[HN Gopher] A National Evil - the curse of the goitre in Switzer...
       ___________________________________________________________________
        
       A National Evil - the curse of the goitre in Switzerland
        
       Author : _ihaque
       Score  : 372 points
       Date   : 2023-12-27 15:34 UTC (7 hours ago)
        
 (HTM) web link (www.lrb.co.uk)
 (TXT) w3m dump (www.lrb.co.uk)
        
       | Faaak wrote:
       | A really pleasant to read story. It's funny because I live in
       | Switzerland and some of my friends debate the "ioded salt", and
       | prefer to consume "natural salt" without the additives. Funny how
       | history can repeat itself.
       | 
       | I'm always impressed with all these doctors that would question
       | the approach, try new protocols, and end up by finding a cure
        
         | k__ wrote:
         | How come that the disease wasn't widespread earlier?
        
           | marcinzm wrote:
           | Why do you say it wasn't present earlier?
        
             | k__ wrote:
             | The article made that impression on me.
        
           | zweifuss wrote:
           | This might interest you:
           | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169859/
           | 
           | "The interests of people in the thyroid gland have always
           | been immense because of the widespread prevalence of its
           | diseases. Therefore the earliest references to the gland date
           | back to 1st century AD. The Chinese, Egyptian, Indian, Greek
           | and Byzantine medicines are especially rich in their
           | knowledge on the subject."
        
           | tekla wrote:
           | I am always flabbergasted when people question incredibly
           | effective public health initiatives.
           | 
           | https://en.wikipedia.org/wiki/Goitre#History
           | 
           | https://en.wikipedia.org/wiki/Iodized_salt#In_public_health_.
           | ..
           | 
           | > Worldwide, iodine deficiency affects two billion people and
           | is the leading preventable cause of intellectual and
           | developmental disabilities.[1][2] According to public health
           | experts, iodisation of salt may be the world's simplest and
           | most cost-effective measure available to improve health, only
           | costing US$0.05 per person per year
        
             | evanjrowley wrote:
             | It may not be a question of the initiative itself, rather,
             | what conditions in Switzerland at the time led to an uptick
             | in iodine deficiencies.
        
               | suchire wrote:
               | Maybe they should just RTFA
        
               | masklinn wrote:
               | There was no uptick, CIDS was endemic to the alps as far
               | back as roman times. Its consequences literally slipped
               | into linguistic vernaculars (e.g. french as the insult
               | "cretin des alpes", lit. "cretin from the alps", and
               | "cretin" was the original term for CIDS-induced mental
               | impairment).
        
             | raverbashing wrote:
             | Tiktok mind and some angry people can't comprehend how hard
             | it was to actually get to the cause and solution to a lot
             | of diseases
        
             | k__ wrote:
             | Can I get some benefits of doubt please? :D
             | 
             | I don't question the initiative.
             | 
             | The article just read like it was some strange illness that
             | affected Switzers around a certain time.
        
               | hef19898 wrote:
               | The article mentions comments from the 19th century about
               | the same subject.
               | 
               | I think, that Switzerland, and especially those remote
               | mountain regions, stayed more isolated than similar
               | regions in France or Austria well into the early 20th
               | century, making the issue stand out more in comparison.
        
               | bbu wrote:
               | The country: Switzerland The people: Swiss
               | 
               | The word Switzer isn't in use since a very long time :)
        
               | k__ wrote:
               | Sorry, I was lazy and just translated Schweizer without
               | checking :D
        
             | concordDance wrote:
             | > I am always flabbergasted when people question incredibly
             | effective public health initiatives.
             | 
             | I think it comes from a generalised distrust of
             | governments/big institutions. Which comes from hearing
             | (often heavily distorted) stories about things like
             | Tuskegee Syphilis, MKULTRA, CIA vaccinators in Afghanistan
             | and Thalidomide.
        
           | bee_rider wrote:
           | I think it was.
           | 
           | We just don't think about it because we've defeated it
           | completely by putting iodine in the most popular spice, and
           | also people in the past were afflicted by all sorts of
           | horrible illnesses. It doesn't stand out from the noise of
           | the past being generally a mess.
        
             | k__ wrote:
             | Ah, okay.
             | 
             | The article just read like there were some unusual strange
             | things going on around 1900 in Switzerland.
        
               | jeffrallen wrote:
               | Swiss geology (retreat of the glaciers 10000 years ago)
               | meant that the normal local products that would give a
               | population iodine (milk and eggs) were themselves iodine-
               | poor. A few parts of Switzerland which were not glaciated
               | (i.e. Jura) did not have iodine deficient populations.
               | 
               | Other places in the world had different geology and this
               | different levels of natural iodine.
        
               | VintageCool wrote:
               | The article referenced mentions of goitre in Switzerland
               | from Victor Hugo in 1839, Mark Twain in 1880, a medical
               | survey in 1883, and Roman authors like Vitrivius and
               | Pliny the Elder. It also mentioned that the iodine idea
               | had been going around for a hundred years before the
               | activities of the heroes of our story.
               | 
               | Iodine had not been seen as a successful cure before
               | because excess iodine causes a horrible condition. The
               | key difference here was that Hunziker proposed regular
               | use in minute quantities, and then Bayard tested the
               | hypothesis with careful measurements and convincing
               | evidence.
        
               | the_mitsuhiko wrote:
               | Goethe wrote in 1779 about his travels to Switzerland:
               | "Die scheusslichen Kropfe haben mich ganz und gar ublen
               | Humors gemacht ("The horrible goiters have given me a
               | very bad sense of humour"). Definitely plenty of earlier
               | historic evidence.
        
           | gpvos wrote:
           | What makes you think it wasn't? The article doesn't claim so.
        
           | nyokodo wrote:
           | > How come that the disease wasn't widespread earlier?
           | 
           | The article makes reference to the Madonna on the Albrecht
           | Durer's Dresden Altarpiece having an obvious goiter. That was
           | produced in the late 15th to early 16th century. That's
           | evidence from the article that the problem was so common then
           | that it was depicted in sacred art.
        
