[HN Gopher] Cancer vaccines: the next immunotherapy frontier ___________________________________________________________________ Cancer vaccines: the next immunotherapy frontier Author : CharlesW Score : 76 points Date : 2022-11-24 19:25 UTC (3 hours ago) (HTM) web link (www.nature.com) (TXT) w3m dump (www.nature.com) | adamredwoods wrote: | >> Effective vaccines are likely to be combined with other | immunostimulatory approaches including adoptive T cell therapies | and to be deployed in postsurgical adjuvant settings to prevent | relapses. | | Mostly post-surgical, but I wouldn't be surprised if eventually | used for metastatic as well. Good luck to all involved. | mcbain wrote: | Immunotherapy is also being trialled as a neoadjuvant with | promising results. | [deleted] | hanselot wrote: | SketchySeaBeast wrote: | Yes, if you're in close proximity with someone with cancer you | will not get their cancer after getting the vaccine. Before | too. | peteradio wrote: | That's actually 0% effective. | mfcl wrote: | No, but they will decrease the severity of the disease and you | will be more likely to survive, maybe. Also, know that a shot | will provoke a small tumor that should go away by itself after | a few days. | christkv wrote: | These are therapeutic vaccines customised to each case. My father | is heavily involved with this working on one targeting brain | cancers. | | It's not a silver bullet but it will help if the patient responds | and the cancer is not aggressive enough to kill the patient | before the immune system is reactivated to fight the cancer | successfully. | | If it does work it looks very likely there will be no relapse. | Buttons840 wrote: | A medicine that sometimes stops a bad thing from happening is | hard for people to appreciate, because if it works you'll never | know it, and it might have some side effects. | | We need to improve public education about why we believe these | medicines work. I want to see the studies presented on social | media: "We gave 30,000 people this drug and you won't believe | what happened!" Less censoring people and more presenting the | studies in a way people can understand. Less appealing to | authority and more appealing to observations; yes, you observed | your 2 relatives, and I observed 30,000 people, judge for | yourself which is more persuasive. | | Most people aren't going to read your 3 paragraph abstract, let | alone the the full paper. You have to tell them the observations | in a few sentences, preferably with minimal added interpretation. | anonporridge wrote: | https://en.wikipedia.org/wiki/Preparedness_paradox | ajsnigrutin wrote: | > I want to see the studies presented on social media: "We gave | 30,000 people this drug and you won't believe what happened!" | | We've had two years of that... get vaccinated and you won't get | it, also get vaccinated and you won't get your grandparents | ill! | | Somehow all the censoring was done on people who didn't believe | these claims. | bamboozled wrote: | To be fair we also now have stories that some people were | injured from the vaccines ? | mig39 wrote: | I guess we were hearing different messages? | | I thought the vaccine message was "get vaccinated so you | won't die when you get it." | dimitrios1 wrote: | That was the updated messaging from DNC HQ because the | first one was clearly wrong. | vinyl7 wrote: | It depended in the day of the week. Sometimes it was slow | the spread, sometimes it was to prevent getting covid, | other times it was to reduce the severity if you got it. | sdiacom wrote: | I think a big part of it is that COVID has become an | attention point in our lives, it entirely dominated the | media cycle for months. There's something everyone wants | to hear about and _we just don't know that much about | it_, so the media increasingly plays telephone with | itself in an attempt to report anything. | | Various people gave their hopefully somewhat informed | opinion at the time to different members of the media, | who reported on it with different levels of accuracy, | attributing often undue levels of confidence to it. And | that quickly mutated into "the media's trusted sources | can confirm that the experts definitely know the vaccine | will have exactly these effects and will be effective for | these specific cases" | | I think it's worth questioning what influence there was | in which narratives did or didn't get pushed, but I also | think it's worth keeping in mind that the media is also | just... fallible. | Buttons840 wrote: | My point was that should not be the message. Promising | people the vaccine will save them is a false hope, people | look around and find someone who got vaccinated but still | died and now the trust is broken. | | Instead, tell people about the trial control group vs | treatment group, let people see that there is risk on both | sides, but that the treatment group was ultimately better | off. Use minimal interpretation. I'd like to see so much | focus on the trial outcomes that the number of people who | died in both groups is a household fact that families talk | about. | thinkmcfly wrote: | Just give angry religious zealots a crash course in | genetics and epidemiology, its so easy! Why isn't the CDC | doing this? /s | Buttons840 wrote: | Presumably more people are getting sick and dying in the | control group. People can understand "more people dead" | even without taking a genetics course. | jfengel wrote: | You'd be surprised. The data is overwhelming, and this | group of highly trained techies still contains many who | call the COVID vaccines "clot shot". | | There is nothing so obvious that people cannot fail to | understand if sufficiently motivated. | throwaway0x7E6 wrote: | because there were a lot of different, often contradicting | messages | ajsnigrutin wrote: | > DR. ROCHELLE WALENSKY, CDC DIRECTOR | | > And we have -- we can kind of almost see the end. We`re | vaccinating so very fast, our data from the CDC today | suggests, you know, that vaccinated people do not carry the | virus, don`t get sick, and that it`s not just in the | clinical trials but it`s also in real world data. | | https://web.archive.org/web/20210402002315/https://www.msnb | c... | Krssst wrote: | In April 2021 the original strain was still dominent if I | record well, against which the vaccines were much more | effective against getting COVID. | thelittleone wrote: | Do you have a source for this? | jostmey wrote: | Cancer vaccines would be given to someone with cancer. These | vaccines would not be preventative | bitxbitxbitcoin wrote: | That there is confusion just emphasizes that the term | therapeutic vaccine needs more education around it. | | When I think of vaccines, I think of something that's | preventative - regardless of the mechanism. Even the coming | "Lyme Disease" vaccine is still preventative though it's more | of a tick bite vaccine. | | Someone please school me. | | Why is it a therapeutic vaccine - what's wrong with calling | it a treatment? | svara wrote: | It's a vaccine because it doesn't work on the cancer | directly but rather teaches your immune system to attack | the cancer. | mig39 wrote: | Giving HPV vaccines to teens (including boys) seems to be | preventative. | bawolff wrote: | Which is not the type of vaccine the article is about. | the-printer wrote: | > "We gave 30,000 people this drug and you won't believe what | happened!" | | Lab coat Clickbait? | pydry wrote: | >Less appealing to authority and more appealing to observations | | Antivaxxers aren't scientifically inclined skeptics who will | change their minds if fed more objective, impartial evidence. ___________________________________________________________________ (page generated 2022-11-24 23:00 UTC)