[HN Gopher] Leaked grant proposal details high-risk coronavirus ...
       ___________________________________________________________________
        
       Leaked grant proposal details high-risk coronavirus research
        
       Author : BellLabradors
       Score  : 134 points
       Date   : 2021-09-24 16:15 UTC (6 hours ago)
        
 (HTM) web link (theintercept.com)
 (TXT) w3m dump (theintercept.com)
        
       | Consultant32452 wrote:
       | My hypothesis on this whole mess.
       | 
       | China was going to do bioweapon research and there was nothing we
       | or anyone else could do about it.
       | 
       | Quietly funding research in Wuhan was a way for the US IC to keep
       | an eye on what China was doing.
       | 
       | Something from that lab escaped. It's not clear or particularly
       | relevant to me whether what escaped was directly involved in the
       | particular experiments we funded. In my mind if the US funded 50
       | experiments and China funded 50 other experiments of
       | categorically the same type, and one of those 100 escaped, both
       | are culpable regardless of whether it was on of our 50 or their
       | 50.
       | 
       | Fauci and other officials can't just come out and say "This is
       | part of a top secret weapons/intelligence program where we were
       | using this funding to spy on China." And so they will lie in
       | public. They will lie under oath. And there will be no
       | consequence because the people (Congress/Presidents/etc) with the
       | classified truth are all similarly culpable (they probably
       | okayed/funded it).
        
         | dosman33 wrote:
         | This train of thought is entirely too charitable. The US has
         | the NSA, CIA, NRO, etc. for a reason and it's not to combat
         | domestic terrorism. We don't have to be sponsoring their work
         | to find out what they were doing. But I can understand the need
         | to rationalize this somehow.
        
       | ryeights wrote:
       | Why is this being flagged? Genuinely asking.
        
         | Invictus0 wrote:
         | HN has lots of quiet pro-China readers
        
         | meibo wrote:
         | Every anti-chinese story on here usually gets flagged into
         | oblivion(or page 2, even with plenty of upvotes), be it by bots
         | or Chinese tech workers.
        
           | president wrote:
           | HN (Y Combinator) has an incentive to curb posts that could
           | potentially make China angry. Being a forefront Silicon
           | Valley investment company, they have to play the globalist
           | game. Therefore, I suspect there may be policies in place,
           | whether spoken or unspoken to suppress these types of posts.
           | I don't doubt that there are bots or Chinese nationals that
           | also downvote/flag these posts as well.
        
         | justapassenger wrote:
         | I've flagged it. Article is ok. But the title on HN is a cheap
         | clickbait.
         | 
         | Someone, in USA, asking for a grant in the past doesn't point
         | to anything about origins of SARS-CoV-2.
        
           | Pick-A-Hill2019 wrote:
           | Unless the Intercept changed the page the submission also
           | breaks the guidelines about editorializing submission titles.
           | TFA headline reads: Leaked Grant Proposal Details High-Risk
           | Coronavirus Research (I didn't flag it, just voicing a
           | possible reason for the submission to be flagged)
        
           | BellLabradors wrote:
           | What do you think of these quotes?:
           | 
           | ""Some kind of threshold has been crossed," said Alina Chan,
           | a Boston-based scientist and co-author of the upcoming book
           | "Viral: The Search for the Origin of Covid-19." Chan has been
           | vocal about the need to thoroughly investigate the
           | possibility that SARS-CoV-2 emerged from a lab while
           | remaining open to both possible theories of its development.
           | For Chan, the revelation from the proposal was the
           | description of the insertion of a novel furin cleavage site
           | into bat coronaviruses -- something people previously
           | speculated, but had no evidence, may have happened.
           | 
           | Richard Ebright, a molecular biologist at Rutgers University
           | who has espoused the possibility that SARS-CoV-2 may have
           | originated in a lab, agreed. "The relevance of this is that
           | SARS Cov-2, the pandemic virus, is the only virus in its
           | entire genus of SARS-related coronaviruses that contains a
           | fully functional cleavage site at the S1, S2 junction," said
           | Ebright, referring to the place where two subunits of the
           | spike protein meet. "And here is a proposal from the
           | beginning of 2018, proposing explicitly to engineer that
           | sequence at that position in chimeric lab-generated
           | coronaviruses."
           | 
           | Martin Wikelski, a director at the Max Planck Institute of
           | Animal Behavior in Germany, whose work tracking bats and
           | other animals was referenced in the grant application without
           | his knowledge, also said it made him more open to the idea
           | that the pandemic may have its roots in a lab. "The
           | information in the proposal certainly changes my thoughts
           | about a possible origin of SARS-CoV-2," Wikelski told The
           | Intercept. "In fact, a possible transmission chain is now
           | logically consistent -- which it was not before I read the
           | proposal."
           | 
           | But others insisted that the research posed little or no
           | threat and pointed out that the proposal called for most of
           | the genetic engineering work to be done in North Carolina
           | rather than China. "Given that the work wasn't funded and
           | wasn't proposed to take place in Wuhan anyway it's hard to
           | assess any bearing on the origin of SARS-CoV-2," Stephen
           | Goldstein, a scientist who studies the evolution of viral
           | genes at the University of Utah, and an author of the recent
           | Cell article, wrote in an email to The Intercept."
        