           | kergonath wrote:
           | It was. Cretinism was one of the manifestations of iodine
           | deficiency. The trope of _cretin des Alpes_ (lit. cretin from
           | the Alps) existed for a reason. The manifestation was goitres
           | and stunted development, with people who seemingly stopped
           | growing up around 14. Pretty much the story's subject. It was
           | a public health problem before iodised salt.
           | 
           | https://en.m.wikipedia.org/wiki/Congenital_iodine_deficiency.
           | ..
        
           | srott wrote:
           | In Slovakia, another landlocked country with lack of natural
           | iodine from rainfall or diet, dementia became part of the
           | culture. 30% (!!!) of population suffered from dementia.
           | Iodizing salt raised IQ by 10 point every 10~ years but the
           | damage is irreparable...
        
           | ufo wrote:
           | It was widespread but has always been particularly worse in
           | inland mountainous regions. To this day, efforts remain to
           | eliminate iodine deficiency worldwide.
           | https://ign.org/scorecard/
        
         | mytailorisrich wrote:
         | With the complex supply chains and processed/ready-made food we
         | have nowadays I am wondering how much iodine makes its way into
         | the diet of the Swiss today even without ioded table salt.
         | 
         | I suspect that one of the issues was that most/all food used to
         | be sourced locally, especially eggs and milk, which are good
         | sources of iodine, with seafood probably mostly absent from the
         | Swiss diet.
         | 
         | Edit: apparently nowadays, and taking animal feed into account,
         | Switzerland imports about 50% of its food.
        
           | bombcar wrote:
           | Most processed food uses uniodized salt iirc, which is
           | actually becoming a problem in parts of the USA where
           | populations eat nothing but processed food.
        
             | mytailorisrich wrote:
             | My understanding is that in general there no need for
             | supplements with a normal, balanced diet, especially with
             | eggs, dairy products, grains, and others if iodine is
             | naturally present in the environment.
             | 
             | So if Switzerland imports a lot of those, raw, or in
             | prepared/processed food, or even the animal feed for its
             | hens and cows the Swiss today probably already get much
             | more iodine in their diet than 100 years ago.
        
               | dr_kiszonka wrote:
               | I was curious about your point about normal diet and have
               | just looked it up. According to tables 1 and 2 in this
               | article [0], it may be hard for some people to get enough
               | (RDA) iodine from normal, not fortified foods.
               | 
               | 0. https://ods.od.nih.gov/factsheets/Iodine-
               | HealthProfessional/
        
               | oivey wrote:
               | People have been struggling to get enough iodine for a
               | hundred+ years. That's why it's added to salt. This isn't
               | a 21st century problem.
        
               | mytailorisrich wrote:
               | Isn't that what the whole article is about?
               | 
               | But the point is that Switzerland's environment is
               | especially poor in iodine hence the specific health
               | problems it used to have, and which were much less
               | serious in neighbouring countries.
        
               | eyphka wrote:
               | While the cases were high in switzerland, they were not
               | unique.
               | 
               | Link to an academic article discussing how the USA is now
               | in the dangerzone of iodine deficiency.
               | 
               | https://link.springer.com/article/10.1007/s12011-018-1606
               | -5#....
        
               | mytailorisrich wrote:
               | Of course they were not unique (though perhaps extreme).
               | I must say I don't get how the replies in this thread
               | relate to my comments...
        
           | 082349872349872 wrote:
           | Aromat uses iodised salt, so despite Zweifel the swiss have
           | nothing to fear
        
         | lostlogin wrote:
         | What are the arguments used against iodised salt? Where would
         | they get their iodine?
        
           | emmet wrote:
           | they're afraid it'll give them 5G or whatever shite they make
           | up on the spot
        
           | meepmorp wrote:
           | Some people dislike the flavor of iodized salt. But what
           | would you expect from future cretins?
        
             | ch4s3 wrote:
             | There's literally no way anyone can taste the difference
             | between iodized and non iodized table salt blind to the
             | source. There's just so little there, it seems the Swiss
             | standard is something like 25 mg/kg. There's probably more
             | plastic in the salt than iodine at this point.
        
               | tonfa wrote:
               | > There's probably more plastic in the salt than iodine
               | at this point.
               | 
               | Probably not in swiss salt tho (it's usually mountain
               | salt, not sea salt).
        
               | ch4s3 wrote:
               | I thought it was clear that I meant that in jest. My
               | point was that the amount of iodine is imperceptibly
               | small.
        
               | masklinn wrote:
               | People almost certainly confuse iodine with anticaking
               | agents.
        
               | tonfa wrote:
               | But microplastic in sea salt is a real thing (and might
               | be a bit worrying, personally I now always go for
               | mountain salt, deposited pre-anthropocene era)
        
               | ch4s3 wrote:
               | Sure. Even still you're talking about a highly abrasive
               | product often packed in plastic. But none of that is
               | material to my point.
        
               | caymanjim wrote:
               | What an absurd thing to fixate on. There are a million
               | other things you consume that are going to have more
               | microplastics in them.
        
               | ufo wrote:
               | Sadly, this is the argument that people give -\\_(tsu)_/-
        
             | lostlogin wrote:
             | The article mentions that blind taste testing couldn't
             | detect it at 10x the strength.
             | 
             | Surely people test before claiming such things?
             | 
             | "Unicef, concerned about the sensitivity of children to odd
             | flavours, commissioned a study in which rice was prepared
             | with salt iodised at ten times the maximum recommended
             | concentration. In double-blind taste tests, the iodine was
             | undetectable."
        
               | shakil wrote:
               | Iodized salt is almost always the industrially produced
               | variety, pure NaCL and much more salty than the natural
               | varieties - either sea or mountain salts that typically
               | include other minerals and are milder in flavor.
        
               | kergonath wrote:
               | We have iodised sea salt around here, and it's not more
               | nor less industrial than standard sea salt. It's true
               | that the flavour is different than hand-processed sea
               | salt or _fleur de sel_ because of those impurities (which
               | include microplastics and other less-than-ideal
               | compounds, though, even though I love and use mostly
               | barely-processed sea salt), but it is neither more nor
               | less salty.
        
