[HN Gopher] The antimicrobial resistance crisis needs action now ___________________________________________________________________ The antimicrobial resistance crisis needs action now Author : ikbdsk Score : 37 points Date : 2022-12-25 21:41 UTC (1 hours ago) (HTM) web link (journals.plos.org) (TXT) w3m dump (journals.plos.org) | mustafabisic1 wrote: | I bet all those antibiotics prescribed for covid didn't help as | well. That was happening on a massive scale in my country | eschaton wrote: | Why were doctors prescribing antibiotics for COVID?! | pram wrote: | I think some of those 'kits' countries were distributing to | people early-on (before the vaccine) contained stuff like | doxycycline. | AustinDev wrote: | Secondary infections of bacterial pneumonia were common with | COVID iirc. | dopylitty wrote: | A study just came out showing that co-infections weren't | common [0] | | 0: https://academic.oup.com/ofid/article/9/Supplement_2/ofa | c492... | anbende wrote: | When I was in Peru, they kind of prescribed antibiotics for | everything. Persistent cold? Antibiotics. Like that. | | Source: lived there with Peruvian partner for 18 months. | getoj wrote: | Same deal in Japan, every time my kid has a cold her mum | takes her to the doctor and comes home with antibiotics. | When I get a cold the first thing anyone asks is whether I | went to the doctor yet. For what? "Medicine." | silisili wrote: | Even in the US, pre COVID, every time I went to to doctor with | a bad cold/flu, they'd just give you a Z Pak(antibiotics) and | say...if it's bacterial this will kill it, if it's viral it'll | work itself out. So I can definitely see how they're | overprescribed. | seunosewa wrote: | They are cheaper than the tests to determine whether they're | needed. | zw7 wrote: | Z-pak (azithromycin) is not the recommended antibiotic for | bacterial sinus infections nor pneumonia (common bacterial | infections associated with upper respiratory infections) per | most guidelines. Interestingly though, it does have anti- | inflammatory properties in addition to its main antibacterial | effect. When I see a clinician prescribe a Z-pak (urgent | cares are notorious for having a low threshold for | prescribing Z-paks), part of me wonders if it's to avoid | overuse and potential resistance to appropriate antibiotics | and placate patients who want a quick fix. | | The downside is that since they feel better from the anti- | inflammatory effect, its supports their initial thought they | needed antibiotics and in the future will always think they | need them, even though they very likely only have a viral | infection. | xahrepap wrote: | I'm still amazed at how many people are able to get their dr to | prescribe them antibiotics just by asking. | | I knew someone who had a cold and said "but I asked my Dr for | some antibiotics and I'm taking DayQuil so I'll be better in a | day or two" | | Im always left open mouthed gaping at them like... even if YOU | don't know. But at least the Dr should ... | YLYvYkHeB2NRNT wrote: | US doctors have to do everything to keep patients happy. CMS | rules their careers with satisfaction metrics. Hospital | ADMINS really push it on them. Complaints lead to job loss. | therusskiy wrote: | My wife has just got better from a case of pneumonia that | developed rapidly within several hours. If not for antibiotics... | | We are back to medieval times if antibiotics stop working. | throwaway0x7E6 wrote: | >if | | when | DrJohanson wrote: | [dead] | zosima wrote: | I am quite sure, that if a sufficient bounty was given out for | developing new kinds of antimicrobials, they'd be developed in no | time. | | The problem is that cost and risk of development and trials is | too large for the current rewards, and hence there is very little | new antimicrobials being developed. There are very many promising | leads though, and either making development cheaper (by requiring | smaller or fewer clinical trials) or ensuring good prices or | bounties for successful development would likely create a | plethora of antimicrobials in a quite short time frame. | lofatdairy wrote: | This is actually completely right. I believe there's some | policy in the works in the US after talking to a friend who's | doing some consulting work to help align the Cost-Benefit side | of antimicrobial development. | | I can't say if there's a plethora of drugs just waiting to be | released after CT requirements are lowered, but definitely | there is less of an R&D incentive currently because pts who | take antimicrobials only take them temporarily and cases where | you need an advanced antimicrobial to deal with an AMR case are | thankfully uncommon. | | Edit: I think this is the specific bill: | https://www.congress.gov/bill/117th-congress/house-bill/3932... | pazimzadeh wrote: | There are alternatives to antimicrobials being developed. Instead | of directly killing bacteria and therefore putting selective | pressure on them, you can prevent their ability to bind to host | surfaces and wash them away. The best example is probably | mannosides, which are high affinity mannose analogues currently | in clinical trial in humans for UTI treatment. | | https://pubmed.ncbi.nlm.nih.gov/22089451/ | SonOfLilit wrote: | How is this putting less selection pressure on them? | nextos wrote: | We need more research in bacteriophages. They can be engineered | to avoid any resistance, and they can replace antibiotics in all | use cases. | | Besides, they are much more selective. Getting antibiotics when | needed is OK, but they can lead to other health complications | down the road. ___________________________________________________________________ (page generated 2022-12-25 23:00 UTC)