[HN Gopher] Jailed baby gene scientist 'should be made responsib...
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       Jailed baby gene scientist 'should be made responsible' for the
       children
        
       Author : acqbu
       Score  : 35 points
       Date   : 2022-03-19 21:25 UTC (1 hours ago)
        
 (HTM) web link (www.thetimes.co.uk)
 (TXT) w3m dump (www.thetimes.co.uk)
        
       | fabian2k wrote:
       | Informing the children about the experiment is the very least
       | they should do. And I think 18 is a bit too late, I probably
       | would do it a bit earlier than that. Anything after that has to
       | be their own choice, like it is for everyone else.
       | 
       | This was just a completely reckless and unethical experiment, I
       | hope it didn't cause serious damage to those kids.
        
       | encryptluks2 wrote:
       | I mean this is messed up, but I've seen a lot more widespread
       | abuse in the medical field that doctors and governments
       | supported. Just look at what happened to Rosemary Kennedy. Where
       | was the justice for children lobotomized? Or those used in
       | government research?
        
         | danuker wrote:
         | Stuff of nightmares.
        
         | radicaldreamer wrote:
         | Not only in the past either, there are ongoing scams where
         | elders are being preyed upon to inject stem cells into various
         | organs (including where they end up blind etc.)
         | 
         | They are entered into bogus "trails" as legal protection for
         | these "doctors" and the clinic.
        
           | doctorhandshake wrote:
           | Big if true. Link?
        
         | elliekelly wrote:
         | That other medical atrocities have happened and gone unpunished
         | doesn't make this one acceptable.
        
       | acqbu wrote:
       | http://archive.today/2LOd5
        
       | jdrc wrote:
       | Better to just monitor the kids for side effects of ccr5
       | deactivation . By the time they grow up gene editing will be
       | common place so i dont think that s something to worry about.
        
       | The_rationalist wrote:
       | The martyrs of the future are often the demons of their time
        
         | elliekelly wrote:
         | Conducting experiments on people without consent does not a
         | martyr make.
        
           | bpodgursky wrote:
           | Preserving the status quo doesn't make you a hero either.
           | 
           | HIV resistance is optional, sure. What about conceiving a
           | child with sickle cell anemia? Why is that more ethical than
           | trying to give a child a healthier life?
           | 
           | We do a lot of medical treatments on children without their
           | consent. There are now (experimental!) open-heart surgeries
           | of children in the womb. Is that unacceptable too?
        
             | krisoft wrote:
             | I'm not sure what you are arguing about. There is a process
             | to decide if a medical procedure is ethical or not. It
             | involves an ethics board where people who know much more
             | about both ethics and the proposed procedure than the
             | average HN commenter make a decision. If you feel this
             | process did come up with bad decisions please elaborate.
             | But the researcher in question didn't bother to get a
             | decision, just falsified one for himself. That doesn't
             | sound right, really.
        
             | HideousKojima wrote:
             | >What about conceiving a child with sickle cell anemia?
             | 
             | You mean one with heightened malaria resistance?
        
       | gleenn wrote:
       | Pretty wild, especially also the implications of the children
       | having their own children and passing the mutated genes. I wonder
       | also why there is a deactivated gene that prevents HIV
       | infection... did we have this ability for a long time but it fell
       | out of use and was selected off?
        
         | donkarma wrote:
         | HIV is a pretty recent disease and the gene that was
         | deactivated serves a useful purpose against West Nile
        
         | zdragnar wrote:
         | I doubt that this gene "only" prevents HIV infection. The
         | unintended consequences of activating that gene could be very
         | diverse, and not fully expressed in any one child. Most
         | adaptations have trade-offs, some quite severe (sickle cell
         | anemia protecting against malaria, as an example).
        
         | PragmaticPulp wrote:
         | > I wonder also why there is a deactivated gene that prevents
         | HIV infection... did we have this ability for a long time but
         | it fell out of use and was selected off?
         | 
         | It's a gene for a specific receptor that has certain other
         | functions in the body. Certain strains of HIV just happen to
         | use this receptor for viral entry, but it has other functions
         | in the body.
         | 
         | The specific CCR5 mutation has positive effects for resistance
         | to certain HIV strains but actually worsens resistance to
         | certain other diseases. There's also a big question of how
         | specific and accurate his editing actually was, of course.
        
       | verisimi wrote:
        
         | crummy wrote:
         | The link says no? Do you have a reliable source that says
         | Pfizer's vaccine uses CRISPR?
        
           | bnjemian wrote:
           | The comment above by verisimi was factually incorrect. The
           | Pfizer vaccine contains MRNA. MRNAs are short-lived nucleic
           | acids (not DNA) that exert their function in the cytoplasm of
           | the cell (not nucleus, where DNA lives and Cas9 exerts its'
           | action) and are used to translate proteins. The proteins
           | coded for by the MRNA sequences in vaccines (Pfizer, Moderna)
           | code for the S1 spike protein, which occurs on the surface of
           | the SARS-CoV-2. After their translation, these proteins are
           | then recognized as foreign by the immune system of the host
           | (i.e. person), leading to an immune response. There is no
           | Cas9 enzyme in MRNA vaccines.
        
           | SirGiggles wrote:
           | TL;DR: The grandparent's source is a load of horseshit, and
           | it seems evident an agenda is being pushed.
           | 
           | The grandparent's source came from a person going by Manul
           | Ashwadka [1]. I've added their comment in specific and as we
           | can also see from the link that Manul's sources are from his
           | own posted studies [2] (a guess based on the published
           | initials on Zenodo) which from what I can gather is not peer
           | reviewed.
           | 
           | Further more, in an attempt to find out more about the author
           | of the paper, the link to his/her/their blog as found on a
           | hyperlink from Zenodo leading to ORCiD results in the
           | following (now defunct) webpage: https://fight-against-gates-
           | new-world-order.mozello.com/blog... [3].
           | 
           | With this avenue blocked, any publicly information we can
           | find about Manul Ashwadka (whom I suspect is the same as
           | M.A.) is their posts on Quora which essentially devolve into
           | accusing Quora of censoring posts for disagreeing with the
           | Biden administration, justifying the Russian Federation
           | invasion of Ukraine, blaming Dr. Fauci for creating the
           | pandemic, blaming the US for a variety of things, etc...
           | 
           | [1] https://qr.ae/pGLEdZ (a shortened URL leading to Quora)
           | 
           | [2] https://zenodo.org/record/6210570#.YiJnV5XhRPz
           | 
           | [3] https://orcid.org/0000-0003-0048-882X
        
       | [deleted]
        
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       (page generated 2022-03-19 23:00 UTC)