               | pixl97 wrote:
               | That is more about crystal size and roughness than
               | anything else. Some companies are working on nanoscale
               | crystals of salt that allow you to use significantly less
               | salt for the same saltiness profile based on these
               | properties.
        
             | mosburger wrote:
             | FWIW, that was addressed in the article:
             | 
             | > Whatever chefs might claim, this fact is well
             | established: in 1995, Unicef, concerned about the
             | sensitivity of children to odd flavours, commissioned a
             | study in which rice was prepared with salt iodised at ten
             | times the maximum recommended concentration. In double-
             | blind taste tests, the iodine was undetectable.
        
               | meepmorp wrote:
               | I'm just repeating what people have told me.
        
               | CogitoCogito wrote:
               | In this instance it seems you should avoid this habit.
        
           | wouldbecouldbe wrote:
           | Depends on the salt, there are few that hardly contain more
           | then dairy, but some salts contain enough to make it make
           | sense.
           | 
           | My main issue with normal salt is the anti-caking ingredient
           | needed to not have it stick together, in general not needed
           | with sea salt and a real grinder.
        
             | EdwardDiego wrote:
             | You hate sand, huh.
        
               | morsch wrote:
               | The anti caking I commonly see in salt is potassium
               | cyanide [ferrocyanide, actually, see below].
               | 
               | https://en.m.wikipedia.org/wiki/Potassium_ferrocyanide
        
               | brilee wrote:
               | I'm sure you're aware that ferrocyanide is not the same
               | thing as cyanide - the cyanide is bound so tightly to the
               | iron center that it is nontoxic.
        
               | oynqr wrote:
               | That is not potassium cyanide.
        
               | morsch wrote:
               | Yes, sorry, shouldn't post in a hurry. I amended my post.
               | I'm not worried about the stuff at all, I buy salt with
               | it all the time. But it's not sand, that's all I wanted
               | to say.
        
               | tekla wrote:
               | Skipped High School Chemistry huh? Read the Wiki
               | 
               | >Potassium ferrocyanide is nontoxic, and does not
               | decompose into cyanide in the body. The toxicity in rats
               | is low, with lethal dose (LD50) at 6400 mg/kg.[2] The
               | kidneys are the organ for ferrocyanide toxicity.[11]
        
               | wouldbecouldbe wrote:
               | Most common one used here is Sodium Ferrocyanide :
               | https://en.wikipedia.org/wiki/Sodium_ferrocyanide
               | 
               | Also used as a coating in welding among other things. And
               | like other commentor said, a nephew of cyanide.
               | 
               | Now Im sure most of us will be fine, but I prefer not to
               | eat that a few times a day. If you think that makes me
               | foolish, be my guest.
               | 
               | It's also not needed, there are plenty of other sources
               | of Iodine, and sea salt from the grinder is perfectly
               | fine.
        
           | jghn wrote:
           | I've 100% switched to kosher salt & various sea salts with my
           | own cooking. Not because I'm anti-iodine, but because I like
           | those salts better for cooking purposes. Given how much
           | attention was paid to using kosher salt in cooking by people
           | like Alton Brown over the last 20 years I would expect I'm
           | far from an outlier.
        
             | ramraj07 wrote:
             | Isn't kosher salt literally just regular salt but in a
             | particular particle size? I also use Himalayan and kosher
             | salt but thats because I eat a ton of junk food which has
             | iodised salt. If you're health conscious and don't do that,
             | it's probably not a bad idea to keep iodised salt and add
             | it in times it's not that important you need to pinch the
             | exact right amount in your fingers or whatever.
        
               | kergonath wrote:
               | You pretty much cannot have too much iodine. It is a good
               | idea to use iodised salt in general.
               | 
               | [edit] fair enough, I need to qualify that. You pretty
               | much cannot get too much iodine with something that looks
               | like a normal diet, and in any case iodised salt is not
               | what push iodine levels over the top. And in a normal
               | diets, iodine deficiency is much, much more likely than
               | iodine overload.
        
               | saturn_vk wrote:
               | The article states otherwise
        
               | manymatter wrote:
               | Well, the article brings up iodine overdose from popular
               | medications at the time, but you pretty much can't get
               | too much iodine from iodized salt without having consumed
               | way too much salt.
        
               | romwell wrote:
               | >The article states otherwise
               | 
               | No it doesn't. You're ignoring the context.
               | 
               | You _can 't_ have too much iodine when it's obtained from
               | iodized salt.
               | 
               | ...because you can't handle that much salt.
               | 
               | From the article: 10x'ing the concentration of iodine in
               | salt had no adverse effects. You'd have to eat salt by
               | the pound daily to reach levels where iodine is harmful,
               | but at that point, that'll be the least of your worries.
        
               | tomrod wrote:
               | To be fair to the interlocuters, kergonath left the salt
               | out of his or her or their comment.
        
               | MichaelZuo wrote:
               | > You pretty much cannot have too much iodine.
               | 
               | Based on what reasoning?
        
               | kashunstva wrote:
               | > You pretty much cannot have too much iodine
               | 
               | You may wish to research the Wolff-Chaikoff effect.
        
             | kergonath wrote:
             | That's fine for people who have a balanced diet rich enough
             | in iodine. Which, to be fair, should be most people
             | bothering about sea salt in the first place. For those who
             | do not, it's unfortunate, though. There is a reason why
             | adding iodine is a good idea in the first place.
        
           | kergonath wrote:
           | Pretty much the same as against fluorine in water in the
           | States: it's unnatural/a globalist conspiracy/killing our
           | traditional way of life/a plot to subdue the people for
           | <reasons>.
           | 
           | There is no scientifically sound reason against it.
        
             | tourmalinetaco wrote:
             | There's scientifically sound reasons for not wanting to
             | drink fluorine, namely that the science is still out for
             | whether it's useful when used alongside regular topical
             | applications. Not to mention excessive fluorine can stain
             | or pit the teeth, and that it may even destroy nerve
             | tissue.
             | 
             | https://www.hsph.harvard.edu/magazine/magazine_article/fluo
             | r...
        
