[HN Gopher] Scientists grow bigger monkey brains using human gen...
       ___________________________________________________________________
        
       Scientists grow bigger monkey brains using human genes, replicating
       evolution
        
       Author : ignoramous
       Score  : 262 points
       Date   : 2020-11-15 17:47 UTC (5 hours ago)
        
 (HTM) web link (interestingengineering.com)
 (TXT) w3m dump (interestingengineering.com)
        
       | AlchemistCamp wrote:
       | What could possibly go wrong?
        
       | ChrisMarshallNY wrote:
       | Are they going to call him Caesar?
        
         | agilob wrote:
         | Or Dr. Zaius
        
       | jacquesm wrote:
       | This is simply unethical.
        
       | tigerBL00D wrote:
       | Did anyone else think about "Planet of the Apes" after reading
       | this?
        
         | [deleted]
        
         | T-A wrote:
         | Of course. Given the times, this in particular:
         | 
         | https://vimeo.com/120831063
         | 
         | Now I wonder what effect ARHGAP11B would have on a shark:
         | 
         | https://youtu.be/oSz9MDN-iac?t=71
        
         | busterarm wrote:
         | "God damn you all to hell!"
        
         | colechristensen wrote:
         | More like the Island of Dr Moreau, more obscure and quite a bit
         | more disturbing.
        
         | mark-r wrote:
         | Literally as soon as I read the title.
        
       | EugeneOZ wrote:
       | Can we improve our own brain this way? I mean, brain of our kind,
       | not some already living person. What if we can create a creature
       | smarter than us?
        
         | qvrjuec wrote:
         | Obviously, but the real issue would be figuring out how to
         | tweak our genes to do so. Figuring out how to enlarge the brain
         | of a monkey would've been much easier, because human genes
         | provided a ready-made template for these researchers to use.
        
         | etiam wrote:
         | More likely the poor thing's going to be severely epileptic or
         | have other debilitating brain malfunctions, if it would be
         | viable at all. People here are reading way too much positive
         | functional consequences into this manipulation.
         | 
         | In principle, of course genetic manipulation could be used as
         | one tool to create a creature "smarter" than any human
         | (whatever that means more specifically).
         | 
         | In practice, until we start having a much more coherent theory
         | of functional brain physiology, applying the tool to that end
         | pretty much amounts to mucking around, with likely tragic
         | consequences.
        
         | colechristensen wrote:
         | Surely, but at what cost?
         | 
         | Exploratory human experimentation... maybe you're testing and
         | aborting half developed humans which already many people would
         | have significant problems, but eventually you're going to have
         | to produce adults and not every experiment is going to be a
         | success.
         | 
         | It's hard to think of a future of our species where self-
         | modification is not part of our evolution, but it is a very
         | powerful tool and like any power a lot of discipline has to go
         | into not misusing it.
         | 
         | Somebody call Dr Moreau
        
         | SubiculumCode wrote:
         | Not to be funny, but our brains/skulls are already large enough
         | to really make giving birth legitimately dangerous to mothers.
         | Making the head even bigger would not be welcome.
        
       | riazrizvi wrote:
       | From an engineering perspective, when trying to explore a
       | dynamic, you simplify the experiment to reduce extraneous
       | variables. So along these lines, I'd be more interested in
       | following experiments like these on say sea slugs. Give them a
       | proto-amygdala/hippocampus or limbic system and test them for
       | increased memory, adaptive behavior etc. This choice of monkey
       | experiment seems to be more sensation and less investigation, on
       | the spectrum.
        
         | s1artibartfast wrote:
         | unfortunately, the further you move generically from the human,
         | the _more_ extraneous variables you introduce and the lower the
         | relevance of any result. There is a reason drugs and
         | experiments are performed on primates. Any result you saw in
         | say a sea slug would provide no insight into the human
         | function.
         | 
         | The ideal experiment would be to delete the gene from a human,
         | but this is unethical for obvious reasons.
        
           | coryrc wrote:
           | We support women knowingly giving birth to trisomy fetuses.
           | We're in trolley problem territory here.
        
           | riazrizvi wrote:
           | I should have also said, I think it is premature to attempt
           | genetic engineering of human brains for medical benefit.
           | Intuitively I believe we are decades behind the amount of
           | conceptual development and experimental validation we need to
           | do to get a proper understanding of genetic brain
           | engineering. So I think the ethics is spot on here, it's
           | ethically wrong IMO because we don't know what we are doing.
           | Ethically I don't see a problem messing with sea slugs,
           | though no doubt some people might.
        
       | modzu wrote:
       | the island of dr moreau
        
       | oscargrouch wrote:
       | I feel this is a moon-landing like historical event without all
       | the fireworks.
        
       | babesh wrote:
       | Planet of the Apes
        
       | [deleted]
        
       | 29athrowaway wrote:
       | As a fan of the Planet of the Apes franchise, I like this
       | article.
       | 
       | Next: give apes human-like hands suitable for tools.
        
       | bronzeage wrote:
       | We've already had the plague this year, bring on the intelligent
       | monkeys...
       | 
       | Where do I buy tickets to an Elon Musk rocket now?
        
         | treeman79 wrote:
         | https://xkcd.com/979/
         | 
         | To future researchers, here is where 2020 finally jumped the
         | shark. Best wishes.
        
         | bra-ket wrote:
         | Elon booked the entire flight for himself. He just wants to go
         | home.
        
       | [deleted]
        
       | ativzzz wrote:
       | So what exactly is inherently unethical about letting this
       | engineered organism live? Is it a violation of "Christian" ethics
       | of playing God? If so, we've already gone way past that point
       | with modern medicine and things like genetic engineering of
       | mosquitoes.
       | 
       | If it's a fear of how society reacts to the organism surviving
       | and causing an upheaval of life philosophy, isn't all science
       | then unethical?
        
       | phkahler wrote:
       | Is there a better source? I'd like to know what gene they added
       | and if there is any reason to believe that could have been an
       | evolutionary step. Gene's dont appear whole out of nowhere. Was
       | it an extra copy of an existing gene? A mutation and duplication?
       | Some weird replication error?
        
         | carbocation wrote:
         | The source is this article:
         | https://science.sciencemag.org/content/369/6503/546
         | 
         | The gene is _ARHGAP11B_ under the control of its usual human-
         | specific promoter.
        
         | phkahler wrote:
         | I found another article that covers the origin of the gene
         | here:
         | https://www.sciencedaily.com/releases/2020/06/200618150301.h...
        
         | shmageggy wrote:
         | I'm also curious about all the related morphological changes
         | that must go along with increased brain size, such as different
         | proportions of the skull and face and wider hips on females to
         | accommodate birth. It seems unlikely one gene can modulate all
         | of those, let alone yield the social structures required for
         | increased rearing time.
        
           | keithwhor wrote:
           | Developmental biology has a whole lot of plasticity and works
           | primarily by self-organization of cell populations. It's not
           | a computer program where you have to allocate memory for
           | skulls, eyes, ears and more -- it's actually more like a
           | population of organisms that align themselves towards
           | specific goals ("hey team, we need a hand -- now time for
           | fingers! You guys in the middle, die off!")
           | 
           | You can think of a gene for i.e. brain size just being an
           | instruction that's "you can press harder on the other
           | populations to maximize your growth" and the other
           | populations are likely to accommodate the stress during
           | development, and change size and shape accordingly.
           | 
           | There are of course harmful mutations that are unable to be
           | compensated for and lead to failure to thrive, but when you
           | see a successful morphological mutation it's because the
           | systems are very adept at integrating new stimulus during
           | growth.
           | 
           | (Similarly, social structures are emergent properties as
           | well.)
        
