[HN Gopher] Missing Link Between Alzheimer's and Vascular Diseas...
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Missing Link Between Alzheimer's and Vascular Disease Found?
Author : geox
Score : 90 points
Date : 2022-05-25 21:10 UTC (1 days ago)
(HTM) web link (www.cuimc.columbia.edu)
(TXT) w3m dump (www.cuimc.columbia.edu)
| rileyphone wrote:
| I would also point to the effects of lipid peroxidation, of which
| it sounds like the "toxic proteins" at the root of the matter may
| be a product of. In any case, I've gone back to using normal
| deodorant.
| mjevans wrote:
| I can't stand perfumes and in the past I've had reactions to
| antiperspirants. So: Daily shower with soap and water. Ideally
| after any workout (so the closer to a blue collar day I've had
| the later the shower).
| treeman79 wrote:
| Migraines and or autoimmune issues?
| boppo1 wrote:
| Seconding your confidence in normal deoderant.
| jtbayly wrote:
| Can you point me to anything to read on why you'd want to do
| that?
| aaaaaaaaata wrote:
| Aluminum, and other metals, aren't good to stuff into the
| holes in your skin.
|
| Source: sense
| ErikCorry wrote:
| If you are looking for a mechanism for why a healthy vascular
| system protects against alzheimers there's a pretty good
| candidate here.
|
| https://www.youtube.com/watch?v=He6HMnMbxAc#t=15m09s
|
| My TL;DW is:
|
| * Most neurodegenerative diseases are associated with a buildup
| of proteins.
|
| * The brain does not have the lymphatic system which cleans waste
| proteins out of other organs.
|
| * Instead it has cerebro-spinal fluid, which may have some of the
| same function.
|
| * There's no "CSF-heart" that pumps CSF around the brain.
|
| * Instead the pulse in the arteries has an indirect pumping
| effect because the arteries in the brain are embedded in CSF.
|
| * Therefore having a healthy pulse/blood circulation serves to
| help clean the brain.
|
| * But only when you sleep, so don't skimp on the sleep time HN-
| readers!
| [deleted]
| pedalpete wrote:
| As a sleep-tech founder, I completely agree with the "don't
| skimp on sleep" part.
|
| * The brain doesn't work on the lymphatic system, but on the
| glymphatic system [1] * The glymphatic clearance mostly occurs
| in slow wave sleep, and linked to slow oscillations (just
| happens to be the function of sleep we are focusing on at
| https://soundmind.co) [2]
|
| 1 - https://neuronline.sfn.org/scientific-
| research/understanding....
|
| 2- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698404/#:~:tex
| ....
| steve76 wrote:
| echelon wrote:
| The disease may have multiple causes. I wouldn't at all be
| surprised if some other area of health decline gives rise to the
| disease state. A number of investigators are looking into
| vascular health, for instance.
|
| Here's an article I posted a while back that implicates liver
| health and was able to mechanistically induce the disease in rat
| models:
|
| https://news.ycombinator.com/item?id=29393937
| JPLeRouzic wrote:
| The same team is now launching a phase II study to test
| Probucol:
|
| https://pubmed.ncbi.nlm.nih.gov/35190446/
|
| _" recent studies suggest that increased plasma concentrations
| of lipoprotein-Ab compromise the brain microvasculature,
| resulting in extravasation and retention of the lipoprotein-Ab
| moiety. The latter results in an inflammatory response and
| neurodegeneration ensues. Probucol, a historic cholesterol-
| lowering drug, has been shown in murine models to suppress
| lipoprotein-Ab secretion, concomitant with maintaining blood-
| brain-barrier function, suppressing neurovascular inflammation
| and supporting cognitive function."_
| phnofive wrote:
| > cerebrovascular disease, by interacting with FMNL2, reduces the
| clearance of amyloid in the brain.
|
| Hopefully, this sets the stage for a targeted therapy which could
| finally test the amyloid beta theory:
|
| "When drugs that have been shown to reduce amyloid-b are given to
| people who are expected to develop Alzheimer's disease and they
| still don't work, says Murphy, "that would absolutely convince me
| we've been misled and it has to be wrong"."
|
| (From https://www.nature.com/articles/d41586-018-05719-4 )
| pedalpete wrote:
| The link through a gene is interesting, but that may not be the
| only link.
|
| We work in the sleep space at https://soundmind.co, specifically
| working on increasing the effectiveness of deep sleep through
| stimulating slow-wave oscillations.
|
| Current research in the stimulation we are using is looking at
| the impact of stimulating SWOs on diabetes, as well as the impact
| on clearing of amyloid plaques.
|
| There is also a relationship between cortisol and hypertension,
| cortisol is also improved through proper sleep, and the
| stimulation we are working with.
|
| I'm not saying altering genes is not the solution, but how many
| people have the FML2 gene, and this research was on zebrafish and
| mice. The research we are have implemented is in people.
| msie wrote:
| Did someone try to remove amyloid plaque from the brain of an
| Alzheimer's patient and see what happens? I've heard of studies
| that disproved the amyloid theory.
| JPLeRouzic wrote:
| There were at least 17 unsuccessful clinical trials (phase II
| and III) that tried to do that:
|
| https://clinicaltrials.gov/ct2/results?cond=Alzheimer+Diseas...
| pedalpete wrote:
| No idea why you are being downvoted.
|
| Yes, removing the plaque has been tried and has so far been
| unsuccessful at improving Alzheimer's.
|
| The way I picture it (and I'm not an expert, still learning
| about this stuff myself) is to look at amyloid plaque as a clog
| in a pipe between nerve cells. Now picture the blockage putting
| a crack in the pipe. You can clear the blockage, but you still
| have a cracked pipe, so anything you send down the pipe will
| spill out.
|
| We have no way of fixing the broken pipe, so we must prevent
| the build up of the plaque in the first place.
| phnofive wrote:
| As far as I can tell, no therapy has been successful in
| removing or preventing specifically either or both of beta and
| tau amyloid without secondary effects that washed out any
| prospective benefit.
|
| The amyloid hypothesis is of course disputed, but largely
| because stopping whatever causes plaque formations could
| prevent or lessen the impact of Alzheimer's has proven so
| difficult and would ultimately provide little benefit to those
| already suffering with the disease.
| phnofive wrote:
| The closest we've come to removing plaques, I should mention,
| is aducanumab, which does seem to reduce beta, but has little
| to no effect on even slowing cognitive decline, much less
| stopping or reversing it. Nonetheless, the FDA has approved
| this drug, paving the way for Biogen to charge $56K a year
| for the treatment.
|
| https://n.neurology.org/content/98/15/619
| xeromal wrote:
| https://en.wikipedia.org/wiki/Betteridge%27s_law_of_headline...
|
| The question mark always makes me extra suspect of the headline.
| sokoloff wrote:
| The general pattern holds, but to be fair, this one seems like
| it could best be answered with "Maybe".
| BrianOnHN wrote:
| > "Maybe."
|
| Aka "probably 'no' without further evidence."
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