[HN Gopher] Better drainage of brain debris improves Alzheimer's... ___________________________________________________________________ Better drainage of brain debris improves Alzheimer's disease therapies Author : JPLeRouzic Score : 36 points Date : 2021-04-28 20:09 UTC (2 hours ago) (HTM) web link (padiracinnovation.org) (TXT) w3m dump (padiracinnovation.org) | api wrote: | This is fascinating... could Alzheimers be a result of a | lymphatic analogue of arteriosclerosis or artery blockage? | | If so then maybe similar treatments might work. | Zababa wrote: | In mice. Still, it's nice that it's working (in mice). | jonplackett wrote: | I think I'm gonna get a pet mouse. | | We really have a lot of excellent therapies to keep mice | healthy. | 1e-9 wrote: | Perhaps this is why physical exercise appears to reduce the risk | of Alzheimer's disease[1]. Our lymphatic system relies on muscle | contractions to move lymph. So, increasing exercise results in | increased lymph flow, which might then clear more amyloid-beta | from our brain. | | [1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113559/ | plutonorm wrote: | I was actually wondering today if hot/cold cycling the head | could increase lymphatic drainage and increase cerebrospinal | fluid cycling. | | Cold shower, hot shower, cold shower etc on the head... Will I | become mega mind? | voisin wrote: | Fascinating! As someone not familiar with how the lymph system | operates, do you care to explain how muscle contractions | outside the brain cause the lymph system in the brain to expel | waste? I understood the blood-brain barrier sort of insulated | the brain from a lot of this kind of thing. | throwaway5752 wrote: | Lymph is fascinating. It is your _other_ circulatory system. | | Capillaries are are so narrow they can only allow a single | erythrocyte through at the same time. The pressure from your | heart causes fluid leakage from the thin vessels. Lymph | ducts/nodes help get this fluid back into your blood. Since | the heart doesn't pump lymph, that helps move it through your | body is actually your musculoskeletal system. That is to a | certain degree true from your venous / return flow in your | "normal" circulatory system, too. It's why your feet can | swell if you're sitting down too much. I'd speculate that | lymphatic flow efficiency has local and systemic elements | that contribute to it (and so your leg muscles moving lymph | help your overall lymphatic system health). | plutonorm wrote: | This didn't answer the question, like at all! ___________________________________________________________________ (page generated 2021-04-28 23:00 UTC)