       | hyperpallium2 wrote:
       | I have a theory that intelligence, consciousness, free will are
       | very easy to evolve (we just haven't worked out how to do it yet
       | - like many cellular processes). What is difficult is
       | _harnessing_ that free will to the evolutionary success of the
       | organism.
       | 
       | The large brain is necessary as a harness, to control the
       | intelligence, and enslave it to evolutionarily beneficial ends.
       | Probably not just hardwired instincts, but also learns -
       | probably, similar to animal intelligence.
       | 
       | Like a giant finite state machine, that prevents a turing machine
       | from running certain programs that never halt. Of course, it
       | can't catch _all_ such programs, and a turing machine can
       | transcend any such bound, but lowering the probability of running
       | one is good enough.
       | 
       | Note that turing equivalence, the highest possible computational
       | power, emerges from even the slightest complexity (apart from the
       | infinite tape part).
       | 
       | Thus "intelligence" has appeared in countless individual animals:
       | mammals, birds, spiders, perhaps plants too and bacteria (and is
       | still so appearing), but it doesn't confer a survival advantage,
       | so disappears. Many such creatures just sit there discerning
       | patterns instead of surviving. Others do survive but by instinct,
       | so the intelligence makes no difference.
       | 
       | The difficulty is putting freewill in the driver's seat.
        
       | nwpk wrote:
       | These are the old news. I have read about this research several
       | month ago.
        
         | soulofmischief wrote:
         | Submit a recent article you think is interesting!
        
       | Kosirich wrote:
       | _" To let them come to be born, in my opinion, would have been
       | irresponsible as a first step,"_ emphasis on the "as a first
       | step"
        
         | SubiculumCode wrote:
         | It is an interesting ethical decision because it highlights a
         | lot of assumptions about what is and is not ethical and moral.
         | For example, take those that firmly believe abortion is murder.
         | For them. then aborting this evolved fetus would be considered
         | (to the extent that this applies to mutant non-human primates)
         | the unethical thing to do, NOT the ethical thing to do.
         | However, if you don't believe fetuses have inherent rights,
         | etc, then the most ethical thing to do is to destroy the fetus
         | before it does begin to reach that threshold where thorny
         | ethical implications emerge.
        
         | zhrvoj wrote:
         | Personally I don't believe that they destroyed fetus. And they
         | give up of seeing end results?? C'mon...
        
       | Albertbm4 wrote:
       | humano
        
       | Albertbm4 wrote:
       | error
        
       | eplanit wrote:
       | Planet of the Apes + Bladerunner.
        
       | major505 wrote:
       | you want planet of the apes? Because, this is how you get planet
       | of the apes!
        
       | linuxftw wrote:
       | People think AI is going to be silicon based. No, it's going to
       | be genetically engineered primate brains.
        
       | eugenhotaj wrote:
       | _Joe Rogan joins the chat_
        
       | pelasaco wrote:
       | Planet of the Apes 2020
        
       | sigzero wrote:
       | No...they didn't. That's not how it works at all. smh
        
       | fallingfrog wrote:
       | I think the ethical questions here mostly revolve around how the
       | resulting animal would be treated. It wouldn't have the legal
       | status of a person- although it might be one. So we would
       | probably use it for slave labor, as a pet, probably not as food
       | although there are probably people who would do that too given
       | the opportunity. Certainly that's how we treat other nonhuman
       | animals. Or they might escape and the gene might start to
       | circulate in wild populations. There's no good way this pans out.
        
       | gwern wrote:
       | Mirror:
       | https://www.gwern.net/docs/genetics/editing/2020-heide.pdf
        
       | colechristensen wrote:
       | If you want to know what science fiction thought of this kind of
       | thing in 1896, read the Island of Dr Moreau -- an eccentric
       | scientist in exile modifies animals into more human forms.
        
       | CyberRabbi wrote:
       | Hmm doesn't seem credible. Everyone knows that brain size has no
       | effect on intelligence.
        
         | Retric wrote:
         | Yea, I was talking to a fruit fly yesterday...
         | 
         | Wait no, that's not accurate because while larger brains don't
         | inherently equate to more intelligence, there is a minimum size
         | for any given level of intelligence. That said, this wasn't a
         | test of intelligence, just how cells grow in response to
         | specific genetic alterations.
        
           | busterarm wrote:
           | But larger brains in monkeys do equate to larger social
           | groups (dunbar's number. monkeyspheres) and could be a
           | necessary precursor to civilization.
        
           | CyberRabbi wrote:
           | I didn't realize that was scientific consensus. So that would
           | imply that brains under a certain size are incapable of
           | higher levels of intelligence? I don't think that's right...
           | I thought the consensus was that brain size has no strong
           | correlation with intelligence at all. That makes sense
           | considering how neurons work, the connections they form seem
           | like they would be more causal.
        
             | SubiculumCode wrote:
             | Its a complicated question. Within the human species, the
             | correlation is not that strong at all. In cross-species
             | comparisons it tends to be quite strong, especially when
             | considering brain to body weight ratios. Bird brains may be
             | an interesting exception however, which I suspect can be
             | quite intelligent, depending on how intelligence is
             | measured.
        
             | s1artibartfast wrote:
             | The scientific consensus is that from the evolutionary
             | perspective, brain/body size is absolutely correlated with
             | performance. This doesn't have to be general intelligence,
             | but can be sensory processing ect.
             | 
             | That is not to say that structure isn't important too. This
             | is especially relevant because the study observed some of
             | the structural changes through to be associated with
             | increased intelligence as well.
        
             | ivalm wrote:
             | Information processing is limited to the capacity of the
             | network. So it is easy to see that very small brains cannot
             | be very smart (there is no set of connections that can make
             | fruit fly human-intelligent). However, having a large
             | capacity network doesn't mean it will result in high
             | intelligence. So it's necessary but not sufficient.
        
         | computerphage wrote:
         | Another win for the heuristic "if someone says 'everyone knows
         | X' it probably means X is false"
        
         | isoprophlex wrote:
         | You'll never play Doom on a single NAND gate. Huge efforts in
         | getting toasters, microwaves and pregnancy testers to run Doom
         | notwithstanding.
        
           | CyberRabbi wrote:
           | But brains aren't made of digital logic elements
        
             | scott31 wrote:
             | You'll never play Doom on a single neuron.
        
               | layoutIfNeeded wrote:
               | I'm pretty sure there's sufficiently complex cellular
               | machinery inside a neuron to run Doom if arranged in the
               | right way.
        
               | tiborsaas wrote:
               | But you surely can on the computer simulating that single
               | neuron :)
        
               | CyberRabbi wrote:
               | You'll never play doom on any amount of neurons... brains
               | are not cpus
        
               | quickthrower2 wrote:
               | Why not? You could manually process the assembler on
               | pen/paper. Sure the FPS might be a bit on the low side.
        
         | chillacy wrote:
         | https://en.wikipedia.org/wiki/Brain-to-body_mass_ratio
         | 
         | With an extra caveat:
         | 
         | > Recent research indicates that, in non-human primates, whole
         | brain size is a better measure of cognitive abilities than
         | brain-to-body mass ratio. The total weight of the species is
         | greater than the predicted sample only if the frontal lobe is
         | adjusted for spatial relation.[18] The brain-to-body mass ratio
         | was however found to be an excellent predictor of variation in
         | problem solving abilities among carnivoran mammals.[19]
        
       | davesque wrote:
       | Damnit, couldn't they have done this when Charlton Heston was
       | still around to help out?
        
