[HN Gopher] One sleepless night can rapidly reverse depression f...
       ___________________________________________________________________
        
       One sleepless night can rapidly reverse depression for several days
       in mice
        
       Author : clouddrover
       Score  : 220 points
       Date   : 2023-11-02 20:43 UTC (2 hours ago)
        
 (HTM) web link (news.northwestern.edu)
 (TXT) w3m dump (news.northwestern.edu)
        
       | ge96 wrote:
       | What's your secret? I'm always manic
        
       | not-my-account wrote:
       | Queue people blogging about their monthly "sleep fast" for
       | optimized mood and focus.
        
         | ge96 wrote:
         | For me it's forcing myself to only sleep 6 hours so I get
         | through my day with loud music, caffeine and self hate.
        
         | catchnear4321 wrote:
         | plenty of people force themselves to stay up all night once in
         | a blue moon for mental health reasons, all without blogging
         | about it.
        
           | nehal3m wrote:
           | Really, this is a thing? I've never heard about it.
           | 
           | I used to stay up late sometimes when I was younger, but that
           | was because the world went to sleep and I felt at peace doing
           | my own thing. It wasn't because I was trying to feel better
           | the next day, in fact it tended to screw the next day up.
        
             | Obscurity4340 wrote:
             | There's something to it. Also with dissociatives. Something
             | about these substances or practices can help "reset" you
             | like pulling the plug on an electrical device and forcing
             | it to reboot with refreshed state
        
               | catchnear4321 wrote:
               | pushing the system to a point where it flips over to a
               | different operating mode. overheating your phone until it
               | reboots. ctrl+alt+del.
               | 
               | it usually feels a little precarious. maybe not for
               | others. but there's definitely an aspect of futzing with
               | your mortality, with your primary systems.
               | 
               | but if it works...
        
               | Obscurity4340 wrote:
               | I think there's some shared aspect of "too many
               | background processes running--must reboot in safe mode!".
               | Its also a bit impairing to the point you're not exactly
               | "you" so you have a better chance of viewing things with
               | different eyes which might be all it takes for someone to
               | get to that point where they are aware and able to act on
               | incremental changes in-line with that which appears in
               | such a state
        
             | catchnear4321 wrote:
             | the second day, you slept poorly, mistakes don't matter.
             | and that's just an added bonus on top of the biological
             | changes.
             | 
             | it is more about the third day.
             | 
             | not surprising to not hear about it. it isn't permanent, so
             | catching a "practitioner" in the right moment to bring up
             | the topic, while being in the right moment, is unlikely.
             | 
             | plus, bodies are weird, and laws are scary. should everyone
             | do this? probably not, and probably for differing reasons.
        
           | ghostie_plz wrote:
           | Just sharing an anecdote - I noticed this effect in college
           | for myself. Since then i do one or two all nighters a year
           | specifically for this
        
           | penjelly wrote:
           | this runs counter to what i understood, we had allnighters
           | for productivity or bonding among friends. But i never
           | wouldve guessed not sleeping for a night would make you feel
           | _better_ under some circumstances, always figured the health
           | drawbacks would worsen the issue
        
         | ngngngng wrote:
         | That's exactly where my brain went. Now I need a Huberman Labs
         | podcast telling me how I can incorporate this with my
         | supplements and cold showers to achieve my maximum potential.
        
       | shikshake wrote:
       | This must be why new parents always seem so bubbly and happy!
       | 
       | But seriously, that's very interesting and explains what I've
       | experienced. I've been in a depression since quitting my phd a
       | couple months ago and not having a direction in life, but
       | whenever I have trouble sleeping I end up feeling better the next
       | day. Maybe I'll trying utilizing it to get my portfolio looking
       | better.
        
         | fsloth wrote:
         | I went several years more or less depressed and observed this
         | phenomenon and utilized it. Night of Kerbal Space Program and
         | next day the world is much better. For a while. Also, a lot
         | fuzzier. And I couldn't code very well (just good enough to do
         | my job so everyone was happy but I could _feel_ slipping).
         | 
         | Therapy and SSRI:s worked much better in the end.
         | 
         | But, for sure in a pinch it does alleviate unbearable darkness.
         | The problem is it gives some, and takes a god damn lot -
         | especially when entering middle age, when you (or I at least)
         | can't shrug off sleep debt as easily.
         | 
         | The interesting thing is that this apparently was not well
         | known during my therapy. I discussed this effect with my
         | therapist, and she was skeptical and non-plussed. No hard
         | feelings there, I'm super pleased she was robustly evidence
         | based. But very happy to read these results in any case to
         | validate my personal discovery.
        
           | romwell wrote:
           | Seconding everything you wrote.
           | 
           | Emphasizing:
           | 
           | - "The problem is it gives some, and takes a god damn lot"
           | 
           | - "Therapy and SSRI:s worked much better in the end"
           | 
           | Still resort to this sometimes when I'm not on a schedule
           | (i.e. between jobs).
        
           | harimau777 wrote:
           | > Therapy and SSRI:s worked much better in the end.
           | 
           | How did you find that therapy helped you? I've started
           | therapy a few months back and so far I can't find all that
           | much value in it. They can't fix any of the stuff that is
           | making me depressed, so it mostly feels like I'm mainly
           | getting self help style advice.
        
             | Hard_Space wrote:
             | I've been in therapy over six years, and also did it for a
             | shorter spell in the early 1990s.
             | 
             | A few months is really the start of the relationship - it
             | usually takes that long for most people to establish trust
             | with their therapist. That doesn't mean you have the right
             | therapist, but it is hard to know this early on.
        
             | runlaszlorun wrote:
             | That's my experience as well- though my therapy was a while
             | ago. I had worked a stretch of utterly miserable jobs back
             | then and conversation would always drift back to the work
             | mess I likely left just prior and only frustrate me more. I
             | saw several, mostly because I'd be on different insurance
             | plans, etc. But not once did anyone say "maybe you need a
             | new career path?" If anyone of them had followed that up
             | with "and since procrastination is a problem why don't we
             | work on helping you get there", I'd be singing the praises
             | of the field.
             | 
             | I'm not hating on the profession or anything and I have
             | friends who swear by it. But each of them, after a bunch of
             | these sessions I could almost see a hint in their eyes of
             | "damnit... none of this crap is working." Like I slightly
             | felt bad for them in a way. Slightly.
             | 
             | And honestly, given the trajectory of the world, I'd be
             | more concerned if many people _weren't_ depressed.
             | 
             | Out of the field, personally I did like Acceptance and
             | Commitment Therapy (ACT), but it mostly reinforced what I'd
             | learned from a decade of meditation and my buddhist
             | practice.
        
               | pr0zac wrote:
               | While I def got more from therapy, I concur regarding ACT
               | being the methodology that worked best for me and that
               | it's wild how much it overlaps with mindfulness and
               | Buddhist practices.
        
             | pr0zac wrote:
             | You might not have a good fit with your therapist. It took
             | me a few tries but once I found someone with a similar mode
             | of thinking I got a lot more out of the discussions because
             | she said things (often the same things as the prior
             | shrinks) in a way that resonated with my brain better.
             | 
             | In that regard, therapy never fixed my problems, but it did
             | help me recognize unhealthy thinking patterns and provide
             | mechanisms for handling them, both of which have helped me
             | avoid spirals and getting trapped in negative thought
             | processes.
        