             | jayd16 wrote:
             | When someone is hawking a book and playing up the subject
             | of that book, take it with a grain of salt.
        
             | dekhn wrote:
             | Are you a scientist?
             | 
             | I was. I can tell you that all of those quotes require a
             | great deal of inspection and you cannot take them at face
             | value.
             | 
             | At the very least, most scientists speak ultra-confidently
             | about this beliefs (beyond their own internal level of
             | confidence) because they've learned to use narrative
             | techniques to make their beliefs sound true.
             | 
             | Any scientist who is actively speculating that this funding
             | is "strong evidence" rather than saying "it's logically
             | consistent and seems more than coincidental" is just wrong.
             | That's a big mistake a lot of the early folks who claiimed
             | it was human engineered made. The evidence is not strong,
             | but not strong enough to convince a rational person.
        
               | mandmandam wrote:
               | There is a thing that you are full of. I'mma be polite
               | but you are full to the brim of it.
               | 
               | edit: Wow, flagged within one minute. That's not weird at
               | all /s
               | 
               | So I'll expand: The comment above is ridiculous for 7
               | reasons. Try to find them all.
        
           | titzer wrote:
           | > in USA
           | 
           | The first page of the document listed collaborators from the
           | Wuhan Institute of Virology.
        
       | AlbertoGP wrote:
       | There is a live stream right now by Dr. Kevin McCairn
       | (neuroscientist) commenting on this paper, a grant application
       | from EcoHealth Alliance (Peter Daszak) detailing what they were
       | going to do in Wuhan: https://youtu.be/ayNMSFp7pOE
        
         | taurusnoises wrote:
         | "Video removed by uploader." Is there anything about this virus
         | that isn't suspicious!? Like, can't even a YouTube video stay
         | up when it's supposed to?
        
         | [deleted]
        
       | phkahler wrote:
       | Some people:
       | 
       | >> Vincent Racaniello, a professor of microbiology and immunology
       | at Columbia University, was adamant that the proposal did not
       | change his opinion that the pandemic was caused by a natural
       | spillover from animals to humans. "There are zero data to support
       | a lab origin 'notion,'" Racaniello wrote in an email.
       | 
       | There seems to be zero data to support his spillover idea too.
       | But now we have documentation of people wanting to do the exact
       | experiments that could lead to this, and he's still sticking to
       | his fantasy.
       | 
       | I dont think the point here is to definitively determine the
       | origin of this virus, it's to point to the fact that unchecked
       | scientists are wanting to do exactly the kind of experiments that
       | could kill us all. IIRC an Ebola gene was successfully put in a
       | flu virus years ago but contained - hemorrhagic influenza anyone?
       | 
       | This stuff needs to stop.
        
       | chrsw wrote:
       | I could be missing something but this isn't exactly the smoking
       | gun the title makes it seem. I'm sure there are proposals, plans
       | and applications for all types of things. What I'm waiting for,
       | perhaps naively, is strong evidence, revelated an independent
       | investigation, that there was some foul business going on here.
       | Until I see that, I'm more inclined to rely on the word of
       | experts who have no connection to any of this. A novel aspect of
       | a viral genome isn't enough for me to leap to the conclusion that
       | it's human made.
        
         | subsubzero wrote:
         | I think the chain of evidence is suspicious to say the least.
         | 
         | 1. In 2018 EcoHealth Alliance(Peter Dazsak and team) apply to a
         | grant to darpa for viral modification research and highlight a
         | change in "furin cleavage site" at the same location as
         | covid-19's change, this change has never been seen before in
         | nature.
         | 
         | 2. In the darpa proposal is listed "Wuhan institute of
         | virology" as a team member, this was a year before the covid-19
         | outbreak in wuhan in 2019.
         | 
         | 3. Rather damning for Peter Dazsak is he publicly denied any
         | plausibility in the idea of a lab created source for covid-19,
         | while behind the scenes at the same time telling his two
         | students to distance themselves from this darpa proposal as the
         | virus was rapidly spreading through cities in the world.
         | 
         | 4. Even more unusual is that Peter Daszak and Linfa Wang, two
         | of the researchers who submitted the proposal, did not
         | previously acknowledge it until now.
        
