[HN Gopher] Inflammation in the gut is encoded by neurons in the... ___________________________________________________________________ Inflammation in the gut is encoded by neurons in the brain Author : nabla9 Score : 101 points Date : 2022-01-10 20:16 UTC (2 hours ago) (HTM) web link (www.nature.com) (TXT) w3m dump (www.nature.com) | skim_milk wrote: | For me, the thing that sucks most about IBS is the medication. | The link between mind/body/pain/inflammation is pretty obvious | when you start taking strong anti-inflammatory drugs, at least | for me! Evidently, everyone in my family tree responds really | poorly to steroids and other anti-inflammatory drugs - a relative | of mine committed suicide after taking steroids for IBS with | absolutely no evident mental problems before treatment, leaving | behind his young family. Personally, I'd rather die early from my | gut diseases than go back on anti-inflammatory drugs, even the | modern biologic ones that supposedly have _no_ side-effects. | There 's just no way to target inflammation with drugs without | severely impacting the brain (at least with me and my family's | biology). | kerneltime wrote: | I recently came across a term "Functional Medicine" | https://www.ifm.org which looks at the body as a whole and | tries to root cause metabolic issues which can often result in | IBS cures.. most older medicinal practices always considered | the body as a unified system which make sense in terms of how | it is engineered but modern medicine tries to break things down | and often misses the cross specialization impacts. Best of | luck! | serverholic wrote: | I have autonomic-dysfunction, basically my nervous system | malfunctions in (luckily) mild ways. I've noticed that if I go | from an unhealthy lifestyle to suddenly living a healthy | lifestyle there's often a period where I feel sick, pale, and | faint. | | Luckily this effect only lasts a few days for me but it's made | me wonder if our bodies find ways around malfunctioning and | then can't adjust quickly enough if the malfunction is reduced | or removed. | emerongi wrote: | Above all, for all readers: talk about these things with your | doctors. There is a lot of anecdotal evidence online and it's | just like negative reviews: the people with positive | experiences aren't really talking about it much. | | As someone with a bowel disease, I can thank medicine for | giving my life back. | wombatmobile wrote: | I'm not sure how to discuss TFA because I can only read half a | paragraph of it due to the paywall. | | Instead of commenting speculatively, I'm going to wait for | someone to post more of the article, or a link to the full | article. | csours wrote: | Is there a good intermediate/undergraduate level write up of this | inflammation link? There's a lot of quackery out there on this | subject, so I don't trust search results. | sooheon wrote: | Seems like a novel finding, so the paper in OP's link (and | references) would be the best place to start. | dekhn wrote: | a note: when Nature says "Inflammation in the gut is encoded by | neurons in the brain" it really means "some inflammation in the | gut is associated with neurons in the brain". Not "all", just | some. scientists and science journalists often write PR that | makes the work sound more general than it is. And "encoded" is a | really squishy term. Just because neurons "light up" when you | apply a condition, and can replicate that condition under some | circumstances, doesn't mean the data is "encoded". | bryan0 wrote: | non-paywalled summary? | panabee wrote: | Article on related research: https://www.quantamagazine.org/new- | science-shows-immune-memo... | | Summary of article on related research: More than a century | later, in a paper published today in Cell, the neuroimmunologist | Asya Rolls has shown that a similar kind of conditioning extends | to immune responses. Using state-of-the-art genetic tools in | mice, her team at the Technion in Haifa, Israel, identified brain | neurons that became active during experimentally induced | inflammation in the abdomen. Later, the researchers showed that | restimulating those neurons could trigger the same types of | inflammation again. | andrewpkyap wrote: | I don't think that it's wise to start imagining how this finding | would implicate diseases, much less "other diseases". | echelon wrote: | It feels like we're on the precipice of linking a number of | neurodegenerative diseases [1], auto-immune diseases [2], and a | whole host of other ailments to immune and gut health. | | Likewise finding incredible links for liver (potentially | Alzheimer's [3]) and pulmonary health (air quality, heart disease | [4]). | | Who knew? But it seems obvious in retrospect. We're truly | dynamical, vastly interlinked systems. | | [1] | https://bmcmedicine.biomedcentral.com/articles/10.1186/s1291... | | [2] | https://www.sciencedaily.com/releases/2019/02/190219080742.h... | | [3] https://news.ycombinator.com/item?id=29393937 | | [4] https://www.epa.gov/sciencematters/linking-air-pollution- | and... | CoastalCoder wrote: | That's my hope as well. | | But that's somewhat tempered by reports of reproducibility | crises in scientific / academic research. | | I wish I had a better sense of the extent to which that matters | for stories like this. | Ozzie_osman wrote: | I wonder if this has implications for pain management as well. Ie | is the brain doing the same thing for things like chronic back | pain (the pain triggers some neural imprint, but the imprint can | then trigger the pain again even if the underlying physical | problem had gone away). | eli_gottlieb wrote: | >Writing in Cell, Koren et al.3 demonstrate that inflammation in | the abdominal cavity results in the stimulation of certain | neurons in a brain area called the insular cortex, or the insula. | Artificial reactivation of these 'immune-imprinted' neurons is | sufficient to generate organ-specific recall of inflammatory | responses that resemble the initial inflammatory episode. | | Ok, so there are gut/vagal interoceptors for inflammation. Their | ascending fibers land in the insula, which is, of course, the | primary interoceptive cortex. What's new here? | ramraj07 wrote: | What's new is that the neurons can trigger back the same | inflammation that got imprinted on them. | 52-6F-62 wrote: | I don't have access to the article, and I'm probably not | versed enough to understand it fully anyway. | | So, if I may ask you, or the larger thread-- | | this is implying the the inflammation will repeat if the | neurons are activated [in such a way]? | | Could/would this impact one-time sufferers of SIRS and/or | acute pancreatitis (being an inflammatory disease)? | | Would it match the original severity? | treeman79 wrote: | Having dealt with an autoimmune condition and been involved with | various forums I have seen a strong pattern. | | First trying lots of medications. Sometimes this goes well. | Sometimes not. | | Then supplements. | | Then eventually people get serious about diet. Turns out there is | a diet built around autoimmune conditions. Autoimmune Protocol | Diet. Many people have great success with it. Not all. | | Would love so see some studies on it. ___________________________________________________________________ (page generated 2022-01-10 23:00 UTC)