             | Aeolun wrote:
             | Therapy helped me when I did it in a group. Mostly in
             | making me realize how good I had it.
             | 
             | People that weren't able to drive, weren't able to go
             | outside at all etc. I was just permanently afraid.
             | 
             | What I gained from my other sessions was mostly a 'get out
             | of jail' free card to unload all of my thoughts. You can
             | only do that on your family and friends so many time before
             | it starts to wear on them hearing the same things again.
             | But my therapist is paid for that shit, so I have no
             | compunctions.
             | 
             | SSRI worked much better on a daily basis, but the therapy
             | was nice when things were bad.
        
         | leetrout wrote:
         | I noticed something similar (see also: my comment about using
         | magnesium and getting better sleep on the thread about deep
         | sleep yesterday).
         | 
         | When I get ~5ish hours of sleep one night a week I am
         | surprisingly more alert the next day but I also crash much
         | harder by night. I cannot sustain multiple days of little sleep
         | but one short night doesn't seem to have such a detrimental
         | effect.
        
           | manvillej wrote:
           | I wonder if this is why ADHD people struggle with sleep.
        
             | Obscurity4340 wrote:
             | We have many reasons aha. Always good to start chipping
             | away at the list ;)
        
           | pstadler wrote:
           | One of my teachers told us to make sure we're getting a good
           | amount of sleep two nights before an important event (exam,
           | job interview, competition, you name it). One can easily cope
           | with a single sleepless night, but not with two in a row.
        
         | danielvaughn wrote:
         | There's something about getting 2-3 hours of sleep that makes
         | me feel like I'm on top of the world throughout the day. I've
         | always assumed it was a kind of wild delirium.
        
           | Obscurity4340 wrote:
           | The sleep quality is super lossless and actually gainful when
           | you compress it by allowing a slight sleep debt to accrue
        
             | dgb23 wrote:
             | Are you claiming that 2-3h of sleep is enough or healthy?
        
               | Obscurity4340 wrote:
               | Why don't you try it and see? Some of my best sleeps were
               | after a sleepless night and for only like 1-3 hours,
               | caffeine or other stimulants in the blood be damned
               | 
               | Edit: also make sure you have bright blue light during
               | wakeup/morning/day and mellow non-overhead
               | orangey/amber/yellow light (nothing east of yellow) at
               | evening/night. Red 2 hours before bedtime for bonus
               | "points"
        
               | LeafItAlone wrote:
               | My experience does not match up with yours here.
               | 
               | Given work deadlines I have a lot of experience with full
               | all-nighters and 1-3 hour nights.
        
               | Obscurity4340 wrote:
               | Can you comment on sleep hygiene and the stuff i
               | mentioned about light? Do you sleep in complete darkness
               | in a slightly cooler ambient setting and really get a lot
               | of bright line first thing at waketime?
        
               | whateverman23 wrote:
               | > Why don't you try it and see?
               | 
               | I feel great after a few beers, but keeping that state is
               | a very bad idea. "try it and see" is not a great idea
               | when it comes to your brain.
        
               | Obscurity4340 wrote:
               | I don't think you build up a "Beer Debt" that grows as it
               | depletes like sleep and hunger. Cute wrong example but
               | there's really nothing all that malevolent or
               | irresponsible about the suggestion. Maybe keep it to the
               | weekend (like don't start till Friday/Sat night) and
               | obviously you need the set it up so you don't have to be
               | places or hold meaningful convos although Im not going to
               | rule them totally out
        
               | whateverman23 wrote:
               | > there's really nothing all that malevolent or
               | irresponsible about the suggestion
               | 
               | You are underestimating the impact of sleep deprivation,
               | and the ability for a person to recognize the impacts
               | while sleep deprived.
               | 
               | https://bmcpublichealth.biomedcentral.com/articles/10.118
               | 6/s...
               | 
               | "It was concluded that sleep deprivation has a greater
               | impact on driving performance than a BrAC of 22 mg/100mls
               | of breath, as measured by driving simulation. Coffee is
               | not an effective countermeasure for sleep deprived
               | driving and drivers' ability to judge this impairment is
               | suggested to be limited."
        
               | Obscurity4340 wrote:
               | Can I ask how heavily everyone desire I pre-caveat the
               | main lede here in order to get the discussion centered
               | more on the idea itself and competing views on the extent
               | to which folk's have found some usecase or success with
               | it? Like, obviously if you're a pilot who needs to be
               | able to thread needles and sew while you're able to still
               | control the plane should maybe wait till they're relieved
               | of duty for the weekend or some amount of time allowing
               | the latitude to try this thing out but I feel like
               | there's an amount of obtuseness and ridgidity on display
               | here.
               | 
               | Edit: also, Polyphasic is insane so anyone making a false
               | equivalence here can simply stop. I'm referring to an
               | occasional all-nighter for the joint purposes of
               | resetting ones mental slate and also helping prime
               | oneself for a better quality and faster easing-into the
               | next sleep
        
               | whateverman23 wrote:
               | > in order to get the discussion centered more on the
               | idea itself and competing views on the extent to which
               | folk's have found some usecase or success with it?
               | 
               | So you only want "competing" views if they line up with
               | your views?
               | 
               | The study was about driving, something many/most of us do
               | on a regular basis. It shows that:
               | 
               | 1. Sleep deprivation while driving is comparable to being
               | intoxicated while driving.
               | 
               | 2. Those who are sleep deprived are not reliably able to
               | recognize their impairment.
               | 
               | If you think it's "obtuse" to bring this up, then I don't
               | know what you're trying to do here. Those are extremely
               | important pieces of information to bring up.
        
               | mrexroad wrote:
               | I have extensive experience with it. I would disagree
               | that there's nothing irresponsible. I don't recommend
               | anyone try skipping a night just to see. Blood pressure,
               | heart rate, and glucose levels can easily go to shit and
               | exacerbate underlying any conditions. FWIW it would take
               | me 1-2 weeks after shifting to a polyphasic before seeing
               | any benefits (which makes sense, respective to jet lag).
               | I can easily skip a single night (without stimulants,
               | etc) and run off adrenaline the next day, but the day
               | after sleeping again I'm useless state of sleep-lag-wtf.
               | 
               | Mediocre analogy: something like polyphasic sleep with
               | extremely disciplined sleep-hygiene is like using a stack
               | of high-interest credit cards for the rewards/benefits,
               | but if you make a mistake then there's a high cost and
               | it's not really tenable forever. Skipping a night of
               | sleep outright is basically a pay-day loan.
        
