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5 Recommended Articles from PLOS Biology Associate Editor Richard Hodge

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Date: 2021-07-01 00:00:00

In our final installment of this recommended article series from our staff editors, Associate Editor Richard Hodge shares 5 picks for the PLOS Biology community.

Identification of 3′ UTR motifs required for mRNA localization to myelin sheaths in vivo

From the Abstract

“To investigate how mRNAs are targeted to myelin sheaths, we tested the hypothesis that transcripts are selected for myelin enrichment through consensus sequences in the 3′ untranslated region (3′ UTR).“

In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators

From the Abstract

“We conclude that APC/C coordinates crosstalk between cell cycle and chromatin regulatory proteins. This has potential consequences in normal cell physiology, where the chromatin environment changes depending on proliferative state, as well as in disease.“

Acetylation-mediated remodeling of the nucleolus regulates cellular acetyl-CoA responses

From the Abstract

“Our findings highlight acetylation-mediated control of the nucleolus as an important hub linking acetyl-CoA fluctuations to cellular stress responses.“

Histamine-induced biphasic activation of RhoA allows for persistent RhoA signaling

From the Abstract

“Thus, two divergent pathways enable both rapid activation and persistent signaling in receptor-mediated RhoA signaling via intricate temporal regulation.

Structural analyses of the PKA RIIβ holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma

From the Abstract

“These results provide new insights into how the finely tuned allosteric PKA signaling network is disrupted by the oncogenic J-C subunit, ultimately leading to the development of FL-HCC.“

Thank you to all our staff editors who shared exciting, interesting, and thought-provoking reads with our community. Missed a post? Click below to access the full series.

Want more from PLOS Biology? Visit our homepage for the latest news and articles from our researchers.

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[1] Url: https://biologue.plos.org/2021/07/01/5-recommended-articles-from-plos-biology-associate-editor-richard-hodge/

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