               | kleton wrote:
               | Only the measurable decrease in IQ from municipal water
               | fluoridation, which can seen when comparing Portland,
               | where they do not fluoridate, to similar large cities in
               | the PNW where they do.
        
               | lostlogin wrote:
               | > the science is still out for whether it's useful when
               | used alongside regular topical applications.
               | 
               | That's a meaningless comparison. The whole point is that
               | people aren't doing topical application.
               | 
               | A similar debate to this is the adding folate to flour or
               | bread.
        
             | Cockbrand wrote:
             | Well, fluoridated water tastes really... well, _special_ ,
             | and it almost feels like an indirect subsidy for the water
             | filter industry. Iodine in salt is (to my taste) pretty
             | neutral in comparison.
             | 
             | [EDIT: as pointed out in a child comment, the taste
             | actually comes from chlorine, not fluoride.]
        
               | naremu wrote:
               | Isn't that taste chlorine from the sanitation process?
               | 
               | Either way I actually do assume water filter companies
               | lobby to keep public water as subpar an option as
               | possible, there's certainly no incentive not to.
        
               | Cockbrand wrote:
               | Yes, you're right, I mixed up fluoride and chlorine. And
               | thus my previous comment doesn't make sense any more. My
               | apologies!
        
             | colechristensen wrote:
             | There is scientific reason against it, just not matching
             | many of the conspiracy nuts' rhetoric.
             | 
             | Most of Western Europe bans fluoridation. It can make your
             | bones a little less elastic and a little more brittle, and
             | there are a few other known or potential negative effects.
             | 
             | There are also just better ways to prevent cavities.
        
               | naremu wrote:
               | This seems like the sane, boring reality. People with
               | modern dental routines probably don't benefit from the
               | original purposes of fluoridation the same way people in
               | the early 1900s only just getting electricity did.
               | 
               | But people only just getting electricity in the early
               | 1900s easily benefited more than were harmed by such
               | things. Poor dental health gets scary quick.
               | 
               | I guess the question becomes how low do you lower the bar
               | for those who would willingly devoid themselves of sane
               | things to include in their lives. How much freedom does
               | one man have to harm his self, though he thinks as a
               | self, costs to him are more often than not also costs
               | incurred to society (and usually a society that'd prefer
               | to not see people do self harmful things)
               | 
               | At least in the US though, it seems that popular
               | opposition to fluoridation started with cold war era
               | conservative conspiracies (precious bodily fluids). So,
               | you know.
        
             | palemoonale wrote:
             | This from a country where tapwater unfortunately typically
             | tastes like crap?
             | 
             | (b/c it is chlorinated)
        
               | pixl97 wrote:
               | Unless it is significantly over chlorinated tasting like
               | crap isn't because of the chlorine, in general the
               | causation will be reversed here. Places that use a lot of
               | chlorine are typically trying to kill off things that
               | both taste bad and will try to kill you.
        
             | dllthomas wrote:
             | You forgot "sap and impurify all of our precious bodily
             | fluids"
        
               | TheCleric wrote:
               | I deny them my essence.
        
             | kleton wrote:
             | In Deutschland, the iodized salt is nearly always
             | iodized+fluoridated, whereas the only other option is plain
             | salt with neither.
        
           | dfxm12 wrote:
           | I always heard if you eat seafood, you get enough iodine and
           | can stick to plain salt. It looks like milk and eggs are a
           | good source as well.
           | 
           | https://www.medicalnewstoday.com/articles/iodine-rich-foods
        
         | analog31 wrote:
         | They probably get plenty of iodine from packaged food since it
         | doesn't all come from the same region any more.
        
           | wahern wrote:
           | The salt used in processed and prepared foods usually isn't
           | iodized, contributing to declining iodine intake given the
           | increasing consumption of these foods.
        
             | tomjakubowski wrote:
             | industrially farmed cattle are often fed iodized salt,
             | which can make their dairy products a good source of
             | iodine. depends on the farm's practices though
             | 
             | https://pubmed.ncbi.nlm.nih.gov/29221567/
        
             | ufo wrote:
             | Depends on the country. That's the case in the USA but I'm
             | not sure if it applies in Europe.
        
             | analog31 wrote:
             | Good point. I'd hope that there are other sources of iodine
             | than salt in regions that have higher iodine content --
             | after all, salt was just the vehicle chosen for the
             | supplement. But I can also see what you say about prepared
             | foods.
        
           | chasil wrote:
           | One interesting use of iodine supplementation is during
           | nuclear accidents, where it is given to flood the thyroid and
           | prevent unstable iodine isotopes from being taken up.
           | 
           | "Iodine-131 (usually as iodide) is a component of nuclear
           | fallout, and is particularly dangerous owing to the thyroid
           | gland's propensity to concentrate ingested iodine and retain
           | it for periods longer than this isotope's radiological half-
           | life of eight days. For this reason, people at risk of
           | exposure to environmental radioactive iodine (iodine-131) in
           | fallout may be instructed to take non-radioactive potassium
           | iodide tablets... Ingestion of [a] large dose of non-
           | radioactive iodine minimises the uptake of radioactive iodine
           | by the thyroid gland."
           | 
           | https://en.wikipedia.org/wiki/Iodine#Other_formulations
        
             | ufo wrote:
             | I-131 also has some interesting history as the very first
             | application of radioactive isotopes in a medical setting.
             | It's used to treat hyperthyroidism and thyroid cancer.
        
           | the_mitsuhiko wrote:
           | Unclear but Germany is monitoring iodine intake and
           | insufficiency is on the rise.
           | 
           | https://www.klartext-
           | nahrungsergaenzung.de/wissen/lebensmitt...
        
       | NelsonMinar wrote:
       | Lovely article. It reminds me of the relationship of scurvy and
       | Vitamin C. Despite scurvy being largely understood around 1750
       | the knowledge was forgotten or replaced with wrong theories as
       | late as 1911. https://idlewords.com/2010/03/scott_and_scurvy.htm
        
         | routerl wrote:
         | Lovely. Thanks for posting that.
         | 
         | With all our popular narratives about the inevitability of
         | scientific progress, it's always refreshing (from a historical
         | point of view) and important (from a personal, ethical
         | perspective) to remember that there's no guarantee that
         | chronologically later developments will necessarily be
         | improvements on earlier conclusions.
         | 
         | It brings to mind our current replication crises in science.
        
