[HN Gopher] Clinical trial of mRNA universal influenza vaccine c... ___________________________________________________________________ Clinical trial of mRNA universal influenza vaccine candidate begins Author : geox Score : 60 points Date : 2023-05-15 20:42 UTC (2 hours ago) (HTM) web link (www.nih.gov) (TXT) w3m dump (www.nih.gov) | smallmouth wrote: | [flagged] | maxerickson wrote: | Yeah, that's literally the point of the study, recruiting a | small group of people to go first and see how it goes. | JohnFen wrote: | I was hit hard by my first covid booster, and every traditional | flu shot I've ever had has made me as sick as I've been from the | flu itself (which is why I don't get flu shots anymore). | | I wonder if an mRNA flu shot would be twice as bad, or better, in | terms of impact on my health? | weaksauce wrote: | there's a lot of people that get a bad cold and think it's the | flu. the actual flu can be insanely debilitating. (some get a | lighter infectious dose and they escape a real bad case though) | valianteffort wrote: | I got covid in early 2021, and got the J&J shot at the end of | the year. In both cases I had a fever, except the J&J lasted | two days vs actual covid that lasted one. I have not been sick | with covid since then. | | I have never had a flu shot, and also never had the flu in over | thirty years. I just don't see why I should get myself sick to | risk not getting sick(er)? Anytime I mention this people call | me antivax. | | I was never skeptical about taking shots until the way the | government handled covid. There is no chance I will take | something that hasn't been thoroughly tested and proven to | actually work the way our standard immunization schedule does. | Someone1234 wrote: | > which is why I don't get flu shots anymore | | You could try one of the non-egg based vaccines and see if that | helps with your side effects for example Flublok | Quadrivalent[0] | | [0] https://www.cdc.gov/flu/prevent/qa_flublok-vaccine.htm | JohnFen wrote: | Yeah, I might. Friends have suggested such alternatives to me | as well. I'm not opposed, but I also am not highly motivated | to try, because I haven't actually come down with the flu | since my children grew up and moved out a couple of decades | ago. | theGnuMe wrote: | That's why the do these studies. But more seriously ask your | doctor. | [deleted] | JoeAltmaier wrote: | It's funny, flu shots can make you feel sick. That's your body | reacting and your immune system adjusting. | | But compared to _actually getting the flu_ , you get to skip | the part where the disease eats at your organs and rips through | your body destroying things. | | So yes, you may feel sick after a flu shot. But I consider the | alternative makes it worthwhile. | Herring wrote: | [flagged] | pil4rin wrote: | "A universal influenza vaccine would be a major public health | achievement and could eliminate the need for both annual | development of seasonal influenza vaccines, as well as the need | for patients to get a flu shot each year," | | So, one shot and no more flu? ever? | dannyw wrote: | *Until the flu variants mutate to be more vaccine resistant. | CyberDildonics wrote: | I'm pretty sure that's already the problem. | jewayne wrote: | Viruses don't "resist" vaccines, because vaccines don't act | directly against viruses. We're not talking about antibiotics | here. | francisduvivier wrote: | Well that's how they make it sound, but they actually just said | not annually. | | But it doesn't make a lot of sense to me since influenza will | be mutating to escape the immune response. | weaksauce wrote: | > But it doesn't make a lot of sense to me since influenza | will be mutating to escape the immune response. | | unless there is sufficient number of people that take it and | it works well enough to eradicate it like say polio was. | Someone1234 wrote: | Unfortunately the only real answer to that is: We don't have | the data on either question yet. | | Hemagglutinin has 18 subtypes, this style of vaccines are | targeting them all, but we don't have data on how complete | coverage will be (and or how common a mutation exists that | could allow partial of complete circumvention). | | We also don't have data on how long before the immune system | needs to be retrained (aka re-vaccinated). | | This isn't to foo-foo this vaccine; this legitimately could | create a "universal" vaccine that could last years with only | some minor reformulation every so often to catch new sub-types | of HA. | | TL;DR: This thing could be great. We'll need more data to know. | jewayne wrote: | No. The goal is one shot that doesn't have to change from year | to year. We already know that the flu doesn't have a long | enough incubation period for humans to gain lifetime immunity. | Which means that even if this vaccine works and is effective | against all flu viruses past, present, and future, it will | probably still be a good idea to get a universal flu booster | every year. | amluto wrote: | I'm not convinced that mRNA vaccines as they currently exist | are well suited for repeated boosting against the same virus. | See, for example: | | https://www.science.org/doi/10.1126/sciimmunol.adg7327 | | And also the quite disappointing efficacy that the CDC | reports for repeated Covid boosters. | viraptor wrote: | "no annual" doesn't mean "just one". Lots of vaccines wear off | after a few years and need a booster. (There's lots of people | who don't know about it / don't get reminded and never get | them) | ortusdux wrote: | I'm not a doctor/immunologist, but as I understand it the flu | shot targets 4-5 different strains. Each year they have to ID | what they believe will be this season's leading strains, and | then blend together the mix ahead of time. This takes a lot of | work, and sometimes they get it wrong and 8th most common | strain surges and it's a scramble to save lives. | | So I think the promise of a 'universal' vaccine means one that | would target all/most strains. | ptdn wrote: | It does mention a hope for long-term durable immune response, | but the point about being able to pre-emptively roll out a | universal vaccine is probably more important. This would lower | the total rate of infections by a lot and allow people to | reliably get a useful vaccine without waiting to see which | strains are dominant that year. (Also, an immune response | doesn't mean complete immunity. mRNA Covid vaccines don't | prevent you from getting Covid. It lowers the severity and | spread.) | mc32 wrote: | That would be nice... recent history would tell us those claims | are wildly optimistic. | viraptor wrote: | Good to keep in mind, but also those are slightly different | cases. One is a low number of very recent strains that | mutated quickly, the other one is a large number of | established strains we've been researching for ages. | maxerickson wrote: | It's easy to nay say, the COVID mRNA vaccines were great, | it's nuts that people hold them to some imagined standard. | | Like a single dose is less effective than multiple doses, | especially if later doses are targeted at the circulating | virus, but the first shot has an enormous protective effect, | alerting the immune system to the type of virus. | adastra22 wrote: | Only if you vaccinate all the wild animals that carry it too. | m3kw9 wrote: | [flagged] | ortusdux wrote: | I wonder if this would be a candidate for nasal delivery? | CyberDildonics wrote: | Why would it be and why would that be important if it's | something you need once every few years? ___________________________________________________________________ (page generated 2023-05-15 23:00 UTC)