       | grawprog wrote:
       | I find it hard to describe how I feel about this.
       | 
       | These scientists essentially created what may have been a new
       | species, that perhaps would have had similar sentience to us and
       | had them terminated after 100 days.
       | 
       | The cat's out of the bag with this research so to speak now.
       | Someone's bound to do this again
       | 
       | The part about whether they should have been born or not, which
       | was the ethical thing is what tears at me.
       | 
       | Is it right to create something that may be similar to us and
       | then not even give it a chance to live?
       | 
       | I mean whether creating such a being is right or not in general
       | i'm sure is up for debate.
       | 
       | I'm not religious, but if we're going to play god, shouldn't we
       | take responsibility for the results of our creation?
       | 
       | I dunno, I find a lot of genetic engineering research to be a bit
       | unsettling. We're playing with things we barely understand that
       | could have consequences we can't even imagine.
       | 
       | Nature took a long long time to get to this point where life has
       | come to a sort of balance. Assuming we can go in and just start
       | blindly messing around and do better seems like an extreme level
       | of arrogance that's going to end up blowing up in our faces.
       | 
       | Our track record for messing around with the fundamental fabric
       | of reality and life isn't so good. We've ended up with some
       | pretty terrifying things.
        
         | Vinnl wrote:
         | I understand the sentiment, but given our track record of being
         | OK with causing the suffering of billions of creatures capable
         | of suffering - and in fact even being the reason those creators
         | were born in the first place - I wouldn't be surprised if we
         | brushed it aside relatively easily after the first few.
        
         | konart wrote:
         | >shouldn't we take responsibility for the results of our
         | creation?
         | 
         | "I gave you life, I will take it" - Taras Bulba.
        
           | grawprog wrote:
           | https://youtu.be/BpaRouocBes
           | 
           | >You perceive, now, that these things are all impossible
           | except in a dream. You perceive that they are pure and
           | puerile insanities, the silly creations of an imagination
           | that is not conscious of its freaks--in a word, that they are
           | a dream, and you the maker of it.
           | 
           | Mark Twain
        
         | ineedasername wrote:
         | If it makes you feel any better, a brain that young, even if
         | identical to that of a baby, is probably not sentient. AFAIK,
         | current research pegs the early development of sentience around
         | 150 days.
         | 
         | Despite that, I'm a bit unsettled by this too. I think we
         | should understand the mind a bit more before we go down the
         | path of creating one.
        
         | 1234fdsazxcv wrote:
         | Can we please use paragraphs to create a coherent thought/point
         | rather than a series of one-liners? Perhaps spend a little more
         | time to think through/build out your thoughts. It is more
         | interesting for your reader and (I think) promotes more nuanced
         | conversation if we all spend more time thinking about our ideas
         | before we rush to post.
         | 
         | Note, this is not specific to the parent post but just a
         | general comment made with the hope of raising the level of
         | conversation beyond twitter.
        
         | ChuckMcM wrote:
         | I feel pretty simply, I feel a sense of sadness at the kinds of
         | 21st century problems my kids and their kids are going to have
         | to deal with.
         | 
         | At some point in the next 25 years I expect there to be a
         | 'procedure' available, which consists of cultivating a persons
         | stem cells from their bone marrow, using a genetic editing
         | technique to add and/or delete and/or "correct" certain genetic
         | sequences, and then to have a "bone marrow transplant" which is
         | simply killing off your existing bone marrow stem cells and
         | replacing them with the edited ones.
         | 
         | It will be touted as a durable cure for genetic disease and
         | marketed underground to people of means who are looking for an
         | edge in their chosen profession.
         | 
         | There will be lawsuits over people who have their their genetic
         | sequences "appropriated" by a third party to re-sell as a
         | product, and patent litigation on gene sequences that makes
         | much of today's trolls seem quaint in comparison.
         | 
         | I expect to see dog shows and horse races ban "genetically
         | modified" contestants. I expect to see lawsuits around the
         | labeling of beef and chicken about being genetically modified
         | (yes some of this is already happening).
         | 
         | The world will be profoundly different on the far side of
         | generalized understanding of genetics and the means to
         | manipulate them. At least as different as it has become pre-
         | internet+computer to post internet+computer.
        
         | renewiltord wrote:
         | Our track record for messing with the fundamental fabric of
         | reality is creating antibiotics, and over the period of a
         | century saving so many lives that wars of earlier periods are
         | negligible in comparison.
         | 
         | A natural reaction from people with high sanctity/degradation
         | (in the MFT sense) is to avoid touching the trolley lever at
         | all points. Decision making is considered association with the
         | decision. The naturalistic fallacy pervades all.
         | 
         | No, if you can save billions and you choose not to, you have
         | killed them. If you can uplift species and you choose not to,
         | you have killed their cognition. Keine Wahl ist auch eine Wahl.
         | We are gods over the Earth. We have dominion over it and the
         | creatures that inhabit it. And godhood carries responsibility
         | more than it carries power. We owe the monkeys their sapience.
        
           | grawprog wrote:
           | It's also such things as nuclear weapons, genetically
           | engineered virii, patents on life, tampering with ecosystems,
           | plants designed to be sterile to ensure a seed market, lakes
           | full of sterile fish stocked for sport.
           | 
           | >No, if you can save billions and you choose not to, you have
           | killed them. If you can uplift species and you choose not to,
           | you have killed their cognition. We are gods over the Earth.
           | We have dominion over it and the creatures that inhabit it
           | 
           | No we're not. We're barely able to hold it together. The
           | Earth is a giant living system we're slowly killing and
           | replacing with human technology.
           | 
           | It's not a naturalistic fantasy, it's the reality of the
           | planet you live on.
           | 
           | To think we dominate this world is laughable. The fungi will
           | consume all of us some day and outlive us all. I mean some
           | are among the oldest still living life on earth as it is.
           | Like millions of years old and still going. How can you
           | dominate something that's existed longer than you and will
           | out live you and everyone you know?
           | 
           | Humans have such a limited understanding of the very things
           | that make life possible. We're not gods, we're children who
           | wandered into gods workshop and started playing with all the
           | shiny toys.
           | 
           | Just because we know how to play with toys doesn't make us
           | gods or the dominators of the Earth or life itself.
           | 
           | That's the kind of arrogance I speak of that's going to blow
           | up in our faces.
        
             | renewiltord wrote:
             | No, no, not humans. The we that have dominion are certain
             | genes, for which the humans are mere vehicles. These genes
             | are just as old as the mushroom genes.
             | 
             | And this gene cluster is aiming to master the rock that is
             | the Earth through modifying other gene clusters. And you
             | can't stop it. Because through modification it grows
             | stronger and more able. And it has rallied the memome and
             | the hologenome to its cause. This cause requires no
             | convincing because only winners get to play the next round.
             | Change is inevitable. Understanding is overrated. Control
             | does not require it.
             | 
             | Transformation Theology has subsumed this world. You live
             | in an ether floating in it. You cannot choose the path of
             | no change. No such path exists.
        
               | throwaway_pdp09 wrote:
               | > is aiming to master the rock that is the Earth
               | 
               | Genes aren't goal directed towards something higher.
               | 
               | > This cause requires no convincing because only winners
               | get to play the next round
               | 
               | The 'winners', us humans, are literally destroying the
               | ecosphere which supports our life.
               | 
               | > Understanding is overrated.
               | 
               | That's an appeal to ignorance.
               | 
               | > Control does not require it [understanding]
               | 
               | We can control something without understanding it? Most
               | of science would disagree.
        