           | BioResearcher2 wrote:
           | This is rather damning for other reasons that people may not
           | even realize. DARPA is a rather fast moving agency, and DARPA
           | grants can be fairly short term with a fast turnaround in
           | comparison to say NIH or NSF. Thus for DARPA grants (and
           | others, but especially DARPA), it's extremely common have
           | already started some aspects of the research in order to make
           | the timelines in the grant achievable. Thus as someone in a
           | nearby field (not something with such hefty security issues,
           | but bio-related), when I see it say that they wrote down they
           | wanted to insert this site into the virus, that is a public
           | admission that someone in some lab has already started
           | gathering preliminary data showing that it could work.
        
         | willupowers wrote:
         | The leaks reveal the confidence of a proposal and path to
         | accomplish the genetic manipulation that Daszak and his
         | associates have been aggressively refuting. This information
         | contradicts those previous statements. It appears Daszak may
         | have conflicts of interest that need more investigation.
        
         | derbOac wrote:
         | There must have been something about the title that changed, so
         | I'm responding to something that's maybe a bit different with
         | context. However...
         | 
         | Some other sites' coverage of this highlighted some of the
         | grant content a bit more prominently. I agree it's not quite a
         | smoking gun, but the content of the grant that was discussed
         | was eerily similar to what's been put together by investigating
         | organizations. It's akin to if you were trying to solve a
         | burglary and concluded "if this happened, the suspects would
         | have done A, B, D, and H", and then later you found some emails
         | sent back and forth by the suspects saying "hey how about we do
         | A, B, D, and H?" It's not proof they actually did it but it's
         | about as close as you can get to a smoking gun without it being
         | a smoking gun.
         | 
         | The timing is also uncanny.
         | 
         | I don't want to miscommunicate the extent to which I think the
         | grant proposal proves anything, as I don't think it does, but
         | it blurs the moral difference so much that I start to find
         | myself wondering why as a society we shouldn't react with
         | _some_ things as if it did. That is, I don 't think it rises to
         | some level where I would say it definitely proves beyond a
         | reasonable doubt that anyone did anything, but I do think it
         | compels some deep reflection about the scientific-media-
         | authority-academic-funding complex.
        
         | dang wrote:
         | The submitted title ("New Leaked Documents Point to Engineered
         | Lab Origin for SARS-CoV-2") broke the site guidelines badly by
         | editorializing. Submitters: please don't do that--it will
         | eventually cause you to lose submission privileges on HN.
         | Instead, follow the site guidelines, which include: " _Please
         | use the original title, unless it is misleading or linkbait;
         | don 't editorialize._"
         | 
         | https://news.ycombinator.com/newsguidelines.html
         | 
         | (I'm assuming, of course, that it wasn't the article title that
         | got subsequently changed. If that was the case, ignore the
         | above.)
        
           | klyrs wrote:
           | > (I'm assuming, of course, that it wasn't the article title
           | that got subsequently changed. If that was the case, ignore
           | the above.)
           | 
           | Not the first time I've seen you say this. Would it be
           | worthwhile to fetch articles when they're submitted, if only
           | for your own sanity?
        
             | dang wrote:
             | Fetching them in a way that information (like titles) can
             | be meaningfully extracted from is a lot harder than it
             | sounds - we've worked on it in the past and got bogged down
             | in lots of details and corner cases etc. An easier way
             | might be to rely on one of the archiving services, e.g.
             | archive.org. If a snapshot could be taken at submission
             | time than it would be there to refer to later.
             | 
             | On the other hand, titles changing on the fly isn't _that_
             | big a headache, as far as the chain of sanity-affecting
             | headaches goes. NYT does it all the time, or used to. The
             | main thing I don 't like to do is scold someone for
             | breaking the title guideline and then finding out later
             | that it was the site, not the submitter, that changed it.
        
             | xoa wrote:
             | The truly irritating thing is that even that wouldn't
             | necessarily be enough, because so many sites actually do
             | live A/B/C/[n] title tests simultaneously to randomized
             | sets of users then choose whichever one gets the most
             | clicks or whatever metric first. Even without any manual
             | shenanigans. So there's a window where merely refreshing or
             | browsing from a different IP will yield a different title.
             | Sometimes evidence is left in the URL or interactions with
             | older systems on the a site but that's all baroque.
             | 
             | Probably not worth the effort on HN to try to automate vs
             | just treating it case by case. It doesn't usually seem to
             | be a problem. "Pre-optimization is the root of all evil"
             | and all that.
        
         | fredgrott wrote:
         | short biology explanation as I do not know how much the HN
         | readers has.
         | 
         | We did not have the tools to do genetic manipulation as far s
         | the physical techniques until recently...ie they were not
         | around when I took biochem in 1990s.
         | 
         | HOWEVER, we still do not have enough concrete knowledge about
         | this domain to reliably design anything on purpose including
         | viruses organs ,etc.
         | 
         | Anybody that states otherwise is a danger to themselves and
         | others. Blunt as I can put that.
        