               | Obscurity4340 wrote:
               | []
        
               | mrexroad wrote:
               | Not to be flippant, but that's called sleep deprivation.
               | I did this daily for 18-24mo straight, sleeping a 3h
               | block early morning (~4:30-7:30) and a 27min nap aligned
               | with my sleep/wake cycle during mid-afternoon. I did this
               | without caffeine, stimulants, sugar, etc. After having
               | more kids I couldn't keep the daily consistency required
               | and scaled back to 1-3x a week. I spent years convinced
               | that it elevated my coding, insights, etc., and there was
               | a degree of truth to it, as it did mitigate the worst of
               | my ADHD. Then I got medicated and suddenly everything in
               | the world that had always screamed for my attention 24/7
               | started quieting down a little. It took me another decade
               | or two to break more of the coping mechanisms I'd
               | developed in my late teens for ADHD and dyslexia. I could
               | ramble down several tangents for paragraphs here, but
               | I'll just throw out my personal note that while there
               | were clear cognitive benefits (note: I'm sidestepping the
               | increasingly clear long term cognitive risks indicated in
               | recent research), the muscular-skeletal costs we're
               | greater.
               | 
               | As they say, adrenaline is a hell of a drug.
        
               | Obscurity4340 wrote:
               | Its def not a lifestyle, I don't feel like I made that
               | super obvious. I'm talking about a once in a blue moon
               | type deal where you need a hard reset. Sorta like how
               | most people rarely turn off their phones, things get
               | fucky with it eventually, and it needs a hard reset or
               | reboot. Don't get too hung up on the metaphors, but I've
               | experienced it working and I'm not exactly an n=1
        
           | joshspankit wrote:
           | For a while there have been theories stating that monophasic
           | sleep 8 hours a night is actually disordered sleep. Maybe
           | that's worth looking at again.
        
         | wouldbecouldbe wrote:
         | I don't know.
         | 
         | Seems very correlated with people having a good reason to pull
         | an all nighter.
         | 
         | Whether kids or business.
         | 
         | Meaning makes us tick
        
           | fellowniusmonk wrote:
           | Yeah, meaning is great, or you know, having something
           | exciting or enjoyable to look forward to... but also, I used
           | to heavily experience this type of emotional lift from lack
           | of sleep but when I started taking Beta Blockers a decade ago
           | the benefit stopped overnight never to return.
           | 
           | Adrenaline and the bodies "stress" responses really are a
           | wonder drug, you have to completely reconfigure your life and
           | processes when it goes away.
        
           | dotnet00 wrote:
           | Yeah I feel like this is probably a big part of it. Nothing
           | does away with my depressive existential dread better than
           | just having any kind of work to do, be it working on a
           | personal skill or employment related work.
        
           | culi wrote:
           | It's an experimental study not an observational study. So
           | that correlation won't have an effect here
        
       | smokel wrote:
       | ... in mice.
        
         | henryaj wrote:
         | It is very well established in humans too.
         | https://en.wikipedia.org/wiki/Wake_therapy
        
           | Murfalo wrote:
           | Indeed, the article title is a little misleading! Sleep
           | depravation producing short-term improvements in human
           | depression has been well known for some time. What the
           | authors actually propose is an underlying mechanism to that
           | improvement, in mice...
        
         | jl6 wrote:
         | > In a new study, researchers induced mild, acute sleep
         | deprivation in mice and then examined their behaviors and brain
         | activity. Not only did dopamine release increase during the
         | acute sleep loss period, synaptic plasticity also was enhanced
         | -- literally rewiring the brain to maintain the bubbly mood for
         | the next few days.
         | 
         | What's a mouse like when it's in a bubbly mood?!
        
           | smokel wrote:
           | Perhaps we misread, and "their" refers to the researchers,
           | not to the mice!
        
           | stevenwoo wrote:
           | Further in the article they discuss monitoring activity of
           | dopamine neurons and modifying individual neurons in the
           | brains of these mice (which has parts analogous to human in
           | many ways including emotion) and describing the behavior of
           | sleep deprived mice which sort of implies what the normal
           | behavior is.
        
         | pvaldes wrote:
         | Are we talking about that small mammal that is a nocturnal
         | species?
        
         | dang wrote:
         | Indeed. Inmiced. Thanks!
        
       | the_cat_kittles wrote:
       | i have noticed i have a sleepless night every once and a while,
       | maybe once a month, and i usually have been feeling bad
       | emotionally leading up to it. and i do usually feel better the
       | next day, despite expecting to feel bad from no sleep
        
         | AlexandrB wrote:
         | I always thought it was related to anxiety. After staying up
         | late it feels like I'm forced to focus on what's important
         | because I don't have the mental capacity to let my mind wander
         | and worry about stuff.
        
       | bobsmooth wrote:
       | Once I go past 24hr I get really loopy and giggly.
        
         | jackcosgrove wrote:
         | Not sleeping for over 72 hours is the threshold for insanity.
        
           | slenk wrote:
           | I was awake that long once. I can understand why that
           | threshold exists
        
       | shtopointo wrote:
       | What about all the other studies claiming that poor sleep causes
       | depression? Not sure what to trust these days. Gut tells me poor
       | sleep won't make you ahem "your brain feel slap-happy, loopy and
       | almost giddy" (very scientific).
        
         | croes wrote:
         | From the article
         | 
         | >Chronic sleep loss is well studied, and it's uniformly
         | detrimental effects are widely documented," Kozorovitskiy said.
         | "But brief sleep loss -- like the equivalent of a student
         | pulling an all-nighter before an exam -- is less understood.
        
           | thibaut_barrere wrote:
           | I guess it also depends on what your past has been.
           | 
           | After going through a "sleep-deprived burnout cycle", I found
           | that any all-nighter will pull me back into the emotions I
           | got at that time, even if I feel originally great physically
           | & mentally.
           | 
           | So, YMMV!
        
         | mrbungie wrote:
         | I guess just one sleepless night is not the same as chronic
         | poor sleep patterns.
         | 
         | Also, it's interesting because sleepless nights are kind of a
         | sign in bipolar disorder patients that an (hypo)-manic episode
         | is about to occur or is actually occurring.
        
         | coldtea wrote:
         | > _What about all the other studies claiming that poor sleep
         | causes depression?_
         | 
         | What about them?
         | 
         | This is about one sleepless night every several days/week for
         | an already depressed person.
         | 
         | Not about non-depressed people continuously sleeping poorly
         | (which is where poor sleep would cause depression).
        
       | Jerrrry wrote:
       | The "morning hormonal" dump that gets offset by not sleeping
       | could easily shift neuro-chemistry.
       | 
       | For (sufficiently) depressed people, any perceived shift is
       | likely going to be a improvement.
       | 
       | Related, similar studies have postured that nights with
       | occasional stirrups lead to a more rested day, un-intuitively.
       | 
       | The variation in sleep requirements within groups may have more
       | obvious evolutionary benefits; the security of camps overnight
       | depend on those who stay up overnight to stand guard or
       | occasionally tend to the fire.
        
         | rottencupcakes wrote:
         | My entire life, I've been a night owl. I'm prone to depression
         | in the mornings. I prefer to avoid doing anthing in the AM. In
         | the evenings, I can have a lot of get-up-and-go energy and can
         | be positive about a lot of ideas, but when I wake up the next
         | morning, my entire mood has shifted and I'm often quite
         | negative.
         | 
         | Staying up all night (or only getting a few hours of sleep)
         | avoids that mental reset that causes my entire mood to shift.
         | 
         | I wonder if this is related to the phenomenon studied.
        