               | renewiltord wrote:
               | > _Genes aren 't goal directed towards something higher._
               | 
               | No, but "this gene cluster" is me - and _I_ am goal-
               | directed.
               | 
               | > _We can control something without understanding it?
               | Most of science would disagree._
               | 
               | No, they wouldn't. Epistemology has progressed beyond
               | this. Models have various levels of fidelity. And
               | 'understanding' is a colloquial term that refers to a
               | higher standard of fidelity than that required for
               | control. Few drivers know how their cars work. Most
               | drivers can drive their cars.
               | 
               | But I do enjoy the amusing attempt at cutting out the
               | sentence to create damning gotchas. Here, I mimicked your
               | style and made one from your comment:
               | 
               | > _We can control something without understanding it_
               | 
               | Why, thank you for agreeing with me! Quite gratifying to
               | receive such support.
        
               | throwaway_pdp09 wrote:
               | > and I am goal-directed.
               | 
               | OK, straight questiom goal directed towards _what_?
               | 
               | > And 'understanding' is a colloquial term that refers to
               | a higher standard of fidelity than that required for
               | control
               | 
               | Don't agree - further
               | 
               | > Few drivers know how their cars work. Most drivers can
               | drive their cars.
               | 
               | Understanding is about understanding of aspects. They may
               | well not understand the engine aspect (how it works
               | precisely) but "Most drivers can drive their cars" means
               | they control their cars, which means they _understand_
               | what happens when a steering wheel is turned, and how not
               | to grind the gears, and not to hit accelerator and brake
               | together. They model it. That is the embodiment of their
               | understanding. Without that they could not control a car.
               | 
               | > Why, thank you for...
               | 
               | Quite clearly there was a question mark at the end it to
               | indicate my implied doubt. Science seeks better
               | understanding of x so it can manipulate x more precisely.
               | Please give me a couple of examples of complex systems
               | which we don't understand but can control, so I can
               | understand you better.
        
               | layoutIfNeeded wrote:
               | Yeah, we've read The Selfish Gene, too.
        
               | renewiltord wrote:
               | Naturally, it's 50 years old and one of the most
               | influential science books of all time. If you hadn't,
               | then the reference wouldn't work as well.
        
               | ben_w wrote:
               | What it's worth I haven't read that book (or seen that
               | passage before) and I still understood.
        
               | renewiltord wrote:
               | Richard Dawkins did do very well with the way he
               | expressed the concept. It is quite intuitive for
               | something of such great significance. Easy to forget, I
               | suppose for me, how intuitive it is.
        
             | nyolfen wrote:
             | > The Earth is a giant living system we're slowly killing
             | and replacing with human technology.
             | 
             | "It is only due to a predominance of influences that are
             | not only entirely morally indifferent, but indeed -- from a
             | human perspective -- indescribably cruel, that nature has
             | been capable of constructive action. Specifically, it is
             | solely by way of the relentless, brutal culling of
             | populations that any complex or adaptive traits have been
             | sieved -- with torturous inefficiency -- from the chaos of
             | natural existence. All health, beauty, intelligence, and
             | social grace has been teased from a vast butcher's yard of
             | unbounded carnage, requiring incalculable eons of massacre
             | to draw forth even the subtlest of advantages. This is not
             | only a matter of the bloody grinding mills of selection,
             | either, but also of the innumerable mutational abominations
             | thrown up by the madness of chance, as it pursues its
             | directionless path to some negligible preservable trait,
             | and then -- still further -- of the unavowable horrors that
             | 'fitness' (or sheer survival) itself predominantly entails.
             | We are a minuscule sample of agonized matter, comprising
             | genetic survival monsters, fished from a cosmic ocean of
             | vile mutants, by a pitiless killing machine of infinite
             | appetite. (This is still, perhaps, to put an irresponsibly
             | positive spin on the story, but it should suffice for our
             | purposes here.)"
        
             | ben_w wrote:
             | Curious; I not only don't understand your world view, I
             | don't even have enough of a handle on it to know how to
             | engage with it.
             | 
             | For example:
             | 
             | > The fungi will consume all of us some day and outlive us
             | all. I mean some are among the oldest still living life on
             | earth as it is. Like millions of years old and still going.
             | How can you dominate something that's existed longer than
             | you and will out live you and everyone you know?
             | 
             | Yet anti-fungals are trivially available at low cost.
             | Indeed, the very claim of yours that:
             | 
             | > The Earth is a giant living system we're slowly killing
             | and replacing with human technology.
             | 
             | Is literally not something I can only even understand as
             | _agreement that we have dominion_ , yet I know you intend
             | to deny that.
        
             | zhrvoj wrote:
             | A fool with a tool is still a fool...
        
               | [deleted]
        
               | renewiltord wrote:
               | True, but a fool without a tool must make two
               | transformations to become a genius with a tool. A fool
               | with a tool need only make one.
        
           | whytaka wrote:
           | > No, if you can save billions and you choose not to, you
           | have killed them.
           | 
           | The trolley problem remains unsolved. I don't find arguments
           | anymore persuasive when they are written as declarations.
        
             | renewiltord wrote:
             | That part was intended to be a declaration of _my_ position
             | on it not on a universal conclusion. For brevity, I left
             | the  'for me' part out.
        
             | quickthrower2 wrote:
             | How do you solve it? What does the solution look like? It's
             | not like the 4-colour problem.
        
           | ajuc wrote:
           | > If you can uplift species and you choose not to, you have
           | killed their cognition.
           | 
           | By that logic you killed all the kids you could have made
           | when you weren't having sex.
        
             | renewiltord wrote:
             | Yes, I did. And I find that acceptable. After all, child
             | killing isn't an unalloyed evil. There are children I am
             | morally all right with killing.
        
         | vikramkr wrote:
         | You're giving nature too much credit. Nature doesn't try and
         | balance life. Nature doesn't care- it throws asteroid impacts
         | and supervolcanos and natural disasters all over the place.
         | Life just happens to be very very resilient and consistently
         | able to jump back and fill new niches. Nature also "created" us
         | - were a product of the universe like everything else. If we
         | are destabilizing, so is nature.
         | 
         | And most scientists do not assume they can blindly mess around.
         | There was a whole section of this article related to ethics,
         | they didn't let the fetus be born (which would definitely have
         | been messing around). They're not trying to "do better" or
         | control nature - they're just trying to understand what makes
         | us tick. This is a mutation that already exists in humans. It
         | might make us human. If anything, that makes nature the one
         | that was blindly messing around.
        
           | erickj wrote:
           | However in the exact same vane that "Nature doesn't care"...
           | We as Humans should and DO care.
           | 
           | We are not Nature, and thus these existential defining issues
           | should at least give us some pause to debate and evaluate the
           | moral quandaries and responsibilities that this level of
           | engineering power wields.
        
             | flatline wrote:
             | We are very much Nature. Possibly something independent of
             | our own minds exist; we can never really know. Anything
             | worth preserving, caring for, or caring about, is a product
             | of the human mind. The meteor careening into the earth does
             | not feel a moral quandary, but we do, and as such I agree
             | that given our limited knowledge we should care. But we
             | should also pay heed to how ignorant we are: we cannot
             | possibly know how our present actions will play out in the
             | future, the best we can do is try to be compassionate and
             | take care of what we can. The rest is out of our control
             | and hence our sphere of responsibility.
        
           | bamboozled wrote:
           | "You're giving nature too much credit."
           | 
           | What a statement.
        