           | vladms wrote:
           | Depends what you mean by "development", as the article does
           | not describe developments on treating scurvy, but rather
           | somehow random actions based on wrong assumptions (ex: limes
           | are the same as lemons; acidity is all that matters).
           | 
           | And even if in this case the initial solution was correct, it
           | was still observing a correlation, as they had no clue why
           | lemons do the job.
           | 
           | My conclusion based on the article is that just experimenting
           | is not enough, you also need to develop and test a complex
           | understanding of the system. We probably don't cherish enough
           | as a society, that some of us (as in: trained researchers,
           | etc.) have a mindset that expects both replication and
           | understanding, even if being humans we don't always reach
           | this ideal.
        
         | chihuahua wrote:
         | The article you're linking to is one of my favorite pieces of
         | writing ever.
        
           | NelsonMinar wrote:
           | Maciej has a real gift for writing. His three part travelogue
           | of visiting Yemen has been on my mind a lot recently. He
           | published the first installment just a few months before the
           | civil war started. https://idlewords.com/2015/05/ta_izz.htm
        
         | pixl97 wrote:
         | Before the internet I was like "how could we lose information
         | like that and replace it with junk", but now I'm like "oh, I
         | see exactly how that happens"
        
         | Kalium wrote:
         | It's worth noting the critical details: how to prevent scurvy
         | was understood, but the underlying mechanisms were not. This
         | mattered because it meant _why_ the treatment worked was not
         | understood, with the result being a resurgence when a
         | supposedly effective treatment turned out to be ineffectual.
         | 
         | Basically, it's easy to think we understand something when we
         | have a solution to it, but the two should not be automatically
         | conflated.
        
       | bill38 wrote:
       | Goitre and cretinism was present in French Alps too.
        
         | eep_social wrote:
         | > In the last ice age, a permanent ice sheet formed over the
         | Alps. Up to one kilometre thick, its tremendous weight ground
         | against the terrain. It thawed and refroze in stages, and with
         | every thaw, meltwater washed out the rubble. Over the course of
         | 100,000 years, this ice sheet tore the top 250 metres of rock
         | and soil from the surface of the Swiss Central Plateau. At its
         | peak, about 24,000 years ago, it extended across all the
         | northern cantons. It did not reach the Jura or Ticino. In 1964,
         | Dr Franz Merke, a Basel surgeon, showed that the extent of the
         | ice sheet 'corresponded precisely' with the prevalence of
         | goitre: Switzerland had been stripped of its iodine.
        
         | skrebbel wrote:
         | Nothing in the article suggests it magically stopped at the
         | border.
        
       | catgary wrote:
       | That was a fascinating read - there's even a great villain in
       | Eugene Bircher (not to get into politics, but he definitely seems
       | to have trailblazer the "right wing populist attacks successful
       | public health measures" strategy).
        
         | karmakurtisaani wrote:
         | Not to be confused with Max Bircher-Benner, the inventor of
         | Birchermuesli.
        
         | rdevsrex wrote:
         | It's so sad how many people's heath is affected by assholes
         | trying to protect their ego.
        
         | Shacklz wrote:
         | I always find it fascinating that we don't "anti-celebrate"
         | such obvious failures in history more. I remember reading the
         | original article of the author (linked in another comment in
         | here) in German and I haven't ever heard of Bircher before.
         | 
         | Peddling nonsense against better knowledge that causes this
         | amount of suffering deserves ridicule in posterity. We
         | shouldn't just celebrate those who do great things for
         | humanity, but also "anti-celebrate" those who do great harm.
        
           | throwaway8877 wrote:
           | National shaming day.
        
             | hef19898 wrote:
             | I am affraid some people would take this and turn it into a
             | day of celibration...
        
           | lostlogin wrote:
           | If be more in favour of anti-celebrating the bad idea than of
           | pillorying the individual. Though there is the odd individual
           | who needs more criticism.
        
         | hef19898 wrote:
         | My first thought when Bircher's political, and other, actiobs
         | where mentioned in the article, was: Why am I not surprised?
        
           | lostlogin wrote:
           | Opposition to public health measures doesn't seem to be
           | related to left or right politics as far as I can tell -
           | there are numerous examples in both directions and the
           | history is long. Early examples that come to mind include
           | opposition to sewers and small pox vaccines.
        
         | Vespasian wrote:
         | It feels like occasional people have to be reminded of
         | consequences.
         | 
         | Otherwise polio, measles and the like are still as dangerous as
         | they ever were and are ready to make their big return if
         | vaccination rates drop too much. I'm certain even small pox is
         | lurking somewhere out there.
         | 
         | It seems like, unfortunately, humanities book of learned
         | lessons gets reprinted in pain and suffering once in a while.
        
           | catgary wrote:
           | He was reminded every day as his home canton still had high
           | rates of gout and children being born deaf/mute.
        
             | hef19898 wrote:
             | Since he offered treatment packages, that meant a larger
             | customer base?
        
               | catgary wrote:
               | Like dentists who are against fluoride in water, I guess.
        
               | hef19898 wrote:
               | Fluoride in water is different so, as the better
               | alternative is adding it to tooth paste.
        
         | btbuildem wrote:
         | That jumped out at me as well -- the parallels (and political
         | alignments) are unmistakeable. We see the same today with the
         | current plague.
        
         | k33n wrote:
         | I don't understand why tacit support of leftism is allowed but
         | if I counter it, I am immediately flagged.
         | 
         | Very unfair that this is still happening on a site with so many
         | smart people on it.
        