       | sys32768 wrote:
       | Once I hit my 40s, staying up too late causes a sleep hangover
       | that would last a couple of days.
       | 
       | Gone are my days of playing Ultima IV all night and feeling giddy
       | in the morning.
        
       | dralley wrote:
       | It doesn't work for multiple sleepless/almost-sleepless nights in
       | a row, ask me how I know.
        
         | croes wrote:
         | >Chronic sleep loss is well studied, and it's uniformly
         | detrimental effects are widely documented
        
         | romwell wrote:
         | >It doesn't work for multiple sleepless/almost-sleepless nights
         | in a row, ask me how I know.
         | 
         | In other news, beneficial effects of a single cup of coffee
         | don't seem to show up after you have a dozen of them.
        
       | JaDogg wrote:
       | I have some experience with this. But what can happen is sometime
       | you overdo it and burn out physically, and depression hit at the
       | same time. And you will be worse off.
       | 
       | Happiest time of my life was when I was going to gym regularly
       | (about 3 - 4 days per week)
        
       | taude wrote:
       | Can't wait to read about how bio-hackers are using this tool with
       | their optimal morning routine ice-baths and lunchtime cocaine.
        
         | romwell wrote:
         | >and lunchtime cocaine.
         | 
         | In fact, forget the ice baths
        
       | throwaway4837 wrote:
       | Waking up in the mornings helps reset my mental state sometimes.
       | I wonder if it's related. If I have an early morning, I usually
       | find that I'm more productive and have more energy to work out or
       | focus on tasks. There's nothing more depressing than a cycle of
       | waking up at 2pm because you stayed up until 5am. Waking up so
       | late makes me feel like I'm wasting my life.
        
         | hshsbs84848 wrote:
         | I've found that too
         | 
         | Somehow I feel really energized if I wake up like 2-3 hours
         | before my regular time
         | 
         | But only if I haven't done it in a while
         | 
         | Something about disrupting the pattern seems to throw off the
         | usual morning grogginess
        
           | LesZedCB wrote:
           | it's my favorite part about early morning flights. i don't
           | fly often, but when i do travel the following two weeks where
           | i practically jump out of bed at 6-7am are amazing.
        
       | cactusplant7374 wrote:
       | I have a prescription for ketamine and when I take it at night it
       | causes poor sleep and noticeable lethargy the next day. It's not
       | a great thing.
       | 
       | But I think "reversing depression" is codeword for manic and
       | euphoria sensations. It's not targeting the core of what is
       | depression.
        
       | Hard_Space wrote:
       | Having suffered from severe depression for over forty years, this
       | reminds me of when I was 17, 18, etc. and suddenly discovered
       | that if I stayed up for two days, the problem went away. So I
       | knew this a very long time ago; but it always seemed to me that,
       | besides smoking, this was just about one of the worst habits you
       | could develop. By my mid-twenties, I had stopped.
        
         | Waterluvian wrote:
         | My anxiety now is that using THC to sleep will cause issues
         | long term. But without it I literally cannot get to sleep
         | anymore.
         | 
         | Edit: I regret pulling focus off parent comment and OP, but
         | also deeply appreciate everyone's comments.
        
           | datameta wrote:
           | Try Type III cannabis (high cbd hemp). Nowadays it looks and
           | smells like Type I cannabis (the high thc standard variety of
           | weed). It has all the various combinations of cannabinoids,
           | terpenes, and flavonoids that contribute to the entourage
           | effect except for THC (<0.3%). In many if not most cases it
           | can do what Type I medical cannabis can do.
           | 
           | i.e. amongst non-psychoactive hemp flower there are relaxing
           | indicas for insomnia, functional hybrids for chronic pain,
           | sativas for a pick-me-up, etc.
        
             | pstuart wrote:
             | I've not tried it yet, but CBN seems to be the winner in
             | this category. It's legal in all states if pure. Black
             | Friday is coming and I plan on getting some from a vendor
             | I've used in the past. Ping me for that info if you wish.
             | YMMV.
        
           | Loughla wrote:
           | So I feel like you exactly identified the long term problem
           | in the same paragraph.
           | 
           | I learned years ago that any chemical that helps you sleep
           | ensures that you can't sleep without it. I've used everything
           | from thc to Benadryl to lavender and everything in between.
           | 
           | It all had the same effects: slowly degrading effectiveness
           | and sleeplessness without it.
           | 
           | Pro-tip: find the source of your insomnia. Is it chemical or
           | is it electrical or is it just habit? Doing a real sleep test
           | and working with doctors was life changing. Mine was habit
           | and anxiety. Meditation and therapy have helped.
           | 
           | Anecdotal, I know. But what happens when the thc runs out?
           | You crash. That's what I did.
        
             | Waterluvian wrote:
             | Yeah. I've tried. My problem is that 3-4 days of no sleep
             | and I'm just about ready to sign off from this life.
             | 
             | I've managed with 5mg THC pills for years. Never had to
             | increase the dosage. I've never ever slept well. But back
             | before kids it was easier to just sleep in if I had to.
             | 
             | As best as I can tell, the cause is my adhd or related. My
             | brain will simply. Not. Stop. Racing.
        
               | omginternets wrote:
               | Have you tried exercising (>2h before you go to bed,
               | IME), staying away from screens 4h before bed, and
               | dimming the lights 1h before bed?
               | 
               | That was a life-changer for me.
        
               | _puk wrote:
               | Having to quarantine in a small sauna house after
               | travelling introduced me to the delights of crappy
               | internet, multiple daily cold river swims, and no real
               | lighting outside of a few candles.
               | 
               | Needless to say I went from awful sleep to going to bed
               | as the sun went down (in summer), and not waking up until
               | sunrise, all in the matter of days.
               | 
               | Thinking back on it, I really should get back into that.
        
               | Aeolun wrote:
               | Almost as if we're not really built to do anything else
               | :)
        
               | ethanbond wrote:
               | I _highly_ recommend the podcast Sleep With Me. It's
               | extremely weird and the guy's voice isn't exactly
               | "comforting" the way most sleep-inducing things try to
               | be, but give it a few tries.
               | 
               | It's basically bedtime "stories" that are more like
               | improvised narrative mazes that are just interesting
               | enough to keep your interest (and exhaust your brain) but
               | not interesting or meaningful enough to keep you awake.
               | 
               | I went from laying awake for _hours and hours_ as a
               | general nightly routine to falling asleep reliably in
               | 10-20 minutes. I didn't even know it was possible to fall
               | asleep that fast.
               | 
               | As a tip: There's nothing to "get" about the podcast.
               | It's just a treadmill for the overactive parts of your
               | brain.
        
               | Waterluvian wrote:
               | This sounds right down my alley!
        
               | Hard_Space wrote:
               | > just interesting enough to keep your interest (and
               | exhaust your brain) but not interesting or meaningful
               | enough to keep you awake
               | 
               | Exactly. Back when I read more, I would have books to
               | stimulate (daytime/commute reading) and 'bedtime books',
               | which had to be interesting enough to read, but also
               | effortful and ultimately tiring enough to promote sleep.
               | 
               | Now I do the same with TV shows in Plex, late at night.
               | Unusually, it's the documentaries that stop me sleeping,
               | and the classic US TV shows (that I like) that help me
               | drift away.
        
