[HN Gopher] Turning back the clock: Human skin cells de-aged by ...
___________________________________________________________________
Turning back the clock: Human skin cells de-aged by 30 years in
trial
Author : thunderbong
Score : 125 points
Date : 2022-04-08 18:03 UTC (4 hours ago)
(HTM) web link (news.sky.com)
(TXT) w3m dump (news.sky.com)
| javajosh wrote:
| What does this mean for 29-year-olds?!
| speed_spread wrote:
| You're a tester, aren't you?
| intrasight wrote:
| I've been "in trial" (my marriage) for 30 years, and it's done
| nothing good for my skin. :)
| bloodyplonker22 wrote:
| As I hear more and more sycophants say to tech leaders these
| days: "Thank you for the insights".
| Flatcircle wrote:
| It's surprising that with all the regenerative medicine there's
| nothing too revolutionary? I mean they know fasting helps, along
| with regular exercise etc. But I'm surprised there's not a
| specific supplement or whatever that people agree helps prevent
| aging etc.
|
| or some kind of therapy?
|
| You think there'd be something found in the last 20 years, people
| can agree on, that's been helpful to prevent aging?
|
| is there something like that?
| JoeAltmaier wrote:
| Must be lots of low-hanging fruit in biological treatments.
|
| See, I went camping with the Scouts on Isle Royale, at the end of
| the week we were comparing mosquito bites, averaging about 100
| per. Then a young man Luke said offhand "Mosquitoes don't bite
| me."
|
| And sure enough, his skin was totally clear. I said "Luke, you
| bottle that, you're a millionaire."
| rootusrootus wrote:
| > "Mosquitoes don't bite me."
|
| That seems less likely than "My body doesn't generate a
| histamine response which results in a raised bump at the bite
| location."
| Bellamy wrote:
| You gotta explain this to me. I have no idea what this is about
| but made me laugh.
| JoeAltmaier wrote:
| Whatever gene or skin oil or whatever, Luke has it. I wish I
| could do that. I'd pay cash.
| x1798DE wrote:
| I used to get mosquito bites but I stopped getting them as an
| adult. I realized after a while that my skin stopped reacting
| to them even though the mosquitos were still biting me.
|
| I recently managed to coax one into biting me to test my
| hypothesis. I felt it go into my skin and watched it suck for a
| bit, but it didn't get particularly engorged on it. No mark the
| next day. My son had a bitemark from a non-deliberate bite,
| though.
|
| It seems to be a known phenomenon (though I have no idea why it
| happened to me):
| https://outdoors.stackexchange.com/questions/4310/is-it-poss...
| emerged wrote:
| I think for some of us they literally don't even bite
| anymore. They certainly have preferences in blood type. I
| also have super visible veins as a relatively thin athletic
| person, yet they just seem to have no interest in what's on
| the menu.
|
| It's quite a luxury as someone who spends lots of time on
| trails. But I also feel somehow offended. What's so bad about
| MY blood?
| vmception wrote:
| I believe they all follow trails of your breath, which is
| why they can be reliably found above your bed when inside
|
| So its likely about how that smells
|
| Or other trails toward you, while they probably would enjoy
| your blood in actuality even if they think they're
| detecting something related to how the meal would taste or
| its nutrition levels by proxy
|
| Let me know what you all know!
| smileysteve wrote:
| The secret we had in scouts was to take garlic supplements
| starting a week before. Did great at preventing all sorts of
| bites.
| ccleve wrote:
| Related: https://www.caryinstitute.org/news-insights/media-
| coverage/h...
|
| A man who studies ticks was bitten so many times that his body
| developed antibodies to tick saliva, which are now so powerful
| that they kill the ticks.
| knodi123 wrote:
| > "Luke, you bottle that, you're a millionaire."
|
| Or you get assassinated by Big Mosquito Repellent. I wouldn't
| mess with those people. Stick to inventing a cheap carbon-
| negative replacement for gasoline. Far fewer people angry at
| you upsetting the apple cart.
| MisterBastahrd wrote:
| The little permetherin pads that OFF sells are the best
| things anywhere. I used to live in a suburb of New Orleans
| surrounded by swamps, and those things drive mosquitos away.
