[HN Gopher] MS reversed by transplanted immune cells that fight ...
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MS reversed by transplanted immune cells that fight Epstein-Barr
virus
Author : eecc
Score : 69 points
Date : 2022-04-25 09:39 UTC (13 hours ago)
(HTM) web link (www.newscientist.com)
(TXT) w3m dump (www.newscientist.com)
| ortusdux wrote:
| UMass started phase 1 trials of Moderna's mRNA vaccine for
| Epstein-Barr virus this year.
|
| https://www.umassmed.edu/news/news-archives/2022/01/phase-i-...
| giantg2 wrote:
| Paywall. Is there a tl;dr for how adding immune cells targeting a
| virus turns off the autoimmune response?
| neltnerb wrote:
| I also can't get past the paywall, but the virus in question is
| seemingly causally related to developing MS. If the data holds
| up (who knows) it seems like it would imply the latent
| infection is not only triggering but sustaining MS.
| giantg2 wrote:
| That's what I was wondering. But if there is a latent
| infection and the immune system knows it (by attacking the
| myelin), then shouldn't the body already be creating those
| antibodies?
| vmception wrote:
| > I also can't get past the paywall
|
| I mean, there is ...one ...way
| blakesterz wrote:
| There's a bit more details here:
|
| https://www.dailymail.co.uk/health/article-10719181/Multiple...
|
| I think this is the original study?
|
| https://www.nature.com/articles/s41586-022-04432-7
| open-source-ux wrote:
| The New Scientist article is behind a paywall, but this BBC
| article from 14 April discusses the connection between Epstein-
| Barr virus (EBV) and multiple sclerosis. (Note: the article does
| not mention the study in the New Scientist.)
|
| > Studies published this year have convincingly pointed the
| finger at the Epstein-Barr virus.
|
| > "It is very, very strong evidence that this virus is likely to
| be the cause of multiple sclerosis," Prof Gavin Giovannoni, from
| Queen Mary University of London...
|
| > The crucial piece of evidence has come from the US military,
| which takes blood samples from soldiers every two years. These
| are kept in the freezers of the Department of Defense Serum
| Repository and have proven to be a goldmine for research.
|
| > A team at Harvard University went looking through samples from
| 10 million people to establish the connection between Epstein-
| Barr virus (EBV) and multiple sclerosis.
|
| https://www.bbc.co.uk/news/health-61042598
| jiggawatts wrote:
| Systematic biomedical science like this is not done enough.
| Governments should be funding large-scale studies with
| extensive tests taken at regular intervals.
| giantg2 wrote:
| In theory the consent and privacy concerns are preventing
| that. Those concerns are practically non-existent for the
| military.
| wahern wrote:
| Presumably soldiers have the same concerns, they're just
| not presented with the opportunity to refuse.
|
| As for myself, I realize that this is a collective action
| problem partly caused by privacy concerns that (IMO) aren't
| in reality significant enough to outweigh the social
| benefit of participating in data sharing and trials. So
| I've been happy to give consent to 23&Me, Kaiser Medical,
| etc, to collect and use my genetic data. I see it as a
| civic duty, and an easy one at that, at a time when civic
| participation is unconscionably low. I also realize that
| the benefits of the data collected so far by 23&Me and
| Kaiser have been meager, and 23&Me in particular has a
| rather controversial business model, but excessive hand-
| wringing over which organization is most "worthy" of my
| data only adds to the transactional costs of obtaining and
| using the data.
| dmclamb wrote:
| Is this ATA188? The clinical trial is open for that med which
| targets epv infected cells.
| hkt wrote:
| I can't pass the paywall but have the sense that this may
| actually be.. a trial in humans? Can somebody confirm?
| TaupeRanger wrote:
| It is, albeit a small one.
| youeseh wrote:
| How do cures propagate? For example, is there a database of "best
| treatments for disease x"? How much time does it take for
| treatments to become widely available?
| tux3 wrote:
| I think this is the presentation and press release they published
| for this trial:
|
| https://d1io3yog0oux5.cloudfront.net/_d9ae571e8ab35abbf8204c...
|
| https://www.businesswire.com/news/home/20211013005398/en/Ata...
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