[HN Gopher] Emmanuel Mignot wins Breakthrough Prize for discover... ___________________________________________________________________ Emmanuel Mignot wins Breakthrough Prize for discovering cause of narcolepsy Author : crescit_eundo Score : 32 points Date : 2022-09-23 16:38 UTC (6 hours ago) (HTM) web link (med.stanford.edu) (TXT) w3m dump (med.stanford.edu) | JoeAltmaier wrote: | So, can I take an orexin pill and stay awake? The obvious | question, not addressed by the article. | | Googling, I see only dire reviews of orexin tablets, usually due | to the other ingredients. What gives? | | I have episodes of dire fatigue, and a way out of that mess would | be very welcome. | archi42 wrote: | Judging only by that article, I'd say: Not generally. Its | described as inhibiting REM sleep, not sleep or sleepiness in | general. | | Ask a doctor to help you figure this out. Wild guess, as a | random layperson on the internet with no formal qualification: | Could be lack of vitamins (E, D3, B5 or B6) or a melatonin | insufficiency or a irregular sleep schedule or due to | psychological causes. Alcohol and other drugs have quite the | impact (especially in sleep quality). Or a combination or | something completely different; it's like asking "My program is | slow, what can I do?" ;-) | googlryas wrote: | Probably not, because you already have a functioning orexin | system, and presumably whatever modulates that would just | module the extra orexin as well. And anyways, who knows if | consumed orexin even makes it out of your gut and past the | blood-brain barrier. | | You could just take modafinil if you wanted to stay awake. | sorethescore wrote: | This helps explain why Cannabidiol may help with excessive | sleepiness in hypocretindeficient rats. | | https://pubmed.ncbi.nlm.nih.gov/31642794/ ___________________________________________________________________ (page generated 2022-09-23 23:00 UTC)