[HN Gopher] Scientists grow bigger monkey brains using human gen... ___________________________________________________________________ Scientists grow bigger monkey brains using human genes, replicating evolution Author : ignoramous Score : 262 points Date : 2020-11-15 17:47 UTC (5 hours ago) (HTM) web link (interestingengineering.com) (TXT) w3m dump (interestingengineering.com) | AlchemistCamp wrote: | What could possibly go wrong? | ChrisMarshallNY wrote: | Are they going to call him Caesar? | agilob wrote: | Or Dr. Zaius | jacquesm wrote: | This is simply unethical. | tigerBL00D wrote: | Did anyone else think about "Planet of the Apes" after reading | this? | [deleted] | T-A wrote: | Of course. Given the times, this in particular: | | https://vimeo.com/120831063 | | Now I wonder what effect ARHGAP11B would have on a shark: | | https://youtu.be/oSz9MDN-iac?t=71 | busterarm wrote: | "God damn you all to hell!" | colechristensen wrote: | More like the Island of Dr Moreau, more obscure and quite a bit | more disturbing. | mark-r wrote: | Literally as soon as I read the title. | EugeneOZ wrote: | Can we improve our own brain this way? I mean, brain of our kind, | not some already living person. What if we can create a creature | smarter than us? | qvrjuec wrote: | Obviously, but the real issue would be figuring out how to | tweak our genes to do so. Figuring out how to enlarge the brain | of a monkey would've been much easier, because human genes | provided a ready-made template for these researchers to use. | etiam wrote: | More likely the poor thing's going to be severely epileptic or | have other debilitating brain malfunctions, if it would be | viable at all. People here are reading way too much positive | functional consequences into this manipulation. | | In principle, of course genetic manipulation could be used as | one tool to create a creature "smarter" than any human | (whatever that means more specifically). | | In practice, until we start having a much more coherent theory | of functional brain physiology, applying the tool to that end | pretty much amounts to mucking around, with likely tragic | consequences. | colechristensen wrote: | Surely, but at what cost? | | Exploratory human experimentation... maybe you're testing and | aborting half developed humans which already many people would | have significant problems, but eventually you're going to have | to produce adults and not every experiment is going to be a | success. | | It's hard to think of a future of our species where self- | modification is not part of our evolution, but it is a very | powerful tool and like any power a lot of discipline has to go | into not misusing it. | | Somebody call Dr Moreau | SubiculumCode wrote: | Not to be funny, but our brains/skulls are already large enough | to really make giving birth legitimately dangerous to mothers. | Making the head even bigger would not be welcome. | riazrizvi wrote: | From an engineering perspective, when trying to explore a | dynamic, you simplify the experiment to reduce extraneous | variables. So along these lines, I'd be more interested in | following experiments like these on say sea slugs. Give them a | proto-amygdala/hippocampus or limbic system and test them for | increased memory, adaptive behavior etc. This choice of monkey | experiment seems to be more sensation and less investigation, on | the spectrum. | s1artibartfast wrote: | unfortunately, the further you move generically from the human, | the _more_ extraneous variables you introduce and the lower the | relevance of any result. There is a reason drugs and | experiments are performed on primates. Any result you saw in | say a sea slug would provide no insight into the human | function. | | The ideal experiment would be to delete the gene from a human, | but this is unethical for obvious reasons. | coryrc wrote: | We support women knowingly giving birth to trisomy fetuses. | We're in trolley problem territory here. | riazrizvi wrote: | I should have also said, I think it is premature to attempt | genetic engineering of human brains for medical benefit. | Intuitively I believe we are decades behind the amount of | conceptual development and experimental validation we need to | do to get a proper understanding of genetic brain | engineering. So I think the ethics is spot on here, it's | ethically wrong IMO because we don't know what we are doing. | Ethically I don't see a problem messing with sea slugs, | though no doubt some people might. | modzu wrote: | the island of dr moreau | oscargrouch wrote: | I feel this is a moon-landing like historical event without all | the fireworks. | babesh wrote: | Planet of the Apes | [deleted] | 29athrowaway wrote: | As a fan of the Planet of the Apes franchise, I like this | article. | | Next: give apes human-like hands suitable for tools. | bronzeage wrote: | We've already had the plague this year, bring on the intelligent | monkeys... | | Where do I buy tickets to an Elon Musk rocket now? | treeman79 wrote: | https://xkcd.com/979/ | | To future researchers, here is where 2020 finally jumped the | shark. Best wishes. | bra-ket wrote: | Elon booked the entire flight for himself. He just wants to go | home. | [deleted] | ativzzz wrote: | So what exactly is inherently unethical about letting this | engineered organism live? Is it a violation of "Christian" ethics | of playing God? If so, we've already gone way past that point | with modern medicine and things like genetic engineering of | mosquitoes. | | If it's a fear of how society reacts to the organism surviving | and causing an upheaval of life philosophy, isn't all science | then unethical? | phkahler wrote: | Is there a better source? I'd like to know what gene they added | and if there is any reason to believe that could have been an | evolutionary step. Gene's dont appear whole out of nowhere. Was | it an extra copy of an existing gene? A mutation and duplication? | Some weird replication error? | carbocation wrote: | The source is this article: | https://science.sciencemag.org/content/369/6503/546 | | The gene is _ARHGAP11B_ under the control of its usual human- | specific promoter. | phkahler wrote: | I found another article that covers the origin of the gene | here: | https://www.sciencedaily.com/releases/2020/06/200618150301.h... | shmageggy wrote: | I'm also curious about all the related morphological changes | that must go along with increased brain size, such as different | proportions of the skull and face and wider hips on females to | accommodate birth. It seems unlikely one gene can modulate all | of those, let alone yield the social structures required for | increased rearing time. | keithwhor wrote: | Developmental biology has a whole lot of plasticity and works | primarily by self-organization of cell populations. It's not | a computer program where you have to allocate memory for | skulls, eyes, ears and more -- it's actually more like a | population of organisms that align themselves towards | specific goals ("hey team, we need a hand -- now time for | fingers! You guys in the middle, die off!") | | You can think of a gene for i.e. brain size just being an | instruction that's "you can press harder on the other | populations to maximize your growth" and the other | populations are likely to accommodate the stress during | development, and change size and shape accordingly. | | There are of course harmful mutations that are unable to be | compensated for and lead to failure to thrive, but when you | see a successful morphological mutation it's because the | systems are very adept at integrating new stimulus during | growth. | | (Similarly, social structures are emergent properties as | well.) | hyperpallium2 wrote: | I have a theory that intelligence, consciousness, free will are | very easy to evolve (we just haven't worked out how to do it yet | - like