[HN Gopher] Flies neglect food and endure shocks to seek a dopam...
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Flies neglect food and endure shocks to seek a dopamine reward
Author : gmays
Score : 46 points
Date : 2023-10-31 17:33 UTC (5 hours ago)
(HTM) web link (www.dpag.ox.ac.uk)
(TXT) w3m dump (www.dpag.ox.ac.uk)
| thedigitalone wrote:
| I misread the title as 'files' and was very confused for a
| moment.
| VierScar wrote:
| I believe this is very common, with rats starving themselves to
| death next to food while able to get dopamine. Cats too.
|
| As I understand it, it's a reward signal that becomes an
| "expected reward in future" signal with some learning.
|
| Been reading an interesting book that touches on this, AI and
| evolution called A Brief History of Intelligence.
| Podgajski wrote:
| It's not the dopamine, it's the GABA that the dopamine releases
| that they are really craving.
|
| People don't get addicted to dopamine, they get addicted to GABA.
|
| https://pubmed.ncbi.nlm.nih.gov/23034651/#:~:text=GABA%20is%....
| fragmede wrote:
| If that were true, I'd expect gabapentin, which is a GABA
| analogue, to be far more popular. I'm guessing it isn't as
| simple as that though.
| Podgajski wrote:
| It is popular. The street name for gabapentin and Pregabalin
| is "Bud". It is addictive.
|
| https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404313/
|
| https://www.vice.com/en/article/gyz49y/the-strange-drug-
| kill...
|
| GABA analogues are just metabolized a lot in the gut and do
| not get into the brain as easily as triggering the release
| via dopamine and serotonin agonists.
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