       | attachedhead wrote:
       | This seems to be a slightly shortened version of an earlier
       | article by the same author. The swiss weekly magazine "Das
       | Magazin" published a german translation of this longer version in
       | 2019 [1]. It is an absolutely fascinating read.
       | 
       | Since the article from OP is relatively short on images, the
       | following are links to more images from the german article, with
       | captions translated into english. Warning: images contain
       | depictions of the medical condition discussed in the article.
       | YMMV, but i don't consider them 'gross' or NSFW.
       | 
       | Image 1:
       | https://cdn.unitycms.io/images/EzdPT4pM4HAAzsQiwi_L2d.jpg
       | Caption: Woman with goitre in Frienisberg, 1921.
       | 
       | Image 2:
       | https://cdn.unitycms.io/images/5PhByWEba4W8L0W1EnHXiE.jpg
       | Caption: Woman with cretinism, 1928. (Today the word has a
       | derogatory connotation, but primarily describes an illness of
       | great cruelty).
       | 
       | Image 3:
       | https://cdn.unitycms.io/images/Bu0SX8WY4gK8jMZgebpyss.jpg
       | Caption: Six women with cretinism, ca. 1920.
       | 
       | Image 4: https://cdn.unitycms.io/images/8qBQEgsuqq-
       | BMdsEAPN63U.jpg Caption: Found the solution to Switzerland's
       | original curse: Heinrich Hunziker from Adliswil ZH, drawn by
       | Marianne Zumbrunn in 1977.
       | 
       | Image 5:
       | https://cdn.unitycms.io/images/7tdlChuPq-3AIeFiSvh5U1.jpg
       | Caption: Experiments with the snow shovel: the Valais country
       | doctor Otto Bayard, 1937.
       | 
       | Image 6:
       | https://cdn.unitycms.io/images/5JGFFaXN48BA4xOsHXf0Zu.jpg
       | Caption: Sun-tanned outdoorsman: the Herisau general practitioner
       | and later chief physician Hans Eggenberger, undated.
       | 
       | [1] https://www.tagesanzeiger.ch/wie-drei-heldenhafte-aerzte-
       | die... or https://archive.is/rHzSV
       | 
       | edit: formatting, removed german caption texts
        
         | zwirbl wrote:
         | For German speakers there's also this 'Geschichten aus der
         | Geschichte' Podcast episode on the matter which does a fairly
         | good job telling the story IMO.
         | https://www.geschichte.fm/archiv/gag368/
        
           | Vespasian wrote:
           | Can absolutely recommend that one.
           | 
           | A fascinating story overall and a reminder of just one of a
           | number of everyday sicknesses we (as a society) have been
           | able to overcome through science and understanding, despite
           | the occasional step backwards.
        
       | bee_rider wrote:
       | I think, outside Europe, this afflicted lots of places away from
       | the coast, right? Like the middle part of the US.
       | 
       | I've always wondered if the iodine in the air is part of the
       | allure of the seaside.
       | 
       | Coastal areas of course have produced a huge number of successful
       | countries. Most of that must be the trade and logistics
       | advantages. I wonder if getting the iodine right out of the air
       | was another hidden major advantage though.
        
         | ajuc wrote:
         | There are health resorts here in Poland where the whole reason
         | is for them to exist in these particular places is because air
         | there has a lot of iodine and other minerals from sea salt.
         | I've been to one in Kolobrzeg as a child because of my asthma.
         | 
         | There are also inland health resorts where they build huge salt
         | evaporation walls so that people don't have to drive all the
         | way to the sea to breath sea air- for example in Ciechocinek.
         | And it's not modern technology - they have been built in early
         | 19th century already.
         | 
         | https://en.wikipedia.org/wiki/Ciechocinek_graduation_towers
         | 
         | https://pl.wikipedia.org/wiki/Ciechocinek#/media/Plik:Teznie...
        
           | jongjong wrote:
           | Sounds similar to many parts of eastern Europe and Russia.
           | People go to health retreats to drink water from specific
           | natural springs that are high in minerals.
        
             | ajuc wrote:
             | Yeah we have that too, but this is about evaporating it to
             | make the air healthy to breathe. Different benefits
             | compared to drinking.
             | 
             | Here's more about the mechanism:
             | https://en.wikipedia.org/wiki/Graduation_tower
             | 
             | Apparently the first such towers were built in 1600s.
        
         | contingencies wrote:
         | Yes. It was also common in mountainous areas of western China
         | and Tibet.
        
         | l5870uoo9y wrote:
         | To broaden the question; is it proven that sea air is
         | healthier? The top search results point in both directions.
        
           | kergonath wrote:
           | It is not. This kind of ideas is the remnant of the "bad air"
           | theory of diseases propagation, which is not actually a thing
           | and was displaced by germ theory at some point in the 19th
           | century. People clung on to this belief because why not (and
           | there was money to be made bringing rich people to
           | countryside or seaside resorts) but there is no real rational
           | justification. That's not to say that the atmosphere cannot
           | be harmful locally, but the seaside is not particularly
           | healthy.
        
         | masklinn wrote:
         | > I think, outside Europe, this afflicted lots of places away
         | from the coast, right? Like the middle part of the US.
         | 
         | That's exactly where it afflicted people in europe as well,
         | mountainous regions tend to be inlands, and from their
         | remoteness don't have the opportunity for incidental iodine
         | through trade, so they worsen the odds, but historically
         | distance from the sea (and thus lack of sea products) has
         | absolutely been the primary issue. CIDS was also endemic to the
         | english midlands for instance.
         | 
         | > I've always wondered if the iodine in the air is part of the
         | allure of the seaside.
         | 
         | No, intake from air is considered insignificant.
        
         | wirrbel wrote:
         | In my family there is definitely memory of this . My
         | grandmothers generation has seen the old folks with the
         | enlarged neck
        
           | hef19898 wrote:
           | I remember it from my grand-grandparents. It wasn't common-
           | common like in late 19th century Switzerland, but there was
           | at least one case close enough to come across yourself.
        
       | simtel20 wrote:
       | This brought back memories of being told that my grandfather had
       | invested in a factory to make iodized salt in china - probably in
       | the Shanghai area, pre-ww2. I do not believe it was a good
       | business for him, but that is how these things go sometimes. My
       | mother didn't have the visual or historical resources to really
       | show me, as a child, what goiters were.
       | 
       | I never really got it until reading this article. But I've always
       | made sure to have some iodized salt as I cook just to make sure
       | we don't end up deficient, understanding that there was some
       | easily avoided consequences at basically no cost.
        
