It depends what you compare yourself against. Yes, our insignificance on the scale of the Universe (or multi-verse even, which increases our insignificance) or to our galaxy, or to our star system, or to our planet, or to all of the people on the Earth is unquestionable. BUT: Our individual uniqueness cannot be questioned. There is no brain identical to your brain or to my brain. Even twins, ge...netically identical for all intents and purposes - have unique brain patterns - even if similar. In this unimaginably large universe, you are unique. There was, isn't and never will be another beau guffey or kenneth udut or anybody else reading this. And THIS - THIS is our significance. That you are here, even thinking about your insignificance, is unimaginably significant. "