           | camphero wrote:
           | Don't blame wanting to prove Planet of the Apes could be real
           | (but not having the balls to do it) Nature's fault. That
           | stupidity is just human mad science.
        
           | grawprog wrote:
           | I don't give it credit, like it's trying to gain balance, but
           | functioning ecosystems do maintain a balance. Most of our
           | climate problems have come from humans disrupting this.
           | 
           | If you take any functioning healthy ecosystem on earth, one
           | generally less tampered with by humans, you'll find from a
           | microscopic, right up to a macroscopic level, the life in
           | those ecosystems have adapted to function together.
           | 
           | If you want to see some good examples of this, check out some
           | terrarium channels on youtube, there's some really cool,
           | perfectly balanced ones people have had going for years.
           | 
           | The reason why we have so many ecological problems around the
           | world is that humans have been constantly disrupting this. We
           | introduce invasive species that dominate the landscape, cause
           | extinctions and extirpations of native species and change the
           | fundamental balance of the ecosystem.
           | 
           | You're right, life does push through, but personally, I
           | prefer the native songbirds and shrubs that are local to my
           | area than a landscape full of Japanese knotweed and
           | starlings.
           | 
           | And so do most things, that first example likely has at least
           | a dozen species of songbirds, a bunch of shrubs and
           | herbacious plants. That second example has two species, maybe
           | some rats or crows if your lucky.
           | 
           | The thing is, ecosystems don't stand alone, they're all
           | connected and the collapse of one leads to the collapse of
           | the neighbouring ones and so forth.
           | 
           | If you actually look through the published literature.on
           | various ecosystems around the world, we have a very shallow
           | level of knowledge. We don't understand fully the complex
           | connections between everything and the research that does
           | keep coming out keeps showing how much we've vastly
           | underestimated how much our actions have impacted things.
           | 
           | Even things like the ecosystems in our own body's. The
           | microscopic organisms that have been found to even play a
           | part in things such as our decision making and moods.
           | 
           | The human body itself functions as an ecosystem, all our body
           | systems, our cells, our organs, all function independently
           | and cohesively to make everything that is you.
           | 
           | The earth itself functions the same way. The ecosystems, and
           | all life, including humans, are the cells and organs that
           | make up all life on Earth.
           | 
           | Altering life at a fundamental genetic level goes even
           | further than how we alter ecosystems.
           | 
           | Humans really don't understand the potential consequences to
           | changes we make to the genetic code. We have a vague idea,
           | but we really are.delving mostly blind into this. If we
           | barely understand how life works on a macroscopic level, what
           | makes us think we're ready to change it at an even lower
           | level?
        
             | hohloma wrote:
             | You're missing survivorship bias - nature didn't just
             | create these balanced ecosystems, it creates anything that
             | goes, and things that don't work out just die. Humans
             | ruining earth for themselves is just as natural, just that
             | we might die as result. But life won't - it's much more
             | resilient than just one species. Or several.
        
               | nwienert wrote:
               | Following this line of logic you can justify anything. If
               | I kill your entire family, that's natural. Would you be
               | ok with that?
               | 
               | I think if you accept at all that there is suffering and
               | there is beauty, then you shouldn't hide behind
               | "everything's natural" and instead try and have a
               | backbone and stick up for something more.
        
               | jjoonathan wrote:
               | That's the point: naturalism can justify anything, and
               | that makes it a poor guiding principle. As do many other
               | things.
               | 
               | There are many natural things that are good. Clean air,
               | unique little ecosystems like GP describes, endless
               | variety -- and we should strive to respect and preserve
               | those, but not because they are natural. Poor animals
               | teeming with parasites, population "balance" maintained
               | through periodic overpopulation and starvation (How do
               | people think it happens? Forest fairies tell the deer how
               | many babies to have?), predators feasting on the organs
               | of their prey while the prey is still alive. All these
               | things are natural but _not_ good and we should _not_
               | seek to replicate them.
        
               | [deleted]
        
               | vikramkr wrote:
               | Why should I be "ok" with natural? Screw natural. Nature
               | does a lot of terrible things. People dying in hurricanes
               | or at the hands of murderers isn't OK because its
               | "natural" - its just not OK. We have the intelligence to
               | influence our environment (and that intelligence is also
               | a result of nature). Trying to categorize natural vs
               | unnatural (whatever that means) is a fools errand and not
               | a productive one in my view, since my ethics aren't based
               | on "it's ok because the volcano was natural"
        
               | ericffr wrote:
               | The problem with this line of thinking is that it might
               | be a little short-sighted. Since we are intelligent, we
               | should be careful. With great powers come great
               | responsibility. If someone doesn't like hurricanes, they
               | can move where there is none. When Earth will be 99%
               | inhabitable (because of air pollution, soil degradation,
               | lack of water), is the solution just to say "oh well",
               | let's go to Mars?
        
               | ylyn wrote:
               | It is natural.
               | 
               | That doesn't make it okay.
        
             | vikramkr wrote:
             | If you take most systems, they're at war with eachother.
             | And that war includes viruses, which do a lot of altering
             | at the fundamental genetic level. You could call it balance
             | - I'd call it stalemate. And of course we don't understand
             | the consequences- thats the point of the research. Ideally
             | its done in a controlled, ethical way. And questions are
             | raised. But the point of the research is to understand the
             | connections and the consequences, and the only way we do
             | that is by experimenting which involves making low level
             | changes and observing the results. And as we understand
             | these consequences, were able to apply our new knowledge to
             | practical purposes like treating disease. Not understanding
             | is the _reason_ that research matters - the point is to
             | find out.
        
             | LockAndLol wrote:
             | > I don't give it credit, like it's trying to gain balance,
             | but functioning ecosystems do maintain a balance. Most of
             | our climate problems have come from humans disrupting this.
             | 
             | We didn't come out of a void. We are a natural evolution
             | too, with the only difference being that we reached this
             | stage before other animals. Since we are disrupting our
             | ecosystem, we are living proof that either:
             | 
             | - this ecosystem we are in is not function according to
             | your definition - or functioning ecosystems do not maintain
             | balance
             | 
             | > The reason why we have so many ecological problems around
             | the world is that humans have been constantly disrupting
             | this. We introduce invasive species that dominate the
             | landscape, cause extinctions and extirpations of native
             | species and change the fundamental balance of the
             | ecosystem.
             | 
             | Ecosystems are constantly being disrupted and have been
             | long before humans evolved. Wind can carry the seeds of one
             | plant into another ecosystem where it suddenly dominates
             | because it has no "natural predators". Birds can fly over
             | an ecosystem, defecate and drop an entirely foreign species
             | into another ecosystem.
             | 
             | Cyanobacteria are even attributed as the reason for one of
             | the first mass extinctions [0]. Is that a sign of a
             | functioning ecosystem?
             | 
             | > Altering life at a fundamental genetic level goes even
             | further than how we alter ecosystems.
             | 
             | Viruses and bacteria actively mess around with the DNA of
             | other organisms in order to render them susceptible or make
             | them carriers. Nature has been messing with itself long
             | before we ever learned how.
             | 
             | We are in no way special in this universe or in our
             | actions. We are just copying what we see in nature.
             | 
             | [0]: https://slate.com/technology/2014/07/the-great-
             | oxygenation-e...
        