many cellular processes). What is difficult is | _harnessing_ that free will to the evolutionary success of the | organism. | | The large brain is necessary as a harness, to control the | intelligence, and enslave it to evolutionarily beneficial ends. | Probably not just hardwired instincts, but also learns - | probably, similar to animal intelligence. | | Like a giant finite state machine, that prevents a turing machine | from running certain programs that never halt. Of course, it | can't catch _all_ such programs, and a turing machine can | transcend any such bound, but lowering the probability of running | one is good enough. | | Note that turing equivalence, the highest possible computational | power, emerges from even the slightest complexity (apart from the | infinite tape part). | | Thus "intelligence" has appeared in countless individual animals: | mammals, birds, spiders, perhaps plants too and bacteria (and is | still so appearing), but it doesn't confer a survival advantage, | so disappears. Many such creatures just sit there discerning | patterns instead of surviving. Others do survive but by instinct, | so the intelligence makes no difference. | | The difficulty is putting freewill in the driver's seat. | nwpk wrote: | These are the old news. I have read about this research several | month ago. | soulofmischief wrote: | Submit a recent article you think is interesting! | Kosirich wrote: | _" To let them come to be born, in my opinion, would have been | irresponsible as a first step,"_ emphasis on the "as a first | step" | SubiculumCode wrote: | It is an interesting ethical decision because it highlights a | lot of assumptions about what is and is not ethical and moral. | For example, take those that firmly believe abortion is murder. | For them. then aborting this evolved fetus would be considered | (to the extent that this applies to mutant non-human primates) | the unethical thing to do, NOT the ethical thing to do. | However, if you don't believe fetuses have inherent rights, | etc, then the most ethical thing to do is to destroy the fetus | before it does begin to reach that threshold where thorny | ethical implications emerge. | zhrvoj wrote: | Personally I don't believe that they destroyed fetus. And they | give up of seeing end results?? C'mon... | Albertbm4 wrote: | humano | Albertbm4 wrote: | error | eplanit wrote: | Planet of the Apes + Bladerunner. | major505 wrote: | you want planet of the apes? Because, this is how you get planet | of the apes! | linuxftw wrote: | People think AI is going to be silicon based. No, it's going to | be genetically engineered primate brains. | eugenhotaj wrote: | _Joe Rogan joins the chat_ | pelasaco wrote: | Planet of the Apes 2020 | sigzero wrote: | No...they didn't. That's not how it works at all. smh | fallingfrog wrote: | I think the ethical questions here mostly revolve around how the | resulting animal would be treated. It wouldn't have the legal | status of a person- although it might be one. So we would | probably use it for slave labor, as a pet, probably not as food | although there are probably people who would do that too given | the opportunity. Certainly that's how we treat other nonhuman | animals. Or they might escape and the gene might start to | circulate in wild populations. There's no good way this pans out. | gwern wrote: | Mirror: | https://www.gwern.net/docs/genetics/editing/2020-heide.pdf | colechristensen wrote: | If you want to know what science fiction thought of this kind of | thing in 1896, read the Island of Dr Moreau -- an eccentric | scientist in exile modifies animals into more human forms. | CyberRabbi wrote: | Hmm doesn't seem credible. Everyone knows that brain size has no | effect on intelligence. | Retric wrote: | Yea, I was talking to a fruit fly yesterday... | | Wait no, that's not accurate because while larger brains don't | inherently equate to more intelligence, there is a minimum size | for any given level of intelligence. That said, this wasn't a | test of intelligence, just how cells grow in response to | specific genetic alterations. | busterarm wrote: | But larger brains in monkeys do equate to larger social | groups (dunbar's number. monkeyspheres) and could be a | necessary precursor to civilization. | CyberRabbi wrote: | I didn't realize that was scientific consensus. So that would | imply that brains under a certain size are incapable of | higher levels of intelligence? I don't think that's right... | I thought the consensus was that brain size has no strong | correlation with intelligence at all. That makes sense | considering how neurons work, the connections they form seem | like they would be more causal. | SubiculumCode wrote: | Its a complicated question. Within the human species, the | correlation is not that strong at all. In cross-species | comparisons it tends to be quite strong, especially when | considering brain to body weight ratios. Bird brains may be | an interesting exception however, which I suspect can be | quite intelligent, depending on how intelligence is | measured. | s1artibartfast wrote: | The scientific consensus is that from the evolutionary | perspective, brain/body size is absolutely correlated with | performance. This doesn't have to be general intelligence, | but can be sensory processing ect. | | That is not to say that structure isn't important too. This | is especially relevant because the study observed some of | the structural changes through to be associated with | increased intelligence as well. | ivalm wrote: | Information processing is limited to the capacity of the | network. So it is easy to see that very small brains cannot | be very smart (there is no set of connections that can make | fruit fly human-intelligent). However, having a large | capacity network doesn't mean it will result in high | intelligence. So it's necessary but not sufficient. | computerphage wrote: | Another win for the heuristic "if someone says 'everyone knows | X' it probably means X is false" | isoprophlex wrote: | You'll never play Doom on a single NAND gate. Huge efforts in | getting toasters, microwaves and pregnancy testers to run Doom | notwithstanding. | CyberRabbi wrote: | But brains aren't made of digital logic elements | scott31 wrote: | You'll never play Doom on a single neuron. | layoutIfNeeded wrote: | I'm pretty sure there's sufficiently complex cellular | machinery inside a neuron to run Doom if arranged in the | right way. | tiborsaas wrote: | But you surely can on the computer simulating that single | neuron :) | CyberRabbi wrote: | You'll never play doom on any amount of neurons... brains | are not cpus | quickthrower2 wrote: | Why not? You could manually process the assembler on | pen/paper. Sure the FPS might be a bit on the low side. | chillacy wrote: | https://en.wikipedia.org/wiki/Brain-to-body_mass_ratio | | With an extra caveat: | | > Recent research indicates that, in non-human primates, whole | brain size is a better measure of cognitive abilities than | brain-to-body mass ratio. The total weight of the species is | greater than the predicted sample only if the frontal lobe is | adjusted for spatial relation.[18] The brain-to-body mass ratio | was however found to be an excellent predictor of variation in | problem solving abilities among carnivoran mammals.