| Vastly better than mosquito coils and reusable... just dip
| them in more permetherin solution and they'll last for
| another 4 hours. Someone needs to come up with a system that
| involves a rechargable battery pack and a tiny heating
| element along with a little kit for redipping and storage.
| Sportsmen everywhere would love that product.
| chiefalchemist wrote:
| Fewer? Perhaps. But the depth of those pockets are 100x Big
| Mosquito Repellent.
|
| Put another way, we've been going to war over oil for years.
| One more body on that pile isn't difficult to imagine.
| cellis wrote:
| > 100x Big Mosquito [...]
|
| off by about 3 or 4 orders of magnitude unfortunately
| Nition wrote:
| I think the previous comment was being sarcastic. And sort
| of making a joke that whatever you go after, you're going
| to upset some big corp somewhere.
| elorant wrote:
| My dad is like that. I'll stay on a veranda for five minutes
| wearing short pants, I'll easily get two or three bites. He
| stays for half an hour, he's invisible.
| HNHatesUsers wrote:
| jvanderbot wrote:
| Sign me up. Anyone understand the mechanism enough to discuss
| possible commercial treatments and the timeline?
| JoeAltmaier wrote:
| So far, in a petri dish. So a ways to go..
| adanguyenx wrote:
| There are currently 9 companies working on this, and none are
| in clinical trials yet. The closest is turn.bio, which is
| expected to enter clinical trial late this year. So we're 10+
| years away from seeing this in humans.
|
| Here's a full list:
| https://twitter.com/adanguyenx/status/1512138722556334090
| robocat wrote:
| The constraint on lifetime is cancer, and the majority cause of
| cancer is stem-cell copying errors, from what I have read. The
| whole point of the evolution of stem cells is to reduce the
| number of divisions, so that an organism can even survive.
|
| Any solution that involves stem cells needs to also massively
| reduce errors in DNA replication, otherwise cancer would occur.
| jessaustin wrote:
| Not everyone dies of cancer. Presumably someone who otherwise
| would have died years before will be satisfied to die of the
| cancer that life-extending treatment will have caused.
| robocat wrote:
| The question is how many of our diseases are symptoms of the
| underlying cause of DNA replication failure, directly or
| indirectly? Skin tone is an obvious symptom, and similar
| symptoms occur in critical parts of our system. I think
| telomere length is a measure of replication count since the
| first cell is fertilised, which is why telomere length is a
| measure that is correlated with other negative symptoms of
| aging.
| jessaustin wrote:
| IANAPhysician, but I suspect that at least some of the
| diseases that kill people "early" (I'm thinking heart
| disease?) are not only caused by telomeres.
| teekert wrote:
| Damn I don't want to die with the last thing in my ear being the
| news that they can now reverse aging ..
| ben_w wrote:
| I think this is the actual research paper?:
| https://elifesciences.org/articles/71624
| randcraw wrote:
| Also available here in publication format for Aging Cell:
| https://pubmed.ncbi.nlm.nih.gov/35235716/
| space_fountain wrote:
| So if I'm reading this basically they've shown they can perform
| some of the protocols normally used to turn skill cells back
| into stem cells, but stop at a point that leaves the cells
| behaving more youthfully while still remaining differentiated.
| I'm not a biologist, but at a guess this a long, long way from
| being practical. You'd need to solve problems around cancer and
| actually delivering the therapy to the cells
| its_ethan wrote:
| 01100011 wrote:
| I'll wait for Dr. Charles Brenner to chime in on this. So much
| bullshit in the longevity space these days. I appreciate the
| money flowing into this area of research, but it's putting a
| tremendous pressure to show results when there aren't any, and
| the field seems full of bad science.
| adanguyenx wrote:
| For anyone interested in learning more about partial
| reprogramming, I recently wrote a review article on the current
| state of the art: https://www.adanguyenx.com/blog/partial-
| reprogramming
|
| In short, we're still far away from using it in humans (10+
| years). Currently, all companies working on this are in pre-
| clinical stage, with turn.bio as the closest, expecting to go
| into clinical trials late this year.
|
| This tech is exciting but there are still a lot of limitations:
|
| - Risk of cancer: this technology is based on the work of
| Yamanaka in 2006, who discovered 4 factors that can turn any
| cells into pluripotent stem cells. The work in the OP article
| basically used the same 4 factors, but only _partially_ , so that
| the cells became "younger" without losing their identities (i.e.