       | hsuduebc2 wrote:
       | Very nice story. Love this stories of scientific progress. Thank
       | you.
       | 
       | And after reading it whole I must say. Fuck you Bircher.
        
       | pkdpic wrote:
       | Great read, but I'm wondering why this began in the 1920's? Or
       | was it always an issue for human beings living in Switzerland?
        
         | samus wrote:
         | The condition has been described since Roman times, but not
         | only in Switzerland. The problem also exists in other regions
         | in the Alps and other mountain chains across the world.
        
           | masswerk wrote:
           | Speaking of the Alps and related regions, this was also
           | considered a condition typical for Styrians (inhabitants of
           | the country of Styria) in Austria.
        
           | masklinn wrote:
           | > The problem also exists in other regions in the Alps and
           | other mountain chains across the world.
           | 
           | As well as in the lowlands, far enough away from the sea to
           | not have easy access to produces or sea salt through trade.
           | It used to be common in the english midlands and the US
           | midwest (as well as the appalachia and rockies).
        
         | dougmwne wrote:
         | The Victor Hugo quote in the article was from 1839.
         | Biologically speaking, this must have always been an issue. The
         | iodine had washed away from the area long before human
         | settlement. Before modern medicine, it would have been
         | difficult to collect the data and even establish the pattern.
         | People did not travel much in pre-modern times and many of
         | these mountain villages would receive highly educated visitors
         | very infrequently. They may have been barely aware that their
         | situation was anything other than normal. The world was beset
         | with maladies and this was just one medical mystery among all
         | the others. In 1875, life expectancy in Switzerland was just
         | 38, so life must have been harsher than any modern person can
         | imagine.
        
           | margalabargala wrote:
           | > In 1875, life expectancy in Switzerland was just 38
           | 
           | As is usually the case with numbers like this from the past,
           | this is a mean value, not a median value, that is massively
           | skewed downwards by having upwards of 50% child mortality by
           | age 4.
           | 
           | A typical Swiss person in 1875 who had already turned 30
           | could be expected to live to be 70.
           | 
           | Here's an article talking about this phenomenon [0]. They
           | term it "adult modal age at death", i.e. at what age do
           | people tend to die once they have survived childhood? In
           | Sweden, in 1875 an adult woman could be expected to live to
           | be 72, and an adult man to be 69. But the average life
           | expectancy in Sweden in 1875 was only 44.
           | 
           | Per the same article, the modal age at death for adults in
           | Switzerland in 1875 was 70 for both men and women.
           | 
           | [0] https://www.cairn-int.info/article-E_POPU_1204_0683--the-
           | mos...
        
       | phkahler wrote:
       | I am increasingly convinced that the "thyroid hormones" T1, T2,
       | T3, and T4 are simply a place to store iodine. When iodine is
       | needed somewhere in the body it can be taken from T4, converting
       | it to T3. But it's not the case that "T3 is the active form" as
       | you'll read in the literature, it's that the removed iodine is
       | the active or useful thing.
       | 
       | Changing the ratio of T3/T4 does cause a change in TSH (thyroid
       | stimulating hormone) but that's IMHO simply a signal that the
       | iodine is getting used, so please send us more.
       | 
       | There are other tissues in the body that need iodine, as
       | evidenced by the sodium-iodine symporter present on those cells,
       | so to set the recommended daily iodine intake based solely on
       | what the thyroid can use is IMHO a huge mistake.
       | 
       | Some things with interesting iodine research: skin cancer, breast
       | cancer, type 2 diabetes, asthma, polycystic ovaries, fibrocystic
       | breast disease, other cancers. But yeah, it cures goiter...
        
         | samus wrote:
         | ... and congenital deafness, low length growth, neurological
         | impairment, and other symptoms known as Congenital iodine
         | deficiency syndrome.
        
         | lostlogin wrote:
         | > Some things with interesting iodine research: skin cancer,
         | breast cancer, type 2 diabetes, asthma, polycystic ovaries,
         | fibrocystic breast disease, other cancers. But yeah, it cures
         | goiter...
         | 
         | When I search for breast cancer and iodine, I find links that
         | suggest iodine may help prevent that disease - and Japan's low
         | rate of the condition is potentially related to high
         | consumption of iodine.
         | 
         | Are you saying that all those conditions are due to excess
         | iodine?
        
           | vulcan01 wrote:
           | Based on their third paragraph, I assume they mean that
           | people are not eating _enough_ iodine.
        
             | lostlogin wrote:
             | I interpreted that as the opposite - just because the
             | iodine is getting used, it doesn't mean it should have
             | more.
             | 
             | I certainly find more on positive effects of iodine so I
             | think I've misunderstood OP.
        
         | philwelch wrote:
         | If this were true, it would mean that people with
         | hypothyroidism could simply supplement iodine rather than
         | needing to replace the hormones.
        
         | cperciva wrote:
         | _But it 's not the case that "T3 is the active form" as you'll
         | read in the literature, it's that the removed iodine is the
         | active or useful thing._
         | 
         | Supplementation with T3 yields a rapid correction in
         | bradycardia and hypothermia caused by hypothyroidism. We treat
         | with T4 because it has a longer physiological halflife and thus
         | yields more consistent serum levels; but the evidence is
         | incredibly clear that it's T3 which is having an effect, not
         | T4.
        
         | ufo wrote:
         | The thyroid is by far the largest consumer of iodine. It stores
         | iodine in thyroglobulin, which is the precursor to thyroid
         | hormone. I don't know the numbers, but I wouldn't be surprised
         | if the thyroid released more iodine by breaking down
         | thyroglobulin than breaking down thyroid hormone.
        
       | jazzkingrt wrote:
       | I'm Swiss. My grandfather has stories of family members afflicted
       | with Goitre. What a great read!
        
       | jackcosgrove wrote:
       | The use of the term cretin for those with stunted growth due to
       | iodine deficiency was not a pejorative. Cretin is a different
       | spelling of Chretien, French for Christian. It was short for
       | "poor Christian", a term for those suffering misfortune.
        