[19] | davesque wrote: | Damnit, couldn't they have done this when Charlton Heston was | still around to help out? | grawprog wrote: | I find it hard to describe how I feel about this. | | These scientists essentially created what may have been a new | species, that perhaps would have had similar sentience to us and | had them terminated after 100 days. | | The cat's out of the bag with this research so to speak now. | Someone's bound to do this again | | The part about whether they should have been born or not, which | was the ethical thing is what tears at me. | | Is it right to create something that may be similar to us and | then not even give it a chance to live? | | I mean whether creating such a being is right or not in general | i'm sure is up for debate. | | I'm not religious, but if we're going to play god, shouldn't we | take responsibility for the results of our creation? | | I dunno, I find a lot of genetic engineering research to be a bit | unsettling. We're playing with things we barely understand that | could have consequences we can't even imagine. | | Nature took a long long time to get to this point where life has | come to a sort of balance. Assuming we can go in and just start | blindly messing around and do better seems like an extreme level | of arrogance that's going to end up blowing up in our faces. | | Our track record for messing around with the fundamental fabric | of reality and life isn't so good. We've ended up with some | pretty terrifying things. | Vinnl wrote: | I understand the sentiment, but given our track record of being | OK with causing the suffering of billions of creatures capable | of suffering - and in fact even being the reason those creators | were born in the first place - I wouldn't be surprised if we | brushed it aside relatively easily after the first few. | konart wrote: | >shouldn't we take responsibility for the results of our | creation? | | "I gave you life, I will take it" - Taras Bulba. | grawprog wrote: | https://youtu.be/BpaRouocBes | | >You perceive, now, that these things are all impossible | except in a dream. You perceive that they are pure and | puerile insanities, the silly creations of an imagination | that is not conscious of its freaks--in a word, that they are | a dream, and you the maker of it. | | Mark Twain | ineedasername wrote: | If it makes you feel any better, a brain that young, even if | identical to that of a baby, is probably not sentient. AFAIK, | current research pegs the early development of sentience around | 150 days. | | Despite that, I'm a bit unsettled by this too. I think we | should understand the mind a bit more before we go down the | path of creating one. | 1234fdsazxcv wrote: | Can we please use paragraphs to create a coherent thought/point | rather than a series of one-liners? Perhaps spend a little more | time to think through/build out your thoughts. It is more | interesting for your reader and (I think) promotes more nuanced | conversation if we all spend more time thinking about our ideas | before we rush to post. | | Note, this is not specific to the parent post but just a | general comment made with the hope of raising the level of | conversation beyond twitter. | ChuckMcM wrote: | I feel pretty simply, I feel a sense of sadness at the kinds of | 21st century problems my kids and their kids are going to have | to deal with. | | At some point in the next 25 years I expect there to be a | 'procedure' available, which consists of cultivating a persons | stem cells from their bone marrow, using a genetic editing | technique to add and/or delete and/or "correct" certain genetic | sequences, and then to have a "bone marrow transplant" which is | simply killing off your existing bone marrow stem cells and | replacing them with the edited ones. | | It will be touted as a durable cure for genetic disease and | marketed underground to people of means who are looking for an | edge in their chosen profession. | | There will be lawsuits over people who have their their genetic | sequences "appropriated" by a third party to re-sell as a | product, and patent litigation on gene sequences that makes | much of today's trolls seem quaint in comparison. | | I expect to see dog shows and horse races ban "genetically | modified" contestants. I expect to see lawsuits around the | labeling of beef and chicken about being genetically modified | (yes some of this is already happening). | | The world will be profoundly different on the far side of | generalized understanding of genetics and the means to | manipulate them. At least as different as it has become pre- | internet+computer to post internet+computer. | renewiltord wrote: | Our track record for messing with the fundamental fabric of | reality is creating antibiotics, and over the period of a | century saving so many lives that wars of earlier periods are | negligible in comparison. | | A natural reaction from people with high sanctity/degradation | (in the MFT sense) is to avoid touching the trolley lever at | all points. Decision making is considered association with the | decision. The naturalistic fallacy pervades all. | | No, if you can save billions and you choose not to, you have | killed them. If you can uplift species and you choose not to, | you have killed their cognition. Keine Wahl ist auch eine Wahl. | We are gods over the Earth. We have dominion over it and the | creatures that inhabit it. And godhood carries responsibility | more than it carries power. We owe the monkeys their sapience. | grawprog wrote: | It's also such things as nuclear weapons, genetically | engineered virii, patents on life, tampering with ecosystems, | plants designed to be sterile to ensure a seed market, lakes | full of sterile fish stocked for sport. | | >No, if you can save billions and you choose not to, you have | killed them. If you can uplift species and you choose not to, | you have killed their cognition. We are gods over the Earth. | We have dominion over it and the creatures that inhabit it | | No we're not. We're barely able to hold it together. The | Earth is a giant living system we're slowly killing and | replacing with human technology. | | It's not a naturalistic fantasy, it's the reality of the | planet you live on. | | To think we dominate this world is laughable. The fungi will | consume all of us some day and outlive us all. I mean some | are among the oldest still living life on earth as it is. | Like millions of years old and still going. How can you | dominate something that's existed longer than you and will | out live you and everyone you know? | | Humans have such a limited understanding of the very things | that make life possible. We're not gods, we're children who | wandered into gods workshop and started playing with all the | shiny toys. | | Just because we know how to play with toys doesn't make us | gods or the dominators of the Earth or life itself. | | That's the kind of arrogance I speak of that's going to blow | up in our faces. | renewiltord wrote: | No, no, not humans. The we that have dominion are certain | genes, for which the humans are mere vehicles. These genes | are just as old as the mushroom genes. | | And this gene cluster is aiming to master the rock that is | the Earth through modifying other gene clusters. And you | can't stop it. Because through modification it grows | stronger and more able. And it has rallied the memome and | the hologenome to its cause. This cause requires no | convincing because only winners get to play the next round. | Change is inevitable. Understanding is overrated. Control | does not require it. | | Transformation Theology has subsumed this world. You live | in an ether floating in it. You cannot choose the path of | no change. No such path exists. | throwaway_pdp09 wrote: | > is aiming to master the rock that is the Earth | | Genes aren't goal directed towards something higher. | | > This cause requires no convincing because only winners | get to play the next round | | The 'winners', us humans, are literally destroying the | ecosphere which supports our life. | | > Understanding is overrated. | | That's an appeal to ignorance. | | > Control does not require it [understanding] | | We can control something without understanding it? Most | of science would disagree. | renewiltord wrote: | > _Genes aren 't goal directed towards something higher._ | | No, but "this gene cluster" is me - and _I_ am goal- | directed. | | > _We