         | JPKab wrote:
         | There is a long chain of improbable coincidences required to
         | believe that the virus came directly to humans from animal
         | reservoirs in nature.
         | 
         | Coincidence 1.) Wuhan is roughly 1800 KM away from the caves in
         | Yunnan province where previous bat-borne coronaviruses jumped
         | to humans harvesting bat guano in earlier SARS outbreaks. It is
         | a massive metropolitan area, and far more cosmopolitan than
         | many westerners believe. They don't eat bats in Wuhan, and bats
         | were never present at wet markets. Possible for a virus to jump
         | from bats to humans here, but unlikely based on priors and the
         | realities of horseshoe bats being highly unlikely to come into
         | contact with urbanized humans at a level to transmit a virus
         | that isn't adapted to human lung receptors.
         | 
         | Coincidence 2.) Wuhan has 2 different facilities where bat-
         | borne coronavirus research took place. There are only a few of
         | these labs in the entire world, and none others in all of
         | China.
         | 
         | Coincidence 3. ) Unlike both SARS-1 and MERS, where animal
         | reservoirs for both were found within months, almost 2 years
         | later, no animal reservoir has been identified for SARS-2.
         | Unlike both MERS and SARS-1, SARS-2 has never been particularly
         | infectious to other animal species. SARS-1 in its early stages
         | was still highly transmissible between bats. SARS-2 never
         | exhibited this characteristic.
         | 
         | Coincidence 4. ) The evidence that would have easily exonerated
         | the labs was deliberately destroyed by the CCP early in the
         | pandemic, with extensive blocking of access to any and all
         | foreign investigators.
         | 
         | Coincidence 5.) The same city where this outbreak occurred was
         | a known location, based on other grants to EcoHealth Alliance,
         | of researching bat coronavirus experiments involving the use of
         | "humanized mice". No, "humanized" isn't some novel, sci-fi or
         | conspiracy theory idea. They are genetically modified mice
         | which are routinely used in research. The variety used in the
         | lab were engineered to have human ACE-2 receptors lining their
         | respiratory tissue. Sounds crazy, I know, but here's the grant
         | summary (it was awarded) for the research, and notice the
         | "humanized mice" at the very end of the text:
         | https://reporter.nih.gov/search/xQW6UJmWfUuOV01ntGvLwQ/proje...
         | 
         | All of this evidence is circumstantial, but every day that goes
         | by where no zoonotic reservoir is identified (the CCP isn't
         | looking at all, because they know the answer) increasingly
         | points to this being a lab accident and a subsequent coverup by
         | a paranoid authoritarian regime, along with a scientific
         | community desperate to prevent virology from being impacted the
         | way nuclear energy research was by Chernobyl.
        
         | baja_blast wrote:
         | there will never be an independent investigation
        
           | chrsw wrote:
           | If this is true, then I think we have a bigger problem on our
           | hands. Even if there's no lab connection to the COVID-19
           | outbreak.
        
             | mensetmanusman wrote:
             | Is China a bigger problem than the pandemic? Hmmmm....
        
         | imbnwa wrote:
         | I mean, even in the case that occurs, what is the endgame?
         | _Fine_ China? _Sanction_ China? _Demand_ accountability from
         | China? Not happening, not when they make everyone 's chips
         | among other things.
         | 
         | Can someone enlighten me about the value of this theory? It
         | just seems like another vector of anti-establishment distrust
         | discourse with a more intelligent veneer; easy to profit off of
         | (clicks, book sales, etc) and doesn't require a conclusion.
        
           | api wrote:
           | If this were true, the US is also involved. That would mean
           | both countries are responsible.
        
           | jtdev wrote:
           | They don't "make everyone's chip's"... that would be Taiwan.
           | 
           | Regarding what should be done: stop giving money to China for
           | GoF research would be a great start...
        
             | speed_spread wrote:
             | GoF? Is China still caught in the OO Design Pattern trap?
        
               | burnished wrote:
               | Gain of Function.
        
           | JumpCrisscross wrote:
           | > _Fine China? Sanction China? Demand accountability from
           | China?_
           | 
           | If China caused this and then lied about it, there would
           | absolutely be geopolitical will to organize and extract
           | concessions.
        
           | cameldrv wrote:
           | Perhaps if we have zero recourse against China in this sort
           | of situation, then the first step would be to work to remove
           | the conditions that lead to that lack of recourse.
        
           | majormajor wrote:
           | This was a proposal to DARPA from a US-based group so the "if
           | it came from the Wuhan lab we need to deal with China" part
           | of the common reaction to the lab-origins idea seems wildly
           | unfounded.
           | 
           | If it came from a lab - hell, even if it DIDN'T come from a
           | lab, but _could have_ - then we need to globally think about
           | what sort of things we 're doing and how safely we can do
           | them.
        