| turning into stem cells). This requires understanding the right
| dosage for every cell type so we don't go overboard and turn them
| into dedifferentiated cells which could lead to cancer
|
| - Cell specificity, microenvironment, etc.: reprogramming is
| finicky and the right dosage is dependent on the cell type or the
| environment around the cells. This is important because you have
| to figure out the right dosage for each cell type so as to avoid
| cancer
|
| - Delivery: it's easy to deliver gene therapy to skin cells on a
| dish, not so much to other cell types or organs in the bodies --
| that's why we have not seen very impressive results when this is
| used on live normal mice
| baron816 wrote:
| This is the kind of thing that could possibly be worth
| trillions of dollars. This is something that tens or hundreds
| of millions of people would be willing to pay thousands of
| dollars per year on. Now that we have some sort of evidence
| that it's possible, I wouldn't be surprised if companies threw
| billions of dollars worth of research to make it happen, and
| that could mean getting a product to market sooner rather than
| later.
| fgimenez wrote:
| > I wouldn't be surprised if companies threw billions of
| dollars worth of research to make it happen
|
| Well you are correct. Altos labs (https://altoslabs.com/) is
| basically every "who's who" in science doing this with
| billions of dollars. Including Wolf Reik who is featured in
| the article.
| godelski wrote:
| > This is the kind of thing that could possibly be worth
| trillions of dollars.
|
| I think it would also have a profound impact on society and
| culture. Just how we think about the world differently as our
| lifespan extends. I think that makes a lot of people scared.
|
| Discussing this with others I see a few things people are
| highly concerned with but I'm unsure if they would actually
| happen (as in, I'm uncertain either way). The first is over
| population. The reason I'm not convinced this would be a
| problem is that most western countries have declining
| populations (without immigration) and world wide we've seen
| dramatic reductions in birth rates. World fertility rate is
| about 2.4 (replacement level is 2.0)[0]. The other aspect is
| political. People think change happens on the generation
| level. But I'm not entirely convinced of this either. We can
| take attitudes of same sex-marriage as an example[1][2]. A
| generation is 20 years but our (US) views have changed
| substantially faster than that. Especially if you include
| LGBT[3] (I couldn't find timeline sources for European
| attitudes as easily. Even when looking for specific countries
| and including quotes). I agree that there's a correlation
| with generations, but I'm not convinced it is a principle
| component.
|
| I also wonder how we would think about the future.
| Interesting to be is that a lot of Eastern cultures typically
| are more future oriented in their thinking (as compared to
| typical Western, and I wouldn't say by too much). I would
| expect that longer lifespans would put pressure to be more
| cognizant. Would a crisis that is 100 years out seem as far
| away? Hard to say. We might even have to live with longer
| lifetimes for awhile for that to happen.
|
| All I know is that it would cause big changes. But I'm not
| sure that should stop us from pursuing this technology unless
| we see major pitfalls ahead of time and find that they are
| insurmountable obstacles to overcome. There are clearly
| issues with increased longevity (especially the
| disproportionate use of it) as many dystopian SciFis have
| pointed out. But I think it is better that we at least
| discuss these things in the open since the technology itself
| is no longer in the realm of fantasy but has graduated to the
| realm of possibility. There's too much money being put in
| this technology now for us to not take the questions of the
| impact of it seriously. Even if 10+ years out (even 50+) I
| don't think we should dismiss them. If we're talking about
| culture shifts, maybe one of the best things we could do is
| talk about the impacts (pros/cons and how to use them in fair
| and equitable means) of technologies before they are here.
| Maybe we could have some of that discussion here?
|
| I'm normally not a big CGP Grey person, but I do like this
| video on the Fable of the Dragon Tyrant[4]
|
| [0] https://data.worldbank.org/indicator/SP.DYN.TFRT.IN?locat
| ion...
|
| [1] https://news.gallup.com/poll/350486/record-high-support-
| same...
|
| [2] https://www.pewresearch.org/religion/fact-sheet/changing-
| att...
