "this is how we've always done it" | which is the opposite of the point. | | I would really like to see the mental health community rally | behind getting people into recovery-style support groups where | people encourage each other to socialize, eat healthier, and | get more exercise. That would put all three of the most | effective ways to fight depression and anxiety into practice. | Of course then the problem is that prescribing virtually free | services isn't in the economic interest of for-profit systems. | carabiner wrote: | The money quote: | | > Study author Kristen Syme, a recent WSU Ph.D. graduate, | compares treating anxiety, depression, or PTSD with | antidepressants to medicating someone for a broken bone without | setting the bone itself. She believes that these problems "look | more like sociocultural phenomena, so the solution is not | necessarily fixing a dysfunction in the person's brain but fixing | dysfunctions in the _social world_. " | | This is EXACTLY what Kaczynski said: | | > The concept of 'mental health' in our society is defined | largely by the extent to which an individual behaves in accord | with the needs of the system and does so without showing signs of | stress ... Instead of removing the conditions that make people | depressed, modern society gives them antidepressant drugs. In | effect, antidepressants are a means of modifying an individual's | internal state in such a way as to enable him to tolerate social | conditions that he would otherwise find intolerable. | vorpalhex wrote: | Kaczynski ends up positing a kind of return to the natural | state as the ultimate solution (which he basis his actions on). | The issue being that historically, these problems existed in | earlier times even if not discussed in detail. Kaczynski blames | "the state of the world" without ever listing some state where | the problem didn't exist. | | > "Research on depression, anxiety, and PTSD, should put | greater emphasis on mitigating conflict and adversity and less | on manipulating brain chemistry." | | Whereas Kaczynski blames society, the world at large, the paper | sets these up as smaller addressable issues. You can identify | "kid B needs extra recess" more readily than abolish schools as | Kaczynski calls for. | swebs wrote: | He's a pretty agreeable guy if you ignore all the bombings. | Nav_Panel wrote: | Yeah and also what psychoanalysts have said for the last 100+ | years. All Kaczynski offers is a normative stance. | throwaway0a5e wrote: | So why didn't anxiety, depression and PTSD abound in historical | societies that were always at risk of some bad thing (usually | famine but also sometimes invasion)? | | Bad stuff has always happened and always will happen. Something | about modern society makes us bad at dealing with it in a healthy | way. | | I don't doubt that there might be some mismatch between the | environment our biology is optimized for and the one we live in | now but it seems like these conditions weren't common, or if they | were they weren't a problem, among our ancestors who lived under | different circumstances. | calimac wrote: | Ibogaine treatment for Anxiety, Depression, and PTSD is amazingly | effective. Individuals who have taken treatment express years of | growth packed into days. | | https://ibogaineclinic.com https://youtu.be/ltJfEfnM2ek | johnnujler wrote: | It took humans thousands of years to adapt to the side-effects of | the agricultural(Neolithic) revolution | (https://www.discovermagazine.com/planet-earth/the-worst- | mist...). I think we are in a similar situation--psychological | revolution?--where the side-effects due to social media, | globalization, and other related phenomenons are starting to | change the landscape. My guess is we will soon see that the | plateau we have attained in the form of psychological disorders | will slowly fade away in couple more generations as people start | adapting to this kind of stress. Maybe our generation is | evolution's transition point? At least I hope that it is, I've | never seen this at this level of intensity with my | grandparents'/parents' generation and I do not want to see this | with the next generation. | billman wrote: | Another thing to think about is that these responses may cross | generations. i.e the anxiety someone experiences today may be due | to trauma suffered by thier grandparents. The mind is a wonderful | thing, but there is so much that we don't understand about | it/ourselves. | podgaj wrote: | This happens through epigentic changes, not through the mind or | the brain. | | https://www.sciencemag.org/news/2019/07/parents-emotional-tr... | raindeer3 wrote: | "Anxiety may be due to chronic activation of the fight or flight | system. PTSD may occur when trauma triggers the freeze response | which helps animals disconnect from pain before they die, and | depression may be a chronic activation of that same freeze | response." Isn't this a quite good definition of disorders? If a | system is chronically activated when it should not, it seems like | a disorder. | fnord77 wrote: | when these conditions persist after the adversity has passed, | that's maladaptive. | dredmorbius wrote: | Is a leg that remains fractured after a physical shock has | passed also maladaptive? | fnord77 wrote: | if it doesn't heal in some reasonable amount of time after | the trauma and remains fractured indefinitely, then yes. | holidayacct wrote: | Anxiety is a disorder of the nervous system that is a by-product | of civilization. We are one of the only mammals that gets | anxiety, if you get anxiety in the wild you won't be alive much | longer. | | Depression and PTSD are not responses to adversity. If you face | adversity and suffer depression or PTSD you were raised | psychologically weak in a way that is dangerous to you. | | There are people who have survived civil wars, drought and mass | starvation all over the world that don't have these problems get | out of your bubble. | tsimionescu wrote: | > There are people who have survived civil wars, drought and | mass starvation all over the world that don't have these | problems get out of your bubble. | | And