           | [deleted]
        
           | gmkiv wrote:
           | The value is to inform the larger discussion of the risks and
           | benefits of gain of function research.
        
           | willupowers wrote:
           | The leaks reveal the confidence of a proposal and path to
           | accomplish the genetic manipulation that Daszak and his
           | associates have been aggressively refuting. This information
           | contradicts those previous statements. It appears Daszak may
           | have conflicts of interest that need more investigation.
        
           | iammisc wrote:
           | The value is that it shows the American media for what it
           | is... CCP apologists more willing to believe the communist
           | government of China than a sitting American president with
           | access to classified evidence. And also their use of 'woke'
           | language to hide truth.
        
             | woodruffw wrote:
             | I'm not sure I'm following: are you saying that the current
             | president should be believed, or the former one? Similarly,
             | are you saying that either president has cited classified
             | information that directly contradicts the media's reporting
             | on COVID-19?
             | 
             | To my recollection, neither president has forcefully
             | declassified _any_ evidence that supports the more
             | egregious claims made about COVID (that it was
             | intentionally leaked). In the mean time, there seems to be
             | ample  & bipartisan willingness among the general public to
             | at least entertain more benign "accidental leak" theories.
        
               | iammisc wrote:
               | Robert Redfield former CDC director said trump had access
               | to intelligence implicating the lab. Biden presumay does
               | as well.
               | 
               | Also, nowhere here is any claim it was intentional.
        
         | BellLabradors wrote:
         | I agree with your characterisation of the evidence, except I
         | think "Points to" is not synonymous with "smoking gun" so I
         | don't think the criticism of the title is valid. In terms of
         | how important this evidence is, it isn't just "a novel aspect
         | of a viral genome", it is the aspect of the genome which is
         | hardest to square with a natural origin. And it is an aspect
         | that scientists involved in this research explicitly proposed
         | inserting into coronaviruses. From the article:
         | 
         | "Let's look at the big picture: A novel SARS coronavirus
         | emerges in Wuhan with a novel cleavage site in it. We now have
         | evidence that, in early 2018, they had pitched inserting novel
         | cleavage sites into novel SARS-related viruses in their lab,"
         | said Chan. "This definitely tips the scales for me. And I think
         | it should do that for many other scientists too."
         | 
         | Richard Ebright, a molecular biologist at Rutgers University
         | who has espoused the possibility that SARS-CoV-2 may have
         | originated in a lab, agreed. "The relevance of this is that
         | SARS Cov-2, the pandemic virus, is the only virus in its entire
         | genus of SARS-related coronaviruses that contains a fully
         | functional cleavage site at the S1, S2 junction," said Ebright,
         | referring to the place where two subunits of the spike protein
         | meet. "And here is a proposal from the beginning of 2018,
         | proposing explicitly to engineer that sequence at that position
         | in chimeric lab-generated coronaviruses."
         | 
         | And then what's more, they sat on the fact that they had
         | requested funding for this research for the last 18 months,
         | when the world has been desperately trying to find any relevant
         | information on the virus' origins. The fact that they did not
         | put this forward themselves in in and of itself suspect.
        
           | bb88 wrote:
           | To me the title of the article should have been:
           | 
           | "Leaked DARPA proposals adds weight to lab-engineered sars-
           | cov-2 hypothesis"
           | 
           | ...or something along those lines. The problem is that
           | "points to" is a pretty strong direct relationship. But these
           | docs aren't directly related apparently (since the research
           | was rejected by DARPA). It just shows that labs were
           | potentially interested in creating such viruses. But that
           | does hint that such a scenario could have been possible.
        
             | willupowers wrote:
             | The leaks reveal the confidence of a proposal and path to
             | accomplish the genetic manipulation that Daszak and his
             | associates have been aggressively refuting. This
             | information contradicts those previous statements. It
             | appears Daszak may have conflicts of interest that need
             | more investigation.
        
           | chrsw wrote:
           | I guess "smoking gun" is too strong. Maybe what I should have
           | said is something like "there's been a new development which
           | completely changes the characterization of the sequence of
           | events leading up to the pandemic."
           | 
           | What you're saying is worth looking deeper into, but it's not
           | enough to start making claims yet, imo. There are probably
           | hundreds or thousands of proposals and papers floating around
           | now that talk about different things one can do with genetic
           | engineering. If something should arise that is related to the
           | concepts in some of those papers you wouldn't necessarily
           | jump to the conclusion that there's a causal connection. Not
           | without more information, anyway.
           | 
           | "it is the aspect of the genome which is hardest to square
           | with a natural origin" This doesn't tell me it's artificially
           | created. The most this tells me is it's not well understood.
           | 
           | "The fact that they did not put this forward themselves in in
           | and of itself suspect." It could be related. Or it could be
           | unrelated and there maybe some other explanation. My point
           | is, when you want to charge someone with a serious crime,
           | which I think this falls under, you need to come with some
           | pretty strong evidence that directly ties whoever is involved
           | to the events of the crime. This evidence may very well exist
           | and it's not been shared publicly.
        