               | Timon3 wrote:
               | I used to have the same sleep problem (head won't stop
               | racing), and mindfulness exercises throughout the day
               | have greatly improved things for me. In a way it feels
               | like the ability to turn it down for a time, long enough
               | to get so tired it doesn't start back up again.
               | 
               | One trick I found myself is to visualise things in the
               | noise from your closed eyes. Try to interpret something
               | you can vaguely see, and then try to visualise it. This
               | imposes a kind of clear image for a short duration for
               | me, from which I try to see and visualise something else
               | in there and so on, kind of like a visual association
               | chain. That really gets me sleepy after a couple of
               | minutes!
        
               | Aeolun wrote:
               | > visualise things in the noise from your closed eyes
               | 
               | Ooh, the visualization whirlwind. This is the first time
               | I've ever hear anyone talk about it or had to give it a
               | name. At least for me it's just tons of images flashing
               | before my eyes, rapidly changing, only tenuously guided
               | by my mind.
        
               | interstice wrote:
               | This sounds familiar, I got to a point a few years ago
               | where even if I could get to sleep I'd wake up at 3-4am
               | with every last problem racing around my mind, but have
               | never felt good with any amount of sleep.
               | 
               | In the end I went to the GP for anxiety and came out with
               | a depression diagnosis and a bottle of Lexapro. Lucky for
               | me I didn't get the crazy side effects and in combination
               | with melatonin at least getting to sleep is no longer a
               | problem.
               | 
               | In the past I've also found that deliberately clearing my
               | thoughts is a way to slip from 'day mode' to those dozy
               | random thoughts, but its often hard to remember in the
               | moment and doesn't always work.
        
               | tomcam wrote:
               | See my profile if you'd like to create a tiny support
               | group. I have had horrifically bad insomnia for half a
               | century. At the moment I'm having luck with 600mg
               | gabapentin + 20mg Belsomra but that's only a couple weeks
               | gold.
        
               | NickC25 wrote:
               | I'm with you - I have a few hits of some low-grade stuff
               | maybe an hour or two before bed, and then I doze off
               | naturally when it's dark out.
               | 
               | i also eat well, and make sure to not have blue light
               | exposure for the last hour of my day.
               | 
               | But what really helped me, especially since I have crazy
               | ADHD, is exercise. I lift when I get up, and do 1-2 hours
               | of hard HIIT in the evenings after work. My body is
               | absolutely shot by the time I'm done so I really don't
               | have the energy to have my brain go all over the place.
               | This coupled with a nice cold plunge in the evenings
               | after said workouts (and another cold shower before I
               | sleep), and good nutrition has helped me big time.
               | 
               | The THC does help, especially if I do it at the right
               | time. If I smoke in the afternoons I am absolutely
               | destroyed by sundown. I do fear it's creating an
               | addiction or a physical dependence, but I value my sleep
               | considerably.
        
             | hotpotamus wrote:
             | Getting to the source certainly sounds ideal, but I wonder
             | - if you find a variety of substances help though develop
             | tolerance, couldn't you rotate them to try and keep them
             | effective?
        
           | bobbylarrybobby wrote:
           | If you cannot fall asleep without a drug then I'd say the
           | drug has already caused issues
        
             | micromacrofoot wrote:
             | well the issue was not being able to fall asleep without a
             | drug
             | 
             | so falling asleep with a drug is an improvement
        
           | bdamm wrote:
           | Being unable to sleep is a common withdrawal symptom for
           | cannabis use disorder. Congratulations, you are habituated,
           | and long-term problems are likely accumulating as you are
           | losing out on REM sleep and probably developing emotional and
           | physical conditions related to cannabis use. Good luck!
        
             | teaearlgraycold wrote:
             | Yeah. I used to smoke a tiny bit every day and it really
             | fucked me up.
        
             | johnnyanmac wrote:
             | damn, so I'm screwed and I don't even get to enjoy the
             | upsides of cannabis. Rough world.
        
               | cmyr wrote:
               | I've smoked weed before bed most nights for at least a
               | decade, and if I happen to skip a night I... still sleep
               | fine, unless I've had no exercise that day.
        
           | hotnfresh wrote:
           | I _can_ get to sleep without it. I just can 't be _sure_ I
           | 'll be able to get to sleep without it. Like 30%-40% odds
           | I'll have serious sleep trouble if I don't take it, so I take
           | it most nights.
           | 
           | Amazing stuff, much better than the sleeping pill
           | prescription I had years back (Lunesta).
        
           | 1980phipsi wrote:
           | My brother basically needs THC to sleep.
           | 
           | Or strenuous physical activity all day.
        
             | jackcosgrove wrote:
             | > Or strenuous physical activity all day.
             | 
             | The lack of strenuous physical activity all day is a real
             | problem with modern life. We did not evolve to be
             | sedentary.
        
               | Waterluvian wrote:
               | I've added an hour of exercise to my day and while it
               | hasn't solve my sleeping problems, I can't live without
               | it anymore. It just makes _everything_ else feel easier.
        
               | tomcam wrote:
               | Same. Nor does all-day physical activity
        
           | manmal wrote:
           | Tapering off very slowly (over weeks or months) will probably
           | work better than cold turkey.
        
             | Waterluvian wrote:
             | I'm just now sure how to taper off. They don't come in
             | smaller doses than 5mg and that's where I'm at.
        
               | manmal wrote:
               | Split it until it's 0mg.
        
               | tomcam wrote:
               | Hang on, is it working? Didn't you say you take 5mg and
               | it's been working for years at that level? I'd rank that
               | as a win...
        
               | heavyset_go wrote:
               | What form is it in? If its a capsule with dissolved oil,
               | break the capsule and dilute the oil.
               | 
               | If it's a solid, just break it.
               | 
               | If you can buy a THC tincture, you can easily use
               | dilution and volumetric dosing to titrate your doses down
               | over time.
        
           | nwienert wrote:
           | If you can, try Semaglutide.
           | 
           | I am a top % light sleeper - hard to sleep, inconsistent,
           | never could sleep outside of basically ideal conditions.
           | 
           | Was prescribed Tirzepatide (similar to Semaglutide) and it
           | fixed my sleep like nothing else has - I actually _feel
           | tired_ at a normal hour and _doze off_ , two thing I never
           | really did before. At the lowest dose you won't lose weight
           | beyond the first few months, and you can maintain weight with
           | small effort even still. So even if you are completely
           | healthy weight, it could be useful.
           | 
           | I wouldn't normally think recommending a totally unrelated
           | drug for sleep issues would be sane, but it also happens to
           | have a ton of other positive effects for me at least. And the
           | safety profile seems solid, esp compared to other sleep
           | drugs. Plus not psychoactive and actually reduces your
           | addictive behaviors especially in terms of nicotine/THC.
           | Certainly a lot better side effect profile than THC (imo,
           | from research).
        
             | Waterluvian wrote:
             | I appreciate this greatly. After reading a lot of these
             | comments I think I'm smart enough to realize it's time to
             | get help. I'll speak with them about this idea and others.
        