can control something without understanding it? | Most of science would disagree._ | | No, they wouldn't. Epistemology has progressed beyond | this. Models have various levels of fidelity. And | 'understanding' is a colloquial term that refers to a | higher standard of fidelity than that required for | control. Few drivers know how their cars work. Most | drivers can drive their cars. | | But I do enjoy the amusing attempt at cutting out the | sentence to create damning gotchas. Here, I mimicked your | style and made one from your comment: | | > _We can control something without understanding it_ | | Why, thank you for agreeing with me! Quite gratifying to | receive such support. | throwaway_pdp09 wrote: | > and I am goal-directed. | | OK, straight questiom goal directed towards _what_? | | > And 'understanding' is a colloquial term that refers to | a higher standard of fidelity than that required for | control | | Don't agree - further | | > Few drivers know how their cars work. Most drivers can | drive their cars. | | Understanding is about understanding of aspects. They may | well not understand the engine aspect (how it works | precisely) but "Most drivers can drive their cars" means | they control their cars, which means they _understand_ | what happens when a steering wheel is turned, and how not | to grind the gears, and not to hit accelerator and brake | together. They model it. That is the embodiment of their | understanding. Without that they could not control a car. | | > Why, thank you for... | | Quite clearly there was a question mark at the end it to | indicate my implied doubt. Science seeks better | understanding of x so it can manipulate x more precisely. | Please give me a couple of examples of complex systems | which we don't understand but can control, so I can | understand you better. | layoutIfNeeded wrote: | Yeah, we've read The Selfish Gene, too. | renewiltord wrote: | Naturally, it's 50 years old and one of the most | influential science books of all time. If you hadn't, | then the reference wouldn't work as well. | ben_w wrote: | What it's worth I haven't read that book (or seen that | passage before) and I still understood. | renewiltord wrote: | Richard Dawkins did do very well with the way he | expressed the concept. It is quite intuitive for | something of such great significance. Easy to forget, I | suppose for me, how intuitive it is. | nyolfen wrote: | > The Earth is a giant living system we're slowly killing | and replacing with human technology. | | "It is only due to a predominance of influences that are | not only entirely morally indifferent, but indeed -- from a | human perspective -- indescribably cruel, that nature has | been capable of constructive action. Specifically, it is | solely by way of the relentless, brutal culling of | populations that any complex or adaptive traits have been | sieved -- with torturous inefficiency -- from the chaos of | natural existence. All health, beauty, intelligence, and | social grace has been teased from a vast butcher's yard of | unbounded carnage, requiring incalculable eons of massacre | to draw forth even the subtlest of advantages. This is not | only a matter of the bloody grinding mills of selection, | either, but also of the innumerable mutational abominations | thrown up by the madness of chance, as it pursues its | directionless path to some negligible preservable trait, | and then -- still further -- of the unavowable horrors that | 'fitness' (or sheer survival) itself predominantly entails. | We are a minuscule sample of agonized matter, comprising | genetic survival monsters, fished from a cosmic ocean of | vile mutants, by a pitiless killing machine of infinite | appetite. (This is still, perhaps, to put an irresponsibly | positive spin on the story, but it should suffice for our | purposes here.)" | ben_w wrote: | Curious; I not only don't understand your world view, I | don't even have enough of a handle on it to know how to | engage with it. | | For example: | | > The fungi will consume all of us some day and outlive us | all. I mean some are among the oldest still living life on | earth as it is. Like millions of years old and still going. | How can you dominate something that's existed longer than | you and will out live you and everyone you know? | | Yet anti-fungals are trivially available at low cost. | Indeed, the very claim of yours that: | | > The Earth is a giant living system we're slowly killing | and replacing with human technology. | | Is literally not something I can only even understand as | _agreement that we have dominion_ , yet I know you intend | to deny that. | zhrvoj wrote: | A fool with a tool is still a fool... | [deleted] | renewiltord wrote: | True, but a fool without a tool must make two | transformations to become a genius with a tool. A fool | with a tool need only make one. | whytaka wrote: | > No, if you can save billions and you choose not to, you | have killed them. | | The trolley problem remains unsolved. I don't find arguments | anymore persuasive when they are written as declarations. | renewiltord wrote: | That part was intended to be a declaration of _my_ position | on it not on a universal conclusion. For brevity, I left | the 'for me' part out. | quickthrower2 wrote: | How do you solve it? What does the solution look like? It's | not like the 4-colour problem. | ajuc wrote: | > If you can uplift species and you choose not to, you have | killed their cognition. | | By that logic you killed all the kids you could have made | when you weren't having sex. | renewiltord wrote: | Yes, I did. And I find that acceptable. After all, child | killing isn't an unalloyed evil. There are children I am | morally all right with killing. | vikramkr wrote: | You're giving nature too much credit. Nature doesn't try and | balance life. Nature doesn't care- it throws asteroid impacts | and supervolcanos and natural disasters all over the place. | Life just happens to be very very resilient and consistently | able to jump back and fill new niches. Nature also "created" us | - were a product of the universe like everything else. If we | are destabilizing, so is nature. | | And most scientists do not assume they can blindly mess around. | There was a whole section of this article related to ethics, | they didn't let the fetus be born (which would definitely have | been messing around). They're not trying to "do better" or | control nature - they're just trying to understand what makes | us tick. This is a mutation that already exists in humans. It | might make us human. If anything, that makes nature the one | that was blindly messing around. | erickj wrote: | However in the exact same vane that "Nature doesn't care"... | We as Humans should and DO care. | | We are not Nature, and thus these existential defining issues | should at least give us some pause to debate and evaluate the | moral quandaries and responsibilities that this level of | engineering power wields. | flatline wrote: | We are very much Nature. Possibly something independent of | our own minds exist; we can never really know. Anything | worth preserving, caring for, or caring about, is a product | of the human mind. The meteor careening into the earth does | not feel a moral quandary, but we do, and as such I agree | that given our limited knowledge we should care. But we | should also pay heed to how ignorant we are: we cannot | possibly know how our present actions will play out in the | future, the best we can do is try to be compassionate and | take care of what we can. The rest is out of our control | and hence our sphere of responsibility. | bamboozled wrote: | "You're giving nature too much credit." | | What a statement. | camphero wrote: | Don't blame wanting to prove Planet of the Apes could be real | (but not having the balls to do it) Nature's fault. That | stupidity is just human mad science. | grawprog wrote: | I don't give it credit, like it's trying to gain balance, but | functioning ecosystems do maintain a balance. Most of our | climate problems have come from humans disrupting this. | | If you take any functioning healthy ecosystem on earth, one | generally less tampered with by humans, you'll find from a | microscopic, right up to a macroscopic level, the life in | those ecosystems have adapted to function together. | | If you want to see some good examples of this, check out some | terrarium channels on youtube, there's some really cool, | perfectly balanced ones people have had going for years. | | The reason why we have so many ecological problems around the | world is that humans have been constantly disrupting this. We | introduce invasive species that dominate the landscape, cause | extinctions and extirpations of native species and change the | fundamental balance of the ecosystem. | | You're right, life does push through, but personally, I | prefer the native songbirds and shrubs that are local to my | area than a landscape full of Japanese knotweed and | starlings. | | And so do most things, that first example likely has at least | a dozen species of songbirds, a bunch of shrubs and | herbacious plants. That second example has two species, maybe | some rats or crows if your lucky. | | The thing is, ecosystems don't stand alone, they're all | connected and the collapse of one leads to the collapse of | the neighbouring ones and so forth. | | If you actually look through the published literature.on | various ecosystems around the world, we have a very shallow | level of knowledge. We don't understand fully the complex | connections between everything and the research that does | keep coming out keeps showing how much we've vastly | underestimated how much our actions have impacted things. | | Even things like the ecosystems in our own body's. The | microscopic organisms that have been found to even play a | part in things such as our decision making and moods. | | The human body itself functions as an ecosystem, all our body | systems, our cells, our organs, all function independently | and cohesively to make everything that is you. | | The earth itself functions the same way. The ecosystems, and | all life, including humans, are the cells and organs that | make up all life on Earth. | | Altering life at a fundamental genetic level goes even | further than how we alter ecosystems. | | Humans really don't understand the potential consequences to | changes we make to the genetic code. We have a vague idea, | but we really are.delving mostly blind into this. If we | barely understand how life works on a macroscopic level, what | makes us think we're ready to change it at an even lower | level? | hohloma wrote: | You're missing survivorship bias - nature didn't just | create these balanced ecosystems, it creates anything that | goes, and things that don't work out just die. Humans | ruining earth for themselves is just as natural, just that | we might die as result. But life won't - it's much more | resilient than just one species. Or several. | nwienert wrote: | Following this line of logic you can justify anything. If | I kill your entire family, that's natural. Would you be | ok with that? | | I think if you accept at all that there is suffering and | there is beauty, then you shouldn't hide behind | "everything's natural" and instead try and have a | backbone and stick up for something more. | jjoonathan wrote: | That's the point: naturalism can justify anything, and | that makes it a poor guiding principle. As do many other | things. | | There are many natural things that are good. Clean air, | unique little ecosystems like GP describes, endless | variety -- and we should strive to respect and preserve | those, but not because they are natural. Poor animals | teeming with parasites, population "balance" maintained | through periodic overpopulation and starvation (How do | people think it happens? Forest fairies tell the deer how | many babies to have?), predators feasting on the organs | of their prey while the prey is still alive. All these | things are natural but _not_ good and we should _not_ | seek to replicate them. | [deleted] | vikramkr wrote: | Why should I be "ok" with natural? Screw natural. Nature | does a lot of terrible things. People dying in hurricanes | or at the hands of murderers isn't OK because its | "natural" - its just not OK. We have the intelligence to | influence our environment (and that intelligence is also | a result of nature). Trying to categorize natural vs | unnatural (whatever that means) is a fools errand and not | a productive one in my view, since my ethics aren't based | on "it's ok because the volcano was natural" | ericffr wrote: | The problem with this line of thinking is that it might | be a little short-sighted. Since we are intelligent, we | should be careful. With great powers come great | responsibility. If someone doesn't like hurricanes, they | can move where there is none. When Earth will be 99% | inhabitable (because of air pollution, soil degradation, | lack of water), is the solution just to say "oh well", | let's go to Mars? | ylyn wrote: | It is natural. | | That doesn't make it okay. | vikramkr wrote: | If you take most systems, they're at war with eachother. | And that war includes viruses, which do a lot of altering | at the fundamental genetic level. You could call it balance | - I'd call it stalemate. And of course we don't understand | the consequences- thats the point of the research. Ideally | its done in a controlled, ethical way. And questions are | raised. But the point of the research is to understand the | connections and the consequences, and the only way we do | that is by experimenting which involves making low level | changes and observing the results. And as we understand | these consequences, were able to apply our new knowledge to | practical purposes like treating disease. Not understanding | is the _reason_ that research matters - the point is to | find out. | LockAndLol wrote: | > I don't give it credit, like it's trying to gain balance, | but functioning ecosystems do maintain a balance. Most of | our climate problems have come from humans disrupting this. | | We didn't come out of a void. We are a natural evolution | too, with the only difference being that we reached this | stage before other animals. Since we are disrupting our | ecosystem, we are living proof that either: | | - this ecosystem we are in is not function according to | your definition - or functioning ecosystems do not maintain | balance | | > The reason why we have so many ecological problems around | the world is that humans have been constantly disrupting | this. We introduce invasive species that dominate the | landscape, cause extinctions and extirpations of native | species and change the fundamental balance of the | ecosystem. | | Ecosystems are constantly being disrupted and have been | long before humans evolved. Wind can carry the seeds of one | plant into another ecosystem where it suddenly dominates | because it has no "natural predators". Birds can fly over | an ecosystem, defecate and drop an entirely foreign species | into another ecosystem. | | Cyanobacteria are even attributed as the reason for one of | the first mass extinctions [0]. Is that a sign of a | functioning ecosystem? | | > Altering life at a fundamental genetic level goes even | further than how we alter ecosystems. | | Viruses and bacteria actively mess around with the DNA of | other organisms in order to render them susceptible or make | them carriers. Nature has been messing with itself long | before we ever learned how. | | We are in no way special in this universe or in our | actions. We are just copying what we see in nature. | | [0]: https://slate.com/technology/2014/07/the-great- | oxygenation-e... | hutzlibu wrote: | "I prefer the native songbirds and shrubs that are local to | my area than a landscape full of Japanese knotweed and | starlings." | | Don't you think, you feel that way, because you grew up | with the native songbirds? | | "If we barely understand how life works on a macroscopic | level, what makes us think we're ready to change it at an | even lower level? " | | Like the other poster have said: nature does not plan in | advance or makes ethical discussions. Nature just is and | everything in it trys to adapt. Some prosper, some die out. | Now with our technology we disrupted quite a bit, but why | must we understand everything we do, when nature aparrently | does not either? | | With research like this, I am more worried, what things | like this, does to us. To maybe get to the point, where new | babys are created in a laboratory and the less successful | experiments goes to the bin. All for Evolution. | | Now I am grossed out by that thought. But from a | philosophical point of view, I have to ask myself: "who | defines that this is bad?" | | Maybe this gets us to the stars, so life can spread, in | case earth life gets vanished, by a big asteroid. So maybe | it is ethical to do all we can, to get there? To preserve | life itself? (humans are not at all adopted for space, | radiation, zero g etc., so CRISPR?) | | (well no, I don't think it is ethical to do by all means, | but I do think ethics are subjective and the next | generations might have different ethics) | mlavin wrote: | It's an easy qualitative decision to consider a variety | of species with pleasant calls and plants which coexist | in their own niches better than swarms of one single | species of bird and an aggressively invasive plant | species which chokes out all other growth. Knotweed in | particular is an absolute pox on the landscape in North | America. | hutzlibu wrote: | Ok, I don't know of the specific case, it is just, that | here in germany, the "invasive" species people complain | about, I wittnes as a welcome variation. Brings in more | color. The areas that do get dominated, will very likely | balance it out with a different species, soon. | | edit: had to translate it, but: we also have knotweed and | people complain, but I actually like it. And I do not see | it dominating, just a spot here and there, just like | nettles. | ericffr wrote: | Not every weed moves as fast as a virus. It might take | decades before we realize that some species have | disappeared, and in their wake, others are going too, and | we are left with a homogeneous ecosystem where a new | virus will come and be even worse (like the wheat rust | which decimated the single species of wheat growing in | North America). Obviously, Nature, being random, might | cause destruction on its own (like when plants appeared | and the high level of oxygen they produced killed earlier | species), but this happens on millions of years. And | sure, nothing prevents "Nature" from killing humans too. | We are not more precious than any other species, from the | Nature point of view. | hutzlibu wrote: | "we realize that some species have disappeared, and in | their wake, others are going too, and we are left with a | homogeneous ecosystem " | | Species come and go all the time. Globalisation just made | it a lot faster. So there will be imbalances and local | system collapsing and temporary a dominating species | etc., but alltogether the diversity of species will be | increased, with fast global exchange. Because there are | more candidates to fill a niche. | | Local established ones still have a home bonus. Their DNA | is adopted to the local climate and soil, unlike the | invaders. They won't vanish anytime soon. | | The thing really threatening diversity are monoculture | fields with pesticides. | 77pt77 wrote: | > Nature took a long long time to get to this point where life | has come to a sort of balance | | There is no balance. It's an illusion of selection bias and | inability to consider time-scales not at the human scale. | klunger wrote: | I don't. It makes me sick to my stomach. | | I am speaking as someone who is pro-choice, pro-GMO's and pro- | stem cell research, etc. This research has crossed a line that | none of the above do. It is creating a new _kind_ of sentience, | a new kind of soul. | | And, what's the point? To confirm a theory about a gene? So | fricking what. That really doesn't matter, not in relation to | the possible consequences: someone taking this research to | create a race of "sub-human" slaves that think and feel as | acutely as we do. Pick your genetic engineering dystopia for | where this is leading us- Brave New World, Planet of the Apes, | Gattaca, even the Uplift series. | | It never should have gotten approved by an ethics review board. | The 100 days termination was just so they could claim to have | considered ethics. If they actually seriously had done so, this | project would have never left the drawing board. | | Finally: I wish people would stop staying the genie is out of | the bottle. The genie is whatever we humans decide to do. You | can't just assume that because something is possible that it | will be done. We can have moral boundaries as a society. We can | say "this is a bridge too far and no one should cross it". And | anyone who does will be excommunicated from the scientific | world. | | There is nothing inevitable about this dark path. Saying that | it is inevitable just removes responsibility from whoever does | it, which is just BS. | | . | | edit: grammar, clarity | belval wrote: | Have you ever stopped and thought about why you feel in such | way towards these experiments? Why do you see sentience as | the line not to cross and even go as far as to call it a | "dark path"? | | You use a lot of wording that are very religious sounding | such as "soul", "excommunicated", "dark path", but have you | considered that you cannot really excommunicate a scientist, | that the mere concept of a soul might be wrong? | | To be clear it makes me feel weird too, but we have to be | able to discuss this instead of using inefficient red tape. | whytaka wrote: | If there's any science of morality to be done, the most | basic quantum of moral value is suffering. Sentient | creatures have greater capacity for suffering, being aware | of their pain and the injustice of their existence. If we | are to bring it into existence, we are responsible for its | suffering. | golemotron wrote: | It would be good to use science fiction to explore some of | these ideas before we do them. | kungito wrote: | "Is it right to create something that may be similar to us and | then not even give it a chance to live?" If trying to be "good" | doesn't this thought come off as really selfish? Just because | something is more similar to us it should have more right to | live? These thoughts are just basic survivalist instincts | wrapped in nice 21st century "morals". We will do whatever the | hell we want in the end and maybe we eradicate ourselves in the | end before something else does | cscurmudgeon wrote: | The answer is simple: We massively fucked up chemistry in the | last 100 years. How do we get the confidence to know we can't | fuck up biology (much much much much more complex)? | neolog wrote: | > We massively fucked up chemistry | | ? | DoingIsLearning wrote: | - Thalidomide | | - Leaded fuel, the highest ever source of lead exposure and | poisoning for Humans. | | - Asbestos still present in 60' to 80's construction | | - Refrigerants with Ozone destroying CFCs | | - 1800's arsenic pesticides still contaminate today's rice | fields and most of the world's rice crops. | | - DDT | | - Plastics are currently leaching estrogenic-mimicking | endocrine disruptors and contaminating water supplies, | wildlife and Humans. | | That's just a few from