       | roca wrote:
       | Daszak should be compelled to reveal everything he knows and all
       | relevant evidence --- all proposals, all emails, all files, any
       | other documentation.
       | 
       | I'm mystified why this hasn't already happened. I mean, his
       | career depends on government largesse so it shouldn't even
       | require coercion. Full cooperation or no cash.
        
         | pishpash wrote:
         | You're assuming the government has a different interest than
         | him.
        
         | someguydave wrote:
         | what he knows might embarrass or reveal dishonesty from others
         | in the government or those seeking positions in the government
        
         | hn_throwaway_99 wrote:
         | I've been _extremely_ wary of how some of the evidence of
         | Covid-19 origins have come about, particular because so much of
         | it has been presented as  "Well, we've never seen this before,
         | so it must have lab origins."
         | 
         | That said, I think the context around this is _extremely_
         | damning for Daszak. I didn 't realize this until reading the
         | Wikipedia article on Daszak, but _he_ was the one that
         | organized the Feb 2020 letter in the Lancet condemning
         | suggestions of a lab origin for Covid-19 as conspiracy
         | theories. But how could he do this while conveniently leaving
         | out that his own organization _was_ involved in highly risky
         | coronavirus research?
         | 
         | Again, I don't think this news puts us much closer to
         | uncovering the origins of Covid-19, but it _does_ show how some
         | of these folks leading the charge of  "it had to be natural"
         | were at the very least being duplicitous in their
         | communications.
        
       | lamontcg wrote:
       | 1. There is no viral backbone anyone knows of which would have
       | been used in this research
       | 
       | 2. There is no spike protein anyone knows of which would have
       | been used in this research
       | 
       | 3. The PRRAR furin cleavage site is not one humans would have
       | tried it is unlike any other known furin cleavage sites in
       | coronaviruses
       | 
       | 4. There are now many known related sarbecoviruses which have
       | been found with furin cleavage sites
       | 
       | 5. Furin cleavage sites have independently evolved in multiple
       | different branches of coronaviruses, probably a dozen times that
       | we know of now.
       | 
       | 6. The furin cleavage site is short and can easily happen through
       | recombination with another virus due to coinfection.
       | 
       | 7. This is very likely what happened due to infection with the
       | SARS-CoV-2 ancestor and an HKU9-like virus.
       | 
       | It is not particularly suspicious that the thing which we were
       | worried about happening and causing a zoonotic spillover event is
       | the thing which actually happened.
        
         | createdapril24 wrote:
         | These are all very compelling claims. I am wondering if you can
         | provide at least one reference for each. E.g. "There are now
         | many known related sarbecoviruses which have been found with
         | furin cleavage sites" is a claim that can be referenced pretty
         | easily with a link to papers reporting said sarbecoviruses.
        
       | recursivedoubts wrote:
       | if you called someone crazy at some point for suggesting this as
       | a possibility, it is time to pause and reflect
        
         | WarOnPrivacy wrote:
         | It is reasonable & responsible to downplay theories that get
         | constructed in absence of sufficient and meaningfully qualified
         | evidence.
        
           | dabbledash wrote:
           | GP didn't say "if you thought there was insufficient evidence
           | before, you have some reflecting to do!"
        
             | WarOnPrivacy wrote:
             | I'm advocating a principle that applies well to the OP.
        
               | dabbledash wrote:
               | Then your comment would make more sense as a response to
               | the OP.
               | 
               | If anything it seems like you would agree that in the
               | absence of evidence humility is appropriate. People who
               | acted like only fringe conspiracy theorists would even
               | consider lab origins should reflect on their
               | overconfidence and arrogance. It's not a slam dunk either
               | way and probably never will be, if i had to guess.
        
           | jtdev wrote:
           | Animal origin theory/wet market/etc. have zero "meaningfully
           | qualified evidence", are you as skeptical about those
           | theories?
        
           | iammisc wrote:
           | Such as the theory, presented often without evidence, that
           | Sars-Cov-2 came from an imaginary population of bats in
           | Wuhan?
        
             | jayd16 wrote:
             | Its fine to call someone crazy if they're posting about
             | some coverup about bats without any evidence too, no?
        
