[HN Gopher] The Pied Piper of Psychedelic Toads
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       The Pied Piper of Psychedelic Toads
        
       Author : mitchbob
       Score  : 25 points
       Date   : 2022-03-21 13:41 UTC (1 days ago)
        
 (HTM) web link (www.newyorker.com)
 (TXT) w3m dump (www.newyorker.com)
        
       | pmoriarty wrote:
       | See "Open Letter Concerning Abuses by Octavio Rettig and Gerry
       | Sandoval":
       | 
       | https://www.dmt-nexus.me/forum/default.aspx?g=posts&t=86872
        
         | jamal-kumar wrote:
         | Thanks for posting this as the new yorker article kinda just
         | scratche on it, which is a real shame considering these people
         | have left death in their wake. Absolutely garbage journalism to
         | somehow omit that there's murder arrest warrants out for them.
         | There are so many psychologically manipulative, abusive people
         | working in these spaces. Literally these people are just
         | profiteering crackheads who got into making money on giving
         | waaaaaay too powerful psychedelics to innocent people who don't
         | know any better. They need to be popped out like bad pimples.
         | 
         | 5-meo-dmt is extremely powerful stuff and unlike DMT it can
         | cause you to end up in the hospital or dead. It's not something
         | to be trifled with. It made a friend of mine's mom really lose
         | her sense of what is even real anymore. I usually see these
         | sorts of negative results in people who are long-term abusing
         | hard drugs like stimulants or opiates over time, not like
         | immediately after a few sessions of a psychedelic.
        
       | mythrwy wrote:
       | I caught one of these toads once when I lived in Arizona. On a
       | golf course. They look kind of like big frogs.
       | 
       | At the time I had no idea what it was (probably a good thing, I
       | was young and a bit adventurous). Just a toad. I let him go by
       | the water hazard.
        
       | twomoonsbysurf wrote:
       | I don't recommend it.
       | 
       | It is incredibly intense-- even traumatic. And there is no
       | precise "dosing".
       | 
       | Stay away from all drugs. Drugs do not lead to enlightenment.
       | They do not lead to some hidden knowledge. They throw your neuro-
       | chemicals out of balance-- potentially forever if you're
       | misfortunate.
       | 
       | Hallucinogens can affect you forever, negatievely, and never
       | stop-- and there is no cure if they do, for example:
       | "Hallucinogen-persisting perception disorder (HPPD) is a long-
       | lasting and potentially permanent syndrome characterized by a
       | spontaneous recurrence of perceptual/visual disturbances".
       | 
       | It is not worth the risk. You have only one brain-- don't tamper
       | with its health and safety. Again-- there's no hidden knowledge
       | there, no enlightenment. It's not worth it: put your focus on
       | something valuable, productive, and safe.
        
         | Zababa wrote:
         | > Drugs do not lead to enlightenment. They do not lead to some
         | hidden knowledge.
         | 
         | This reminds me of something near the end of "Fear and Loathing
         | in Las Vegas":
         | 
         | > We are all wired into a survival trip now. No more of the
         | speed that fueled the 60s. That was the fatal flaw in Tim
         | Leary's trip. He crashed around America selling "consciousness
         | expansion" without ever giving a thought to the grim meat-hook
         | realities that were lying in wait for all the people who took
         | him seriously. All those pathetically eager acid freaks who
         | thought they could buy peace and understanding for three bucks
         | a hit. But their loss and failure is ours too. What Leary took
         | down with him was the central illusion of a whole lifestyle
         | that he helped to create. A generation of permanent cripples,
         | failed seekers, who never understood the essential old-mystic
         | fallacy of the acid culture: The desperate assumption that
         | somebody - or at least some force - is tending the light at the
         | end of the tunnel.
         | 
         | My own experience is relatively tame. I'd say the worst part
         | was the difference between my expectations and reality. The
         | "hidden knowledge" you talk about and the "fallacy of the acid
         | culture" are a good illustration of that. But I wouldn't call
         | this life-altering or destroying. It's like going to a country
         | that you really want to go to, only to find out it's not what
         | you expected. I've seen many people that would rationalize this
         | by saying "the drugs showed you what you needed, that you need
         | to manage your expectations", but you can rationalize/anaylze
         | any situation in your life like that. I went to Chernobyl and
         | had a great time, so I should try to go out of my comfort zone
         | more often. I didn't do my best in school and regret it, so I
         | should try to work have to have less/no regrets. Everything has
         | meaning once you search for it.
        
         | systemsignal wrote:
         | Have you seen this study on how psilocybin substantially
         | reduced depression and anxiety in people with life threatening
         | cancer?
         | 
         | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367557/
         | 
         | Would love to know if you know anything else in the world that
         | can do that repeatably
        
         | burner556 wrote:
         | Drugs are actually tons of fun. I think in the long run all
         | drugs become detrimental (alc, caffeine, etc) but wow you can
         | have experiences you will never forget and they def-o change
         | the way you look at the world.
         | 
         | I would recommend everybody I know to experiment with drugs. I
         | don't recommend becoming dependent on ANY drugs.
        