               | heavyset_go wrote:
               | A lot of "help" in this space are things like z-drugs,
               | benzos, antihistamines like hydroxyzine, low doses of
               | atypical antipsychotics like Seroquel, and
               | antidepressants like Trazodone and mirtazapine.
               | 
               | IMO, THC can be the lesser of two evils in comparison.
        
           | pstuart wrote:
           | You'll get plenty of advice and it's worth evaluating it all
           | (as we're all different), but trazodone has been a miracle
           | worker in aiding sleep. It's cheap, well understood, and the
           | only negative aspect I've encountered is the risk of priapism
           | (which can sound like a joke but should be taken _very_
           | seriously)
        
             | nwienert wrote:
             | Trazodone felt like a Nuke to me, tried it for sleep but
             | whew what a crazy strong (bad) feeling it gave me.
        
             | tomcam wrote:
             | Did nothing for me
        
               | ProfessorLayton wrote:
               | Same. All it did was give me an incredible hangover the
               | next day, blurry vision, tremors, and -- scariest of all
               | -- made me feel sad. Had to quit within a week. Glad it
               | works for others, but easily one of the worst things I've
               | ever tried.
        
           | yankoff wrote:
           | I had a period when I used THC (edibles) for sleep every day.
           | This was one of the worst things I have ever done to myself.
           | At first, you don't notice much side effects, but slowly it
           | creeps up on you. It makes you depressed, depletes of any
           | motivation, gives brain fog and you may just feel weird over
           | all. When I quit I was amazed by how much better I started
           | feeling and by how much my cognitive function improved.
           | 
           | I would highly recommend getting off it asap. Maybe taper off
           | if you can't quit right away. First nights will be tough:
           | sleepless, cold sweats, crazy dreams, but then it should get
           | much much better. Be well!
        
             | ben_jones wrote:
             | ~10 years from now we're going to have better data on
             | chronic THC consumption and after being a heavy user I'm
             | pretty confident it's going to shock a lot of people with
             | negative externalities.
             | 
             | Tip for getting off weed - start by lowering the damn
             | dosage. A lot of commonly used products are the equivalent
             | of a triple shot. And folks do it daily.
        
             | ProfessorLayton wrote:
             | >It makes you depressed, depletes of any motivation, gives
             | brain fog and you may just feel weird over all
             | 
             | YMMV. That's me on a sleepless night.
        
           | heavyset_go wrote:
           | Look into weaker THC analogues like delta-8-THC or
           | delta-10-THC. They have weaker binding profiles and half-
           | lives than normal THC does.
           | 
           | Same thing with CBD and its analogues.
           | 
           | CBN will knock me out and it isn't active at CB1 like THC is,
           | so it doesn't get you high.
        
         | thowaway91234 wrote:
         | I recently was forced off of SSRIs after nearly ten years
         | because I lost my psychiatrist and couldn't get a new one
         | because the waitlists were ridiculous.
         | 
         | After 10 years on them, the next 6 months were absolute hell (i
         | legit thought at one point I might go full Joaquin Phoenix in
         | Joker) but I made it through, no small part thanks to my
         | wonderful amazing wife.
         | 
         | Rebound depression have been an issue - though in general I
         | feel like I am much better off without the antidepressants now
         | than with them - and I've also noticed that pulling an all
         | nighter would actually fix the rebounds for a bit. A small dose
         | of melatonin before bed worked wonders for me now. I sleep
         | better and the rebounds are extremely rare.
        
           | erikpukinskis wrote:
           | Just a side note for anyone reading: you can get an SSRI
           | prescription from your GP (general practitioner i.e. normal
           | doctor) you don't need to go through a psychiatrist.
           | 
           | This is especially true if you are at risk for withdrawal,
           | they will want to prevent that.
        
             | fsckboy wrote:
             | any medical doctor of any specialization can legally
             | prescribe anything. that doesn't make it a good idea. a
             | piece of supporting evidence is that the doctor's
             | malpractice insurance may not cover any "cowboy"
             | prescribing tendencies.
        
               | ksenzee wrote:
               | GPs routinely prescribe SSRIs. Even pediatricians. At
               | least in the US.
        
               | H8crilA wrote:
               | A lot of non-psychiatrist doctors prescribe SSRIs around
               | the world, and that's a very good thing. These drugs are
               | safe.
        
               | ksenzee wrote:
               | Agreed.
        
               | erikpukinskis wrote:
               | That's fair. But I'll note that the "General" in "General
               | Practitioner" means they specialize in the wide range of
               | health problems that occur frequently in the general
               | population. That includes things like depression,
               | anxiety, ADHD, etc.
               | 
               | I wouldn't advocate you get a prescription for
               | antipsychotics from your orthopedist, but SSRIs from a GP
               | is probably pretty safe.
               | 
               | Obviously, it depends on the doctor and the symptoms. But
               | a good GP will also refer you out to a specialist when
               | needed. That's a big part of their job: assessing when to
               | call in a specialist.
        
               | rl3 wrote:
               | As other comments said, GPs routinely prescribe SSRIs.
               | Moreover, it's not remotely cowboy to ensure continuity
               | of care arising from exigent circumstances.
        
               | 3c6bYDXLMj wrote:
               | You can always tell when someone is American because
               | they'll make statements like this without qualifying it
               | with a jurisdiction.
               | 
               | Where I live? This is 100% factually false.
        
               | brokencode wrote:
               | If all you need is a refill on a prescription you've been
               | taking for 10 years, how is that "cowboy" prescribing?
               | Also, these are trained professionals with years of
               | education we're talking about, not some random dude off
               | the street.
        
           | Hard_Space wrote:
           | > would actually fix the rebounds for a bit.
           | 
           | I can't prove it, but even dumb teenage me felt instinctively
           | that extreme sleep deprivation was likely to take a long and
           | possibly permanent toll. I don't think anything that extreme
           | can really be practiced in moderation, because it's more like
           | taking heroin than eating too many cakes, etc., i.e., it's
           | not a 'granular' indulgence.
           | 
           | I would hesitate to call this a hot take on my part, since I
           | am guessing that in that period of my life, I probably stayed
           | up for two days on several hundred occasions, if not more.
           | 
           | For anyone else suffering from severe depression, this is an
           | easy answer, maybe; but there are better easy answers than
           | this. Cannabis (I am not a partaker since I was an student)
           | would be better than this.
           | 
           | Really, do anything but this. It's not 'free'; nothing that
           | works is free.
        
           | Mortiffer wrote:
           | That's terrible man.
           | 
           | I hate being dependent on a doc. Try to reduce this horrible
           | risk by going up and down on dose to get a little stock pile
           | to feel a bit safer.
           | 
           | But changes little I guess
        
         | PreachSoup wrote:
         | Seems that I'm in the opposite. If I don't get enough sleep I
         | would have noticeable bad mood.
        
       | zdragnar wrote:
       | Weird, whenever I pull an all nighter my mood is usually
       | noticeably depressed for the following two days.
       | 
       | I also used to be a bit of an insomniac, and one sleepless night
       | could easily throw off my circadian rhythm, creating all sorts of
       | extra anxiety, which translates into demand avoidance, stress and
       | furthering depression.
        