               | iammisc wrote:
               | Except there was no bat coverup. The american media
               | bought into that theory without any evidence while
               | simultaneously castigating and ridiculing the lab leak
               | one. The coverup of the lab leak theory in the press was
               | thus in plain sight.
        
             | tshaddox wrote:
             | I mean, if it's a random comment on the Internet that makes
             | a claim without presenting evidence, yet evidence does
             | exist and is readily available, I don't have much of a
             | problem with that. After all, you just made the claim that
             | the theory is often present without evidence without
             | actually presenting evidence of _that_ claim. The real
             | question is what evidence exists, not what evidence may or
             | may not be presented with every online comment you may come
             | across.
        
             | andyxor wrote:
             | there is a lab called "Wuhan Coronavirus Research Lab" in
             | the epicenter of coronavirus pandemic ground zero, and
             | there is evidence of lab members seeking (and getting)
             | grants in the US for dangerous gain-of-function research in
             | the last few years, doesn't it make you stop and think?
        
         | martythemaniak wrote:
         | I've asked people to explain to me why I should care one way or
         | another, beyond curiosity, and no one has been able to answer
         | yet.
         | 
         | That is to say, is there an actual person who is perfectly fine
         | with all the terrible things the CCP plainly does, but finding
         | out that they've been incompetently handling research will
         | suddenly make them change their views?
        
           | iammisc wrote:
           | Yes... Many people claim 'global warming' or 'globalization'
           | make pandemics more frequent and more likely and want us to
           | spend lots of money preparing for pandemics. However, if this
           | pandemic turned out to be engineered or modified, then there
           | is a political solution to this enhanced likelihood of
           | pandemics from rogue nations.
        
         | tshaddox wrote:
         | "Suggesting this as a possibility" is a pretty weak statement.
         | But it's actually good to criticize someone for claiming _that
         | it happened_ without having any evidence, even if there happens
         | to later be evidence that it happened.
        
           | Viliam1234 wrote:
           | Depends on whether your criticism was "we don't know for sure
           | whether it happened" or "it did not happen".
        
           | bopbeepboop wrote:
           | You're assuming that because you were unaware of that
           | evidence, that others were as well.
           | 
           | But we've known since the COVID outbreak that there was
           | experiments making novel corona viruses infect humanized mice
           | in Wuhan just before two of the WIV researchers got sick and
           | a nearby military event also got sick. We've further known
           | that COVID-19 has a DNA structure unlike natural viruses --
           | matching a bat virus except for a single protein that appears
           | to be from a pangolin virus.
           | 
           | It was always clear the preponderance of evidence pointed
           | towards a lab leak -- and that claims of a natural virus were
           | special pleading by interested parties or a political stunt
           | by media parties.
           | 
           | You were always irrational and acting based on propaganda to
           | question a lab leak -- it was the only reasonable and
           | supported-by-evidence hypothesis the entire time.
        
         | [deleted]
        
         | speed_spread wrote:
         | My problem with people saying "but it was engineered!" is that
         | it the origin does not change what our reaction should be. The
         | virus is here and now we have to face it. Whether it's a
         | natural mutation, part of a big masterplan, or an accidental
         | release is a matter of international politics, in which most of
         | us have very little, if anything to contribute.
        
           | baja_blast wrote:
           | yes, but if this research continues we are all at risk of
           | another highly contagious human adapted virus escaping again.
           | The goal should be to try and ban this type of research
           | worldwide. While zoonotic viruses are always a risk, they are
           | far easier to contain due to the time it takes for a virus to
           | gain enough mutations to be easily infectious to other humans
           | such as what happened with SARs1 and MERS. Researchers
           | developing viruses to be highly adapted for humans just
           | creates viruses that are impossible to contain like COVID.
        
           | angelzen wrote:
           | If we go back to business as usual, covid will be far from
           | the last allegedly engineered virus to kill millions. The
           | health sciences establishment is in dire need of a reality
           | check, their actions have consequences reaching well beyond
           | petty grant politicking.
        
             | Factorium wrote:
             | Its unlikely the virus was engineered expressly to kill
             | millions - it seems increasingly likely that the virus was
             | engineered to drive mRNA vaccine sales, as well as to
             | disrupt the 2020 American election (by forcing an
             | unprecedent switch to mail-in paper ballots and upending a
             | vibrant US economy - at the same time as China was
             | struggling under international tariffs).
             | 
             | Just look at what an investment in BioNTech would have done
             | if you bought in October 2019:
             | 
             | https://www.google.com/finance/quote/BNTX:NASDAQ?window=5Y
             | 
             | You'd be 25x in less than 2 years.
             | 
             | How convenient for the Gates Foundation to invest $55
             | million in September 2019!
             | https://investors.biontech.de/news-releases/news-release-
             | det...
             | 
             | The chief innovation of mRNA vaccines is that instead of
             | using expensive egg cultures, you can reproduce viral
             | proteins inside the vaccinated patient themselves. This
             | presumably means much cheaper manufacturing.
             | 
             | Additionally, you can drive long-term vaccine sales, since
             | antibodies based on a single protein (spike) are more
             | likely to fail compared to immunity based on the complete
             | protein structure. We're already seeing this now with the
             | 'need' for booster shots in response to variants driven by
             | these leaky vaccines.
        