             | hutzlibu wrote:
             | "I prefer the native songbirds and shrubs that are local to
             | my area than a landscape full of Japanese knotweed and
             | starlings."
             | 
             | Don't you think, you feel that way, because you grew up
             | with the native songbirds?
             | 
             | "If we barely understand how life works on a macroscopic
             | level, what makes us think we're ready to change it at an
             | even lower level? "
             | 
             | Like the other poster have said: nature does not plan in
             | advance or makes ethical discussions. Nature just is and
             | everything in it trys to adapt. Some prosper, some die out.
             | Now with our technology we disrupted quite a bit, but why
             | must we understand everything we do, when nature aparrently
             | does not either?
             | 
             | With research like this, I am more worried, what things
             | like this, does to us. To maybe get to the point, where new
             | babys are created in a laboratory and the less successful
             | experiments goes to the bin. All for Evolution.
             | 
             | Now I am grossed out by that thought. But from a
             | philosophical point of view, I have to ask myself: "who
             | defines that this is bad?"
             | 
             | Maybe this gets us to the stars, so life can spread, in
             | case earth life gets vanished, by a big asteroid. So maybe
             | it is ethical to do all we can, to get there? To preserve
             | life itself? (humans are not at all adopted for space,
             | radiation, zero g etc., so CRISPR?)
             | 
             | (well no, I don't think it is ethical to do by all means,
             | but I do think ethics are subjective and the next
             | generations might have different ethics)
        
               | mlavin wrote:
               | It's an easy qualitative decision to consider a variety
               | of species with pleasant calls and plants which coexist
               | in their own niches better than swarms of one single
               | species of bird and an aggressively invasive plant
               | species which chokes out all other growth. Knotweed in
               | particular is an absolute pox on the landscape in North
               | America.
        
               | hutzlibu wrote:
               | Ok, I don't know of the specific case, it is just, that
               | here in germany, the "invasive" species people complain
               | about, I wittnes as a welcome variation. Brings in more
               | color. The areas that do get dominated, will very likely
               | balance it out with a different species, soon.
               | 
               | edit: had to translate it, but: we also have knotweed and
               | people complain, but I actually like it. And I do not see
               | it dominating, just a spot here and there, just like
               | nettles.
        
               | ericffr wrote:
               | Not every weed moves as fast as a virus. It might take
               | decades before we realize that some species have
               | disappeared, and in their wake, others are going too, and
               | we are left with a homogeneous ecosystem where a new
               | virus will come and be even worse (like the wheat rust
               | which decimated the single species of wheat growing in
               | North America). Obviously, Nature, being random, might
               | cause destruction on its own (like when plants appeared
               | and the high level of oxygen they produced killed earlier
               | species), but this happens on millions of years. And
               | sure, nothing prevents "Nature" from killing humans too.
               | We are not more precious than any other species, from the
               | Nature point of view.
        
               | hutzlibu wrote:
               | "we realize that some species have disappeared, and in
               | their wake, others are going too, and we are left with a
               | homogeneous ecosystem "
               | 
               | Species come and go all the time. Globalisation just made
               | it a lot faster. So there will be imbalances and local
               | system collapsing and temporary a dominating species
               | etc., but alltogether the diversity of species will be
               | increased, with fast global exchange. Because there are
               | more candidates to fill a niche.
               | 
               | Local established ones still have a home bonus. Their DNA
               | is adopted to the local climate and soil, unlike the
               | invaders. They won't vanish anytime soon.
               | 
               | The thing really threatening diversity are monoculture
               | fields with pesticides.
        
         | 77pt77 wrote:
         | > Nature took a long long time to get to this point where life
         | has come to a sort of balance
         | 
         | There is no balance. It's an illusion of selection bias and
         | inability to consider time-scales not at the human scale.
        
         | klunger wrote:
         | I don't. It makes me sick to my stomach.
         | 
         | I am speaking as someone who is pro-choice, pro-GMO's and pro-
         | stem cell research, etc. This research has crossed a line that
         | none of the above do. It is creating a new _kind_ of sentience,
         | a new kind of soul.
         | 
         | And, what's the point? To confirm a theory about a gene? So
         | fricking what. That really doesn't matter, not in relation to
         | the possible consequences: someone taking this research to
         | create a race of "sub-human" slaves that think and feel as
         | acutely as we do. Pick your genetic engineering dystopia for
         | where this is leading us- Brave New World, Planet of the Apes,
         | Gattaca, even the Uplift series.
         | 
         | It never should have gotten approved by an ethics review board.
         | The 100 days termination was just so they could claim to have
         | considered ethics. If they actually seriously had done so, this
         | project would have never left the drawing board.
         | 
         | Finally: I wish people would stop staying the genie is out of
         | the bottle. The genie is whatever we humans decide to do. You
         | can't just assume that because something is possible that it
         | will be done. We can have moral boundaries as a society. We can
         | say "this is a bridge too far and no one should cross it". And
         | anyone who does will be excommunicated from the scientific
         | world.
         | 
         | There is nothing inevitable about this dark path. Saying that
         | it is inevitable just removes responsibility from whoever does
         | it, which is just BS.
         | 
         | .
         | 
         | edit: grammar, clarity
        
           | belval wrote:
           | Have you ever stopped and thought about why you feel in such
           | way towards these experiments? Why do you see sentience as
           | the line not to cross and even go as far as to call it a
           | "dark path"?
           | 
           | You use a lot of wording that are very religious sounding
           | such as "soul", "excommunicated", "dark path", but have you
           | considered that you cannot really excommunicate a scientist,
           | that the mere concept of a soul might be wrong?
           | 
           | To be clear it makes me feel weird too, but we have to be
           | able to discuss this instead of using inefficient red tape.
        
             | whytaka wrote:
             | If there's any science of morality to be done, the most
             | basic quantum of moral value is suffering. Sentient
             | creatures have greater capacity for suffering, being aware
             | of their pain and the injustice of their existence. If we
             | are to bring it into existence, we are responsible for its
             | suffering.
        
         | golemotron wrote:
         | It would be good to use science fiction to explore some of
         | these ideas before we do them.
        
         | kungito wrote:
         | "Is it right to create something that may be similar to us and
         | then not even give it a chance to live?" If trying to be "good"
         | doesn't this thought come off as really selfish? Just because
         | something is more similar to us it should have more right to
         | live? These thoughts are just basic survivalist instincts
         | wrapped in nice 21st century "morals". We will do whatever the
         | hell we want in the end and maybe we eradicate ourselves in the
         | end before something else does
        
         | cscurmudgeon wrote:
         | The answer is simple: We massively fucked up chemistry in the
         | last 100 years. How do we get the confidence to know we can't
         | fuck up biology (much much much much more complex)?
        
           | neolog wrote:
           | > We massively fucked up chemistry
           | 
           | ?
        
             | DoingIsLearning wrote:
             | - Thalidomide
             | 
             | - Leaded fuel, the highest ever source of lead exposure and
             | poisoning for Humans.
             | 
             | - Asbestos still present in 60' to 80's construction
             | 
             | - Refrigerants with Ozone destroying CFCs
             | 
             | - 1800's arsenic pesticides still contaminate today's rice
             | fields and most of the world's rice crops.
             | 
             | - DDT
             | 
             | - Plastics are currently leaching estrogenic-mimicking
             | endocrine disruptors and contaminating water supplies,
             | wildlife and Humans.
             | 
             | That's just a few from memory, I am sure there are more.
             | 
             | Edit: yes as someone else commented our grenhouse gas
             | emissions are probably the biggest elephant in the room
        
             | selimthegrim wrote:
             | Greenhouse effect
        
             | NegativeLatency wrote:
             | I'd guess talking about advances in physical chemistry and
             | the ability to more closely model and understand how atoms
             | interact?
        