         | baxtr wrote:
         | Is your normal state depressed though? I don't think it works
         | for "normal" people.
        
           | Kbelicius wrote:
           | The study was done on mice. Are there depressed mouse that
           | are used in such experiments or is this just an opinion on
           | why zdragnar might not feel these effects? This is a genuine
           | question.
        
             | baxtr wrote:
             | Ah god to know. I missed the mice part... I feel the same
             | as OP. Whenever I miss a night I'm in a terrible mood. It
             | was just my opinion.
        
             | WJW wrote:
             | It is possible to artificially induce depression in mice,
             | yes. Obviously, the whole field is insanely fraught with
             | ethical dilemmas.
        
         | kzrdude wrote:
         | This is like me too. I'm normally not depressed, but every time
         | sleep is affected, it throws me off and leads me down to
         | viewing the world negatively.
        
         | Hard_Space wrote:
         | Yes, the 'sleep hangover': the after-effect that told me that
         | what I was doing to myself by regularly staying up for 48 hours
         | was similar to drinking a quart or two of scotch.
        
       | jvm___ wrote:
       | https://www.reddit.com/r/hangovereffect/
       | 
       | This sub-reddit is dedicated to people who've noticed this effect
       | for ADHD and probably depression as well. Drinking alcohol
       | somehow causes the same 'reversal' of symptoms, either motivation
       | or other mood problems. Lots of discussion as to what causes it -
       | and questions/theories on how to reproduce without alcohol.
       | 
       | Alcohol causing sleeplessness, or sleep that's not the usual
       | quality might be an explanation.
        
         | SkyPuncher wrote:
         | Shame that I cannot view that without the app
        
           | Tempest1981 wrote:
           | https://old.reddit.com/r/hangovereffect/
        
         | disiplus wrote:
         | I have ADHD, did never tried it with alcohol, but sleep
         | deprivation works. I used it when working on important projects
         | with deadlines. You kind of feel like in a parallel universe
         | after a couple of a day if it's a interesting subject for you,
         | ADHD gives you hyper focus, and sleep deprivation gives you
         | this energy to push thru. It's like you don't even need the
         | medication. If you combine it with ADHD medications it's like
         | delirium. But anyway it comes all crashing after couple of days
         | and you have to pick yourself up. I did it for import projects,
         | but don't recommend it.
        
       | lucia-goldsmith wrote:
       | The article "One Sleepless Night Can Rapidly Reverse Depression
       | for Several Days" is a fascinating and promising piece of
       | research. The findings suggest that sleep loss could be a
       | potential treatment for depression, which is a debilitating
       | condition that affects millions of people worldwide.
       | 
       | I am particularly interested in the implications of this research
       | for many people. I believe that this research could lead to new
       | and innovative treatments for depression, which would be a major
       | breakthrough in the field of mental health.
       | 
       | However, I am also aware of the potential risks associated with
       | sleep loss. Sleep is essential for physical and mental health,
       | and sleep deprivation can have a number of negative consequences,
       | including cognitive impairment, increased risk of accidents, and
       | worsening of existing mental health conditions.
       | 
       | Therefore, I believe that it is important to carefully consider
       | the potential benefits and risks of sleep loss before using it as
       | a treatment for depression. More research is needed to determine
       | whether sleep loss can be safely and effectively used in a
       | clinical setting.
       | 
       | I am optimistic that this research will lead to new and effective
       | treatments for depression. I am also hopeful that this research
       | will raise awareness of the importance of sleep for both physical
       | and mental health.
        
         | IntrepidPig wrote:
         | Was this written by an LLM?
        
           | lucia-goldsmith wrote:
           | No, it was not written by a language model (LLM). I know one
           | of the authors, Mingzheng Wu, and have followed his work
           | closely, including his papers on the rapid enhancement of
           | glutamate-evoked dendritic spinogenesis in the medial
           | prefrontal cortex through dopaminergic mechanisms, and the
           | suppression of neuropathic pain through inhibition of YAP/TAZ
           | activity in the spinal cord.
        
           | warthog wrote:
           | If you mean the comment, I think so. That's why it is
           | probably flagged
        
       | myth_drannon wrote:
       | You get rid of depression but acquire dementia.
        
         | maipen wrote:
         | The article actualy says that if it's a routine thing then
         | other problems will start to set in, obviously. They also
         | mention that your probably better off going for a walk or going
         | to the gym. This is just another possible tool that we could
         | use strategicaly, but very rarely, to combat depression or
         | feeling down.
        
       | aatd86 wrote:
       | I'm not depressed but just in case, time to go clubbin' like I'm
       | nineteen again.
        
         | tomcam wrote:
         | Weirdly I am in my 60s and have no trouble pulling all-
         | nighters. I went clubbing like twice in my 20s and found it
         | dull af, but coding all night is still not a problem for me.
         | 
         | I have always been an atrocious sleeper.
        
       | permo-w wrote:
       | the problem with this is that sleep loss has myriad other
       | consequences; something I often discover when I take ADHD
       | medication. it's all well and good being productive for a day,
       | but when you wake up the next day at 2pm, things start to fall
       | apart
        
       | pazimzadeh wrote:
       | And can promote mania/psychosis, which seem related (higher
       | energy levels)
        
       | chupapimunyenyo wrote:
       | > Chronic sleep loss is well studied, and it's uniformly
       | detrimental effects are widely documented," Kozorovitskiy said.
       | 
       | I believe he didn't say "it's", he probably said "its".
        
         | m463 wrote:
         | sort of interesting how your/you're, its/it's,
         | shrimps/softwares and others sort of unconsciously makes what
         | you're reading less authoritative in a 4th wall way.
        
           | chupapimunyenyo wrote:
           | Not even unconsciously, I stop reading anything I've been
           | reading once I meet one of these. It's disrespectful to the
           | reader to not even check what's the correct spelling of a
           | word you are using, and in my opinion indicates that the
           | writer is not intelligent enough to recognize patterns in
           | text, it really isn't that hard to see how a word is used in
           | the wild. Kind of a hot take
        
             | kzrdude wrote:
             | You can't put all people on a scale like that, less
             | intelligent vs more intelligent. Some people are great with
             | letters and words and spot typos quickly, some just don't
             | see it as easily. They can still be very intelligent in
             | other aspects. People are different.
        
               | chupapimunyenyo wrote:
               | You know, you are right. I agree, but it still drives me
               | nuts seeing this, maybe it's just ignorance? I expect a
               | higher standard from a .edu website
        
       | bussetta wrote:
       | Whenever I feel down, I binge watch something usually late into
       | nights and I feel better next day. I wonder if it's due to the
       | lack of sleep.
        
         | simonbarker87 wrote:
         | Same for me. I don't feel stress in the typical way, in fact
         | for years I don't think I got stressed. My wife eventually
         | correlated me "checking out" for a few evenings in a row and
         | smashing through a TV series or two as my stress relief valve.
         | To me I just thought I wanted to watch TV, to her she noticed
         | it always happened when events around me would be making other
         | people "be stressed out".
        
       | Terr_ wrote:
       | Periodically skipping-a-sleep (in order to shift the next
       | bedtime) is also one approach to treat Delayed Sleep Phase
       | Syndrome (DSPS), which is also correlated to depression.
        