       | twobitshifter wrote:
       | Daczak serves on the WHO team to investigate the virus origins,
       | but this did not get mentioned in any reports. Instead he warns
       | other not to discuss it. He does not include notes that research
       | was done on modifying bat viruses to make them infectious to
       | human cells. These behaviors look like a guilty person, do they
       | not?
       | 
       | The wuhan and eco-health researchers had already started work on
       | the furin cleavage sites and why would they stop when DARPA
       | blocked it? Funding can't only come from the US. Did CCP also
       | block this research?
       | 
       | > there is published evidence that the Wuhan Institute of
       | Virology was already engaged in some of the genetic engineering
       | work described in the proposal and that viruses designed in North
       | Carolina could easily be used in China.
        
       | WarOnPrivacy wrote:
       | Even with this one bit of evidence (assuming it actually
       | indicates what we think it might) we aren't there yet. We might
       | be eventually but not today.
        
       | andyxor wrote:
       | If it looks like a duck, swims like a duck, and quacks like a
       | duck, then it probably is a duck
        
       | jtdev wrote:
       | Go back and listen to the exchanges between Rand Paul and Dr.
       | Fauci... Fauci repeatedly lied before Congress regarding funding
       | for this GoF research which now appears to have been the source
       | of the virus. This shouldn't be a partisan issue... trust the
       | science.
        
       | jasonlaramburu wrote:
       | Was EcoHealth Alliance, the group referenced in the article,
       | working in Wuhan?
        
         | jtdev wrote:
         | Yes, they funded GoF research at WIV. And it's founder Peter
         | Daszak worked to undermine the lab leak theory as a member of
         | the WHO COVID19 origins investigation team... can you say
         | "conflict of interest"?
        
         | AlbertoGP wrote:
         | Yes they were, in particular with the Wuhan Institute of
         | Virology, and Peter Daszak himself was in Wuhan in October
         | 2019.
         | 
         | EcoHealth just got defunded by the US Congress with bipartisan
         | support:
         | https://twitter.com/GReschenthaler/status/144122144752803020...
        
           | rich_sasha wrote:
           | In addition there was some controversy as they were behind
           | the Lancet open letter that first renounced the idea of a lab
           | origin. They got a bunch of scientists associated with their
           | organisation to sign it, without mentioning EcoHealth by name
           | or stating competing interest.
           | 
           | My spidey sense is certainly tingling, though of course no
           | smoking guns. But the jigsaw pieces fit. Can't get the
           | funding in North Carolina? Let's try Wuhan.
        
           | NoGravitas wrote:
           | This grant proposal, in particular, however, was to do work
           | in North Carolina.
        
             | AlbertoGP wrote:
             | Citing from the grant application, page 12:
             | 
             | > We will conduct in vitro pseudovirus binding assays,
             | using established techniques, and live virus binding assays
             | (at WIV _[Wuhan Institute of Virology]_ to prevent delays
             | and unnecessary dissemination of viral cultures)
             | 
             | https://www.documentcloud.org/documents/21066966-defuse-
             | prop...
        
       | WarOnPrivacy wrote:
       | I agree with the comment from justapassenger. The title has been
       | altered from the headline into inflammatory clickbait.
        
         | BellLabradors wrote:
         | The article has been previously submitted with and has
         | languished without interest, I think that the Intercept's
         | headline alone is underplaying it a little and is not suited to
         | this forum. I think if you read the article, the HN headline
         | above is accurate. What specifically do you think is
         | inaccurate? Even in tone?
        
           | WarOnPrivacy wrote:
           | That's a reasonable question. First - my understanding is
           | that we're expected to repost headlines verbatim, even if
           | they kind of suck. It's not some unbreakable rule but it's an
           | objective we should commit to.
           | 
           | Past that, I offer that headlines that will lead _the public
           | we have_ toward thoughtful, measured, conclusions (that
           | reflect where we actually are) - this would seem to be our
           | best goal.
        
             | BellLabradors wrote:
             | Fair enough, it seems I can't edit it now, Dang obviously
             | feel free to do so.
        
         | willupowers wrote:
         | The leaks reveal the confidence of a proposal and path to
         | accomplish the genetic manipulation that Daszak and his
         | associates have been aggressively refuting. This information
         | contradicts those previous statements. It appears Daszak may
         | have conflicts of interest that need more investigation.
        
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