[HN Gopher] Diagnosing cancer by profiling the immune system ___________________________________________________________________ Diagnosing cancer by profiling the immune system Author : jostmey Score : 41 points Date : 2023-04-20 20:50 UTC (2 hours ago) (HTM) web link (github.com) (TXT) w3m dump (github.com) | jjtheblunt wrote: | This was a plot twist in an episode of CSI:Miami several years | ago. | | Identical twins were implicated in a crime for which DNA was left | behind, and they thought they were safe by being twins. But they | also had distinct T cell (etc) signatures and that solved the | case. | ajb wrote: | Getting a readout of the immune system sounds like a huge | advance. I'm a little surprised to first hear about it as a | cancer diagnosis tool rather than as an autoimmune disease | diagnosis tool | nextos wrote: | I've been working on this area for quite long, and I think it's | just a matter of time it becomes huge. Right now, a major | roadblock is that paired RNA-seq, which also gives paired TCR | alpha and beta chain data, is too expensive compared to bulk | TCR-seq. The latter has limited resolution and more technical | noise. | | However, Microsoft Research has a preprint that employs bulk | TCR-seq where they are able to detect Lyme, which was | particularly difficult using antibody assays and often mistaken | for multiple sclerosis: | https://www.medrxiv.org/content/10.1101/2021.07.30.21261353v... | | AFAIK, there are a few startups in stealth mode and non-stealth | mode collecting big repertoire datasets. In those datasets, one | can even measure the effects of vaccinations that occurred | decades ago. | jostmey wrote: | Trying to raise money for something like that! | penny11k wrote: | Regarding cancer treatment, wonder how much more advancement did | they get on that polio treatment. Where lot of test subjects with | a brain tumor was treated by injecting polio virus into them. | | https://www.uhhospitals.org/blog/articles/2020/01/clinical-t... | rosywoozlechan wrote: | All the really interesting stuff is always written in python, | (AI, science research stuff like this). Here I am and I haven't | written any python in over 10 years now, ever since go overtook | python after it's v3 debacle. ___________________________________________________________________ (page generated 2023-04-20 23:00 UTC)