         | pmoriarty wrote:
         | It is a risk, but so is riding in a car, which can cause
         | irreparable brain damage or death if one is injured in a car
         | accident. Skiing, skydiving, and scuba diving carry similar
         | risks. Even crossing the street is risky.
         | 
         | As adults we evaluate risks and make a decision as to whether
         | the benefits outweigh the risks.
         | 
         | I don't think we can say a priori whether something is too
         | risky for someone without knowing the person and their
         | circumstances. Some people are really at the end of their rope
         | and desperate to try anything, and have already tried many
         | risky things (like antidepressants or other medication, each of
         | which carries their own risks and possibly severe side effects)
         | and will continue doing risky things without a fraction of the
         | potential benefits of psychedelics.
         | 
         | There have been studies which show that psychedelics help
         | people, even to the point of "curing" some of them after a
         | single dose. The evidence so far shows enormous promise and far
         | more effectiveness than traditional antidepressants for severe-
         | treatment resistant depression.
         | 
         | How can we tell people who are suffering, some of whom are
         | suicidal even, that they shouldn't try something which holds so
         | much promise?
         | 
         | Yes, there are risks, and no guarantees. But steps can be taken
         | to maximize the chances of a positive experience... such as
         | doing it in a safe setting with a trusted, trained therapist or
         | guide, and spending a lot of time afterwards integrating the
         | experience with a therapist.
         | 
         | Some other recommendations for enhancing safety:
         | 
         | - lie in the recovery position[1], with the mouth facing
         | downward so fluid can drain
         | 
         | - abstain from food and drink for at least 4 or 5 hours
         | beforehand
         | 
         | - don't mix substances
         | 
         | - thoroughly vet anyone you entrust your safety to, and stay
         | away from facilitators who mess with your body or mind during
         | the experience
         | 
         | Also see the best practices guide of _The Conclave_ : [2]
         | 
         | [1] - https://en.wikipedia.org/wiki/Recovery_position
         | 
         | [2] - https://theconclave.info/
        
         | braingenious wrote:
         | > Stay away from all drugs. Drugs do not lead to enlightenment.
         | They do not lead to some hidden knowledge. They throw your
         | neuro-chemicals out of balance-- potentially forever if you're
         | misfortunate.
         | 
         | Counterpoint: I have done quite a lot of DMT and 5-MeO-DMT and
         | they were both fun and interesting substances.
         | 
         | My advice is: Do _not_ stay away from drugs unless: a) that is
         | your personal preference, b) you have a specific medical issue
         | that precludes being able to experiment with something safely
         | or c) you are not curious enough to educate yourself thoroughly
         | about a substance before trying it out.
         | 
         | HPPD is wildly exaggerated by almost exclusively people that
         | have a vested interest in policing other people's behavior and
         | values. Belief in the dangers of "the ability of any substance
         | to permanently change your brain in a negative and nonspecific
         | way" (a hilarious logically impossible supposition) almost
         | always follow up with "don't do drugs, instead do what I tell
         | you to do. Read my self help book or convert to my religion. My
         | values are the best values."
        
         | photochemsyn wrote:
         | All psychedelics are at least as safe as alcohol, if consumed
         | responsibly. We accept alcohol even though drinking too much at
         | one sitting can kill you and drunk people routinely smash their
         | cars into other cars, etc., so 'safety' is a relative concept.
         | Caution is clearly the best approach.
         | 
         | However, the claim that 'hallucinogens can affect you forever,
         | negatively and never stop' is unsupported. These drugs share a
         | common receptor as the basis of their action, the 5-HTP
         | receptor, which is involved with sensory perception at some low
         | level in the brain. This can result in 'visions' or intensified
         | color perception or numerous other effects (synthesia, etc.)
         | Some people enjoy the experience, others do not. The most
         | important rule for the neophyte experimentalist to follow is
         | 'less is more'.
         | 
         | Personally I found psychedelics immensely therapeutic and a
         | great aid to quitting alcohol, and also of great benefit to my
         | 3D-visualization skills. I'd also note that consumer culture
         | norms ('more is always better') can cause disasters when mixed
         | with psychedelics.
         | 
         | However as I note in another comment, toads are a horrible
         | source of 5-MeO-DMT due to the fact that toads of this type
         | contain a variety of other toxins.
        
       | photochemsyn wrote:
       | The article briefly notes there are other sources of
       | 5-methoxy-N,N-dimethyltryptamine, but it's very brief:
       | 
       | > "Although the most concentrated source of 5-MeO-DMT is the
       | Sonoran Desert toad, the compound is also produced by some plant
       | species in Latin America, where it was traditionally used in
       | snuffs."
       | 
       | The author fails to mention that these toads also contain an
       | additional spectrum of toxins:
       | 
       | https://en.wikipedia.org/wiki/Bufotenin#Toads
       | 
       | The plant-based snuffs containing 5-MeO-DMT, 5-OH-DMT, etc. in
       | contrast are likely far safer, and have a very long history of
       | use, for example the Cebil seed, Anandenanthera colubrina, has
       | been used for thousands of years in the northwestern Argentine
       | region of Puna. That would be a far better source for any
       | therapeutic use than toads.
       | 
       | All in all, not a very well researched article, and overly
       | sensationalist as well.
        
       | mitchbob wrote:
       | Archived: https://archive.ph/xYDlq
        
       | Alex3917 wrote:
       | 5-MeO was extremely well known in 2013. It had already been
       | featured multiple times on every psychedelic podcast, and there
       | were multiple books about it. This whole article seems vaguely
       | fake to me.
        
         | pmoriarty wrote:
         | I'd bet anything that the overwhelming majority of people in
         | the world have never heard of it, and don't listen to
         | psychedelic podcasts either.
        
       | thanatos519 wrote:
       | Highly recommended substance.
       | 
       | See also https://erowid.org/columns/teafaerie/
        
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       (page generated 2022-03-22 23:00 UTC)