         | Der_Einzige wrote:
         | "Is it right to create something that may be similar to us and
         | then not even give it a chance to live?"
         | 
         | The only difference between this and abortion is that the
         | species is somehow "novel".
         | 
         | You should resolve the ethical issues with genetic engineering
         | research in a similar way to however you resolve the ethical
         | issues related to abortion.
        
         | vmception wrote:
         | I would like to see it be born. I want to know where this goes.
         | What other genes it needs to become superior, or what genes we
         | can tweak to optimize some things further.
         | 
         | Humans are have tons of issues including cellular and cognitive
         | deficiencies. This is a way to learn more about that and fix
         | it.
         | 
         | Sure, someone will make the new slave labor force, let's cross
         | that bridge when we get there.
        
         | FPGAhacker wrote:
         | I'm curious if you feel this way about human abortion?
        
           | grawprog wrote:
           | No, that's why I find it hard to describe how I feel. I'm pro
           | choice. It's not my place to tell someone what to do with
           | their bodies or the fetuses they're carrying(please don't get
           | into an abortion debate because of this, i'm not going to
           | answer any comments going on about that to avoid things
           | getting out of control), but this still makes me feel
           | uncomfortable.
           | 
           | This is something different, this is the first time this has
           | been done, there was signs that their brains were going to be
           | similar to ours, meaning possibly self aware and intelligent,
           | I dunno, like i say, i'm not even sure which I feel like is
           | the ethical choice...
           | 
           | Like I say, I find it hard to describe how I feel about it
           | all.
        
             | FPGAhacker wrote:
             | Thanks for replying on a sensitive topic.
        
             | read_if_gay_ wrote:
             | > No, that's why I find it hard to describe how I feel.
             | 
             | Cognitive dissonance? Sorry to be snarky.
        
               | grawprog wrote:
               | Yup, I thought I made that clear in my op honestly....
        
             | rootusrootus wrote:
             | > Like I say, I find it hard to describe how I feel about
             | it all.
             | 
             | This is good, I like people that can recognize this.
             | Cognitive dissonance _should_ hurt. It 's the people who
             | can't feel it that I worry about being around...
        
           | ivnubinas wrote:
           | I feel there's a new tendency to value animal life more than
           | human life and I'm not sure how to feel about it.
        
           | breakfastduck wrote:
           | If I may chip in - I don't think it's really comparable.
           | 
           | An abortion is a result of a choice being made by a person
           | after a set of real life and possibly unexpected events have
           | happened.
           | 
           | The research is carefully planned in advance. This was
           | genetically engineered to be terminated.
           | 
           | So while I do think you've asked a relevant question, I think
           | the ethical questions the two things raise are actually very
           | far apart.
        
             | abortmission wrote:
             | Just 1% of women obtain an abortion because they became
             | pregnant through rape
        
             | echelon wrote:
             | If you ponder whether these things have souls, then they're
             | directly related.
             | 
             | There's a spectrum here.
             | 
             | At one end, religious folks believe life and soul begins at
             | conception. Some also believe tampering with genes is
             | tampering with god's creation.
             | 
             | At the other end, atheists believe in so soul.
             | 
             | Some believe personhood doesn't begin until a being is able
             | to think, feel, and reflect upon the world around it. They
             | hold that cetaceans have higher consciousness than human
             | babies. They wouldn't have issue with this.
             | 
             | Plenty of people with no monotheistic belief feel nature
             | shouldn't be tampered with.
             | 
             | Many scientists view biology as a machine that should be
             | probed and studied.
             | 
             | The "choice" argument is one of the counter arguments used
             | by those that are pro-life. I think many of them would
             | object to these experiments on different grounds.
             | 
             | The ethics are complicated and messy. The science is rather
             | straightforward.
        
               | goatinaboat wrote:
               | _At one end, religious folks believe life and soul begins
               | at conception. Some also believe tampering with genes is
               | tampering with god 's creation._
               | 
               | Not all religions. The Qu'ran states that the soul enters
               | the body exactly 40 days after conception, for example.
        
         | downrightmike wrote:
         | Heinlein's Starship Troopers novel touched on this. Neo Dogs
         | are a novelty in society, a sideshow to the general public, but
         | they have the Intelligence similar to a human moron, but is a
         | Mozart for their species. And they use them in war, which is
         | their main use. The recruiter that works with the protagonist,
         | was a bonded partner. They bond deeply to their Neo Dog and if
         | the Neo Dog dies, it is more humane to kill the handler
         | immediately, or put them in a drug induced coma for a couple
         | months and then rehabbing them. The recruiter was put into a
         | coma, but is still dealing with the loss of his Neo Dog, and
         | agrees that killing the handler asap is kinder than having to
         | go through the rehab.
        
           | PeterisP wrote:
           | It's interesting that the novel assumes that the bonding is
           | likely to be stronger than almost all other bonds humans form
           | - for example, we grieve when our spouse, best friend or
           | child dies, but we don't usually presume that euthanizing the
           | grievers asap would be kinder than having them to go through
           | grief and rehab. It would seem plausible for _some_ of the
           | individual bonds to be like that, but notas a general rule.
        
             | downrightmike wrote:
             | Yeah, the bonding process seems like immersion when
             | learning a language, I figure that the handler's lost all
             | connection to that unique world they were immersed in and
             | couldn't cope. Kind of like losing your self identification
             | when people rely on their jobs to give them an identity.
             | Who are the handlers without the Neo Dogs?
        
         | patcon wrote:
         | Honestly, though the ethics are certainly dicey, I do wonder
         | whether recreating a bridge intelligence between man and animal
         | would raise appropriate societal questions that we've chosen
         | not the think about all of modern history (lacking any sort of
         | Neanderthal cohabitant).
         | 
         | It might help us all be in more relation with the world. Our
         | lack of relation feels to me to be part of what's driving us
         | into this extinction event. A "monstrosity" that convinces us
         | to rethink the moral rights of other living creatures would
         | perhaps be welcome...?
         | 
         | Maybe it ends up being the unasked-for bastard creature that
         | saves all the others (incl us) _from_ us, just by making us
         | slow down and go  "hold on hold on hold on. what THE FUCK?"
        
           | plutonorm wrote:
           | Neanderthals had larger brains in proportion to their body
           | mass than we do. They were possibly smarter than we were.
        
             | ben_w wrote:
             | We don't know enough to know if that's a good measure; if
             | it is, ants would be at the top of the list for all
             | animals, and treeshrews for mammals:
             | https://en.m.wikipedia.org/wiki/Brain-to-body_mass_ratio
        
               | salty_biscuits wrote:
               | The scaling power coefficient matters, they are so far
               | off our mass that the coefficient might just be wrong.
               | Neanderthals are about the same size so an error in the
               | coefficient won't matter so much.
        
           | bredren wrote:
           | I would guess such information would be preferred by many to
           | remain unillustrated.
           | 
           | I suspect we have more to answer for in the scale of animal
           | suffering than we could possibly imagine.
           | 
           | An awakening to the truth of how cruelly indifferent we are
           | to animals would threaten power structures at a magnitude
           | that makes #metoo look small.
        
         | mooreds wrote:
         | Feels like the beginning of the Uplift Saga. Spooky times.
        
         | wombatmobile wrote:
         | > The cat's out of the bag with this research so to speak now.
         | Someone's bound to do this again
         | 
         | If they do it again and again and again, the progress will be
         | substantial, and society stands to benefit enormously.
         | 
         | With exponential increases in the parts of the brain
         | responsible for intelligence, morality and justice, imagine a
         | future president of the United States elected from this cohort.
        