|
| [3] https://news.gallup.com/poll/1651/gay-lesbian-rights.aspx
|
| [4] https://www.youtube.com/watch?v=cZYNADOHhVY
| makeitdouble wrote:
| > people would be willing to pay thousands of dollars per
| year on.
|
| To note, a huge market segment is are already paying
| thousands of dollars per yer, right now, on skin care (for
| instance the SK-II lineup sells well, and it's 100-250$ a
| bottle)
|
| My semi-cynical view would be that cosmetics companies don't
| have any specific incentive to accelerate the natural march
| of research as long as they stay on the forefront of it and
| have top of the line products. Basically they'd only have
| issues with new players making bolstering entrances and
| disrupting their market with a revolutionary products they're
| not ready to counter.
|
| And the gap between some process being validated, and a
| product with that process being on the market is so huge,
| it's hard to see a non entranched company start investing on
| that without getting noticed.
|
| I'd see it as the same situation as Camera makers when
| digital was coming at the horizon. They only needed to be
| there when the tech is ready, and had no need to bet the farm
| on making it a reality sooner than necessary.
| Wowfunhappy wrote:
| > I'd see it as the same situation as Camera makers when
| digital was coming at the horizon. They only needed to be
| there when the tech is ready, and had no need to bet the
| farm on making it a reality sooner than necessary.
|
| I kind of hate to say it, but isn't this why patents exist?
| The first company to make a product with this tech will
| have exclusivity for 20 years. Shouldn't that be a
| sufficient incentive?
| searchableguy wrote:
| That post is beyond incredible.
|
| Thanks for compiling and condensing all the information into a
| blog post.
| taf2 wrote:
| Perhaps a side effect of this may be a better understanding of
| cancer... or new treatments ...
| relaunched wrote:
| Thank you for the context. Do you have any recommendations as
| to where I can learn more about the state of the art in this
| space?
| nynx wrote:
| Only 10ish years? This is incredible news.
| antihero wrote:
| Shit man I might even be alive by then
| daniel-cussen wrote:
| HahahahHHAHAHAHAHA
|
| I love your username too.
|
| Hey I maybe maybe might be alive by then too! Who knows.
|
| There's life after death.
| amelius wrote:
| Question: is there any skin agent that has been scientifically
| proved to work as advertised?
| kevlened wrote:
| Retinoids like Tretinoin are prescribed for wrinkles if you can
| get past the initial skin irritation [0]
|
| [0] https://www.health.harvard.edu/staying-healthy/do-
| retinoids-...
| nostromo wrote:
| Lots of them, but they are mostly available through
| dermatologists.
|
| Retinol, niacinamide, acid treatments, vitamin c, sun screen,
| botox, microneedling, etc.
| amelius wrote:
| Except for the sun screen, do these have lasting effects, or
| do they only work for the skin cells that a person has at
| this moment (i.e., the effect will be lost in a few months
| when the skin has renewed itself)?
|
| Is there any skin agent that can be used from a relatively
| young age, where the usage will pay off at a later age?
| Again, except for the sun screen.
| jdrc wrote:
| how do young and old cells get along when they coexist in the
| same organism? Will we be able to reprogram specific tissues or
| will we have to rejuvenate the entire primate?
| smm11 wrote:
| Regrowing hair will be the last thing every solved.
| jelliclesfarm wrote:
| I would bet on teeth. Dental services are the biggest money
| makers.
|
| ETA: question.. why aren't we able to regrow teeth and enamel?
| Imagine..if we can reverse cavities and no more root canals
| ever?
| ben_w wrote:
| Nah, too much money in that. Last will be something with little
| obvious outward sign, and I'd guess brain related.
|
| Open question [ELI15]: why can't we tissue culture scalp skin
| for hair, like we can skin in general for treating burns
| victims?
| eric__cartman wrote:
| I don't think it'll be brain related. After all there's no
| use in have a healthy body at an old age if the patient is
| suffering from degenerative illnesses that affect the brain.
| nostromo wrote:
| Actual study: https://pubmed.ncbi.nlm.nih.gov/35235716/
| zarmin wrote:
| I am also hearing buzz about NMN and Resveratrol as anti-aging
| treatment. I would love for someone more qualified than I to
| weigh in.
___________________________________________________________________
(page generated 2022-04-08 23:00 UTC)