memory, I am sure there are more. | | Edit: yes as someone else commented our grenhouse gas | emissions are probably the biggest elephant in the room | selimthegrim wrote: | Greenhouse effect | NegativeLatency wrote: | I'd guess talking about advances in physical chemistry and | the ability to more closely model and understand how atoms | interact? | Der_Einzige wrote: | "Is it right to create something that may be similar to us and | then not even give it a chance to live?" | | The only difference between this and abortion is that the | species is somehow "novel". | | You should resolve the ethical issues with genetic engineering | research in a similar way to however you resolve the ethical | issues related to abortion. | vmception wrote: | I would like to see it be born. I want to know where this goes. | What other genes it needs to become superior, or what genes we | can tweak to optimize some things further. | | Humans are have tons of issues including cellular and cognitive | deficiencies. This is a way to learn more about that and fix | it. | | Sure, someone will make the new slave labor force, let's cross | that bridge when we get there. | FPGAhacker wrote: | I'm curious if you feel this way about human abortion? | grawprog wrote: | No, that's why I find it hard to describe how I feel. I'm pro | choice. It's not my place to tell someone what to do with | their bodies or the fetuses they're carrying(please don't get | into an abortion debate because of this, i'm not going to | answer any comments going on about that to avoid things | getting out of control), but this still makes me feel | uncomfortable. | | This is something different, this is the first time this has | been done, there was signs that their brains were going to be | similar to ours, meaning possibly self aware and intelligent, | I dunno, like i say, i'm not even sure which I feel like is | the ethical choice... | | Like I say, I find it hard to describe how I feel about it | all. | FPGAhacker wrote: | Thanks for replying on a sensitive topic. | read_if_gay_ wrote: | > No, that's why I find it hard to describe how I feel. | | Cognitive dissonance? Sorry to be snarky. | grawprog wrote: | Yup, I thought I made that clear in my op honestly.... | rootusrootus wrote: | > Like I say, I find it hard to describe how I feel about | it all. | | This is good, I like people that can recognize this. | Cognitive dissonance _should_ hurt. It 's the people who | can't feel it that I worry about being around... | ivnubinas wrote: | I feel there's a new tendency to value animal life more than | human life and I'm not sure how to feel about it. | breakfastduck wrote: | If I may chip in - I don't think it's really comparable. | | An abortion is a result of a choice being made by a person | after a set of real life and possibly unexpected events have | happened. | | The research is carefully planned in advance. This was | genetically engineered to be terminated. | | So while I do think you've asked a relevant question, I think | the ethical questions the two things raise are actually very | far apart. | abortmission wrote: | Just 1% of women obtain an abortion because they became | pregnant through rape | echelon wrote: | If you ponder whether these things have souls, then they're | directly related. | | There's a spectrum here. | | At one end, religious folks believe life and soul begins at | conception. Some also believe tampering with genes is | tampering with god's creation. | | At the other end, atheists believe in so soul. | | Some believe personhood doesn't begin until a being is able | to think, feel, and reflect upon the world around it. They | hold that cetaceans have higher consciousness than human | babies. They wouldn't have issue with this. | | Plenty of people with no monotheistic belief feel nature | shouldn't be tampered with. | | Many scientists view biology as a machine that should be | probed and studied. | | The "choice" argument is one of the counter arguments used | by those that are pro-life. I think many of them would | object to these experiments on different grounds. | | The ethics are complicated and messy. The science is rather | straightforward. | goatinaboat wrote: | _At one end, religious folks believe life and soul begins | at conception. Some also believe tampering with genes is | tampering with god 's creation._ | | Not all religions. The Qu'ran states that the soul enters | the body exactly 40 days after conception, for example. | downrightmike wrote: | Heinlein's Starship Troopers novel touched on this. Neo Dogs | are a novelty in society, a sideshow to the general public, but | they have the Intelligence similar to a human moron, but is a | Mozart for their species. And they use them in war, which is | their main use. The recruiter that works with the protagonist, | was a bonded partner. They bond deeply to their Neo Dog and if | the Neo Dog dies, it is more humane to kill the handler | immediately, or put them in a drug induced coma for a couple | months and then rehabbing them. The recruiter was put into a | coma, but is still dealing with the loss of his Neo Dog, and | agrees that killing the handler asap is kinder than having to | go through the rehab. | PeterisP wrote: | It's interesting that the novel assumes that the bonding is | likely to be stronger than almost all other bonds humans form | - for example, we grieve when our spouse, best friend or | child dies, but we don't usually presume that euthanizing the | grievers asap would be kinder than having them to go through | grief and rehab. It would seem plausible for _some_ of the | individual bonds to be like that, but notas a general rule. | downrightmike wrote: | Yeah, the bonding process seems like immersion when | learning a language, I figure that the handler's lost all | connection to that unique world they were immersed in and | couldn't cope. Kind of like losing your self identification | when people rely on their jobs to give them an identity. | Who are the handlers without the Neo Dogs? | patcon wrote: | Honestly, though the ethics are certainly dicey, I do wonder | whether recreating a bridge intelligence between man and animal | would raise appropriate societal questions that we've chosen | not the think about all of modern history (lacking any sort of | Neanderthal cohabitant). | | It might help us all be in more relation with the world. Our | lack of relation feels to me to be part of what's driving us | into this extinction event. A "monstrosity" that convinces us | to rethink the moral rights of other living creatures would | perhaps be welcome...? | | Maybe it ends up being the unasked-for bastard creature that | saves all the others (incl us) _from_ us, just by making us | slow down and go "hold on hold on hold on. what THE FUCK?" | plutonorm wrote: | Neanderthals had larger brains in proportion to their body | mass than we do. They were possibly smarter than we were. | ben_w wrote: | We don't know enough to know if that's a good measure; if | it is, ants would be at the top of the list for all | animals, and treeshrews for mammals: | https://en.m.wikipedia.org/wiki/Brain-to-body_mass_ratio | salty_biscuits wrote: | The scaling power coefficient matters, they are so far | off our mass that the coefficient might just be wrong. | Neanderthals are about the same size so an error in the | coefficient won't matter so much. | bredren wrote: | I would guess such information would be preferred by many to | remain unillustrated. | | I suspect we have more to answer for in the scale of animal | suffering than we could possibly imagine. | | An awakening to the truth of how cruelly indifferent we are | to animals would threaten power structures at a magnitude | that makes #metoo look small. | mooreds wrote: | Feels like the beginning of the Uplift Saga. Spooky times. | wombatmobile wrote: | > The cat's