[HN Gopher] "Pay for success" contracts - a model to develop new... ___________________________________________________________________ "Pay for success" contracts - a model to develop new therapies from old drugs Author : savvak Score : 22 points Date : 2021-09-24 10:58 UTC (12 hours ago) (HTM) web link (crowdfundedcures.medium.com) (TXT) w3m dump (crowdfundedcures.medium.com) | chris_va wrote: | I am not sure why this is written as if drug repurposing is an | under-explored concept. | | Repurposing generics has becoming increasingly popular, because | the clinical trial risk is much better in phase 2/3 (where most | of the money is lost) than for novel compounds. Combine that with | FDA fastrack designation for orphan diseases, and it's become | quite the popular space for innovation. Even some of the papers | "cited" by this article contradict it. | | > This means that if one company pays for the expensive clinical | trials showing that a specific treatment protocol for an off- | patent drug works in a new indication, they cannot prevent others | from "free riding" on this valuable information, which is a "non- | rivalrous non-excludable" public good once it is published online | | This isn't true. Composition of matter patents are not the only | patents. If so, we wouldn't see generic repurposing at all, and | obviously that isn't correct. | pkaye wrote: | Colchicine is a very old drug used to treat gout and other | diseases which went into orphan disease patent because some | company figured out proper dosage. Now the drug became | expensive in the US but everywhere else benefited by knowing | the proper dosage and no increase in price. I'd rather American | consumers not end up solely paying for all these costs. | 1vuio0pswjnm7 wrote: | How do we charge royalties on method of use patents. Do we use | prescription data from pharmacies. For the purposes of | calculating royalties how do we prove whether and how anyone in | posession of a drug actually uses it. | jawns wrote: | My wife and I have been donating to Cures Within Reach | https://www.cureswithinreach.org, which funds repurposing | research. | | This is especially important for rare conditions that are | unlikely to ever see robust R&D purely on the basis of the size | of the market. ___________________________________________________________________ (page generated 2021-09-24 23:00 UTC)