         | philwelch wrote:
         | This whole time I thought it was an ethnic slur against the
         | people of Crete.
        
       | tim333 wrote:
       | Paywall free https://archive.ph/3wrzh
       | 
       | > in 1921, in the city of Bern, 94 per cent of schoolchildren had
       | some swelling of the neck and almost 70 per cent had a goitre.
       | 
       | Gosh - it's surprising that years after discovering relativity
       | and the like they were still figuring that out. (Einstein lived
       | in Bern from 1903 to 1905 and developed his Theory of Relativity
       | there).
        
       | unnamed76ri wrote:
       | I wonder if this was at least a factor in Switzerland remaining
       | neutral in both world wars. If a significant portion of your
       | military age men are unfit for military duty due to goiters, that
       | would certainly affect your ability to conduct a war.
        
         | ng12 wrote:
         | Switzerland had a very active and well trained military during
         | both World Wars. In fact Swiss neutrality is at least partly
         | rooted in the historical role of Swiss mercenaries -- it was a
         | lot easier to sell your mercenaries if you weren't involved in
         | the war.
        
         | tonfa wrote:
         | > I wonder if this was at least a factor in Switzerland
         | remaining neutral in both world wars
         | 
         | probably has more to do with 1515 (Marignano) and 1815
         | (Congress of Vienna, which secured Switzerland as an
         | independent state, while enforcing neutrality).
        
       | btbuildem wrote:
       | What an interesting read! Fascinating to see how the theory was
       | conceived, tested, and put into practice -- and all that in the
       | backdrop of other approaches, even with the spectre of iodine as
       | a poison!
        
       | boobsbr wrote:
       | Happened in the French Alps as well.
       | 
       | Captain Haddock, from Tin Tin used to call people 'cretin des
       | Alpes'.
        
       | rmason wrote:
       | My father told me that goitre's were quite common when he was
       | growing up as a boy in Detroit in the 1920's. In my generation it
       | was totally unknown. Yet I remember people affected by polio as a
       | boy quite well. But I bet that millennials have no personal
       | experience with it at all. Each generation moves forward and I
       | can only hope there is a day when no one has any first hand
       | experience with either cancer or Alzheimer's.
        
         | masklinn wrote:
         | > But I bet that millennials have no personal experience with
         | it at all.
         | 
         | Mass vaccination started in the late 50s and especially early
         | 60s (with Sabin's oral vaccine).
         | 
         | Millennials start in 1981, so they would / could well have
         | known affected adults.
        
         | MBCook wrote:
         | The an entire area of the US that was called the Goiter Belt.
         | Basically the top half. It was _really_ common.
        
         | hankman86 wrote:
         | Only if sensible people continue to run the public health
         | authorities.
         | 
         | You now have people that refuse to vaccinate their children
         | against measles, COVID vaccine hesitancy is a widespread
         | phenomenon with some people resorting to heresay remedies like
         | horse dewormers instead, an anti-vaccine conspiracy theorist is
         | running for US president and polling with double digit numbers.
         | 
         | Health-related insights are particularly susceptible to
         | targeted misinformation. And in an era of social media, this
         | can quickly become a majority opinion.
        
       | dghughes wrote:
       | I had to start taking synthroid since about 5 years in my mid
       | 40s. In my mid 20s I was into Tae Kwon Do and while sparring a
       | guy taller and much heavier punch my in my neck. I have to wonder
       | if he damaged my thyroid.
        
         | ufo wrote:
         | I'd assume that the null-hypothesis is that it's unrelated. The
         | most common cause of hypo is Hashimoto's thyroiditis, an
         | autoimmune condition. More likely to appear the older you get.
        
       | more_corn wrote:
       | Iodine deficiency for everyone not willing to wade through the
       | story.
        
       | speeder wrote:
       | This article made me a little sad.
       | 
       | The article is about how people with a fear of iodine overdose
       | resisted the idea of adding it to salt on first place.
       | 
       | I spent my childhood in Brazil, a country where there are a good
       | amount of natural iodine. Yet the government decided to ignore
       | the risks, seemly well known for more than a century, and jack up
       | the iodine in the salt to levels beyond what any international
       | standard recommend or tested. And now I hypothyroidism caused by
       | iodine overdose.
        
       | tweetle_beetle wrote:
       | For anyone interested in this area, I would highly recommend
       | following the work of Iodine Global Network (and donating if
       | possible).
       | 
       | They work with politicians and industry in a very targetted way
       | to increase the use of iodised salt in food production where it
       | is most needed in the world. They don't directly fund any of the
       | activities, but create the relationships, conditions and
       | understanding for it to happen - meaning they are an extremely
       | effective charity, creating population scale change with very
       | modest funding.
       | 
       | They also do lots of work to try to map the global picture of
       | iodine intake from the very varied data available. Some of the
       | results might surprise you - https://ign.org/scorecard/
        
       | timClicks wrote:
       | It's fascinating how determined people are with their positions,
       | even in the face of overwhelming evidence that their position
       | causes harm. We see similar arguments today against folate
       | fortification of bread and fluoridation of water.
        
       | AlbertCory wrote:
       | I'll always be grateful to the doctor who just noticed my throat
       | being very _slightly_ enlarged, even though I wasn 't
       | complaining. I had my TSH tested and found that I needed the
       | synthetic thyroid hormone. It's cheap and you just take it once a
       | day.
       | 
       | Iodine deficiency is ONE cause of goiter, but not the only one.
       | 
       | https://www.healthline.com/health/hypothryroidism/hashimotos...
        
       | agnosticmantis wrote:
       | Reminds me of John Snow's discovery and demonstration of the
       | cause of cholera, which I learned about in the context of casual
       | inference in this excellent paper by statistician David Freedman:
       | 
       | https://psychology.okstate.edu/faculty/jgrice/psyc5314/Freed...
       | 
       | Actual science looks nothing like the shoddy paper churning that
       | we see in much of econ and social science using questionable and
       | assumption-heavy casual inference methods.
        
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