[HN Gopher] Specific Brain Cells Linked to Parkinson's Disease
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Specific Brain Cells Linked to Parkinson's Disease
Author : elorant
Score : 73 points
Date : 2022-05-08 13:37 UTC (9 hours ago)
(HTM) web link (www.the-scientist.com)
(TXT) w3m dump (www.the-scientist.com)
| raincom wrote:
| L-Dopa is used to treat Parkison's Disease and encephalitis
| lethargica. Cuba long time ago has developed a technique to
| implant nervous cells deep in the brain to fix Parkison's.
| loceng wrote:
| Any source for more information on this?
| saxonww wrote:
| https://www.magazine.medicaltourism.com/article/in-cuba-
| park... http://www.cirencuba.com/en_US/neurological-
| restoration/neur...
|
| Color me _extremely_ skeptical.
| SemanticStrengh wrote:
| L-Dopa is not a treatment. It's absurd to think it is.. Just
| like stimulants, agonists or dopamin precursors. They are
| necessary palliatives except they simultaneously worsen the
| disease because dopamin kill humans since it oxidize.
| Selegiline is one of the few dopaminergics to actually target
| the problem.
|
| Never heard about the Cuba approach, I'll have to study it
| nautilus12 wrote:
| Does this mean parkinson's is caused by not feeling loved?
| JimtheCoder wrote:
| No...no, it doesn't...
| SemanticStrengh wrote:
| Lol actually I wonder wether chronic lack of affection result
| in specific mental disorders and deficits akd how to maximally
| resorb them (e.g Oxytocin?) But that's a no for parkinson.
| Alex3917 wrote:
| As someone growing pawpaws, I'd be interested to know if this
| also holds for progressive supranuclear palsy.
| SemanticStrengh wrote:
| Neurodegenerative diseases are in fact quite simple to
| partially address. As always oxidative stress and mitochondria
| bioenergetics are the critical factor in the chain leading to
| neural apoptosis. Anyone can get revolutionary results with e.g
| Skq1 which is precisely 1000000 times more potent than NAC
| because it exploit the negative charge of the mitochondria to
| be attracted to it. But even without taking of mitochondria
| targeted antioxidants there exist many potent mitoprotectors,
| see e.g the pictures of saved brain volume in this generic oxys
| rat simulation (accelerated Aging)
| https://www.researchgate.net/publication/221738761_Evaluatio...
| As I often say, the times it takes for scientific knowledge to
| be used by practitioners is often infinity. In fact that is the
| general case. We will have to wait for more people to suffer
| and die because you know running clinical trials is such a 20th
| century thing
| Alex3917 wrote:
| Would Skq1 (or NAC) likely ameliorate mitochondrial damage
| when eating foods with acetogenins? This is the hypothesized
| mechanism of action:
|
| https://pubmed.ncbi.nlm.nih.gov/23180140/
|
| https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6672878/
| Flatcircle wrote:
| Parkinson's disease seems to the disease that scientists are
| primed to make a breakthrough on soon. The side benefit is
| greater understanding of the brain.
| SemanticStrengh wrote:
| https://pubmed.ncbi.nlm.nih.gov/29486701/
| srean wrote:
| Hope that comes to fruition. Any particular reason for
| optimism. Not challenging the optimism, but trying to partake
| in it.
| criddell wrote:
| My dad died earlier this year from complications due to lewy
| body dementia which (AFAIK) is related to Parkinson's. It's a
| truly awful way for a person to spend their last years. I get
| why Robin Williams took control of his end.
|
| Seeing as there is likely a genetics component to these
| diseases, I'm really rooting for these scientists.
| SemanticStrengh wrote:
| Parkinson is essentially a mysterious oversensitization to
| dopamine autoxidation in the dopaminergics neurons mitochondria
| membrane. Parkinson is therefore a solved problem.
| https://pubmed.ncbi.nlm.nih.gov/29486701/
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