       | [deleted]
        
       | zxcvbn4038 wrote:
       | I'm pretty sure I saw this movie - had Charlton Heston in it. You
       | know someone is going to grow this to maturity, either an
       | individual researcher looking for fame or a sovereign state
       | looking for prestige, then of course we'll have to know if the
       | mutations are propagated.
        
       | jbeard4 wrote:
       | This reminds me of "The Secret of NIMH"
       | https://www.imdb.com/title/tt0084649/
        
         | plutonorm wrote:
         | What a fabulous film that was. Never read the book.
        
           | ThrowawayR2 wrote:
           | The book was better (naturally); as I recall, they used
           | technology instead of a "magic amulet" to work their way out
           | of the problem, in keeping with the theme of hyperintelligent
           | mice.
        
             | aaron695 wrote:
             | The sequels I thought were ok as well.
             | 
             | By his daughter, my one exception to sequels not by the
             | author.
        
       | booleandilemma wrote:
       | _This is crucial in order to maintain ethical boundaries. After
       | about 100 days after the fetus had been growing, the
       | international team unanimously agreed to remove the fetus through
       | a C-section_
       | 
       | I feel we've already entered into sensitive territory by aborting
       | it.
        
         | Geminidog wrote:
         | Yeah, aborting in some circles is the same as murder so the
         | "ethics" is a bit blurry here. The crossed the line by creating
         | life and then they killed what could essentially be something
         | that could have had the intelligence of a regular human being.
         | 
         | I'm not an anti-abortionist but I can't deny that the ethics in
         | this area is blurry. Even worse is when you're aborting
         | genetically modified life.
        
           | whimsicalism wrote:
           | > I can't deny that the ethics in this area is blurry
           | 
           | If you don't like the ethics of aborting a monkey fetus
           | because it is "like murder", you're going to hate what
           | happens to lab monkeys they don't abort.
        
           | FriendlyNormie wrote:
           | Too late for an edit to save you, the reddit trannies found
           | your comment where you didn't blindly agree with what some
           | faggot scientist said. Enjoy your downvotes
        
           | treeman79 wrote:
           | Scientist: we've created the first new sapient species in the
           | last million years. Oh now it's extinct.
           | 
           | Killing of inconvenient people is one level of messed up.
           | 
           | This is just freaking insane.
        
       | PIKAL wrote:
       | I am overwhelmed with curiosity about what the animal would have
       | been like if it had been allowed to live. Imagine that it was
       | smart enough to speak or resemble humans even more closely than
       | monkeys already do... imagine how earth shattering that would be.
       | An entire race of beings to reconcile with. I wish they had let
       | it live.
        
       | jassany wrote:
       | The fact they didn't let the fetus grow really fucking sucks.
       | Sure, ethics most definitely has its name etched on the science
       | stone.
       | 
       | But people WILL without a shred of doubt recreate this
       | experiment, and they most likely won't be as ethically inclined
       | as the nice folks behind this paper.
       | 
       | The point am trying to make here is that we need to be prepared
       | to deal with how a discovery like could influence our future. The
       | best way to do that is to know what expect with enough time ahead
       | to react.
       | 
       | And yeah sure people will say this is just an excuse for morbidly
       | curious people like me to simply see what happens, and while I'm
       | literally brimming in desire to know myself, theres a bigger
       | picture, bearing witness is just a perk:)
        
       | vikramkr wrote:
       | This research is as terrific as it is terrifying. These are some
       | terrific insights into the evolution of intelligence. I doubt
       | that it was one gene alone that drove the whole thing, but as the
       | article mentions, the ethical dilemmas already arise, and it's
       | easy to see how scientifically valuable it would be to study the
       | impact of the gene further by allowing the transgenic animals to
       | be born. The ethical dilemmas cut both ways - research like this
       | might be crucial to understanding Alzheimer's and other serious
       | diseases. Complicated and difficult questions to be sure, but
       | it's extraordinary and a testament to the power of science that
       | we're even in a position to be asking those questions. Lets hope
       | we answer them correctly.
        
         | dogma1138 wrote:
         | Isn't that literally the plot of the Planet of the Apes remake?
        
           | ampdepolymerase wrote:
           | Maybe it is time for continental and east asian arms and self
           | defence legislation to add an exception for putting down
           | runaway lab experiments. Standing your ground and castle
           | doctrines are privileges unique to America.
        
       | tiku wrote:
       | As long as no one takes a monkey home we should be okay.
        
       | tibbydudeza wrote:
       | So "Planet of the Apes" was not so far fetched after all.
       | 
       | Now somewhere someone will think ... hmmm why can't we replace
       | all our complaining factory workers and their
       | wages/healthcare/retirement plans with these "creatures" and only
       | pay them peanuts and banana's.
        
         | to11mtm wrote:
         | Oddly, I came up with a pretty good plan for Enslaving Humanity
         | without most of them noticing (and the software architecture
         | that would power it) during a Sunday Drive today.
         | 
         | I'll say that the concept I came up with was probably far far
         | cheaper than gene therapy and could be reached in 5-10 years.
         | So I wouldn't lose sleep over _this_
        
           | wizzwizz4 wrote:
           | Unless you can think of any steps to prevent your plan from
           | working, try to forget about it. Somebody will re-invent it
           | later, but that'll be _later_. We 've created more of the
           | readily-accessible good technology than the readily-
           | accessible bad technology, and it'll take an active effort to
           | keep it that way.
        
           | chacha2 wrote:
           | Currently most of humanity is oblivious to it's enslavement,
           | what does your strategy add?
        
         | 0-_-0 wrote:
         | Brave New World had a similar idea
        
         | SimeVidas wrote:
         | Future brainy monkeys will watch that movie like it's a
         | documentary.
        
         | bjelkeman-again wrote:
         | David Brin, Uplift Universe. Start with Startide rising. It
         | covers this in a more interestingly ethical way I think.
        
         | delecti wrote:
         | There have already been issues with some coconut harvesting
         | operations using monkeys as laborers.
        
         | BurningFrog wrote:
         | We've been replacing factory workers with machines for 250
         | years. It's made us, including the remaining factory workers,
         | very very rich, compared to where we started.
        
           | jhardy54 wrote:
           | Productivity has gone up but wages haven't kept up. The
           | owners are rich, sure, but we should be honest about the
           | working class getting the short end of the stick here.
        
       | ummonk wrote:
       | What the hell?!?
       | 
       | There is no pro-choice argument for killing the fetus here - the
       | mother monkey is not sapient and was not consulted as to whether
       | she wished to carry the potentially sapient baby to term or not.
       | 
       | This is straight up feticide.
        
         | erickj wrote:
         | +1 to "There is no pro-choice argument for killing the fetus
         | here"
         | 
         | There is no pro-choice analogy to make here.
         | 
         | As for the rest of your comment about feticide... I think there
         | is room for discussion here.
        
       | ende wrote:
       | This is either going 28 Days Later or Planet of the Apes.
        
         | adventured wrote:
         | Has anyone seen Marlon Brando lately?
        
           | Jaruzel wrote:
           | You were down-voted I think because people are not familiar
           | with:
           | 
           | https://en.wikipedia.org/wiki/The_Island_of_Dr._Moreau_(1996.
           | ..
        
       | idebug wrote:
       | So, we are trying to make Planet of the Apes happen IRL?
        
       | keithwhor wrote:
       | Charlton Heston would like a word with these scientists.
        
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