       | warthog wrote:
       | Well that's good news. Hate sleep
        
       | k8svet wrote:
       | It's just anecdata, and I am delighted to say that other
       | lifestyle changes have eliminated most of my anxiety/depression,
       | but this was definitely I hack I learned on my own and used at
       | times.
        
       | ltr_ wrote:
       | nice to know, kind of suspected that. for me, a good non sleep
       | night = bye cockroach mode and hello overenthusiastic maniac for
       | a week. quite a ride. 100% recommended.
        
       | darkerside wrote:
       | If you've never tried a Ragnar race, you should consider it. It's
       | a 36 hour-ish team relay race, with non runners driving in a van
       | to meet runners at the next relay spot. You barely sleep, but the
       | 1-2 hours you get are probably the deepest you'll ever feel. The
       | next day you are exhausted and yet feel amazing at the same time.
        
       | jackcosgrove wrote:
       | The mice's symptoms when sleep deprived sound very similar to
       | hypomanic symptoms. The same electrochemical circuits are likely
       | involved, in one case a chemical imbalance inducing
       | sleeplessness, and in another sleeplessness inducing a chemical
       | imbalance.
        
       | girafffe_i wrote:
       | I used to love Mondays, I would work hard during the week
       | studying and working, then Friday I would stay up until sunrise
       | with friends drinking or gaming. I kept this up while working in
       | the corporate world and thought "this is what people mean by
       | feeling refreshed"
       | 
       | It wasn't until I met someone who bent me to be on her schedule,
       | early to bed early to rise on the weekends, where I started
       | feeling depressed by the end of the week, getting Sunday scaries,
       | and having late onset insomnia.
       | 
       | Complete anecdata, but I'm going to start practicing this again
       | on Fridays to see what happens.
        
         | squarepizza wrote:
         | Same. I'm completely anhedonic by Friday when I box myself into
         | a schedule like this, which makes enjoying the weekend feel
         | like a chore.
        
       | robust-cactus wrote:
       | So sleep well and avoid dementia but stop sleeping to avoid
       | depression
        
       | hihungryimdad wrote:
       | I have experience with this and commented on a similar thread in
       | 2018.
       | 
       | https://news.ycombinator.com/item?id=16557500#16558442
       | 
       | Update if anyone cares: I feel like I'm damn near 100%.
        
         | tomcam wrote:
         | None of that worked for me but the important thing is...
         | WONDERFUL that you're still on track! Thanks for sharing and
         | congrats.
        
       | ineedasername wrote:
       | Not for me. I think this will vary by person, especially as
       | causes of depression vary and the whole phenomena is not fully
       | understood.
       | 
       | But for me, depression can be bouts of fatigue and lethargy, but
       | also are sometimes accompanied by crippling thoughts off.. well,
       | things that keep me awake. And losing an entire nights sleep like
       | that was not at all helpful. I felt just as bad or worse, only
       | with some additional things related to sleep loss mixed in.
       | 
       | That said, I also know (not from experience) that even in
       | "normal" people, skipping too much sleep can produce minor bouts
       | of mania (where mania can vary from highly unpleasant to highly
       | energetic/productive/euphoric) so it does make sense to me that
       | some depressed patients response positively to it.
        
         | tomcam wrote:
         | Not for me either. But my insomnia is incredibly bad.
        
       | Daunk wrote:
       | Huh, so maybe that's why I felt like my depression was better in
       | my younger years, cause I slept less?
        
       | arkades wrote:
       | We have known about sleep deprivation causing a remission in
       | suicidal ideation for a while - we have inferred a depression
       | benefit as well, but it's nice to have it quantified.
       | 
       | However, we also know resumption of sleep pretty quickly ends the
       | effect. It's not a sustainable intervention, so much as it an
       | interesting finding for hypothesis generation.
       | 
       | We also see the reverse effect in mania; on balance, regular
       | healthy sleep wins the day.
        
       | philipov wrote:
       | Isn't that just a hypomanic episode?
        
       | jrflowers wrote:
       | For those that enjoy sleep, smoke salvia instead!
       | 
       | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721268/
        
       | pedalpete wrote:
       | The impact of sleep restriction on depression has been known for
       | decades (though most of the research I'm seeing is from late
       | 2010s on [1], this link says "from the beginning of the last
       | century [2])
       | 
       | However, sleep deprivation as a treatment needs to be balanced
       | with the health impact of sleep deprivation itself.
       | 
       | A single night of lost sleep can have significantly detrimental
       | impact on long-term health. Insulin response tanks, cortisol
       | levels increase, HRV decreases, and this becomes a viscious
       | cycle. In addition to increased beta-amyloid deposits associated
       | with Alzheimers [3].
       | 
       | [1] https://www.pennmedicine.org/news/news-
       | releases/2017/septemb... [2]
       | https://www.minervamedica.it/en/journals/minerva-psychiatry/...
       | [3] https://www.nih.gov/news-events/nih-research-
       | matters/sleep-d...
        
       | Zetobal wrote:
       | I am bipolar and when I am in an depressive episode I use the
       | same technique the lift the burden a bit
        
       | havblue wrote:
       | Now that I'm thinking about this, you can pull in an all-nighter
       | on Thursday then wfh on Friday and just catch up on sleep over
       | the weekend. People at work won't mind and the wife and kids will
       | be okay as long as you're caught up for Saturday. This was timely
       | advice.
        
       | arthurofbabylon wrote:
       | In my life, I've observed occasional sleepless nights (one night
       | per 1-3 month period) to coincide with positive moods, abundant
       | activity, and a general sense of fulfillment. And when my mood
       | and motivation drops, I reflect back and recall that it's been a
       | while since I've enjoyed a sleep-free night.
       | 
       | I've always conceived of this as a consequence of being highly
       | dynamic - my system is being stretched/pushed/twisted/strained by
       | skipping sleep [1] - and a correlation to generally being
       | enthusiastic about what's going on (I stayed up all night in the
       | first place because I was obsessed with a fun problem). Of
       | course, it is difficult to parse cause/effect/correlation, so I'm
       | aware of the limits of these observations [2]. However, from the
       | beginning I've felt confident that these sleepless nights were
       | part of a broader pattern of good health.
       | 
       | [1] - As a general rule, I find "stress" to be healthy if it is
       | acute (but survivable!) and unhealthy if it is chronic. This case
       | (sleep) fits the rule... infrequent sleepless nights have a net
       | positive effect, and prolonged sleep deprivation (even mild) is
       | absolutely terrible for pretty much all aspects of health.
       | 
       | [2] - In observing my sense of happiness, I consider "seasons,"
       | or 3-6 months periods, so the previous analysis is actually quite
       | feasible. Do I wake up motivated? Do I feel pleasure lying down
       | to sleep? Am I being kind to the people in my life? Do I enjoy
       | interacting with acquaintances? Do I feel capable? To me these
       | questions offer clarity on some rough level of happiness, and
       | makes possible an imperfect analysis of the effects of something
       | like a sleepless night or other lifestyle change. It's not
       | perfect - but it doesn't need to be perfect, as it is already a
       | more effective analysis than the alternative (no analysis at
       | all).
        
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