[HN Gopher] AstraZeneca Covid-19 vaccine study put on hold due t...
___________________________________________________________________
AstraZeneca Covid-19 vaccine study put on hold due to suspected
adverse reaction
Author : aaavl2821
Score : 119 points
Date : 2020-09-08 21:26 UTC (1 hours ago)
(HTM) web link (www.statnews.com)
(TXT) w3m dump (www.statnews.com)
| yread wrote:
| Where it says "serious adverse reaction" do they mean the adverse
| reaction was serious or that it's an actual grade 3 adverse event
| (SAE)? https://en.wikipedia.org/wiki/Serious_adverse_event
| SparkyMcUnicorn wrote:
| The article seems to indicate that this could be a SAE, but
| also that "the participant is expected to recover".
| dang wrote:
| Other ongoing Covid vaccine thread:
| https://news.ycombinator.com/item?id=24411540
| notatoad wrote:
| maybe this is off-topic, but it's interesting to me that this is
| the first time i've heard this referred to as the "astrazeneca
| vaccine". all the previous good-news stories seemed to call it
| the oxford vaccine.
| mikeyouse wrote:
| So Oxford (the Jenner Institute / Oxford Vaccine Group)
| developed the vaccine but they're partnering with AZ to get it
| tested and then manufactured and distributed if the testing
| goes well. Oxford sponsored the initial studies and AZ is
| taking over now that it's more sophisticated.
|
| Short background here:
|
| https://www.cnbc.com/2020/05/21/coronavirus-us-gives-astraze...
| dekhn wrote:
| This is a US trial, AZ is listed as the Sponsor for the trial,
| https://clinicaltrials.gov/ct2/show/NCT04516746 and the PIs
| listed are both at US.
| seedless-sensat wrote:
| Except the adverse reaction was not in the US trial.
| aphextron wrote:
| It's important to note that the AstraZeneca vaccine is adenovirus
| based [0], not mRNA based like the Pfizer and Moderna candidates.
| It was to be expected that this approach could cause more
| complications. mRNA vaccines have their own issues, but they do
| not involve live viruses being injected [1]. Instead they use
| lipid nanoparticles as a substrate to enter the body's cells [2].
|
| [0] https://www.astrazeneca.com/media-centre/press-
| releases/2020...
|
| [1] https://www.phgfoundation.org/briefing/rna-vaccines
|
| [2] https://www.nature.com/articles/s41586-020-2639-4
| mrfusion wrote:
| So how does this one work? Live adeno's?
| ethbr0 wrote:
| The chimpanzee adenovirus is used as a vector, with its
| payload replaced with instructions to manufacture SARS-CoV-2
| spike protein.
|
| Virus enters body, hopefully survives immune system long
| enough to insert instructions into your cells, your cells
| churn out tons of copies of coronavirus spike protein, your
| immune system sees the surfeit of spike protein and develops
| a response (antibodies and T* cells).
|
| https://blogs.sciencemag.org/pipeline/archives/2020/04/23/a-.
| ..
| aphextron wrote:
| >So how does this one work? Live adeno's?
|
| Yes. It uses a live (weakened) chimpanzee adenovirus to
| insert the spike protein.
|
| https://www.drugs.com/history/azd1222.html
| mrfusion wrote:
| Do the adenos actually have to infect the cells to produce
| the spikes?
| kevin_b_er wrote:
| It could still be an immune system misfire. A vaccine is trying
| to create an large immune system response enough that the real
| infection is thwarted.
|
| With that, a misfire can happen with any vaccine attempt,
| because an immune response is what's required.
| EForEndeavour wrote:
| > rather than producing them outside the body and then
| injecting them
|
| That's not what the Oxford/AZ vaccine does, is it? From what I
| understand, it's a viral vector vaccine engineered to deliver
| DNA that encodes the SARS-CoV-2 spike protein into human cells
| and induce them to express the protein, stimulating the immune
| response.
|
| The plan was never to introduce spike protein "produced outside
| the body." The mechanism of action is getting the body to
| produce spike protein and learn to attack it as foreign. If the
| Oxford/AZ vaccine doesn't "take advantage of your own cells to
| produce the spike protein," I don't know what does.
|
| https://labblog.uofmhealth.org/rounds/top-5-covid-19-vaccine...
| sudosysgen wrote:
| Yes, that was made in comparison to conventional vaccines
| that either use inactivated viruses or viral proteins
| hartator wrote:
| Is this one of the two favorites?
| Marazan wrote:
| Yes. The one in pole position.
|
| Until now.
| mrfusion wrote:
| Is that why the market was down today?
| marc__1 wrote:
| No, the AZN announcement was made after the market closed.
| Take for instance Moderna, who was -13% today, and is +3.7%
| after-hours
| codeisawesome wrote:
| Not tracking the real world anymore
| volkse wrote:
| The russian vaccine is also based on adenovirus vectors. Not
| clear if the method of delivery is to be blamed here, but it
| could be the cause for the adverse effects..
| roody15 wrote:
| "The platform has not been used in an approved vaccine, but has
| been tested in experimental vaccines against other viruses,
| including the Ebola virus."
|
| hmmm... this method of vaccination has never been used in an
| approved vaccine.
| alkonaut wrote:
| You'll find that's the case for several of the front runners.
___________________________________________________________________
(page generated 2020-09-08 23:00 UTC)