similarly, there are people who have been traumatized by | the same events. | | In fact, there are war heroes who have taken bullets for their | comrades, saved platoons, jumped at the enemy, and have been | stricken with PTSD - if you think these people are "weak", then | you probably also consider people who get cancer to be of | inferior stock, right? | podgaj wrote: | It is so shocking to me that people do not think genetic | diversity exists without the human species. | auganov wrote: | If you have two people subject to same circumstances and one | experiences significantly more distress they are weaker in | some sense. | | Doesn't mean they're less virtuous in what they have done. | But obviously everybody should strive to be the one that | comes out unscathed. | dredmorbius wrote: | Addressing only one of your dubious points, there is a | considerable scientific literature on anxiety response in | animals. | | https://scholar.google.com/scholar?q=anxiety%20response%20an... | MaxBarraclough wrote: | This strikes me as a pretty clumsy article. | | > What if mental disorders like anxiety, depression, or post- | traumatic stress disorder aren't mental disorders at all? | | Of course they're disorders. That's why they deserve treatment. | This bears no connection to the question of whether they're | adaptive. Our capacity for physical pain is adaptive, but doctors | still treat pain. | | > With a thorough review of the evidence, they show good reasons | to think of depression or PTSD as responses to adversity rather | than chemical imbalances. | | Besides clueless commentators on the Internet, who is suggesting | depression is simply a matter of 'chemical imbalance'? If that | were the case, it wouldn't be brought on by loneliness, and it | wouldn't be treated with CBT and talking therapy. | podgaj wrote: | And who is to say CBT does not effect chemicals in the brain | and body! Of course it does! everything environmental effects | the chemicals in our body. If you give someone meth they will | have anxiety, if you drink too much you will have depression. | | The state of understanding the gene-environment interaction is | so backwards and slow to catch up with the science it is a | crime. | npwr wrote: | > Besides clueless commentators on the Internet, who is | suggesting depression is simply a matter of 'chemical | imbalance'? If that were the case, it wouldn't be brought on by | loneliness, and it wouldn't be treated with CBT and talking | therapy. | | Most of (all?) chemical depression treatments are based on the | serotoninergic depression hypothesis that has never been | verified. In the recent years more and more arguments come | directly against this hypothesis. Yet SSRIs are still the first | line of treatment for depressive patients. | | https://en.wikipedia.org/wiki/Major_depressive_disorder#Path... | raducu wrote: | Besides raving on and on about ADHD, the article offers little | actionable stuff, dubious reasoning and outright falsehoods at | places (like the fact that antidepressants are no better than | placebo). | disgruntledphd2 wrote: | I wouldn't say that that is a false statement, there's been a | bunch of research in the area, mostly started by this paper: | https://www3.nd.edu/~ghaeffel/Kirsch2002%20Prevention%20&%20... | | Note that the above is an analysis of the data used to approve | the medications from the FDA, so likely to be optimistic. | | The headline finding is that compared to an active placebo | (i.e. one with similar side effects), the benefits of SSRIs are | very small. | | However, if you have a diagnosis of MDD, there is more evidence | for an effect (although it's still pretty small). | | It's a difficult subject to study correctly, because of the | strong commercial pressures (like most drug studies, to be | fair), but depression does seem relatively placebo responsive, | which would suggest either a connection to inflammation or the | body's opioid system. | | This does not mean that people should stop taking anti- | depressants, I'm not a medical doctor etc, but there is some | research to support the assertion around SSRIs and placebo in | the article. | dathinab wrote: | Anxiety & depression might be useful if handled well but if | not... | | The problem is often on the line of you get depression & anxiety | as a symtom of some other problems if you fix the problems fine. | If you don't it can get out control and then you _can become | conditioned to do "bad" responses to all kind of things making | the symptom a illness itself_. And making it really hard to get | out of it. | | Or at least this is how it _often did look like to me_ when I | looked at people with depression & anxiety. | | Just to be clear with "bad" responses I mainly mean thinks like | avoiding problems instead of fixing (or sidestepping) them making | it with every time you do so harder to "fix" that underlying | problem in the future. | lazyeye wrote: | So much of what we think is knowledge is actually just a | construct to allow someone to make some money. You cant make | billions of dollars selling pills through educational reform. | Carbs have a longer shelf-life, high profit margin and are hunger | inducing so fat was demonised. Recycling doesnt work because its | not cost effective but the plastics industry pushes it to shift | responsibility away allowing them to fill our world with garbage. | You cant make money with treatments out of patent so meds like | chloroquine are demonised with cherry-picked research. We are | swimming in an ocean of garbage presented to us as fact. | SzamarCsacsi wrote: | _" When it comes to what labels we use, a change is welcome. | Mental health recovery in part depends on whether patients | believe they can get better. Telling our patients that their | symptoms may be tied to a healthy response to adversity could be | very encouraging."_ | | I find it the exact opposite. For me it seems easier to fix a | mental disorder in my brain than to bring the necessary | sociocultural changes in the world to mitigate my problems. ___________________________________________________________________ (page generated 2020-09-03 23:00 UTC)