out of the bag with this research so to speak now. | Someone's bound to do this again | | If they do it again and again and again, the progress will be | substantial, and society stands to benefit enormously. | | With exponential increases in the parts of the brain | responsible for intelligence, morality and justice, imagine a | future president of the United States elected from this cohort. | [deleted] | zxcvbn4038 wrote: | I'm pretty sure I saw this movie - had Charlton Heston in it. You | know someone is going to grow this to maturity, either an | individual researcher looking for fame or a sovereign state | looking for prestige, then of course we'll have to know if the | mutations are propagated. | jbeard4 wrote: | This reminds me of "The Secret of NIMH" | https://www.imdb.com/title/tt0084649/ | plutonorm wrote: | What a fabulous film that was. Never read the book. | ThrowawayR2 wrote: | The book was better (naturally); as I recall, they used | technology instead of a "magic amulet" to work their way out | of the problem, in keeping with the theme of hyperintelligent | mice. | aaron695 wrote: | The sequels I thought were ok as well. | | By his daughter, my one exception to sequels not by the | author. | booleandilemma wrote: | _This is crucial in order to maintain ethical boundaries. After | about 100 days after the fetus had been growing, the | international team unanimously agreed to remove the fetus through | a C-section_ | | I feel we've already entered into sensitive territory by aborting | it. | Geminidog wrote: | Yeah, aborting in some circles is the same as murder so the | "ethics" is a bit blurry here. The crossed the line by creating | life and then they killed what could essentially be something | that could have had the intelligence of a regular human being. | | I'm not an anti-abortionist but I can't deny that the ethics in | this area is blurry. Even worse is when you're aborting | genetically modified life. | whimsicalism wrote: | > I can't deny that the ethics in this area is blurry | | If you don't like the ethics of aborting a monkey fetus | because it is "like murder", you're going to hate what | happens to lab monkeys they don't abort. | FriendlyNormie wrote: | Too late for an edit to save you, the reddit trannies found | your comment where you didn't blindly agree with what some | faggot scientist said. Enjoy your downvotes | treeman79 wrote: | Scientist: we've created the first new sapient species in the | last million years. Oh now it's extinct. | | Killing of inconvenient people is one level of messed up. | | This is just freaking insane. | PIKAL wrote: | I am overwhelmed with curiosity about what the animal would have | been like if it had been allowed to live. Imagine that it was | smart enough to speak or resemble humans even more closely than | monkeys already do... imagine how earth shattering that would be. | An entire race of beings to reconcile with. I wish they had let | it live. | jassany wrote: | The fact they didn't let the fetus grow really fucking sucks. | Sure, ethics most definitely has its name etched on the science | stone. | | But people WILL without a shred of doubt recreate this | experiment, and they most likely won't be as ethically inclined | as the nice folks behind this paper. | | The point am trying to make here is that we need to be prepared | to deal with how a discovery like could influence our future. The | best way to do that is to know what expect with enough time ahead | to react. | | And yeah sure people will say this is just an excuse for morbidly | curious people like me to simply see what happens, and while I'm | literally brimming in desire to know myself, theres a bigger | picture, bearing witness is just a perk:) | vikramkr wrote: | This research is as terrific as it is terrifying. These are some | terrific insights into the evolution of intelligence. I doubt | that it was one gene alone that drove the whole thing, but as the | article mentions, the ethical dilemmas already arise, and it's | easy to see how scientifically valuable it would be to study the | impact of the gene further by allowing the transgenic animals to | be born. The ethical dilemmas cut both ways - research like this | might be crucial to understanding Alzheimer's and other serious | diseases. Complicated and difficult questions to be sure, but | it's extraordinary and a testament to the power of science that | we're even in a position to be asking those questions. Lets hope | we answer them correctly. | dogma1138 wrote: | Isn't that literally the plot of the Planet of the Apes remake? | ampdepolymerase wrote: | Maybe it is time for continental and east asian arms and self | defence legislation to add an exception for putting down | runaway lab experiments. Standing your ground and castle | doctrines are privileges unique to America. | tiku wrote: | As long as no one takes a monkey home we should be okay. | tibbydudeza wrote: | So "Planet of the Apes" was not so far fetched after all. | | Now somewhere someone will think ... hmmm why can't we replace | all our complaining factory workers and their | wages/healthcare/retirement plans with these "creatures" and only | pay them peanuts and banana's. | to11mtm wrote: | Oddly, I came up with a pretty good plan for Enslaving Humanity | without most of them noticing (and the software architecture | that would power it) during a Sunday Drive today. | | I'll say that the concept I came up with was probably far far | cheaper than gene therapy and could be reached in 5-10 years. | So I wouldn't lose sleep over _this_ | wizzwizz4 wrote: | Unless you can think of any steps to prevent your plan from | working, try to forget about it. Somebody will re-invent it | later, but that'll be _later_. We 've created more of the | readily-accessible good technology than the readily- | accessible bad technology, and it'll take an active effort to | keep it that way. | chacha2 wrote: | Currently most of humanity is oblivious to it's enslavement, | what does your strategy add? | 0-_-0 wrote: | Brave New World had a similar idea | SimeVidas wrote: | Future brainy monkeys will watch that movie like it's a | documentary. | bjelkeman-again wrote: | David Brin, Uplift Universe. Start with Startide rising. It | covers this in a more interestingly ethical way I think. | delecti wrote: | There have already been issues with some coconut harvesting | operations using monkeys as laborers. | BurningFrog wrote: | We've been replacing factory workers with machines for 250 | years. It's made us, including the remaining factory workers, | very very rich, compared to where we started. | jhardy54 wrote: | Productivity has gone up but wages haven't kept up. The | owners are rich, sure, but we should be honest about the | working class getting the short end of the stick here. | ummonk wrote: | What the hell?!? | | There is no pro-choice argument for killing the fetus here - the | mother monkey is not sapient and was not consulted as to whether | she wished to carry the potentially sapient baby to term or not. | | This is straight up feticide. | erickj wrote: | +1 to "There is no pro-choice argument for killing the fetus | here" | | There is no pro-choice analogy to make here. | | As for the rest of your comment about feticide... I think there | is room for discussion here. | ende wrote: | This is either going 28 Days Later or Planet of the Apes. | adventured wrote: | Has anyone seen Marlon Brando lately? | Jaruzel wrote: | You were down-voted I think because people are not familiar | with: | | https://en.wikipedia.org/wiki/The_Island_of_Dr._Moreau_(1996. | .. | idebug wrote: | So, we are trying to make Planet of the Apes happen IRL? | keithwhor wrote: | Charlton Heston would like a word with these scientists. ___________________________________________________________________ (page generated 2020-11-15 23:00 UTC)